CCDC66 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC93_LEIMA

TriTrypDb:

LmjF.21.1030 , LMJLV39_210018000 , LMJSD75_210018200

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC93

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	668	672	PF00656	0.839
CLV_NRD_NRD_1	330	332	PF00675	0.600
CLV_NRD_NRD_1	351	353	PF00675	0.485
CLV_NRD_NRD_1	359	361	PF00675	0.595
CLV_NRD_NRD_1	396	398	PF00675	0.658
CLV_NRD_NRD_1	404	406	PF00675	0.701
CLV_NRD_NRD_1	47	49	PF00675	0.688
CLV_NRD_NRD_1	485	487	PF00675	0.564
CLV_NRD_NRD_1	522	524	PF00675	0.583
CLV_NRD_NRD_1	536	538	PF00675	0.711
CLV_NRD_NRD_1	7	9	PF00675	0.610
CLV_NRD_NRD_1	806	808	PF00675	0.709
CLV_PCSK_FUR_1	349	353	PF00082	0.448
CLV_PCSK_FUR_1	367	371	PF00082	0.708
CLV_PCSK_KEX2_1	351	353	PF00082	0.492
CLV_PCSK_KEX2_1	359	361	PF00082	0.612
CLV_PCSK_KEX2_1	369	371	PF00082	0.604
CLV_PCSK_KEX2_1	396	398	PF00082	0.626
CLV_PCSK_KEX2_1	404	406	PF00082	0.641
CLV_PCSK_KEX2_1	47	49	PF00082	0.688
CLV_PCSK_KEX2_1	485	487	PF00082	0.564
CLV_PCSK_KEX2_1	522	524	PF00082	0.583
CLV_PCSK_KEX2_1	536	538	PF00082	0.711
CLV_PCSK_KEX2_1	6	8	PF00082	0.613
CLV_PCSK_KEX2_1	716	718	PF00082	0.593
CLV_PCSK_KEX2_1	806	808	PF00082	0.716
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.706
CLV_PCSK_PC1ET2_1	716	718	PF00082	0.593
CLV_PCSK_PC7_1	3	9	PF00082	0.614
CLV_PCSK_PC7_1	518	524	PF00082	0.687
CLV_PCSK_SKI1_1	323	327	PF00082	0.586
CLV_PCSK_SKI1_1	372	376	PF00082	0.613
CLV_PCSK_SKI1_1	424	428	PF00082	0.749
CLV_PCSK_SKI1_1	522	526	PF00082	0.580
DEG_APCC_DBOX_1	517	525	PF00400	0.687
DEG_Nend_Nbox_1	1	3	PF02207	0.660
DEG_SPOP_SBC_1	440	444	PF00917	0.750
DEG_SPOP_SBC_1	657	661	PF00917	0.564
DEG_SPOP_SBC_1	664	668	PF00917	0.560
DOC_CKS1_1	417	422	PF01111	0.592
DOC_CKS1_1	736	741	PF01111	0.742
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	463	466	PF00134	0.790
DOC_CYCLIN_yCln2_LP_2	491	497	PF00134	0.709
DOC_MAPK_gen_1	184	191	PF00069	0.685
DOC_MAPK_gen_1	536	544	PF00069	0.660
DOC_MAPK_MEF2A_6	184	191	PF00069	0.685
DOC_PP2B_LxvP_1	175	178	PF13499	0.776
DOC_PP2B_LxvP_1	414	417	PF13499	0.577
DOC_PP2B_LxvP_1	432	435	PF13499	0.674
DOC_PP2B_LxvP_1	457	460	PF13499	0.814
DOC_PP2B_LxvP_1	463	466	PF13499	0.691
DOC_PP2B_LxvP_1	491	494	PF13499	0.654
DOC_PP2B_LxvP_1	607	610	PF13499	0.678
DOC_PP2B_LxvP_1	655	658	PF13499	0.722
DOC_PP4_FxxP_1	683	686	PF00568	0.703
DOC_PP4_FxxP_1	687	690	PF00568	0.702
