Surface antigen-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania major

UniProt:

Q4QC79_LEIMA

TriTrypDb:

LmjF.21.1170 , LMJLV39_210019800 , LMJSD75_210020000

Length:

456

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 69, no: 12
NetGPI	no	yes: 0, no: 81

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Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	5
GO:0005929	cilium	4	82
GO:0016020	membrane	2	28
GO:0042995	cell projection	2	82
GO:0043226	organelle	2	82
GO:0043227	membrane-bounded organelle	3	82
GO:0110165	cellular anatomical entity	1	82
GO:0120025	plasma membrane bounded cell projection	3	82

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Expansion

Sequence features

Q4QC79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC79

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004672	protein kinase activity	3	3
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0140096	catalytic activity, acting on a protein	2	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.228
CLV_NRD_NRD_1	145	147	PF00675	0.267
CLV_NRD_NRD_1	51	53	PF00675	0.555
CLV_NRD_NRD_1	9	11	PF00675	0.762
CLV_PCSK_KEX2_1	454	456	PF00082	0.718
CLV_PCSK_KEX2_1	9	11	PF00082	0.762
CLV_PCSK_SKI1_1	201	205	PF00082	0.468
CLV_PCSK_SKI1_1	52	56	PF00082	0.404
CLV_PCSK_SKI1_1	78	82	PF00082	0.555
CLV_PCSK_SKI1_1	9	13	PF00082	0.732

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A5	Leptomonas seymouri	39%	72%
A0A0N1I121	Leptomonas seymouri	28%	91%
A0A0N1I661	Leptomonas seymouri	32%	80%
A0A0N1I7S5	Leptomonas seymouri	34%	90%
A0A0N1II82	Leptomonas seymouri	31%	66%
A0A0S4IIK7	Bodo saltans	32%	100%
A0A0S4IJN2	Bodo saltans	30%	68%
A0A0S4ILC9	Bodo saltans	35%	83%
A0A0S4IN27	Bodo saltans	38%	84%
A0A0S4IQP4	Bodo saltans	37%	100%

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