Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC83_LEIMA

TriTrypDb:

LmjF.21.1130 , LMJLV39_210019400 , LMJSD75_210019500

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0016020	membrane	2	6
GO:0031090	organelle membrane	3	2
GO:0031984	organelle subcompartment	2	2
GO:0031985	Golgi cisterna	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098791	Golgi apparatus subcompartment	3	2
GO:0110165	cellular anatomical entity	1	7
GO:0005794	Golgi apparatus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5

Expansion

Sequence features

Q4QC83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC83

Function

Biological processes
Term	Name	Level	Count
GO:0000301	retrograde transport, vesicle recycling within Golgi	7	2
GO:0006810	transport	3	2
GO:0006891	intra-Golgi vesicle-mediated transport	6	2
GO:0006996	organelle organization	4	7
GO:0007030	Golgi organization	5	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0016192	vesicle-mediated transport	4	2
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.683
CLV_C14_Caspase3-7	533	537	PF00656	0.695
CLV_C14_Caspase3-7	563	567	PF00656	0.591
CLV_NRD_NRD_1	376	378	PF00675	0.438
CLV_NRD_NRD_1	387	389	PF00675	0.395
CLV_NRD_NRD_1	539	541	PF00675	0.467
CLV_PCSK_KEX2_1	376	378	PF00082	0.438
CLV_PCSK_KEX2_1	387	389	PF00082	0.395
CLV_PCSK_KEX2_1	538	540	PF00082	0.453
CLV_PCSK_PC7_1	372	378	PF00082	0.431
CLV_PCSK_SKI1_1	230	234	PF00082	0.393
CLV_PCSK_SKI1_1	372	376	PF00082	0.383
CLV_PCSK_SKI1_1	444	448	PF00082	0.401
CLV_PCSK_SKI1_1	574	578	PF00082	0.384
CLV_PCSK_SKI1_1	584	588	PF00082	0.269
CLV_Separin_Metazoa	384	388	PF03568	0.621
DEG_APCC_DBOX_1	371	379	PF00400	0.629
DEG_APCC_DBOX_1	423	431	PF00400	0.577
DEG_Nend_Nbox_1	1	3	PF02207	0.670
DEG_SPOP_SBC_1	490	494	PF00917	0.644
DEG_SPOP_SBC_1	83	87	PF00917	0.697
DOC_CYCLIN_yClb5_NLxxxL_5	430	439	PF00134	0.588
DOC_MAPK_gen_1	339	347	PF00069	0.636
DOC_MAPK_gen_1	422	430	PF00069	0.584
DOC_MAPK_gen_1	538	547	PF00069	0.637
DOC_MAPK_MEF2A_6	341	349	PF00069	0.601
DOC_MIT_MIM_1	300	308	PF04212	0.632
DOC_PP2B_LxvP_1	119	122	PF13499	0.671
DOC_PP4_FxxP_1	487	490	PF00568	0.779
DOC_USP7_MATH_1	174	178	PF00917	0.717
DOC_USP7_MATH_1	224	228	PF00917	0.569
DOC_USP7_MATH_1	280	284	PF00917	0.698
DOC_USP7_MATH_1	357	361	PF00917	0.545
DOC_USP7_MATH_1	491	495	PF00917	0.741
DOC_USP7_MATH_1	531	535	PF00917	0.817
DOC_USP7_MATH_1	560	564	PF00917	0.618
DOC_USP7_MATH_1	82	86	PF00917	0.761
DOC_USP7_UBL2_3	202	206	PF12436	0.517
DOC_WW_Pin1_4	183	188	PF00397	0.657
DOC_WW_Pin1_4	388	393	PF00397	0.654
DOC_WW_Pin1_4	527	532	PF00397	0.707
DOC_WW_Pin1_4	92	97	PF00397	0.749
LIG_14-3-3_CanoR_1	129	137	PF00244	0.695
LIG_14-3-3_CanoR_1	223	233	PF00244	0.718
LIG_14-3-3_CanoR_1	282	288	PF00244	0.677
LIG_14-3-3_CanoR_1	35	42	PF00244	0.702
LIG_14-3-3_CanoR_1	376	386	PF00244	0.611
LIG_14-3-3_CanoR_1	44	49	PF00244	0.687
LIG_14-3-3_CanoR_1	574	583	PF00244	0.694
LIG_AP2alpha_2	159	161	PF02296	0.644
LIG_APCC_ABBA_1	254	259	PF00400	0.620
LIG_BRCT_BRCA1_1	483	487	PF00533	0.725
LIG_BRCT_BRCA1_1	63	67	PF00533	0.638
LIG_BRCT_BRCA1_1	86	90	PF00533	0.703
LIG_CaM_IQ_9	333	348	PF13499	0.581
LIG_EVH1_1	487	491	PF00568	0.730
LIG_FHA_1	14	20	PF00498	0.649
LIG_FHA_1	328	334	PF00498	0.714
LIG_FHA_1	603	609	PF00498	0.369
LIG_FHA_2	154	160	PF00498	0.722
LIG_FHA_2	378	384	PF00498	0.607
LIG_FHA_2	527	533	PF00498	0.696
LIG_GBD_Chelix_1	598	606	PF00786	0.325
LIG_LIR_Apic_2	484	490	PF02991	0.727
LIG_MYND_1	54	58	PF01753	0.702
