Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4QC73_LEIMA

TriTrypDb:

LmjF.21.1230 , LMJLV39_210020400 , LMJSD75_210020600

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	6
GO:0032991	protein-containing complex	1	6
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:1990904	ribonucleoprotein complex	2	6

Expansion

Sequence features

Q4QC73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.492
CLV_C14_Caspase3-7	391	395	PF00656	0.444
CLV_MEL_PAP_1	345	351	PF00089	0.469
CLV_NRD_NRD_1	136	138	PF00675	0.515
CLV_NRD_NRD_1	265	267	PF00675	0.656
CLV_NRD_NRD_1	464	466	PF00675	0.616
CLV_NRD_NRD_1	478	480	PF00675	0.520
CLV_NRD_NRD_1	50	52	PF00675	0.803
CLV_NRD_NRD_1	551	553	PF00675	0.639
CLV_NRD_NRD_1	57	59	PF00675	0.634
CLV_NRD_NRD_1	581	583	PF00675	0.694
CLV_NRD_NRD_1	98	100	PF00675	0.555
CLV_PCSK_FUR_1	462	466	PF00082	0.627
CLV_PCSK_KEX2_1	136	138	PF00082	0.515
CLV_PCSK_KEX2_1	464	466	PF00082	0.625
CLV_PCSK_KEX2_1	478	480	PF00082	0.541
CLV_PCSK_KEX2_1	551	553	PF00082	0.601
CLV_PCSK_KEX2_1	581	583	PF00082	0.722
CLV_PCSK_KEX2_1	98	100	PF00082	0.592
CLV_PCSK_SKI1_1	227	231	PF00082	0.319
CLV_PCSK_SKI1_1	280	284	PF00082	0.428
CLV_PCSK_SKI1_1	553	557	PF00082	0.453
CLV_PCSK_SKI1_1	558	562	PF00082	0.486
CLV_PCSK_SKI1_1	577	581	PF00082	0.490
CLV_PCSK_SKI1_1	85	89	PF00082	0.696
DEG_APCC_DBOX_1	279	287	PF00400	0.455
DEG_APCC_DBOX_1	557	565	PF00400	0.524
DEG_ODPH_VHL_1	138	149	PF01847	0.466
DEG_SPOP_SBC_1	443	447	PF00917	0.569
DOC_ANK_TNKS_1	136	143	PF00023	0.496
DOC_ANK_TNKS_1	363	370	PF00023	0.558
DOC_MAPK_gen_1	478	485	PF00069	0.571
DOC_MAPK_gen_1	577	588	PF00069	0.625
DOC_MAPK_MEF2A_6	280	287	PF00069	0.422
DOC_MAPK_MEF2A_6	478	485	PF00069	0.610
DOC_PP4_FxxP_1	402	405	PF00568	0.542
DOC_USP7_MATH_1	225	229	PF00917	0.552
DOC_USP7_MATH_1	259	263	PF00917	0.623
DOC_USP7_MATH_1	362	366	PF00917	0.661
DOC_USP7_MATH_1	424	428	PF00917	0.715
DOC_USP7_MATH_1	463	467	PF00917	0.661
DOC_USP7_MATH_1	50	54	PF00917	0.709
DOC_USP7_UBL2_3	549	553	PF12436	0.558
DOC_USP7_UBL2_3	620	624	PF12436	0.434
DOC_WW_Pin1_4	261	266	PF00397	0.643
DOC_WW_Pin1_4	516	521	PF00397	0.674
DOC_WW_Pin1_4	6	11	PF00397	0.565
DOC_WW_Pin1_4	600	605	PF00397	0.643
LIG_14-3-3_CanoR_1	105	111	PF00244	0.523
LIG_14-3-3_CanoR_1	177	186	PF00244	0.498
LIG_14-3-3_CanoR_1	19	27	PF00244	0.570
LIG_14-3-3_CanoR_1	227	233	PF00244	0.527
LIG_14-3-3_CanoR_1	372	376	PF00244	0.623
LIG_14-3-3_CanoR_1	441	451	PF00244	0.587
LIG_14-3-3_CanoR_1	462	470	PF00244	0.696
LIG_14-3-3_CanoR_1	471	475	PF00244	0.567
LIG_14-3-3_CanoR_1	478	482	PF00244	0.510
LIG_14-3-3_CanoR_1	58	64	PF00244	0.742
LIG_14-3-3_CanoR_1	581	588	PF00244	0.679
LIG_14-3-3_CanoR_1	80	88	PF00244	0.602
LIG_Actin_WH2_2	164	179	PF00022	0.497
