Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC69_LEIMA

TriTrypDb:

LmjF.21.1270 , LMJLV39_210020800 , LMJSD75_210021000

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.468
CLV_C14_Caspase3-7	546	550	PF00656	0.381
CLV_C14_Caspase3-7	572	576	PF00656	0.405
CLV_NRD_NRD_1	31	33	PF00675	0.518
CLV_NRD_NRD_1	367	369	PF00675	0.516
CLV_NRD_NRD_1	383	385	PF00675	0.468
CLV_NRD_NRD_1	516	518	PF00675	0.713
CLV_NRD_NRD_1	617	619	PF00675	0.452
CLV_PCSK_KEX2_1	366	368	PF00082	0.530
CLV_PCSK_KEX2_1	516	518	PF00082	0.713
CLV_PCSK_KEX2_1	617	619	PF00082	0.452
CLV_PCSK_KEX2_1	684	686	PF00082	0.476
CLV_PCSK_KEX2_1	832	834	PF00082	0.665
CLV_PCSK_PC1ET2_1	684	686	PF00082	0.476
CLV_PCSK_PC1ET2_1	832	834	PF00082	0.665
CLV_PCSK_SKI1_1	165	169	PF00082	0.379
CLV_PCSK_SKI1_1	237	241	PF00082	0.405
CLV_PCSK_SKI1_1	617	621	PF00082	0.448
CLV_PCSK_SKI1_1	676	680	PF00082	0.538
CLV_PCSK_SKI1_1	707	711	PF00082	0.307
CLV_PCSK_SKI1_1	76	80	PF00082	0.330
DEG_APCC_DBOX_1	232	240	PF00400	0.474
DEG_SPOP_SBC_1	355	359	PF00917	0.543
DOC_ANK_TNKS_1	398	405	PF00023	0.429
DOC_CKS1_1	88	93	PF01111	0.525
DOC_CYCLIN_RxL_1	704	712	PF00134	0.314
DOC_MAPK_gen_1	217	225	PF00069	0.381
DOC_MAPK_gen_1	32	40	PF00069	0.580
DOC_MAPK_gen_1	607	616	PF00069	0.425
DOC_MAPK_MEF2A_6	217	225	PF00069	0.381
DOC_MAPK_MEF2A_6	428	435	PF00069	0.471
DOC_MAPK_MEF2A_6	651	659	PF00069	0.380
DOC_MAPK_NFAT4_5	428	436	PF00069	0.476
DOC_PP1_RVXF_1	307	313	PF00149	0.397
DOC_PP1_RVXF_1	705	711	PF00149	0.306
DOC_PP2B_LxvP_1	431	434	PF13499	0.476
DOC_USP7_MATH_1	105	109	PF00917	0.460
DOC_USP7_MATH_1	291	295	PF00917	0.399
DOC_USP7_MATH_1	339	343	PF00917	0.835
DOC_USP7_MATH_1	354	358	PF00917	0.534
DOC_USP7_MATH_1	386	390	PF00917	0.446
DOC_USP7_MATH_1	502	506	PF00917	0.798
DOC_USP7_MATH_1	528	532	PF00917	0.426
DOC_USP7_MATH_1	548	552	PF00917	0.254
DOC_USP7_MATH_1	747	751	PF00917	0.605
DOC_USP7_MATH_1	755	759	PF00917	0.600
DOC_USP7_MATH_1	792	796	PF00917	0.423
DOC_USP7_MATH_1	828	832	PF00917	0.530
DOC_USP7_MATH_2	718	724	PF00917	0.580
DOC_USP7_UBL2_3	676	680	PF12436	0.448
DOC_WW_Pin1_4	327	332	PF00397	0.670
DOC_WW_Pin1_4	335	340	PF00397	0.676
DOC_WW_Pin1_4	423	428	PF00397	0.444
DOC_WW_Pin1_4	586	591	PF00397	0.488
DOC_WW_Pin1_4	726	731	PF00397	0.573
DOC_WW_Pin1_4	87	92	PF00397	0.525
LIG_14-3-3_CanoR_1	159	167	PF00244	0.380
LIG_14-3-3_CanoR_1	423	427	PF00244	0.535
LIG_14-3-3_CanoR_1	87	91	PF00244	0.431
LIG_APCC_ABBA_1	432	437	PF00400	0.532
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BIR_III_4	126	130	PF00653	0.415
LIG_BRCT_BRCA1_1	27	31	PF00533	0.578
LIG_BRCT_BRCA1_2	27	33	PF00533	0.588
LIG_CtBP_PxDLS_1	222	226	PF00389	0.470
