Tau95 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase III transcription factor (TF)IIIC subunit, putative

Species:

Leishmania major

UniProt:

Q4QC86_LEIMA

TriTrypDb:

LmjF.21.1100 , LMJLV39_210019100 , LMJSD75_210019200

Length:

700

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000127	transcription factor TFIIIC complex	4	10
GO:0005667	transcription regulator complex	2	10
GO:0032991	protein-containing complex	1	10
GO:0090576	RNA polymerase III transcription regulator complex	3	10

Expansion

Sequence features

Q4QC86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC86

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006352	DNA-templated transcription initiation	6	10
GO:0006384	transcription initiation at RNA polymerase III promoter	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.821
CLV_C14_Caspase3-7	262	266	PF00656	0.574
CLV_C14_Caspase3-7	419	423	PF00656	0.419
CLV_C14_Caspase3-7	449	453	PF00656	0.307
CLV_NRD_NRD_1	216	218	PF00675	0.650
CLV_NRD_NRD_1	245	247	PF00675	0.530
CLV_NRD_NRD_1	248	250	PF00675	0.497
CLV_NRD_NRD_1	511	513	PF00675	0.454
CLV_NRD_NRD_1	542	544	PF00675	0.518
CLV_NRD_NRD_1	567	569	PF00675	0.519
CLV_NRD_NRD_1	59	61	PF00675	0.661
CLV_NRD_NRD_1	608	610	PF00675	0.566
CLV_NRD_NRD_1	640	642	PF00675	0.500
CLV_PCSK_FUR_1	214	218	PF00082	0.698
CLV_PCSK_FUR_1	242	246	PF00082	0.637
CLV_PCSK_FUR_1	540	544	PF00082	0.508
CLV_PCSK_KEX2_1	133	135	PF00082	0.744
CLV_PCSK_KEX2_1	213	215	PF00082	0.619
CLV_PCSK_KEX2_1	216	218	PF00082	0.614
CLV_PCSK_KEX2_1	244	246	PF00082	0.533
CLV_PCSK_KEX2_1	248	250	PF00082	0.467
CLV_PCSK_KEX2_1	511	513	PF00082	0.443
CLV_PCSK_KEX2_1	542	544	PF00082	0.446
CLV_PCSK_KEX2_1	567	569	PF00082	0.519
CLV_PCSK_KEX2_1	59	61	PF00082	0.626
CLV_PCSK_KEX2_1	608	610	PF00082	0.566
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.744
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.651
CLV_PCSK_PC7_1	240	246	PF00082	0.559
CLV_PCSK_PC7_1	538	544	PF00082	0.537
CLV_PCSK_PC7_1	604	610	PF00082	0.555
CLV_PCSK_SKI1_1	217	221	PF00082	0.734
CLV_PCSK_SKI1_1	533	537	PF00082	0.502
DEG_APCC_DBOX_1	146	154	PF00400	0.726
DEG_APCC_DBOX_1	554	562	PF00400	0.478
DEG_SCF_FBW7_1	33	38	PF00400	0.688
DEG_SCF_TRCP1_1	118	124	PF00400	0.562
DEG_SPOP_SBC_1	110	114	PF00917	0.684
DEG_SPOP_SBC_1	37	41	PF00917	0.676
DEG_SPOP_SBC_1	660	664	PF00917	0.696
DOC_CDC14_PxL_1	320	328	PF14671	0.648
DOC_CKS1_1	314	319	PF01111	0.640
