Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC76_LEIMA

TriTrypDb:

LmjF.21.1200 , LMJLV39_210020100 , LMJSD75_210020300

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.616
CLV_C14_Caspase3-7	236	240	PF00656	0.509
CLV_NRD_NRD_1	147	149	PF00675	0.621
CLV_NRD_NRD_1	165	167	PF00675	0.310
CLV_NRD_NRD_1	226	228	PF00675	0.439
CLV_NRD_NRD_1	281	283	PF00675	0.517
CLV_PCSK_KEX2_1	147	149	PF00082	0.621
CLV_PCSK_KEX2_1	165	167	PF00082	0.310
CLV_PCSK_KEX2_1	226	228	PF00082	0.439
CLV_PCSK_KEX2_1	281	283	PF00082	0.565
CLV_PCSK_KEX2_1	290	292	PF00082	0.527
CLV_PCSK_KEX2_1	63	65	PF00082	0.653
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.521
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.653
CLV_PCSK_SKI1_1	166	170	PF00082	0.495
CLV_PCSK_SKI1_1	226	230	PF00082	0.455
DEG_APCC_DBOX_1	15	23	PF00400	0.571
DEG_COP1_1	111	123	PF00400	0.520
DOC_CYCLIN_RxL_1	163	171	PF00134	0.508
DOC_MAPK_gen_1	226	233	PF00069	0.455
DOC_MAPK_MEF2A_6	226	233	PF00069	0.455
DOC_MAPK_RevD_3	47	62	PF00069	0.542
DOC_USP7_MATH_1	106	110	PF00917	0.615
DOC_USP7_MATH_1	146	150	PF00917	0.653
DOC_USP7_MATH_1	283	287	PF00917	0.559
DOC_USP7_MATH_1	47	51	PF00917	0.625
DOC_USP7_MATH_1	94	98	PF00917	0.684
DOC_WW_Pin1_4	132	137	PF00397	0.567
LIG_14-3-3_CanoR_1	147	151	PF00244	0.641
LIG_14-3-3_CanoR_1	46	52	PF00244	0.720
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_FHA_1	228	234	PF00498	0.457
LIG_FHA_1	257	263	PF00498	0.614
LIG_FHA_1	32	38	PF00498	0.556
LIG_FHA_1	52	58	PF00498	0.663
LIG_FHA_2	232	238	PF00498	0.476
LIG_LIR_Gen_1	34	40	PF02991	0.477
LIG_LIR_Nem_3	179	185	PF02991	0.451
LIG_LIR_Nem_3	34	38	PF02991	0.478
LIG_NRBOX	224	230	PF00104	0.524
LIG_SH2_CRK	182	186	PF00017	0.449
LIG_SH2_STAT3	250	253	PF00017	0.468
LIG_SH2_STAT5	209	212	PF00017	0.431
LIG_SH2_STAT5	250	253	PF00017	0.468
LIG_SH3_3	12	18	PF00018	0.512
LIG_SH3_3	131	137	PF00018	0.613
LIG_SH3_3	264	270	PF00018	0.623
LIG_TRAF2_1	234	237	PF00917	0.541
MOD_CK1_1	109	115	PF00069	0.721
MOD_CK1_1	27	33	PF00069	0.592
MOD_CK1_1	50	56	PF00069	0.767
MOD_CK1_1	66	72	PF00069	0.701
MOD_CK2_1	231	237	PF00069	0.481
MOD_CK2_1	94	100	PF00069	0.648
MOD_Cter_Amidation	288	291	PF01082	0.501
MOD_GlcNHglycan	153	156	PF01048	0.527
MOD_GlcNHglycan	26	29	PF01048	0.551
MOD_GlcNHglycan	77	80	PF01048	0.600
MOD_GSK3_1	106	113	PF00069	0.678
MOD_GSK3_1	146	153	PF00069	0.627
MOD_GSK3_1	203	210	PF00069	0.431
MOD_GSK3_1	227	234	PF00069	0.456
MOD_GSK3_1	27	34	PF00069	0.492
MOD_GSK3_1	47	54	PF00069	0.602
MOD_GSK3_1	71	78	PF00069	0.589
MOD_N-GLC_2	21	23	PF02516	0.541
MOD_NEK2_1	110	115	PF00069	0.555
MOD_NEK2_1	168	173	PF00069	0.462
MOD_NEK2_1	202	207	PF00069	0.454
MOD_NEK2_1	83	88	PF00069	0.602
MOD_PK_1	85	91	PF00069	0.602
MOD_PKA_1	63	69	PF00069	0.639
MOD_PKA_2	146	152	PF00069	0.610
MOD_PKA_2	207	213	PF00069	0.435
MOD_PKA_2	63	69	PF00069	0.642
MOD_Plk_1	178	184	PF00069	0.447
MOD_ProDKin_1	132	138	PF00069	0.571
MOD_SUMO_for_1	176	179	PF00179	0.521
TRG_DiLeu_BaEn_1	224	229	PF01217	0.445
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.544
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.572
TRG_DiLeu_LyEn_5	224	229	PF01217	0.521
TRG_ENDOCYTIC_2	182	185	PF00928	0.433
TRG_ENDOCYTIC_2	186	189	PF00928	0.415
TRG_ENDOCYTIC_2	209	212	PF00928	0.431
TRG_ER_diArg_1	146	148	PF00400	0.607
TRG_ER_diArg_1	164	166	PF00400	0.593
TRG_ER_diArg_1	225	227	PF00400	0.448
TRG_NLS_MonoCore_2	60	65	PF00514	0.598
TRG_NLS_MonoExtN_4	60	66	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P384	Leptomonas seymouri	50%	100%
A0A3S7WWL4	Leishmania donovani	93%	100%
A4HBX6	Leishmania braziliensis	76%	100%
A4HZ96	Leishmania infantum	92%	100%
E9AVA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%