Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC70_LEIMA

TriTrypDb:

LmjF.21.1260 , LMJLV39_210020700 , LMJSD75_210020900

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4QC70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.615
CLV_C14_Caspase3-7	328	332	PF00656	0.561
CLV_C14_Caspase3-7	399	403	PF00656	0.612
CLV_C14_Caspase3-7	421	425	PF00656	0.639
CLV_NRD_NRD_1	201	203	PF00675	0.502
CLV_NRD_NRD_1	205	207	PF00675	0.492
CLV_NRD_NRD_1	213	215	PF00675	0.503
CLV_NRD_NRD_1	379	381	PF00675	0.631
CLV_NRD_NRD_1	97	99	PF00675	0.385
CLV_PCSK_KEX2_1	201	203	PF00082	0.502
CLV_PCSK_KEX2_1	205	207	PF00082	0.492
CLV_PCSK_KEX2_1	213	215	PF00082	0.503
CLV_PCSK_KEX2_1	379	381	PF00082	0.631
CLV_PCSK_KEX2_1	97	99	PF00082	0.385
CLV_PCSK_PC7_1	201	207	PF00082	0.519
CLV_PCSK_SKI1_1	189	193	PF00082	0.421
DEG_APCC_DBOX_1	188	196	PF00400	0.416
DEG_APCC_DBOX_1	212	220	PF00400	0.573
DEG_APCC_DBOX_1	62	70	PF00400	0.441
DEG_SCF_TRCP1_1	346	351	PF00400	0.553
DOC_CYCLIN_RxL_1	186	196	PF00134	0.419
DOC_CYCLIN_RxL_1	79	90	PF00134	0.404
DOC_USP7_MATH_1	228	232	PF00917	0.655
DOC_USP7_MATH_1	391	395	PF00917	0.611
DOC_USP7_MATH_1	420	424	PF00917	0.611
DOC_USP7_MATH_1	431	435	PF00917	0.611
DOC_WW_Pin1_4	233	238	PF00397	0.637
DOC_WW_Pin1_4	264	269	PF00397	0.622
DOC_WW_Pin1_4	351	356	PF00397	0.649
DOC_WW_Pin1_4	412	417	PF00397	0.661
LIG_14-3-3_CanoR_1	141	147	PF00244	0.532
LIG_14-3-3_CanoR_1	206	216	PF00244	0.537
LIG_14-3-3_CanoR_1	238	247	PF00244	0.633
LIG_14-3-3_CanoR_1	404	412	PF00244	0.611
LIG_14-3-3_CanoR_1	63	67	PF00244	0.451
LIG_Actin_WH2_2	381	398	PF00022	0.571
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BRCT_BRCA1_1	422	426	PF00533	0.590
LIG_BRCT_BRCA1_1	89	93	PF00533	0.303
LIG_EVH1_1	450	454	PF00568	0.622
LIG_FHA_1	42	48	PF00498	0.413
LIG_FHA_1	66	72	PF00498	0.399
LIG_FHA_2	419	425	PF00498	0.651
LIG_LIR_Apic_2	448	453	PF02991	0.620
LIG_LIR_Gen_1	90	101	PF02991	0.318
LIG_LIR_Nem_3	174	178	PF02991	0.424
LIG_LIR_Nem_3	423	429	PF02991	0.650
LIG_LIR_Nem_3	90	96	PF02991	0.368
LIG_PCNA_yPIPBox_3	26	40	PF02747	0.336
LIG_PDZ_Class_3	495	500	PF00595	0.616
LIG_Rb_LxCxE_1	157	174	PF01857	0.451
LIG_SH2_NCK_1	326	330	PF00017	0.596
LIG_SH2_PTP2	175	178	PF00017	0.418
LIG_SH2_STAT3	369	372	PF00017	0.568
LIG_SH2_STAT5	175	178	PF00017	0.477
LIG_SH2_STAT5	326	329	PF00017	0.576
LIG_SH2_STAT5	429	432	PF00017	0.575
LIG_SH3_2	451	456	PF14604	0.666
LIG_SH3_3	145	151	PF00018	0.541
LIG_SH3_3	244	250	PF00018	0.685
LIG_SH3_3	414	420	PF00018	0.655
LIG_SH3_3	446	452	PF00018	0.674
LIG_SH3_5	322	326	PF00018	0.620
LIG_SUMO_SIM_par_1	2	10	PF11976	0.456