DOC_CYCLIN_RxL_1	527	539	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	571	577	PF00134	0.482
DOC_MAPK_gen_1	508	517	PF00069	0.527
DOC_MAPK_gen_1	564	573	PF00069	0.461
DOC_MAPK_MEF2A_6	22	31	PF00069	0.547
DOC_MAPK_MEF2A_6	234	241	PF00069	0.501
DOC_MAPK_MEF2A_6	511	519	PF00069	0.526
DOC_MAPK_MEF2A_6	567	575	PF00069	0.447
DOC_MAPK_NFAT4_5	234	242	PF00069	0.597
DOC_PP2B_LxvP_1	571	574	PF13499	0.499
DOC_PP2B_PxIxI_1	390	396	PF00149	0.425
DOC_PP4_FxxP_1	70	73	PF00568	0.545
DOC_USP7_MATH_1	111	115	PF00917	0.735
DOC_USP7_MATH_1	187	191	PF00917	0.618
DOC_USP7_MATH_1	20	24	PF00917	0.660
DOC_USP7_MATH_1	285	289	PF00917	0.726
DOC_USP7_MATH_1	322	326	PF00917	0.590
DOC_USP7_MATH_1	359	363	PF00917	0.445
DOC_USP7_MATH_1	397	401	PF00917	0.441
DOC_USP7_MATH_1	409	413	PF00917	0.479
DOC_USP7_MATH_1	493	497	PF00917	0.393
DOC_USP7_MATH_1	50	54	PF00917	0.746
DOC_USP7_MATH_1	659	663	PF00917	0.653
DOC_WW_Pin1_4	31	36	PF00397	0.639
DOC_WW_Pin1_4	313	318	PF00397	0.603
DOC_WW_Pin1_4	4	9	PF00397	0.769
DOC_WW_Pin1_4	522	527	PF00397	0.505
LIG_14-3-3_CanoR_1	186	192	PF00244	0.589
LIG_14-3-3_CanoR_1	22	28	PF00244	0.572
LIG_14-3-3_CanoR_1	504	508	PF00244	0.356
LIG_14-3-3_CanoR_1	511	519	PF00244	0.405
LIG_14-3-3_CanoR_1	555	559	PF00244	0.444
LIG_14-3-3_CanoR_1	609	617	PF00244	0.442
LIG_Actin_WH2_2	498	513	PF00022	0.425
LIG_BIR_III_4	280	284	PF00653	0.615
LIG_BIR_III_4	375	379	PF00653	0.362
LIG_BIR_III_4	648	652	PF00653	0.530
LIG_BRCT_BRCA1_1	123	127	PF00533	0.721
LIG_BRCT_BRCA1_1	680	684	PF00533	0.756
LIG_CtBP_PxDLS_1	599	603	PF00389	0.562
LIG_eIF4E_1	232	238	PF01652	0.519
LIG_EVH1_2	333	337	PF00568	0.333
LIG_FHA_1	160	166	PF00498	0.596
LIG_FHA_1	253	259	PF00498	0.536
LIG_FHA_1	285	291	PF00498	0.665
LIG_FHA_1	309	315	PF00498	0.730
LIG_FHA_1	32	38	PF00498	0.689
LIG_FHA_1	390	396	PF00498	0.368
LIG_FHA_1	472	478	PF00498	0.325
LIG_FHA_1	504	510	PF00498	0.387
LIG_FHA_1	662	668	PF00498	0.576
LIG_FHA_2	174	180	PF00498	0.672
LIG_FHA_2	555	561	PF00498	0.419
LIG_FHA_2	652	658	PF00498	0.748
LIG_GBD_Chelix_1	446	454	PF00786	0.419
LIG_Integrin_RGD_1	86	88	PF01839	0.705
LIG_LIR_Apic_2	69	73	PF02991	0.554
LIG_LIR_Gen_1	218	228	PF02991	0.644
LIG_LIR_Gen_1	23	32	PF02991	0.660
LIG_LIR_Gen_1	309	320	PF02991	0.643
LIG_LIR_Gen_1	386	395	PF02991	0.408
LIG_LIR_Gen_1	499	510	PF02991	0.419
LIG_LIR_Nem_3	23	27	PF02991	0.626
LIG_LIR_Nem_3	309	315	PF02991	0.538
LIG_LIR_Nem_3	386	390	PF02991	0.344
