Putative U4/U6 small nuclear ribonuclear protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U4/U6 small nuclear ribonuclear protein, putative

Species:

Leishmania major

UniProt:

Q4QC84_LEIMA

TriTrypDb:

LmjF.21.1120 , LMJLV39_210019300 , LMJSD75_210019400

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0097526	spliceosomal tri-snRNP complex	5	2
GO:0110165	cellular anatomical entity	1	7
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	6
GO:0005840	ribosome	5	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4

Expansion

Sequence features

Q4QC84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC84

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	2
GO:0016740	transferase activity	2	5
GO:0017069	snRNA binding	5	2
GO:0017070	U6 snRNA binding	6	2
GO:0030621	U4 snRNA binding	6	2
GO:0030627	pre-mRNA 5'-splice site binding	6	2
GO:0036002	pre-mRNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.459
CLV_C14_Caspase3-7	235	239	PF00656	0.632
CLV_C14_Caspase3-7	241	245	PF00656	0.552
CLV_C14_Caspase3-7	324	328	PF00656	0.442
CLV_C14_Caspase3-7	556	560	PF00656	0.764
CLV_NRD_NRD_1	383	385	PF00675	0.554
CLV_NRD_NRD_1	572	574	PF00675	0.656
CLV_NRD_NRD_1	610	612	PF00675	0.680
CLV_PCSK_KEX2_1	52	54	PF00082	0.461
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.459
CLV_PCSK_SKI1_1	275	279	PF00082	0.550
CLV_PCSK_SKI1_1	355	359	PF00082	0.300
CLV_PCSK_SKI1_1	78	82	PF00082	0.372
CLV_PCSK_SKI1_1	84	88	PF00082	0.411
CLV_Separin_Metazoa	608	612	PF03568	0.612
DEG_APCC_DBOX_1	472	480	PF00400	0.538
DEG_SCF_TRCP1_1	122	127	PF00400	0.540
DEG_SPOP_SBC_1	225	229	PF00917	0.656
DOC_CYCLIN_yClb3_PxF_3	477	483	PF00134	0.430
DOC_MAPK_gen_1	198	207	PF00069	0.559
DOC_MAPK_gen_1	78	88	PF00069	0.420
DOC_PP1_RVXF_1	329	336	PF00149	0.382
DOC_PP2B_LxvP_1	102	105	PF13499	0.462
DOC_SPAK_OSR1_1	540	544	PF12202	0.500
DOC_USP7_MATH_1	105	109	PF00917	0.435
DOC_USP7_MATH_1	117	121	PF00917	0.565
DOC_USP7_MATH_1	152	156	PF00917	0.421
DOC_USP7_MATH_1	23	27	PF00917	0.674
DOC_USP7_MATH_1	230	234	PF00917	0.574
DOC_USP7_MATH_1	318	322	PF00917	0.366
DOC_USP7_MATH_1	412	416	PF00917	0.556
DOC_USP7_MATH_1	422	426	PF00917	0.532
DOC_USP7_MATH_1	516	520	PF00917	0.710
DOC_USP7_MATH_1	532	536	PF00917	0.627
DOC_USP7_MATH_1	586	590	PF00917	0.609
DOC_WW_Pin1_4	11	16	PF00397	0.671
DOC_WW_Pin1_4	124	129	PF00397	0.630
DOC_WW_Pin1_4	148	153	PF00397	0.530
DOC_WW_Pin1_4	19	24	PF00397	0.558
DOC_WW_Pin1_4	226	231	PF00397	0.440
DOC_WW_Pin1_4	285	290	PF00397	0.648
DOC_WW_Pin1_4	291	296	PF00397	0.579
DOC_WW_Pin1_4	360	365	PF00397	0.448
DOC_WW_Pin1_4	477	482	PF00397	0.634
LIG_14-3-3_CanoR_1	154	160	PF00244	0.458
LIG_14-3-3_CanoR_1	167	172	PF00244	0.308
LIG_14-3-3_CanoR_1	204	208	PF00244	0.424