DOC_PP4_FxxP_1	764	767	PF00568	0.763
DOC_PP4_FxxP_1	97	100	PF00568	0.585
DOC_USP7_MATH_1	150	154	PF00917	0.732
DOC_USP7_MATH_1	195	199	PF00917	0.671
DOC_USP7_MATH_1	213	217	PF00917	0.780
DOC_USP7_MATH_1	275	279	PF00917	0.813
DOC_USP7_MATH_1	426	430	PF00917	0.749
DOC_USP7_MATH_1	441	445	PF00917	0.559
DOC_USP7_MATH_1	458	462	PF00917	0.513
DOC_USP7_MATH_1	538	542	PF00917	0.737
DOC_USP7_MATH_1	575	579	PF00917	0.772
DOC_USP7_MATH_1	581	585	PF00917	0.730
DOC_USP7_MATH_1	597	601	PF00917	0.738
DOC_USP7_MATH_1	643	647	PF00917	0.701
DOC_USP7_MATH_1	650	654	PF00917	0.723
DOC_USP7_MATH_1	658	662	PF00917	0.702
DOC_USP7_MATH_1	664	668	PF00917	0.596
DOC_USP7_MATH_1	745	749	PF00917	0.752
DOC_USP7_MATH_1	752	756	PF00917	0.658
DOC_USP7_UBL2_3	328	332	PF12436	0.628
DOC_USP7_UBL2_3	424	428	PF12436	0.826
DOC_WW_Pin1_4	119	124	PF00397	0.775
DOC_WW_Pin1_4	132	137	PF00397	0.633
DOC_WW_Pin1_4	160	165	PF00397	0.678
DOC_WW_Pin1_4	167	172	PF00397	0.611
DOC_WW_Pin1_4	204	209	PF00397	0.830
DOC_WW_Pin1_4	224	229	PF00397	0.481
DOC_WW_Pin1_4	235	240	PF00397	0.723
DOC_WW_Pin1_4	247	252	PF00397	0.633
DOC_WW_Pin1_4	271	276	PF00397	0.851
DOC_WW_Pin1_4	416	421	PF00397	0.642
DOC_WW_Pin1_4	484	489	PF00397	0.688
DOC_WW_Pin1_4	573	578	PF00397	0.677
DOC_WW_Pin1_4	637	642	PF00397	0.743
DOC_WW_Pin1_4	693	698	PF00397	0.739
DOC_WW_Pin1_4	735	740	PF00397	0.721
DOC_WW_Pin1_4	748	753	PF00397	0.730
DOC_WW_Pin1_4	768	773	PF00397	0.732
DOC_WW_Pin1_4	785	790	PF00397	0.765
DOC_WW_Pin1_4	808	813	PF00397	0.816
LIG_14-3-3_CanoR_1	246	251	PF00244	0.712
LIG_14-3-3_CanoR_1	276	284	PF00244	0.731
LIG_14-3-3_CanoR_1	592	598	PF00244	0.800
LIG_14-3-3_CanoR_1	688	698	PF00244	0.732
LIG_14-3-3_CanoR_1	785	789	PF00244	0.712
LIG_14-3-3_CanoR_1	806	813	PF00244	0.711
LIG_Actin_WH2_2	469	487	PF00022	0.709
LIG_AP2alpha_2	268	270	PF02296	0.604
LIG_BIR_III_2	556	560	PF00653	0.578
LIG_CtBP_PxDLS_1	203	207	PF00389	0.717
LIG_EH_1	27	31	PF12763	0.672
LIG_EVH1_1	607	611	PF00568	0.691
LIG_EVH1_2	187	191	PF00568	0.686
LIG_FHA_1	161	167	PF00498	0.648
LIG_FHA_1	512	518	PF00498	0.663
LIG_FHA_1	523	529	PF00498	0.510
LIG_FHA_1	664	670	PF00498	0.752
LIG_FHA_1	713	719	PF00498	0.774
LIG_FHA_2	668	674	PF00498	0.833
LIG_FHA_2	795	801	PF00498	0.824
LIG_LIR_Apic_2	681	686	PF02991	0.707
LIG_LIR_Nem_3	160	165	PF02991	0.681
LIG_MYND_1	255	259	PF01753	0.667
LIG_Pex14_2	683	687	PF04695	0.805
LIG_SH2_CRK	133	137	PF00017	0.723