LIG_LIR_Nem_3	499	505	PF02991	0.419
LIG_LIR_Nem_3	545	549	PF02991	0.450
LIG_NRBOX	531	537	PF00104	0.481
LIG_NRBOX	627	633	PF00104	0.494
LIG_PCNA_PIPBox_1	226	235	PF02747	0.525
LIG_PCNA_yPIPBox_3	226	240	PF02747	0.516
LIG_PTB_Apo_2	227	234	PF02174	0.631
LIG_PTB_Apo_2	476	483	PF02174	0.333
LIG_PTB_Phospho_1	227	233	PF10480	0.634
LIG_SH2_CRK	160	164	PF00017	0.679
LIG_SH2_CRK	546	550	PF00017	0.548
LIG_SH2_NCK_1	494	498	PF00017	0.419
LIG_SH2_NCK_1	502	506	PF00017	0.419
LIG_SH2_PTP2	24	27	PF00017	0.652
LIG_SH2_SRC	348	351	PF00017	0.419
LIG_SH2_STAP1	617	621	PF00017	0.490
LIG_SH2_STAP1	624	628	PF00017	0.429
LIG_SH2_STAT5	160	163	PF00017	0.562
LIG_SH2_STAT5	24	27	PF00017	0.652
LIG_SH2_STAT5	475	478	PF00017	0.307
LIG_SH2_STAT5	572	575	PF00017	0.438
LIG_SH3_3	24	30	PF00018	0.590
LIG_SH3_3	328	334	PF00018	0.435
LIG_SUMO_SIM_par_1	391	396	PF11976	0.425
LIG_TRAF2_1	178	181	PF00917	0.741
LIG_TRAF2_1	266	269	PF00917	0.628
LIG_TRAF2_1	396	399	PF00917	0.499
LIG_TRAF2_1	95	98	PF00917	0.703
LIG_TRAF2_2	574	579	PF00917	0.466
LIG_TYR_ITIM	500	505	PF00017	0.362
LIG_TYR_ITIM	544	549	PF00017	0.479
MOD_CK1_1	112	118	PF00069	0.752
MOD_CK1_1	119	125	PF00069	0.747
MOD_CK1_1	23	29	PF00069	0.638
MOD_CK1_1	288	294	PF00069	0.699
MOD_CK1_1	416	422	PF00069	0.480
MOD_CK1_1	496	502	PF00069	0.419
MOD_CK1_1	662	668	PF00069	0.675
MOD_CK2_1	175	181	PF00069	0.677
MOD_CK2_1	263	269	PF00069	0.683
MOD_CK2_1	393	399	PF00069	0.494
MOD_CK2_1	554	560	PF00069	0.442
MOD_CK2_1	92	98	PF00069	0.733
MOD_GlcNHglycan	114	117	PF01048	0.702
MOD_GlcNHglycan	118	121	PF01048	0.698
MOD_GlcNHglycan	166	169	PF01048	0.574
MOD_GlcNHglycan	189	192	PF01048	0.798
MOD_GlcNHglycan	265	268	PF01048	0.717
MOD_GlcNHglycan	273	276	PF01048	0.803
MOD_GlcNHglycan	287	290	PF01048	0.634
MOD_GlcNHglycan	361	364	PF01048	0.412
MOD_GlcNHglycan	379	382	PF01048	0.410
MOD_GlcNHglycan	395	398	PF01048	0.425
MOD_GlcNHglycan	40	43	PF01048	0.708
MOD_GlcNHglycan	456	459	PF01048	0.351
MOD_GlcNHglycan	495	498	PF01048	0.381
MOD_GlcNHglycan	52	55	PF01048	0.654
MOD_GlcNHglycan	677	683	PF01048	0.694
MOD_GlcNHglycan	686	689	PF01048	0.663
MOD_GlcNHglycan	94	97	PF01048	0.814
MOD_GSK3_1	112	119	PF00069	0.780
MOD_GSK3_1	164	171	PF00069	0.634
MOD_GSK3_1	281	288	PF00069	0.756
MOD_GSK3_1	31	38	PF00069	0.596
MOD_GSK3_1	353	360	PF00069	0.405
MOD_GSK3_1	389	396	PF00069	0.445
MOD_GSK3_1	398	405	PF00069	0.497
MOD_GSK3_1	409	416	PF00069	0.175
MOD_GSK3_1	659	666	PF00069	0.608