LIG_SUMO_SIM_par_1	38	44	PF11976	0.385
LIG_SUMO_SIM_par_1	67	72	PF11976	0.392
LIG_TYR_ITIM	173	178	PF00017	0.423
MOD_CDK_SPK_2	233	238	PF00069	0.626
MOD_CK1_1	142	148	PF00069	0.615
MOD_CK1_1	351	357	PF00069	0.623
MOD_CK1_1	41	47	PF00069	0.321
MOD_CK1_1	72	78	PF00069	0.375
MOD_CK2_1	380	386	PF00069	0.637
MOD_CK2_1	391	397	PF00069	0.640
MOD_GlcNHglycan	141	144	PF01048	0.626
MOD_GlcNHglycan	21	24	PF01048	0.535
MOD_GlcNHglycan	223	226	PF01048	0.630
MOD_GlcNHglycan	229	233	PF01048	0.619
MOD_GlcNHglycan	240	243	PF01048	0.509
MOD_GlcNHglycan	327	330	PF01048	0.656
MOD_GlcNHglycan	333	336	PF01048	0.619
MOD_GlcNHglycan	345	349	PF01048	0.516
MOD_GlcNHglycan	364	367	PF01048	0.604
MOD_GlcNHglycan	380	383	PF01048	0.708
MOD_GlcNHglycan	397	401	PF01048	0.507
MOD_GlcNHglycan	432	436	PF01048	0.682
MOD_GlcNHglycan	477	480	PF01048	0.699
MOD_GlcNHglycan	89	92	PF01048	0.385
MOD_GlcNHglycan	93	96	PF01048	0.356
MOD_GSK3_1	208	215	PF00069	0.564
MOD_GSK3_1	233	240	PF00069	0.640
MOD_GSK3_1	344	351	PF00069	0.558
MOD_GSK3_1	407	414	PF00069	0.603
MOD_GSK3_1	416	423	PF00069	0.597
MOD_GSK3_1	427	434	PF00069	0.511
MOD_GSK3_1	65	72	PF00069	0.476
MOD_GSK3_1	87	94	PF00069	0.380
MOD_LATS_1	378	384	PF00433	0.678
MOD_N-GLC_1	331	336	PF02516	0.547
MOD_N-GLC_1	391	396	PF02516	0.599
MOD_N-GLC_1	77	82	PF02516	0.391
MOD_NEK2_1	1	6	PF00069	0.495
MOD_NEK2_1	207	212	PF00069	0.500
MOD_NEK2_1	40	45	PF00069	0.437
MOD_NEK2_1	69	74	PF00069	0.497
MOD_NEK2_2	120	125	PF00069	0.494
MOD_NEK2_2	391	396	PF00069	0.573
MOD_NEK2_2	62	67	PF00069	0.444
MOD_PIKK_1	208	214	PF00454	0.562
MOD_PK_1	380	386	PF00069	0.636
MOD_PKA_2	193	199	PF00069	0.434
MOD_PKA_2	212	218	PF00069	0.468
MOD_PKA_2	221	227	PF00069	0.526
MOD_PKA_2	237	243	PF00069	0.516
MOD_PKA_2	301	307	PF00069	0.629
MOD_PKA_2	378	384	PF00069	0.747
MOD_PKA_2	62	68	PF00069	0.444
MOD_Plk_1	178	184	PF00069	0.560
MOD_Plk_1	391	397	PF00069	0.573
MOD_Plk_1	77	83	PF00069	0.394
MOD_Plk_2-3	270	276	PF00069	0.548
MOD_Plk_4	1	7	PF00069	0.488
MOD_Plk_4	154	160	PF00069	0.464
MOD_Plk_4	359	365	PF00069	0.701
MOD_ProDKin_1	233	239	PF00069	0.637
MOD_ProDKin_1	264	270	PF00069	0.623
MOD_ProDKin_1	351	357	PF00069	0.650
MOD_ProDKin_1	412	418	PF00069	0.660
TRG_DiLeu_BaEn_1	32	37	PF01217	0.373
TRG_ENDOCYTIC_2	175	178	PF00928	0.418
TRG_ER_diArg_1	205	207	PF00400	0.514
TRG_ER_diArg_1	96	98	PF00400	0.385
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWT1	Leishmania donovani	84%	100%
A4HBY1	Leishmania braziliensis	54%	100%
A4HZC3	Leishmania infantum	85%	100%
E9AVB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%