LIG_Actin_WH2_2	405	421	PF00022	0.685
LIG_BRCT_BRCA1_1	96	100	PF00533	0.524
LIG_deltaCOP1_diTrp_1	394	402	PF00928	0.467
LIG_FHA_1	121	127	PF00498	0.473
LIG_FHA_1	170	176	PF00498	0.482
LIG_FHA_1	181	187	PF00498	0.397
LIG_FHA_1	248	254	PF00498	0.472
LIG_FHA_1	312	318	PF00498	0.472
LIG_FHA_1	379	385	PF00498	0.560
LIG_FHA_1	478	484	PF00498	0.621
LIG_FHA_1	581	587	PF00498	0.637
LIG_FHA_1	604	610	PF00498	0.612
LIG_FHA_1	7	13	PF00498	0.567
LIG_FHA_2	229	235	PF00498	0.514
LIG_FHA_2	389	395	PF00498	0.436
LIG_FHA_2	401	407	PF00498	0.561
LIG_FHA_2	517	523	PF00498	0.624
LIG_FHA_2	534	540	PF00498	0.427
LIG_FHA_2	87	93	PF00498	0.659
LIG_LIR_Gen_1	212	220	PF02991	0.447
LIG_RPA_C_Fungi	474	486	PF08784	0.606
LIG_RPA_C_Fungi	547	559	PF08784	0.556
LIG_SH2_STAP1	187	191	PF00017	0.412
LIG_SH2_STAP1	215	219	PF00017	0.419
LIG_SH2_STAP1	386	390	PF00017	0.498
LIG_SH2_STAT3	232	235	PF00017	0.380
LIG_SH2_STAT5	195	198	PF00017	0.410
LIG_SH2_STAT5	232	235	PF00017	0.365
LIG_SH2_STAT5	241	244	PF00017	0.266
LIG_SH2_STAT5	411	414	PF00017	0.626
LIG_SH3_2	47	52	PF14604	0.628
LIG_SH3_3	42	48	PF00018	0.732
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.428
LIG_SUMO_SIM_anti_2	373	379	PF11976	0.625
LIG_SUMO_SIM_anti_2	480	485	PF11976	0.609
LIG_SUMO_SIM_anti_2	510	519	PF11976	0.630
LIG_SUMO_SIM_anti_2	613	620	PF11976	0.602
LIG_SUMO_SIM_par_1	284	290	PF11976	0.428
LIG_SUMO_SIM_par_1	567	574	PF11976	0.666
LIG_SxIP_EBH_1	17	30	PF03271	0.570
MOD_CDK_SPK_2	261	266	PF00069	0.622
MOD_CDK_SPxK_1	261	267	PF00069	0.644
MOD_CDK_SPxxK_3	6	13	PF00069	0.567
MOD_CK1_1	104	110	PF00069	0.415
MOD_CK1_1	228	234	PF00069	0.391
MOD_CK1_1	23	29	PF00069	0.573
MOD_CK1_1	298	304	PF00069	0.422
MOD_CK1_1	309	315	PF00069	0.493
MOD_CK1_1	373	379	PF00069	0.687
MOD_CK1_1	60	66	PF00069	0.752
MOD_CK1_1	603	609	PF00069	0.574
MOD_CK1_1	83	89	PF00069	0.686
MOD_CK2_1	128	134	PF00069	0.494
MOD_CK2_1	400	406	PF00069	0.539
MOD_CK2_1	407	413	PF00069	0.629
MOD_CK2_1	444	450	PF00069	0.607
MOD_CK2_1	533	539	PF00069	0.613
MOD_CK2_1	611	617	PF00069	0.612
MOD_CMANNOS	397	400	PF00535	0.448
MOD_GlcNHglycan	106	109	PF01048	0.455
MOD_GlcNHglycan	130	133	PF01048	0.498
MOD_GlcNHglycan	152	155	PF01048	0.454
MOD_GlcNHglycan	243	246	PF01048	0.308
MOD_GlcNHglycan	261	264	PF01048	0.628
MOD_GlcNHglycan	335	338	PF01048	0.374
MOD_GlcNHglycan	364	367	PF01048	0.688
MOD_GlcNHglycan	38	41	PF01048	0.614
MOD_GlcNHglycan	457	460	PF01048	0.727
MOD_GlcNHglycan	553	556	PF01048	0.588
MOD_GlcNHglycan	59	62	PF01048	0.743
MOD_GlcNHglycan	597	600	PF01048	0.663
MOD_GlcNHglycan	85	88	PF01048	0.697
MOD_GSK3_1	176	183	PF00069	0.588
MOD_GSK3_1	19	26	PF00069	0.686
MOD_GSK3_1	230	237	PF00069	0.448
MOD_GSK3_1	243	250	PF00069	0.283