LIG_CtBP_PxDLS_1	654	658	PF00389	0.379
LIG_deltaCOP1_diTrp_1	638	644	PF00928	0.472
LIG_EH1_1	411	419	PF00400	0.401
LIG_eIF4E_1	412	418	PF01652	0.394
LIG_eIF4E_1	784	790	PF01652	0.687
LIG_FHA_1	112	118	PF00498	0.481
LIG_FHA_1	188	194	PF00498	0.467
LIG_FHA_1	22	28	PF00498	0.447
LIG_FHA_1	293	299	PF00498	0.404
LIG_FHA_1	311	317	PF00498	0.502
LIG_FHA_1	35	41	PF00498	0.553
LIG_FHA_1	47	53	PF00498	0.503
LIG_FHA_1	533	539	PF00498	0.480
LIG_FHA_1	650	656	PF00498	0.387
LIG_FHA_1	83	89	PF00498	0.503
LIG_FHA_2	107	113	PF00498	0.476
LIG_FHA_2	179	185	PF00498	0.524
LIG_FHA_2	403	409	PF00498	0.367
LIG_LIR_Gen_1	152	157	PF02991	0.398
LIG_LIR_Gen_1	232	243	PF02991	0.400
LIG_LIR_Gen_1	246	256	PF02991	0.389
LIG_LIR_Gen_1	279	289	PF02991	0.372
LIG_LIR_Gen_1	306	315	PF02991	0.399
LIG_LIR_Gen_1	35	43	PF02991	0.460
LIG_LIR_Gen_1	638	648	PF02991	0.372
LIG_LIR_Gen_1	704	713	PF02991	0.478
LIG_LIR_Gen_1	798	809	PF02991	0.402
LIG_LIR_Nem_3	112	118	PF02991	0.396
LIG_LIR_Nem_3	125	131	PF02991	0.377
LIG_LIR_Nem_3	152	156	PF02991	0.406
LIG_LIR_Nem_3	232	238	PF02991	0.378
LIG_LIR_Nem_3	246	251	PF02991	0.389
LIG_LIR_Nem_3	306	310	PF02991	0.413
LIG_LIR_Nem_3	35	39	PF02991	0.476
LIG_LIR_Nem_3	543	547	PF02991	0.410
LIG_LIR_Nem_3	621	626	PF02991	0.347
LIG_LIR_Nem_3	637	643	PF02991	0.384
LIG_LIR_Nem_3	704	708	PF02991	0.476
LIG_LIR_Nem_3	798	804	PF02991	0.393
LIG_NRP_CendR_1	832	835	PF00754	0.683
LIG_PCNA_PIPBox_1	414	423	PF02747	0.403
LIG_Pex14_1	640	644	PF04695	0.464
LIG_Pex14_2	153	157	PF04695	0.389
LIG_Pex14_2	264	268	PF04695	0.363
LIG_SH2_CRK	102	106	PF00017	0.437
LIG_SH2_CRK	3	7	PF00017	0.565
LIG_SH2_CRK	307	311	PF00017	0.398
LIG_SH2_CRK	36	40	PF00017	0.552
LIG_SH2_CRK	705	709	PF00017	0.465
LIG_SH2_CRK	799	803	PF00017	0.390
LIG_SH2_NCK_1	774	778	PF00017	0.610
LIG_SH2_PTP2	801	804	PF00017	0.384
LIG_SH2_SRC	624	627	PF00017	0.341
LIG_SH2_STAP1	281	285	PF00017	0.363
LIG_SH2_STAP1	36	40	PF00017	0.552
LIG_SH2_STAP1	624	628	PF00017	0.369
LIG_SH2_STAT3	215	218	PF00017	0.385
LIG_SH2_STAT3	373	376	PF00017	0.505
LIG_SH2_STAT3	560	563	PF00017	0.582
LIG_SH2_STAT5	118	121	PF00017	0.535
LIG_SH2_STAT5	163	166	PF00017	0.357
LIG_SH2_STAT5	192	195	PF00017	0.359
LIG_SH2_STAT5	215	218	PF00017	0.475
LIG_SH2_STAT5	235	238	PF00017	0.243
LIG_SH2_STAT5	36	39	PF00017	0.557
LIG_SH2_STAT5	373	376	PF00017	0.415
LIG_SH2_STAT5	412	415	PF00017	0.401
LIG_SH2_STAT5	421	424	PF00017	0.418
LIG_SH2_STAT5	430	433	PF00017	0.551
LIG_SH2_STAT5	526	529	PF00017	0.472
LIG_SH2_STAT5	536	539	PF00017	0.389
LIG_SH2_STAT5	603	606	PF00017	0.381
LIG_SH2_STAT5	643	646	PF00017	0.404
LIG_SH2_STAT5	774	777	PF00017	0.615
LIG_SH2_STAT5	801	804	PF00017	0.384
