LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Surface antigen-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania major
UniProt:
Q4QC79_LEIMA
TriTrypDb:
LmjF.21.1170 , LMJLV39_210019800 , LMJSD75_210020000
Length:
456

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 125
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 69, no: 12
NetGPI no yes: 0, no: 81
Cellular components
Term Name Level Count
GO:0005929 cilium 4 82
GO:0042995 cell projection 2 82
GO:0043226 organelle 2 82
GO:0043227 membrane-bounded organelle 3 82
GO:0110165 cellular anatomical entity 1 82
GO:0120025 plasma membrane bounded cell projection 3 82
GO:0016020 membrane 2 28
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

Q4QC79
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC79

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 366 370 PF00656 0.228
CLV_NRD_NRD_1 145 147 PF00675 0.267
CLV_NRD_NRD_1 51 53 PF00675 0.555
CLV_NRD_NRD_1 9 11 PF00675 0.762
CLV_PCSK_KEX2_1 454 456 PF00082 0.718
CLV_PCSK_KEX2_1 9 11 PF00082 0.762
CLV_PCSK_SKI1_1 201 205 PF00082 0.468
CLV_PCSK_SKI1_1 52 56 PF00082 0.404
CLV_PCSK_SKI1_1 78 82 PF00082 0.555
CLV_PCSK_SKI1_1 9 13 PF00082 0.732
DOC_CYCLIN_yClb5_NLxxxL_5 129 135 PF00134 0.371
DOC_CYCLIN_yClb5_NLxxxL_5 174 183 PF00134 0.384
DOC_MAPK_gen_1 214 223 PF00069 0.272
DOC_MAPK_gen_1 237 247 PF00069 0.241
DOC_PP1_RVXF_1 308 314 PF00149 0.260
DOC_PP2B_LxvP_1 25 28 PF13499 0.610
DOC_PP2B_LxvP_1 97 100 PF13499 0.364
DOC_PP4_MxPP_1 1 4 PF00568 0.505
DOC_USP7_MATH_1 105 109 PF00917 0.569
DOC_USP7_MATH_1 261 265 PF00917 0.425
DOC_USP7_MATH_1 416 420 PF00917 0.562
DOC_WW_Pin1_4 446 451 PF00397 0.681
LIG_14-3-3_CanoR_1 214 219 PF00244 0.542
LIG_14-3-3_CanoR_1 240 246 PF00244 0.445
LIG_14-3-3_CanoR_1 31 36 PF00244 0.715
LIG_AP2alpha_1 54 58 PF02296 0.266
LIG_APCC_ABBA_1 387 392 PF00400 0.244
LIG_BRCT_BRCA1_1 114 118 PF00533 0.256
LIG_Clathr_ClatBox_1 293 297 PF01394 0.233
LIG_deltaCOP1_diTrp_1 235 238 PF00928 0.456
LIG_deltaCOP1_diTrp_1 307 313 PF00928 0.510
LIG_DLG_GKlike_1 214 221 PF00625 0.268
LIG_FHA_1 154 160 PF00498 0.452
LIG_FHA_1 178 184 PF00498 0.336
LIG_FHA_1 242 248 PF00498 0.333
LIG_FHA_1 275 281 PF00498 0.454
LIG_FHA_1 284 290 PF00498 0.397
LIG_FHA_1 299 305 PF00498 0.409
LIG_FHA_1 349 355 PF00498 0.359
LIG_FHA_1 362 368 PF00498 0.352
LIG_FHA_1 90 96 PF00498 0.491
LIG_FHA_2 68 74 PF00498 0.494
LIG_Integrin_isoDGR_2 127 129 PF01839 0.614
LIG_IRF3_LxIS_1 337 344 PF10401 0.459
LIG_LIR_Gen_1 259 266 PF02991 0.400