MOD_GSK3_1	678	685	PF00069	0.694
MOD_N-GLC_1	651	656	PF02516	0.746
MOD_NEK2_1	413	418	PF00069	0.454
MOD_NEK2_1	454	459	PF00069	0.426
MOD_NEK2_1	684	689	PF00069	0.704
MOD_PKA_2	169	175	PF00069	0.709
MOD_PKA_2	185	191	PF00069	0.743
MOD_PKA_2	281	287	PF00069	0.693
MOD_PKA_2	441	447	PF00069	0.489
MOD_PKA_2	503	509	PF00069	0.343
MOD_PKA_2	510	516	PF00069	0.391
MOD_PKA_2	554	560	PF00069	0.396
MOD_PKB_1	518	526	PF00069	0.512
MOD_Plk_1	308	314	PF00069	0.645
MOD_Plk_1	397	403	PF00069	0.425
MOD_Plk_1	678	684	PF00069	0.778
MOD_Plk_4	398	404	PF00069	0.385
MOD_Plk_4	409	415	PF00069	0.473
MOD_Plk_4	441	447	PF00069	0.444
MOD_Plk_4	496	502	PF00069	0.492
MOD_Plk_4	527	533	PF00069	0.453
MOD_Plk_4	554	560	PF00069	0.383
MOD_Plk_4	66	72	PF00069	0.533
MOD_ProDKin_1	31	37	PF00069	0.643
MOD_ProDKin_1	313	319	PF00069	0.600
MOD_ProDKin_1	4	10	PF00069	0.769
MOD_ProDKin_1	522	528	PF00069	0.498
MOD_SUMO_rev_2	539	549	PF00179	0.474
TRG_DiLeu_BaEn_1	224	229	PF01217	0.659
TRG_DiLeu_BaEn_2	60	66	PF01217	0.690
TRG_DiLeu_BaEn_4	398	404	PF01217	0.419
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.419
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.425
TRG_DiLeu_BaLyEn_6	530	535	PF01217	0.489
TRG_DiLeu_LyEn_5	635	640	PF01217	0.410
TRG_ENDOCYTIC_2	160	163	PF00928	0.689
TRG_ENDOCYTIC_2	24	27	PF00928	0.578
TRG_ENDOCYTIC_2	502	505	PF00928	0.419
TRG_ENDOCYTIC_2	546	549	PF00928	0.537
TRG_ENDOCYTIC_2	572	575	PF00928	0.407
TRG_ER_diArg_1	214	217	PF00400	0.649
TRG_ER_diArg_1	239	242	PF00400	0.591
TRG_ER_diArg_1	244	246	PF00400	0.547
TRG_ER_diArg_1	247	249	PF00400	0.519
TRG_ER_diArg_1	484	487	PF00400	0.307
TRG_ER_diArg_1	510	512	PF00400	0.538
TRG_ER_diArg_1	517	520	PF00400	0.460
TRG_ER_diArg_1	542	544	PF00400	0.518
TRG_ER_diArg_1	566	568	PF00400	0.536
TRG_NLS_MonoCore_2	212	217	PF00514	0.695
TRG_NLS_MonoExtC_3	212	217	PF00514	0.695
TRG_NLS_MonoExtN_4	210	217	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	533	537	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	641	646	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I9	Leptomonas seymouri	50%	94%
A0A1X0NZE8	Trypanosomatidae	32%	100%
A0A3S7WWK4	Leishmania donovani	93%	100%
A0A422NAG1	Trypanosoma rangeli	34%	100%
A4HIW4	Leishmania braziliensis	80%	100%
D0A185	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AGX8	Leishmania infantum	92%	100%
E9AV94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%