LIG_SH3_2	499	504	PF14604	0.603
LIG_SH3_3	328	334	PF00018	0.665
LIG_SH3_3	496	502	PF00018	0.603
LIG_SH3_3	5	11	PF00018	0.475
LIG_SH3_3	75	81	PF00018	0.426
LIG_SUMO_SIM_anti_2	179	184	PF11976	0.433
LIG_SUMO_SIM_anti_2	68	73	PF11976	0.475
LIG_SUMO_SIM_par_1	176	181	PF11976	0.399
LIG_TRAF2_1	290	293	PF00917	0.438
LIG_TRAF2_1	478	481	PF00917	0.725
LIG_TRAF2_1	51	54	PF00917	0.388
LIG_TRAF2_1	530	533	PF00917	0.408
LIG_TRAF2_1	763	766	PF00917	0.613
LIG_TRAF2_1	824	827	PF00917	0.545
LIG_TRFH_1	471	475	PF08558	0.605
LIG_TYR_ITIM	599	604	PF00017	0.363
LIG_TYR_ITIM	797	802	PF00017	0.485
LIG_UBA3_1	390	395	PF00899	0.419
LIG_UBA3_1	537	542	PF00899	0.390
LIG_WW_3	334	338	PF00397	0.685
MOD_CDK_SPK_2	423	428	PF00069	0.440
MOD_CDK_SPxxK_3	87	94	PF00069	0.522
MOD_CK1_1	108	114	PF00069	0.432
MOD_CK1_1	186	192	PF00069	0.466
MOD_CK1_1	357	363	PF00069	0.624
MOD_CK1_1	543	549	PF00069	0.401
MOD_CK1_1	584	590	PF00069	0.328
MOD_CK1_1	669	675	PF00069	0.531
MOD_CK1_1	772	778	PF00069	0.599
MOD_CK1_1	795	801	PF00069	0.362
MOD_CK2_1	300	306	PF00069	0.432
MOD_CK2_1	386	392	PF00069	0.446
MOD_CK2_1	402	408	PF00069	0.443
MOD_CK2_1	451	457	PF00069	0.660
MOD_CK2_1	47	53	PF00069	0.551
MOD_CK2_1	527	533	PF00069	0.427
MOD_CK2_1	632	638	PF00069	0.301
MOD_Cter_Amidation	514	517	PF01082	0.708
MOD_DYRK1A_RPxSP_1	423	427	PF00069	0.525
MOD_GlcNHglycan	172	175	PF01048	0.504
MOD_GlcNHglycan	27	30	PF01048	0.585
MOD_GlcNHglycan	323	326	PF01048	0.633
MOD_GlcNHglycan	341	344	PF01048	0.685
MOD_GlcNHglycan	352	355	PF01048	0.556
MOD_GlcNHglycan	414	417	PF01048	0.391
MOD_GlcNHglycan	488	491	PF01048	0.672
MOD_GlcNHglycan	49	52	PF01048	0.482
MOD_GlcNHglycan	556	559	PF01048	0.433
MOD_GlcNHglycan	571	574	PF01048	0.364
MOD_GlcNHglycan	633	637	PF01048	0.307
MOD_GlcNHglycan	722	725	PF01048	0.698
MOD_GlcNHglycan	758	761	PF01048	0.781
MOD_GlcNHglycan	775	778	PF01048	0.639
MOD_GlcNHglycan	790	793	PF01048	0.430
MOD_GSK3_1	183	190	PF00069	0.515
MOD_GSK3_1	21	28	PF00069	0.485
MOD_GSK3_1	217	224	PF00069	0.395
MOD_GSK3_1	323	330	PF00069	0.628
MOD_GSK3_1	335	342	PF00069	0.783
MOD_GSK3_1	350	357	PF00069	0.633
MOD_GSK3_1	408	415	PF00069	0.423
MOD_GSK3_1	528	535	PF00069	0.503
MOD_GSK3_1	662	669	PF00069	0.452
MOD_GSK3_1	769	776	PF00069	0.639
MOD_GSK3_1	780	787	PF00069	0.569
MOD_GSK3_1	788	795	PF00069	0.395
MOD_GSK3_1	82	89	PF00069	0.510
MOD_N-GLC_1	100	105	PF02516	0.463
MOD_N-GLC_1	25	30	PF02516	0.420
MOD_N-GLC_1	269	274	PF02516	0.414
MOD_N-GLC_1	320	325	PF02516	0.598
MOD_N-GLC_1	726	731	PF02516	0.654
MOD_N-GLC_1	747	752	PF02516	0.717
MOD_N-GLC_1	784	789	PF02516	0.614
MOD_NEK2_1	132	137	PF00069	0.448
MOD_NEK2_1	168	173	PF00069	0.465