LIG_SH2_CRK	495	499	PF00017	0.632
LIG_SH2_NCK_1	128	132	PF00017	0.689
LIG_SH2_NCK_1	133	137	PF00017	0.725
LIG_SH2_NCK_1	554	558	PF00017	0.585
LIG_SH2_STAT5	21	24	PF00017	0.615
LIG_SH2_STAT5	236	239	PF00017	0.787
LIG_SH2_STAT5	474	477	PF00017	0.679
LIG_SH2_STAT5	495	498	PF00017	0.618
LIG_SH2_STAT5	569	572	PF00017	0.721
LIG_SH3_1	89	95	PF00018	0.741
LIG_SH3_3	161	167	PF00018	0.679
LIG_SH3_3	179	185	PF00018	0.687
LIG_SH3_3	207	213	PF00018	0.777
LIG_SH3_3	215	221	PF00018	0.698
LIG_SH3_3	250	256	PF00018	0.746
LIG_SH3_3	414	420	PF00018	0.662
LIG_SH3_3	459	465	PF00018	0.735
LIG_SH3_3	467	473	PF00018	0.619
LIG_SH3_3	605	611	PF00018	0.684
LIG_SH3_3	614	620	PF00018	0.710
LIG_SH3_3	64	70	PF00018	0.691
LIG_SH3_3	691	697	PF00018	0.738
LIG_SH3_3	733	739	PF00018	0.664
LIG_SH3_3	89	95	PF00018	0.709
LIG_SUMO_SIM_par_1	202	207	PF11976	0.714
LIG_TRAF2_1	299	302	PF00917	0.655
LIG_TRAF2_1	31	34	PF00917	0.682
LIG_WRC_WIRS_1	598	603	PF05994	0.662
MOD_CDC14_SPxK_1	771	774	PF00782	0.724
MOD_CDK_SPK_2	119	124	PF00069	0.698
MOD_CDK_SPK_2	224	229	PF00069	0.812
MOD_CDK_SPK_2	271	276	PF00069	0.841
MOD_CDK_SPK_2	772	777	PF00069	0.623
MOD_CDK_SPxK_1	167	173	PF00069	0.549
MOD_CDK_SPxK_1	768	774	PF00069	0.726
MOD_CDK_SPxxK_3	235	242	PF00069	0.746
MOD_CK1_1	160	166	PF00069	0.647
MOD_CK1_1	444	450	PF00069	0.761
MOD_CK1_1	516	522	PF00069	0.613
MOD_CK1_1	600	606	PF00069	0.660
MOD_CK1_1	667	673	PF00069	0.789
MOD_CK1_1	712	718	PF00069	0.742
MOD_CK1_1	748	754	PF00069	0.733
MOD_CK2_1	110	116	PF00069	0.737
MOD_CK2_1	194	200	PF00069	0.746
MOD_CK2_1	235	241	PF00069	0.707
MOD_CK2_1	28	34	PF00069	0.669
MOD_CK2_1	295	301	PF00069	0.649
MOD_CK2_1	667	673	PF00069	0.761
MOD_GlcNHglycan	112	115	PF01048	0.632
MOD_GlcNHglycan	159	162	PF01048	0.647
MOD_GlcNHglycan	192	195	PF01048	0.815
MOD_GlcNHglycan	197	200	PF01048	0.737
MOD_GlcNHglycan	279	282	PF01048	0.691
MOD_GlcNHglycan	297	300	PF01048	0.633
MOD_GlcNHglycan	436	439	PF01048	0.773
MOD_GlcNHglycan	467	470	PF01048	0.745
MOD_GlcNHglycan	481	484	PF01048	0.644
MOD_GlcNHglycan	58	61	PF01048	0.585
MOD_GlcNHglycan	583	586	PF01048	0.583
MOD_GlcNHglycan	593	596	PF01048	0.778
MOD_GlcNHglycan	622	625	PF01048	0.706
MOD_GlcNHglycan	645	648	PF01048	0.733
MOD_GlcNHglycan	691	694	PF01048	0.659
MOD_GlcNHglycan	754	757	PF01048	0.762
MOD_GSK3_1	119	126	PF00069	0.579
MOD_GSK3_1	190	197	PF00069	0.811
MOD_GSK3_1	245	252	PF00069	0.727
MOD_GSK3_1	271	278	PF00069	0.839