LIG_LIR_Gen_1 267 276 PF02991 0.375
LIG_LIR_Gen_1 306 314 PF02991 0.343
LIG_LIR_Gen_1 331 340 PF02991 0.291
LIG_LIR_Gen_1 405 416 PF02991 0.398
LIG_LIR_Gen_1 92 101 PF02991 0.673
LIG_LIR_Nem_3 138 142 PF02991 0.402
LIG_LIR_Nem_3 162 166 PF02991 0.469
LIG_LIR_Nem_3 267 271 PF02991 0.364
LIG_LIR_Nem_3 306 311 PF02991 0.424
LIG_LIR_Nem_3 379 383 PF02991 0.340
LIG_LIR_Nem_3 405 411 PF02991 0.378
LIG_LIR_Nem_3 92 97 PF02991 0.585
LIG_NRBOX 289 295 PF00104 0.363
LIG_NRP_CendR_1 454 456 PF00754 0.498
LIG_Pex14_1 404 408 PF04695 0.293
LIG_Pex14_2 296 300 PF04695 0.499
LIG_Pex14_2 54 58 PF04695 0.329
LIG_SH2_NCK_1 43 47 PF00017 0.542
LIG_SH2_PTP2 408 411 PF00017 0.471
LIG_SH2_STAT5 173 176 PF00017 0.347
LIG_SH2_STAT5 251 254 PF00017 0.336
LIG_SH2_STAT5 408 411 PF00017 0.403
LIG_SH2_STAT5 43 46 PF00017 0.434
LIG_SH3_2 4 9 PF14604 0.468
LIG_SH3_3 1 7 PF00018 0.619
LIG_SUMO_SIM_anti_2 193 198 PF11976 0.485
LIG_SUMO_SIM_par_1 195 200 PF11976 0.420
LIG_SUMO_SIM_par_1 23 30 PF11976 0.477
LIG_SUMO_SIM_par_1 291 297 PF11976 0.457
LIG_SUMO_SIM_par_1 339 345 PF11976 0.348
LIG_SUMO_SIM_par_1 363 369 PF11976 0.430
LIG_UBA3_1 141 147 PF00899 0.271
LIG_WW_2 4 7 PF00397 0.471
MOD_CK1_1 190 196 PF00069 0.428
MOD_CK1_1 344 350 PF00069 0.344
MOD_CK1_1 358 364 PF00069 0.342
MOD_CK1_1 41 47 PF00069 0.489
MOD_CK1_1 442 448 PF00069 0.609
MOD_CK2_1 165 171 PF00069 0.471
MOD_CK2_1 183 189 PF00069 0.404
MOD_CK2_1 261 267 PF00069 0.393
MOD_Cter_Amidation 452 455 PF01082 0.479
MOD_GlcNHglycan 108 111 PF01048 0.542
MOD_GlcNHglycan 131 134 PF01048 0.388
MOD_GlcNHglycan 162 166 PF01048 0.419
MOD_GlcNHglycan 228 231 PF01048 0.318
MOD_GlcNHglycan 252 255 PF01048 0.405
MOD_GlcNHglycan 332 335 PF01048 0.388
MOD_GlcNHglycan 348 351 PF01048 0.320
MOD_GlcNHglycan 372 375 PF01048 0.339
MOD_GlcNHglycan 40 43 PF01048 0.514
MOD_GlcNHglycan 89 92 PF01048 0.464
MOD_GSK3_1 131 138 PF00069 0.354
MOD_GSK3_1 149 156 PF00069 0.461
MOD_GSK3_1 161 168 PF00069 0.451
MOD_GSK3_1 179 186 PF00069 0.331
MOD_GSK3_1 222 229 PF00069 0.359
MOD_GSK3_1 27 34 PF00069 0.615
MOD_GSK3_1 270 277 PF00069 0.346
MOD_GSK3_1 285 292 PF00069 0.373
MOD_GSK3_1 324 331 PF00069 0.324
MOD_GSK3_1 344 351 PF00069 0.315
MOD_GSK3_1 354 361 PF00069 0.305
MOD_GSK3_1 434 441 PF00069 0.500
MOD_GSK3_1 442 449 PF00069 0.588
MOD_GSK3_1 85 92 PF00069 0.491
MOD_N-GLC_1 129 134 PF02516 0.423
MOD_N-GLC_1 177 182 PF02516 0.311
MOD_N-GLC_1 402 407 PF02516 0.402
MOD_N-GLC_2 426 428 PF02516 0.362
MOD_NEK2_1 118 123 PF00069 0.402
MOD_NEK2_1 131 136 PF00069 0.332
MOD_NEK2_1 155 160 PF00069 0.460