MOD_NEK2_1	178	183	PF00069	0.366
MOD_NEK2_1	310	315	PF00069	0.394
MOD_NEK2_1	435	440	PF00069	0.501
MOD_NEK2_1	46	51	PF00069	0.509
MOD_NEK2_1	662	667	PF00069	0.443
MOD_NEK2_1	72	77	PF00069	0.438
MOD_NEK2_2	626	631	PF00069	0.486
MOD_NEK2_2	769	774	PF00069	0.607
MOD_PIKK_1	187	193	PF00454	0.500
MOD_PIKK_1	323	329	PF00454	0.661
MOD_PK_1	217	223	PF00069	0.387
MOD_PKA_1	684	690	PF00069	0.483
MOD_PKA_2	158	164	PF00069	0.415
MOD_PKA_2	21	27	PF00069	0.462
MOD_PKA_2	422	428	PF00069	0.433
MOD_PKA_2	684	690	PF00069	0.483
MOD_PKA_2	720	726	PF00069	0.612
MOD_PKA_2	792	798	PF00069	0.415
MOD_PKA_2	86	92	PF00069	0.431
MOD_Plk_1	100	106	PF00069	0.480
MOD_Plk_1	111	117	PF00069	0.345
MOD_Plk_1	178	184	PF00069	0.423
MOD_Plk_1	291	297	PF00069	0.387
MOD_Plk_1	34	40	PF00069	0.475
MOD_Plk_1	369	375	PF00069	0.429
MOD_Plk_1	548	554	PF00069	0.378
MOD_Plk_1	669	675	PF00069	0.531
MOD_Plk_1	784	790	PF00069	0.607
MOD_Plk_2-3	403	409	PF00069	0.367
MOD_Plk_4	311	317	PF00069	0.488
MOD_Plk_4	34	40	PF00069	0.480
MOD_Plk_4	386	392	PF00069	0.446
MOD_Plk_4	408	414	PF00069	0.422
MOD_Plk_4	532	538	PF00069	0.519
MOD_Plk_4	548	554	PF00069	0.302
MOD_Plk_4	769	775	PF00069	0.608
MOD_Plk_4	792	798	PF00069	0.429
MOD_ProDKin_1	327	333	PF00069	0.670
MOD_ProDKin_1	335	341	PF00069	0.676
MOD_ProDKin_1	423	429	PF00069	0.450
MOD_ProDKin_1	586	592	PF00069	0.484
MOD_ProDKin_1	726	732	PF00069	0.575
MOD_ProDKin_1	87	93	PF00069	0.519
MOD_SUMO_for_1	239	242	PF00179	0.361
MOD_SUMO_rev_2	379	386	PF00179	0.536
MOD_SUMO_rev_2	480	490	PF00179	0.622
MOD_SUMO_rev_2	806	814	PF00179	0.504
TRG_DiLeu_BaEn_3	532	538	PF01217	0.389
TRG_DiLeu_BaEn_4	493	499	PF01217	0.684
TRG_DiLeu_BaEn_4	64	70	PF01217	0.433
TRG_ENDOCYTIC_2	235	238	PF00928	0.411
TRG_ENDOCYTIC_2	281	284	PF00928	0.364
TRG_ENDOCYTIC_2	307	310	PF00928	0.405
TRG_ENDOCYTIC_2	36	39	PF00928	0.557
TRG_ENDOCYTIC_2	430	433	PF00928	0.506
TRG_ENDOCYTIC_2	601	604	PF00928	0.369
TRG_ENDOCYTIC_2	643	646	PF00928	0.505
TRG_ENDOCYTIC_2	705	708	PF00928	0.471
TRG_ENDOCYTIC_2	799	802	PF00928	0.395
TRG_ER_diArg_1	366	368	PF00400	0.530
TRG_ER_diArg_1	516	519	PF00400	0.724
TRG_ER_diArg_1	520	523	PF00400	0.642
TRG_ER_diArg_1	616	618	PF00400	0.453
TRG_NES_CRM1_1	170	184	PF08389	0.500
TRG_Pf-PMV_PEXEL_1	297	302	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	707	712	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	805	810	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P586	Leptomonas seymouri	65%	99%
A0A3S7WWR8	Leishmania donovani	95%	100%
A4HBY2	Leishmania braziliensis	84%	99%
A4HZC4	Leishmania infantum	95%	100%
E9AVB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%