LIG_14-3-3_CanoR_1	482	492	PF00244	0.451
LIG_14-3-3_CanoR_1	540	544	PF00244	0.549
LIG_APCC_ABBA_1	391	396	PF00400	0.609
LIG_BIR_III_4	244	248	PF00653	0.378
LIG_BIR_III_4	327	331	PF00653	0.476
LIG_BRCT_BRCA1_1	13	17	PF00533	0.698
LIG_BRCT_BRCA1_1	187	191	PF00533	0.448
LIG_BRCT_BRCA1_1	414	418	PF00533	0.437
LIG_BRCT_BRCA1_1	479	483	PF00533	0.568
LIG_CSL_BTD_1	361	364	PF09270	0.480
LIG_FHA_1	226	232	PF00498	0.543
LIG_FHA_1	254	260	PF00498	0.390
LIG_FHA_1	291	297	PF00498	0.575
LIG_FHA_1	309	315	PF00498	0.391
LIG_FHA_1	439	445	PF00498	0.464
LIG_FHA_1	543	549	PF00498	0.468
LIG_FHA_2	141	147	PF00498	0.393
LIG_FHA_2	156	162	PF00498	0.478
LIG_FHA_2	322	328	PF00498	0.462
LIG_FHA_2	440	446	PF00498	0.437
LIG_FHA_2	520	526	PF00498	0.701
LIG_LIR_Apic_2	417	422	PF02991	0.504
LIG_LIR_Gen_1	194	202	PF02991	0.503
LIG_LIR_Gen_1	538	548	PF02991	0.526
LIG_LIR_Gen_1	6	15	PF02991	0.658
LIG_LIR_Nem_3	162	168	PF02991	0.459
LIG_LIR_Nem_3	194	199	PF02991	0.507
LIG_LIR_Nem_3	495	501	PF02991	0.339
LIG_LIR_Nem_3	538	544	PF02991	0.495
LIG_LIR_Nem_3	6	11	PF02991	0.668
LIG_MYND_1	474	478	PF01753	0.543
LIG_PCNA_yPIPBox_3	30	43	PF02747	0.518
LIG_Rb_pABgroove_1	375	383	PF01858	0.539
LIG_SH2_CRK	419	423	PF00017	0.488
LIG_SH2_CRK	55	59	PF00017	0.486
LIG_SH2_GRB2like	419	422	PF00017	0.504
LIG_SH2_NCK_1	305	309	PF00017	0.574
LIG_SH2_PTP2	8	11	PF00017	0.716
LIG_SH2_SRC	159	162	PF00017	0.474
LIG_SH2_SRC	419	422	PF00017	0.504
LIG_SH2_STAP1	501	505	PF00017	0.319
LIG_SH2_STAT5	547	550	PF00017	0.511
LIG_SH2_STAT5	8	11	PF00017	0.697
LIG_SH3_1	573	579	PF00018	0.604
LIG_SH3_3	110	116	PF00018	0.476
LIG_SH3_3	169	175	PF00018	0.414
LIG_SH3_3	471	477	PF00018	0.453
LIG_SH3_3	545	551	PF00018	0.630
LIG_SH3_3	573	579	PF00018	0.604
LIG_SUMO_SIM_anti_2	485	493	PF11976	0.403
LIG_SUMO_SIM_par_1	139	146	PF11976	0.377
LIG_UBA3_1	569	575	PF00899	0.651
MOD_CDC14_SPxK_1	229	232	PF00782	0.398
MOD_CDK_SPK_2	11	16	PF00069	0.693
MOD_CDK_SPK_2	477	482	PF00069	0.365
MOD_CDK_SPxK_1	148	154	PF00069	0.394
MOD_CDK_SPxK_1	226	232	PF00069	0.404
MOD_CDK_SPxxK_3	11	18	PF00069	0.683
MOD_CK1_1	120	126	PF00069	0.624
MOD_CK1_1	127	133	PF00069	0.600
MOD_CK1_1	155	161	PF00069	0.428
MOD_CK1_1	182	188	PF00069	0.497
MOD_CK1_1	233	239	PF00069	0.675
MOD_CK1_1	294	300	PF00069	0.637
MOD_CK1_1	3	9	PF00069	0.633
MOD_CK1_1	321	327	PF00069	0.382
MOD_CK1_1	519	525	PF00069	0.709
MOD_CK1_1	542	548	PF00069	0.581
MOD_CK1_1	549	555	PF00069	0.615
MOD_CK1_1	560	566	PF00069	0.515
MOD_CK2_1	519	525	PF00069	0.709
MOD_GlcNHglycan	119	122	PF01048	0.646
MOD_GlcNHglycan	136	139	PF01048	0.439
MOD_GlcNHglycan	181	184	PF01048	0.640
MOD_GlcNHglycan	218	221	PF01048	0.684
MOD_GlcNHglycan	232	235	PF01048	0.444
MOD_GlcNHglycan	240	243	PF01048	0.690
MOD_GlcNHglycan	283	286	PF01048	0.723