MOD_NEK2_1 172 177 PF00069 0.355
MOD_NEK2_1 179 184 PF00069 0.316
MOD_NEK2_1 204 209 PF00069 0.377
MOD_NEK2_1 228 233 PF00069 0.279
MOD_NEK2_1 252 257 PF00069 0.330
MOD_NEK2_1 289 294 PF00069 0.339
MOD_NEK2_1 300 305 PF00069 0.339
MOD_NEK2_1 324 329 PF00069 0.326
MOD_NEK2_1 348 353 PF00069 0.289
MOD_NEK2_1 355 360 PF00069 0.279
MOD_NEK2_1 372 377 PF00069 0.328
MOD_NEK2_1 402 407 PF00069 0.405
MOD_NEK2_1 58 63 PF00069 0.363
MOD_NEK2_2 165 170 PF00069 0.508
MOD_NEK2_2 187 192 PF00069 0.263
MOD_OFUCOSY 75 82 PF10250 0.352
MOD_PIKK_1 112 118 PF00454 0.543
MOD_PKA_1 9 15 PF00069 0.458
MOD_PKA_2 274 280 PF00069 0.440
MOD_PKA_2 9 15 PF00069 0.588
MOD_Plk_1 112 118 PF00069 0.506
MOD_Plk_1 261 267 PF00069 0.515
MOD_Plk_1 344 350 PF00069 0.399
MOD_Plk_2-3 363 369 PF00069 0.243
MOD_Plk_4 241 247 PF00069 0.286
MOD_Plk_4 261 267 PF00069 0.402
MOD_Plk_4 285 291 PF00069 0.358
MOD_ProDKin_1 446 452 PF00069 0.681
TRG_ENDOCYTIC_2 408 411 PF00928 0.427
TRG_ER_diArg_1 454 456 PF00400 0.498
TRG_NES_CRM1_1 189 200 PF08389 0.228
TRG_NLS_MonoExtC_3 145 151 PF00514 0.246
TRG_Pf-PMV_PEXEL_1 167 171 PF00026 0.434

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 39% 72%
A0A0N1I121 Leptomonas seymouri 28% 91%
A0A0N1I661 Leptomonas seymouri 32% 80%
A0A0N1I7S5 Leptomonas seymouri 34% 90%
A0A0N1II82 Leptomonas seymouri 31% 66%
A0A0S4IIK7 Bodo saltans 32% 100%
A0A0S4IJN2 Bodo saltans 30% 68%
A0A0S4ILC9 Bodo saltans 35% 83%
A0A0S4IN27 Bodo saltans 38% 84%
A0A0S4IQP4 Bodo saltans 37% 100%
A0A0S4IR61 Bodo saltans 33% 100%
A0A0S4ISU4 Bodo saltans 35% 69%
A0A0S4IU23 Bodo saltans 30% 77%
A0A0S4IU73 Bodo saltans 40% 91%
A0A0S4IV96 Bodo saltans 38% 75%
A0A0S4IVN7 Bodo saltans 41% 100%
A0A0S4IVQ8 Bodo saltans 36% 76%
A0A0S4IW93 Bodo saltans 30% 75%
A0A0S4IY44 Bodo saltans 29% 68%
A0A0S4IZC7 Bodo saltans 30% 100%
A0A0S4J206 Bodo saltans 37% 74%
A0A0S4J2H8 Bodo saltans 33% 78%
A0A0S4J5A0 Bodo saltans 34% 80%
A0A0S4J7Q5 Bodo saltans 30% 100%
A0A0S4JAQ6 Bodo saltans 29% 89%
A0A0S4JAS1 Bodo saltans 36% 72%
A0A0S4JAW7 Bodo saltans 28% 89%
A0A0S4JB95 Bodo saltans 27% 75%
A0A0S4JD35 Bodo saltans 34% 76%
A0A0S4JDS1 Bodo saltans 27% 86%
A0A0S4JDT0 Bodo saltans 39% 69%
A0A0S4JEK1 Bodo saltans 30% 100%
A0A0S4JEP2 Bodo saltans 27% 78%
A0A0S4JFC9 Bodo saltans 36% 95%
A0A0S4JFY5 Bodo saltans 40% 100%
A0A0S4JL29 Bodo saltans 33% 90%
A0A0S4JMF9 Bodo saltans 34% 100%
A0A0S4JMG0 Bodo saltans 29% 100%
A0A0S4JP43 Bodo saltans 39% 100%
A0A0S4JQW3 Bodo saltans 27% 100%
A0A0S4JSB8 Bodo saltans 38% 82%
