Putative dynein arm light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein arm light chain, putative

Species:

Leishmania major

UniProt:

Q4QC94_LEIMA

TriTrypDb:

LmjF.21.1020 , LMJLV39_210017900 , LMJSD75_210018100

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC94

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.435
CLV_C14_Caspase3-7	264	268	PF00656	0.245
CLV_NRD_NRD_1	107	109	PF00675	0.378
CLV_NRD_NRD_1	149	151	PF00675	0.350
CLV_NRD_NRD_1	198	200	PF00675	0.432
CLV_NRD_NRD_1	244	246	PF00675	0.380
CLV_NRD_NRD_1	7	9	PF00675	0.529
CLV_NRD_NRD_1	79	81	PF00675	0.427
CLV_PCSK_KEX2_1	107	109	PF00082	0.378
CLV_PCSK_KEX2_1	149	151	PF00082	0.357
CLV_PCSK_KEX2_1	198	200	PF00082	0.284
CLV_PCSK_KEX2_1	244	246	PF00082	0.380
CLV_PCSK_KEX2_1	273	275	PF00082	0.372
CLV_PCSK_KEX2_1	279	281	PF00082	0.184
CLV_PCSK_KEX2_1	7	9	PF00082	0.762
CLV_PCSK_KEX2_1	74	76	PF00082	0.387
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.392
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.162
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.387
CLV_PCSK_SKI1_1	157	161	PF00082	0.281
CLV_PCSK_SKI1_1	170	174	PF00082	0.320
CLV_PCSK_SKI1_1	179	183	PF00082	0.275
CLV_PCSK_SKI1_1	198	202	PF00082	0.177
CLV_PCSK_SKI1_1	210	214	PF00082	0.302
CLV_PCSK_SKI1_1	75	79	PF00082	0.392
CLV_Separin_Metazoa	167	171	PF03568	0.378
DEG_Nend_UBRbox_1	1	4	PF02207	0.529
DOC_CKS1_1	103	108	PF01111	0.324
DOC_CYCLIN_RxL_1	154	163	PF00134	0.264
DOC_CYCLIN_RxL_1	195	203	PF00134	0.242
DOC_CYCLIN_RxL_1	72	82	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.596
DOC_MAPK_gen_1	74	85	PF00069	0.406
DOC_MAPK_MEF2A_6	179	186	PF00069	0.294
DOC_MAPK_MEF2A_6	90	98	PF00069	0.447
DOC_MAPK_NFAT4_5	179	187	PF00069	0.313
DOC_MAPK_RevD_3	94	108	PF00069	0.378
DOC_PP2B_LxvP_1	287	290	PF13499	0.504
DOC_PP4_FxxP_1	103	106	PF00568	0.264
DOC_USP7_MATH_1	124	128	PF00917	0.378
DOC_USP7_MATH_1	155	159	PF00917	0.245
DOC_USP7_MATH_1	73	77	PF00917	0.384
DOC_USP7_UBL2_3	217	221	PF12436	0.365
DOC_USP7_UBL2_3	74	78	PF12436	0.401
DOC_WW_Pin1_4	102	107	PF00397	0.308
DOC_WW_Pin1_4	120	125	PF00397	0.283
DOC_WW_Pin1_4	151	156	PF00397	0.331
DOC_WW_Pin1_4	19	24	PF00397	0.603
LIG_14-3-3_CanoR_1	170	177	PF00244	0.245
LIG_14-3-3_CanoR_1	80	84	PF00244	0.432
LIG_APCC_ABBA_1	184	189	PF00400	0.264
LIG_FHA_1	112	118	PF00498	0.284
LIG_FHA_1	151	157	PF00498	0.378
LIG_LIR_Apic_2	101	106	PF02991	0.245
LIG_PCNA_TLS_4	97	104	PF02747	0.245
LIG_PCNA_yPIPBox_3	29	39	PF02747	0.480
LIG_SH2_CRK	64	68	PF00017	0.378
LIG_SH2_NCK_1	64	68	PF00017	0.373
LIG_SH2_PTP2	48	51	PF00017	0.390
LIG_SH2_SRC	48	51	PF00017	0.505
LIG_SH2_SRC	64	67	PF00017	0.343
LIG_SH2_SRC	68	71	PF00017	0.233
LIG_SH2_STAT5	48	51	PF00017	0.408
LIG_SH3_1	64	70	PF00018	0.363
LIG_SH3_2	70	75	PF14604	0.385
LIG_SH3_3	48	54	PF00018	0.393
LIG_SH3_3	64	70	PF00018	0.345
LIG_SH3_3	88	94	PF00018	0.444
LIG_TRAF2_1	40	43	PF00917	0.636
LIG_WRC_WIRS_1	100	105	PF05994	0.245
MOD_CDC14_SPxK_1	154	157	PF00782	0.324
MOD_CDK_SPK_2	102	107	PF00069	0.324
MOD_CDK_SPxK_1	102	108	PF00069	0.378
MOD_CDK_SPxK_1	151	157	PF00069	0.324
MOD_CK1_1	102	108	PF00069	0.324
MOD_CK2_1	245	251	PF00069	0.312
MOD_GlcNHglycan	50	54	PF01048	0.514
MOD_GSK3_1	120	127	PF00069	0.288
MOD_GSK3_1	151	158	PF00069	0.333
MOD_GSK3_1	17	24	PF00069	0.634
MOD_GSK3_1	263	270	PF00069	0.167
MOD_N-GLC_1	10	15	PF02516	0.527
MOD_N-GLC_1	57	62	PF02516	0.466
MOD_NEK2_1	200	205	PF00069	0.278
MOD_NEK2_1	79	84	PF00069	0.427
MOD_NEK2_2	73	78	PF00069	0.403
MOD_PIKK_1	132	138	PF00454	0.378
MOD_PKA_2	148	154	PF00069	0.320
MOD_PKA_2	38	44	PF00069	0.530
MOD_PKA_2	79	85	PF00069	0.428
MOD_Plk_1	57	63	PF00069	0.376
MOD_Plk_4	57	63	PF00069	0.434
MOD_Plk_4	99	105	PF00069	0.245
MOD_ProDKin_1	102	108	PF00069	0.308
MOD_ProDKin_1	120	126	PF00069	0.283
MOD_ProDKin_1	151	157	PF00069	0.331
MOD_ProDKin_1	19	25	PF00069	0.596
MOD_SUMO_for_1	213	216	PF00179	0.245
MOD_SUMO_for_1	220	223	PF00179	0.245
MOD_SUMO_for_1	272	275	PF00179	0.245
MOD_SUMO_rev_2	71	76	PF00179	0.312
TRG_DiLeu_BaEn_1	178	183	PF01217	0.294
TRG_DiLeu_BaEn_1	255	260	PF01217	0.245
TRG_ENDOCYTIC_2	48	51	PF00928	0.371
TRG_ER_diArg_1	106	108	PF00400	0.378
TRG_ER_diArg_1	198	200	PF00400	0.441
TRG_ER_diArg_1	243	245	PF00400	0.396
TRG_NES_CRM1_1	224	239	PF08389	0.329
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q9	Leptomonas seymouri	81%	99%
A0A0S4J6T9	Bodo saltans	32%	100%
A0A0S4J9S1	Bodo saltans	33%	100%
A0A0S4KGN7	Bodo saltans	58%	100%
A0A1X0NVG2	Trypanosomatidae	35%	100%
A0A1X0NXR5	Trypanosomatidae	61%	95%
A0A3Q8IC16	Leishmania donovani	32%	100%
A0A3R7KMX9	Trypanosoma rangeli	35%	100%
A0A3S7WWL7	Leishmania donovani	96%	100%
A0A422NWB3	Trypanosoma rangeli	59%	100%
A4HBW2	Leishmania braziliensis	88%	94%
A4I0S3	Leishmania infantum	32%	100%
D0A1A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
D0A753	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AGX0	Leishmania infantum	96%	100%
E9AIH0	Leishmania braziliensis	37%	100%
E9AV86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	93%
E9AWS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O14645	Homo sapiens	35%	100%
Q39604	Chlamydomonas reinhardtii	34%	100%
Q4FZV3	Rattus norvegicus	35%	100%
Q4QAP9	Leishmania major	35%	100%
Q4R3K5	Macaca fascicularis	33%	100%
Q8BVN8	Mus musculus	35%	100%
Q9VGG6	Drosophila melanogaster	30%	100%
V5B9Q0	Trypanosoma cruzi	34%	81%
V5BR59	Trypanosoma cruzi	34%	100%