MOD_GSK3_1	440	447	PF00069	0.787
MOD_GSK3_1	565	572	PF00069	0.706
MOD_GSK3_1	663	670	PF00069	0.776
MOD_GSK3_1	674	681	PF00069	0.673
MOD_GSK3_1	689	696	PF00069	0.561
MOD_GSK3_1	740	747	PF00069	0.768
MOD_GSK3_1	748	755	PF00069	0.704
MOD_GSK3_1	768	775	PF00069	0.759
MOD_GSK3_1	780	787	PF00069	0.825
MOD_N-GLC_1	78	83	PF02516	0.699
MOD_N-GLC_2	501	503	PF02516	0.769
MOD_NEK2_1	427	432	PF00069	0.747
MOD_NEK2_1	665	670	PF00069	0.815
MOD_PIKK_1	150	156	PF00454	0.740
MOD_PIKK_1	213	219	PF00454	0.707
MOD_PIKK_1	390	396	PF00454	0.720
MOD_PIKK_1	511	517	PF00454	0.717
MOD_PKA_1	522	528	PF00069	0.579
MOD_PKA_1	806	812	PF00069	0.715
MOD_PKA_2	123	129	PF00069	0.576
MOD_PKA_2	245	251	PF00069	0.731
MOD_PKA_2	275	281	PF00069	0.837
MOD_PKA_2	390	396	PF00069	0.720
MOD_PKA_2	522	528	PF00069	0.579
MOD_PKA_2	591	597	PF00069	0.798
MOD_PKA_2	784	790	PF00069	0.714
MOD_PKA_2	806	812	PF00069	0.717
MOD_Plk_4	249	255	PF00069	0.838
MOD_Plk_4	458	464	PF00069	0.733
MOD_Plk_4	565	571	PF00069	0.725
MOD_Plk_4	650	656	PF00069	0.823
MOD_ProDKin_1	119	125	PF00069	0.773
MOD_ProDKin_1	132	138	PF00069	0.634
MOD_ProDKin_1	160	166	PF00069	0.679
MOD_ProDKin_1	167	173	PF00069	0.611
MOD_ProDKin_1	204	210	PF00069	0.826
MOD_ProDKin_1	224	230	PF00069	0.480
MOD_ProDKin_1	235	241	PF00069	0.722
MOD_ProDKin_1	247	253	PF00069	0.633
MOD_ProDKin_1	271	277	PF00069	0.851
MOD_ProDKin_1	416	422	PF00069	0.643
MOD_ProDKin_1	484	490	PF00069	0.688
MOD_ProDKin_1	573	579	PF00069	0.679
MOD_ProDKin_1	637	643	PF00069	0.742
MOD_ProDKin_1	693	699	PF00069	0.740
MOD_ProDKin_1	735	741	PF00069	0.716
MOD_ProDKin_1	748	754	PF00069	0.729
MOD_ProDKin_1	768	774	PF00069	0.735
MOD_ProDKin_1	785	791	PF00069	0.763
MOD_ProDKin_1	808	814	PF00069	0.818
MOD_SUMO_rev_2	368	377	PF00179	0.608
TRG_DiLeu_BaEn_2	678	684	PF01217	0.717
TRG_ENDOCYTIC_2	598	601	PF00928	0.718
TRG_ER_diArg_1	349	352	PF00400	0.447
TRG_ER_diArg_1	36	39	PF00400	0.720
TRG_ER_diArg_1	404	407	PF00400	0.756
TRG_ER_diArg_1	46	48	PF00400	0.702
TRG_ER_diArg_1	484	486	PF00400	0.568
TRG_ER_diArg_1	521	523	PF00400	0.587
TRG_ER_diArg_1	6	8	PF00400	0.617
TRG_ER_diArg_1	806	808	PF00400	0.721
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1W4	Leptomonas seymouri	43%	92%
A0A3S7WWJ6	Leishmania donovani	90%	99%
A4HBW3	Leishmania braziliensis	69%	97%
E9AGX1	Leishmania infantum	90%	99%
E9AV87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%