MOD_GSK3_1	254	261	PF00069	0.545
MOD_GSK3_1	307	314	PF00069	0.471
MOD_GSK3_1	343	350	PF00069	0.464
MOD_GSK3_1	470	477	PF00069	0.595
MOD_GSK3_1	60	67	PF00069	0.666
MOD_GSK3_1	86	93	PF00069	0.583
MOD_N-GLC_1	150	155	PF02516	0.496
MOD_N-GLC_1	362	367	PF02516	0.549
MOD_N-GLC_1	400	405	PF02516	0.522
MOD_NEK2_1	11	16	PF00069	0.571
MOD_NEK2_1	176	181	PF00069	0.533
MOD_NEK2_1	213	218	PF00069	0.569
MOD_NEK2_1	311	316	PF00069	0.489
MOD_NEK2_1	470	475	PF00069	0.596
MOD_NEK2_1	485	490	PF00069	0.547
MOD_PIKK_1	169	175	PF00454	0.475
MOD_PIKK_1	177	183	PF00454	0.464
MOD_PIKK_1	355	361	PF00454	0.571
MOD_PIKK_1	533	539	PF00454	0.574
MOD_PIKK_1	611	617	PF00454	0.623
MOD_PK_1	444	450	PF00069	0.710
MOD_PKA_1	551	557	PF00069	0.558
MOD_PKA_2	104	110	PF00069	0.460
MOD_PKA_2	176	182	PF00069	0.510
MOD_PKA_2	347	353	PF00069	0.491
MOD_PKA_2	36	42	PF00069	0.636
MOD_PKA_2	371	377	PF00069	0.636
MOD_PKA_2	430	436	PF00069	0.710
MOD_PKA_2	437	443	PF00069	0.671
MOD_PKA_2	463	469	PF00069	0.554
MOD_PKA_2	470	476	PF00069	0.542
MOD_PKA_2	477	483	PF00069	0.543
MOD_PKA_2	50	56	PF00069	0.810
MOD_PKA_2	551	557	PF00069	0.680
MOD_PKA_2	57	63	PF00069	0.592
MOD_PKA_2	580	586	PF00069	0.717
MOD_PKA_2	595	601	PF00069	0.645
MOD_PKA_2	64	70	PF00069	0.499
MOD_Plk_1	254	260	PF00069	0.534
MOD_Plk_1	298	304	PF00069	0.430
MOD_Plk_1	306	312	PF00069	0.461
MOD_Plk_1	400	406	PF00069	0.573
MOD_Plk_2-3	507	513	PF00069	0.562
MOD_Plk_4	111	117	PF00069	0.344
MOD_Plk_4	120	126	PF00069	0.356
MOD_Plk_4	281	287	PF00069	0.414
MOD_Plk_4	298	304	PF00069	0.430
MOD_Plk_4	312	318	PF00069	0.445
MOD_Plk_4	323	329	PF00069	0.449
MOD_Plk_4	330	336	PF00069	0.412
MOD_Plk_4	373	379	PF00069	0.627
MOD_Plk_4	407	413	PF00069	0.558
MOD_Plk_4	582	588	PF00069	0.611
MOD_ProDKin_1	261	267	PF00069	0.644
MOD_ProDKin_1	516	522	PF00069	0.673
MOD_ProDKin_1	6	12	PF00069	0.566
MOD_ProDKin_1	600	606	PF00069	0.640
MOD_SUMO_rev_2	228	237	PF00179	0.419
MOD_SUMO_rev_2	466	470	PF00179	0.616
MOD_SUMO_rev_2	53	61	PF00179	0.594
TRG_DiLeu_BaEn_4	413	419	PF01217	0.659
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.566
TRG_ENDOCYTIC_2	206	209	PF00928	0.458
TRG_ENDOCYTIC_2	215	218	PF00928	0.495
TRG_ER_diArg_1	12	15	PF00400	0.573
TRG_ER_diArg_1	135	137	PF00400	0.533
TRG_ER_diArg_1	238	241	PF00400	0.363
TRG_ER_diArg_1	462	465	PF00400	0.572
TRG_ER_diArg_1	580	582	PF00400	0.729
TRG_ER_diArg_1	98	100	PF00400	0.553
TRG_ER_diLys_1	634	638	PF00400	0.636
TRG_NES_CRM1_1	607	622	PF08389	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P386	Leptomonas seymouri	55%	100%
A0A0S4J9X3	Bodo saltans	22%	72%
A0A3Q8IAY0	Leishmania donovani	91%	100%
A4HZC0	Leishmania infantum	92%	100%
E9AVA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%