LIG_PDZ_Class_3	619	624	PF00595	0.435
LIG_SH2_GRB2like	477	480	PF00017	0.600
LIG_SH2_PTP2	590	593	PF00017	0.304
LIG_SH2_SRC	477	480	PF00017	0.600
LIG_SH2_STAT5	590	593	PF00017	0.304
LIG_SH3_2	55	60	PF14604	0.712
LIG_SH3_3	154	160	PF00018	0.631
LIG_SH3_3	485	491	PF00018	0.756
LIG_SH3_3	49	55	PF00018	0.707
LIG_SH3_3	617	623	PF00018	0.450
LIG_SUMO_SIM_par_1	117	123	PF11976	0.716
LIG_SUMO_SIM_par_1	557	564	PF11976	0.572
LIG_SUMO_SIM_par_1	604	611	PF11976	0.504
LIG_TRAF2_2	288	293	PF00917	0.695
LIG_WRC_WIRS_1	125	130	PF05994	0.615
LIG_WRC_WIRS_1	565	570	PF05994	0.483
MOD_CK1_1	120	126	PF00069	0.662
MOD_CK1_1	283	289	PF00069	0.594
MOD_CK1_1	390	396	PF00069	0.587
MOD_CK1_1	40	46	PF00069	0.641
MOD_CK1_1	564	570	PF00069	0.479
MOD_CK2_1	189	195	PF00069	0.601
MOD_CK2_1	281	287	PF00069	0.612
MOD_CK2_1	526	532	PF00069	0.604
MOD_GlcNHglycan	102	105	PF01048	0.585
MOD_GlcNHglycan	177	180	PF01048	0.722
MOD_GlcNHglycan	226	229	PF01048	0.433
MOD_GlcNHglycan	283	286	PF01048	0.593
MOD_GlcNHglycan	364	368	PF01048	0.480
MOD_GlcNHglycan	372	375	PF01048	0.501
MOD_GlcNHglycan	39	42	PF01048	0.632
MOD_GlcNHglycan	394	397	PF01048	0.612
MOD_GlcNHglycan	473	476	PF01048	0.584
MOD_GlcNHglycan	512	515	PF01048	0.593
MOD_GlcNHglycan	532	536	PF01048	0.729
MOD_GlcNHglycan	609	613	PF01048	0.504
MOD_GlcNHglycan	63	66	PF01048	0.626
MOD_GSK3_1	120	127	PF00069	0.618
MOD_GSK3_1	36	43	PF00069	0.613
MOD_GSK3_1	388	395	PF00069	0.564
MOD_GSK3_1	426	433	PF00069	0.455
MOD_GSK3_1	526	533	PF00069	0.646
MOD_GSK3_1	560	567	PF00069	0.451
MOD_GSK3_1	95	102	PF00069	0.588
MOD_N-GLC_1	189	194	PF02516	0.486
MOD_N-GLC_1	44	49	PF02516	0.564
MOD_N-GLC_2	481	483	PF02516	0.533
MOD_NEK2_1	100	105	PF00069	0.670
MOD_NEK2_1	152	157	PF00069	0.628
MOD_NEK2_1	166	171	PF00069	0.554
MOD_NEK2_1	28	33	PF00069	0.594
MOD_NEK2_1	36	41	PF00069	0.554
MOD_NEK2_1	430	435	PF00069	0.430
MOD_NEK2_1	471	476	PF00069	0.598
MOD_NEK2_1	608	613	PF00069	0.493
MOD_NEK2_1	67	72	PF00069	0.604
MOD_NEK2_2	482	487	PF00069	0.592
MOD_PIKK_1	129	135	PF00454	0.744
MOD_PIKK_1	166	172	PF00454	0.704
MOD_PIKK_1	258	264	PF00454	0.518
MOD_PIKK_1	377	383	PF00454	0.498
MOD_PIKK_1	574	580	PF00454	0.459
MOD_PKA_1	387	393	PF00069	0.582
MOD_PKA_2	128	134	PF00069	0.622
MOD_PKA_2	240	246	PF00069	0.553
MOD_PKA_2	281	287	PF00069	0.590
MOD_PKA_2	357	363	PF00069	0.532
MOD_PKA_2	387	393	PF00069	0.558
MOD_PKA_2	43	49	PF00069	0.705
MOD_PKA_2	471	477	PF00069	0.601
MOD_Plk_1	189	195	PF00069	0.499
MOD_Plk_1	210	216	PF00069	0.640
MOD_Plk_1	44	50	PF00069	0.565
MOD_Plk_2-3	13	19	PF00069	0.487
MOD_Plk_4	252	258	PF00069	0.434
MOD_Plk_4	482	488	PF00069	0.613
MOD_Plk_4	95	101	PF00069	0.541
MOD_ProDKin_1	183	189	PF00069	0.566
MOD_ProDKin_1	388	394	PF00069	0.571
MOD_ProDKin_1	527	533	PF00069	0.639
MOD_ProDKin_1	92	98	PF00069	0.697
MOD_SUMO_rev_2	10	16	PF00179	0.477
MOD_SUMO_rev_2	266	275	PF00179	0.497
MOD_SUMO_rev_2	445	451	PF00179	0.473
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.451
TRG_ENDOCYTIC_2	453	456	PF00928	0.476
TRG_ENDOCYTIC_2	590	593	PF00928	0.304
TRG_ER_diArg_1	375	377	PF00400	0.535
TRG_ER_diArg_1	386	388	PF00400	0.464
TRG_ER_diArg_1	538	540	PF00400	0.598
TRG_ER_diArg_1	76	79	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	574	578	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL5	Leptomonas seymouri	40%	93%
A0A3Q8IB66	Leishmania donovani	91%	99%
A4HBX1	Leishmania braziliensis	72%	100%
A4HZ89	Leishmania infantum	91%	99%
E9AV97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%