MOD_GlcNHglycan	338	341	PF01048	0.434
MOD_GlcNHglycan	370	373	PF01048	0.306
MOD_GlcNHglycan	396	399	PF01048	0.509
MOD_GlcNHglycan	424	427	PF01048	0.320
MOD_GlcNHglycan	518	521	PF01048	0.682
MOD_GlcNHglycan	530	533	PF01048	0.454
MOD_GlcNHglycan	534	537	PF01048	0.465
MOD_GlcNHglycan	559	562	PF01048	0.643
MOD_GlcNHglycan	584	587	PF01048	0.743
MOD_GlcNHglycan	588	591	PF01048	0.694
MOD_GSK3_1	120	127	PF00069	0.644
MOD_GSK3_1	148	155	PF00069	0.449
MOD_GSK3_1	185	192	PF00069	0.461
MOD_GSK3_1	19	26	PF00069	0.616
MOD_GSK3_1	226	233	PF00069	0.586
MOD_GSK3_1	281	288	PF00069	0.657
MOD_GSK3_1	290	297	PF00069	0.633
MOD_GSK3_1	304	311	PF00069	0.508
MOD_GSK3_1	318	325	PF00069	0.419
MOD_GSK3_1	440	447	PF00069	0.472
MOD_GSK3_1	528	535	PF00069	0.645
MOD_GSK3_1	539	546	PF00069	0.444
MOD_GSK3_1	555	562	PF00069	0.517
MOD_GSK3_1	582	589	PF00069	0.647
MOD_N-GLC_1	148	153	PF02516	0.366
MOD_N-GLC_1	238	243	PF02516	0.690
MOD_N-GLC_1	394	399	PF02516	0.433
MOD_NEK2_1	17	22	PF00069	0.658
MOD_NEK2_1	189	194	PF00069	0.329
MOD_NEK2_1	260	265	PF00069	0.396
MOD_NEK2_1	278	283	PF00069	0.577
MOD_NEK2_1	439	444	PF00069	0.450
MOD_NEK2_1	483	488	PF00069	0.500
MOD_NEK2_1	539	544	PF00069	0.607
MOD_NEK2_1	582	587	PF00069	0.655
MOD_NEK2_1	70	75	PF00069	0.513
MOD_OFUCOSY	103	109	PF10250	0.375
MOD_PIKK_1	152	158	PF00454	0.476
MOD_PIKK_1	17	23	PF00454	0.626
MOD_PIKK_1	38	44	PF00454	0.579
MOD_PIKK_1	429	435	PF00454	0.526
MOD_PK_1	167	173	PF00069	0.456
MOD_PKA_1	384	390	PF00069	0.592
MOD_PKA_2	203	209	PF00069	0.415
MOD_PKA_2	539	545	PF00069	0.549
MOD_PKA_2	549	555	PF00069	0.567
MOD_Plk_1	444	450	PF00069	0.539
MOD_Plk_2-3	599	605	PF00069	0.766
MOD_Plk_4	140	146	PF00069	0.347
MOD_Plk_4	167	173	PF00069	0.474
MOD_Plk_4	191	197	PF00069	0.403
MOD_Plk_4	318	324	PF00069	0.356
MOD_Plk_4	4	10	PF00069	0.713
MOD_Plk_4	414	420	PF00069	0.496
MOD_Plk_4	543	549	PF00069	0.646
MOD_ProDKin_1	11	17	PF00069	0.661
MOD_ProDKin_1	124	130	PF00069	0.622
MOD_ProDKin_1	148	154	PF00069	0.533
MOD_ProDKin_1	19	25	PF00069	0.552
MOD_ProDKin_1	226	232	PF00069	0.445
MOD_ProDKin_1	285	291	PF00069	0.645
MOD_ProDKin_1	360	366	PF00069	0.448
MOD_ProDKin_1	477	483	PF00069	0.625
TRG_ENDOCYTIC_2	8	11	PF00928	0.716
TRG_ER_diArg_1	76	79	PF00400	0.400
TRG_NLS_MonoExtC_3	572	577	PF00514	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A5	Leptomonas seymouri	60%	95%
A0A0S4JGF5	Bodo saltans	30%	100%
A0A1X0NYH8	Trypanosomatidae	35%	94%
A0A3S7WWM8	Leishmania donovani	93%	100%
A0A422NAK4	Trypanosoma rangeli	40%	100%
A4HBX0	Leishmania braziliensis	81%	100%
D0A183	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AGY0	Leishmania infantum	93%	100%
E9AV96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B548	Trypanosoma cruzi	36%	100%