A0A0S4JTQ7 Bodo saltans 33% 86%
A0A0S4KGV4 Bodo saltans 27% 84%
A0A0S4KHE4 Bodo saltans 33% 100%
A0A0S4KJA7 Bodo saltans 31% 68%
A0A0S4KK37 Bodo saltans 29% 78%
A0A0S4KL26 Bodo saltans 29% 100%
A0A0S4KMV2 Bodo saltans 31% 100%
A0A3Q8IC27 Leishmania donovani 92% 96%
A0A3Q8IIJ9 Leishmania donovani 37% 100%
A0A3S5H6M3 Leishmania donovani 36% 66%
A0A3S5H6M4 Leishmania donovani 38% 69%
A0A3S7WS66 Leishmania donovani 38% 69%
A0A3S7X4J4 Leishmania donovani 37% 100%
A4HBX3 Leishmania braziliensis 67% 100%
A4HJC8 Leishmania braziliensis 36% 100%
A4HVB0 Leishmania infantum 36% 100%
A4HZ93 Leishmania infantum 92% 96%
A4I6S4 Leishmania infantum 37% 100%
A6NIV6 Homo sapiens 27% 81%
D1GJ51 Leishmania infantum 34% 98%
D3ZAL8 Rattus norvegicus 25% 78%
E8NHP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AGG2 Leishmania infantum 35% 69%
E9AGG7 Leishmania infantum 34% 73%
E9AGG9 Leishmania infantum 38% 84%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 89%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 99%
E9B1U6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
O02833 Papio hamadryas 23% 75%
O08742 Mus musculus 25% 80%
P22792 Homo sapiens 25% 84%
P35858 Homo sapiens 25% 75%
P35859 Rattus norvegicus 24% 76%
P70389 Mus musculus 25% 76%
Q00874 Arabidopsis thaliana 28% 100%
Q05091 Pyrus communis 29% 100%
Q1L8Y7 Danio rerio 26% 81%
Q22875 Caenorhabditis elegans 24% 82%
Q25331 Leishmania major 29% 100%
Q4PSE6 Arabidopsis thaliana 29% 100%
Q4Q6B6 Leishmania major 38% 100%
Q4Q6B7 Leishmania major 38% 100%
Q4QGI0 Leishmania major 32% 90%
Q4QGI2 Leishmania major 35% 81%
Q4QGI4 Leishmania major 36% 85%
Q4QGI6 Leishmania major 33% 83%
Q4QGJ0 Leishmania major 33% 72%
Q4QGJ2 Leishmania major 34% 70%
Q4QGJ4 Leishmania major 29% 100%
Q4QGJ6 Leishmania major 33% 80%
Q4QGJ7 Leishmania major 29% 100%
Q4QGJ9 Leishmania major 36% 78%
Q4QGK0 Leishmania major 32% 80%
Q4QGK2 Leishmania major 35% 81%
Q4QGK4 Leishmania major 35% 68%
Q4QGK6 Leishmania major 29% 100%
Q4QGK8 Leishmania major 36% 89%
Q4QGL2 Leishmania major 36% 89%
Q4QGL4 Leishmania major 33% 100%
Q4QGL5 Leishmania major 32% 83%
Q4QGL8 Leishmania major 35% 75%
Q86VH5 Homo sapiens 25% 78%
Q8AVI4 Xenopus laevis 28% 79%
Q8BZ81 Mus musculus 25% 78%
Q940E8 Zea mays 29% 74%
Q9BGP6 Macaca fascicularis 25% 78%
Q9DBB9 Mus musculus 27% 83%
Q9LHF1 Arabidopsis thaliana 26% 92%
Q9M5J9 Arabidopsis thaliana 28% 100%
Q9SKK5 Arabidopsis thaliana 27% 68%
Q9SSD1 Arabidopsis thaliana 27% 92%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS