MsrB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC68_LEIMA

TriTrypDb:

LmjF.21.1280 , LMJLV39_210020900 , LMJSD75_210021100

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	413	417	PF00656	0.659
DEG_APCC_DBOX_1	372	380	PF00400	0.545
DEG_Nend_UBRbox_2	1	3	PF02207	0.638
DEG_SCF_FBW7_1	432	437	PF00400	0.599
DEG_SPOP_SBC_1	10	14	PF00917	0.658
DEG_SPOP_SBC_1	434	438	PF00917	0.603
DOC_CKS1_1	238	243	PF01111	0.498
DOC_CYCLIN_RxL_1	19	30	PF00134	0.651
DOC_MAPK_gen_1	19	27	PF00069	0.751
DOC_MAPK_JIP1_4	21	27	PF00069	0.650
DOC_PP2B_LxvP_1	150	153	PF13499	0.360
DOC_PP2B_LxvP_1	170	173	PF13499	0.349
DOC_PP4_FxxP_1	380	383	PF00568	0.542
DOC_SPAK_OSR1_1	284	288	PF12202	0.361
DOC_USP7_MATH_1	10	14	PF00917	0.827
DOC_USP7_MATH_1	100	104	PF00917	0.530
DOC_USP7_MATH_1	153	157	PF00917	0.367
DOC_USP7_MATH_1	175	179	PF00917	0.530
DOC_USP7_MATH_1	216	220	PF00917	0.402
DOC_USP7_MATH_1	263	267	PF00917	0.545
DOC_USP7_MATH_1	34	38	PF00917	0.602
DOC_USP7_MATH_1	348	352	PF00917	0.581
DOC_USP7_MATH_1	434	438	PF00917	0.603
DOC_USP7_MATH_1	61	65	PF00917	0.573
DOC_USP7_MATH_1	87	91	PF00917	0.661
DOC_USP7_MATH_1	93	97	PF00917	0.773
DOC_USP7_UBL2_3	265	269	PF12436	0.477
DOC_WW_Pin1_4	162	167	PF00397	0.425
DOC_WW_Pin1_4	201	206	PF00397	0.311
DOC_WW_Pin1_4	237	242	PF00397	0.472
DOC_WW_Pin1_4	255	260	PF00397	0.489
DOC_WW_Pin1_4	430	435	PF00397	0.589
LIG_14-3-3_CanoR_1	255	259	PF00244	0.605
LIG_14-3-3_CanoR_1	373	377	PF00244	0.501
LIG_14-3-3_CanoR_1	70	78	PF00244	0.595
LIG_APCC_ABBA_1	183	188	PF00400	0.442
LIG_BRCT_BRCA1_1	257	261	PF00533	0.610
LIG_FHA_1	153	159	PF00498	0.358
LIG_FHA_1	238	244	PF00498	0.510
LIG_FHA_1	48	54	PF00498	0.653
LIG_FHA_2	131	137	PF00498	0.502
LIG_FHA_2	340	346	PF00498	0.528
LIG_FHA_2	411	417	PF00498	0.538
LIG_Integrin_RGD_1	353	355	PF01839	0.590
LIG_LIR_Apic_2	378	383	PF02991	0.536
LIG_LIR_Gen_1	416	426	PF02991	0.515
LIG_LIR_Nem_3	258	264	PF02991	0.494
LIG_LIR_Nem_3	324	328	PF02991	0.392
LIG_LIR_Nem_3	416	422	PF02991	0.511
LIG_Pex14_1	159	163	PF04695	0.348
LIG_REV1ctd_RIR_1	122	132	PF16727	0.336
LIG_SH2_CRK	163	167	PF00017	0.323
LIG_SH2_CRK	197	201	PF00017	0.312
LIG_SH2_NCK_1	163	167	PF00017	0.323
LIG_SH2_STAP1	154	158	PF00017	0.395
LIG_SH2_STAT5	154	157	PF00017	0.419
LIG_SH2_STAT5	325	328	PF00017	0.363
LIG_SH3_3	1	7	PF00018	0.521
LIG_SH3_3	108	114	PF00018	0.412
LIG_SH3_3	203	209	PF00018	0.328
LIG_SH3_3	235	241	PF00018	0.443
LIG_SH3_3	243	249	PF00018	0.539
LIG_SH3_3	256	262	PF00018	0.538
LIG_SH3_3	89	95	PF00018	0.636
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.488
LIG_TRAF2_1	133	136	PF00917	0.447
MOD_CDK_SPxxK_3	237	244	PF00069	0.498
MOD_CK1_1	257	263	PF00069	0.554
MOD_CK1_1	337	343	PF00069	0.453
MOD_CK1_1	37	43	PF00069	0.689
MOD_CK1_1	372	378	PF00069	0.576
MOD_CK1_1	45	51	PF00069	0.578
MOD_CK1_1	5	11	PF00069	0.685
MOD_CK1_1	64	70	PF00069	0.635
MOD_CK1_1	73	79	PF00069	0.585
MOD_CK2_1	130	136	PF00069	0.451
MOD_CK2_1	140	146	PF00069	0.314
MOD_CK2_1	362	368	PF00069	0.603
MOD_DYRK1A_RPxSP_1	237	241	PF00069	0.456
MOD_DYRK1A_RPxSP_1	255	259	PF00069	0.487
MOD_GlcNHglycan	102	105	PF01048	0.516
MOD_GlcNHglycan	29	32	PF01048	0.616
MOD_GlcNHglycan	319	322	PF01048	0.391
MOD_GlcNHglycan	350	353	PF01048	0.543
MOD_GlcNHglycan	36	39	PF01048	0.609
MOD_GlcNHglycan	364	367	PF01048	0.476
MOD_GlcNHglycan	47	50	PF01048	0.511
MOD_GlcNHglycan	65	69	PF01048	0.624
MOD_GlcNHglycan	73	76	PF01048	0.712
MOD_GlcNHglycan	88	92	PF01048	0.608
MOD_GSK3_1	186	193	PF00069	0.516
MOD_GSK3_1	253	260	PF00069	0.535
MOD_GSK3_1	430	437	PF00069	0.564
MOD_GSK3_1	5	12	PF00069	0.638
MOD_GSK3_1	69	76	PF00069	0.603
MOD_N-GLC_2	293	295	PF02516	0.350
MOD_NEK2_1	140	145	PF00069	0.395
MOD_NEK2_1	27	32	PF00069	0.653
MOD_NEK2_1	334	339	PF00069	0.382
MOD_NEK2_2	216	221	PF00069	0.431
MOD_NEK2_2	311	316	PF00069	0.317
MOD_NEK2_2	356	361	PF00069	0.605
MOD_PIKK_1	186	192	PF00454	0.439
MOD_PIKK_1	37	43	PF00454	0.621
MOD_PKA_2	186	192	PF00069	0.383
MOD_PKA_2	254	260	PF00069	0.587
MOD_PKA_2	362	368	PF00069	0.603
MOD_PKA_2	372	378	PF00069	0.544
MOD_PKA_2	45	51	PF00069	0.640
MOD_PKA_2	5	11	PF00069	0.675
MOD_PKA_2	69	75	PF00069	0.611
MOD_Plk_1	334	340	PF00069	0.399
MOD_Plk_1	410	416	PF00069	0.542
MOD_Plk_2-3	146	152	PF00069	0.367
MOD_Plk_4	175	181	PF00069	0.395
MOD_Plk_4	311	317	PF00069	0.304
MOD_Plk_4	334	340	PF00069	0.399
MOD_Plk_4	356	362	PF00069	0.606
MOD_Plk_4	375	381	PF00069	0.431
MOD_ProDKin_1	162	168	PF00069	0.432
MOD_ProDKin_1	201	207	PF00069	0.309
MOD_ProDKin_1	237	243	PF00069	0.486
MOD_ProDKin_1	255	261	PF00069	0.486
MOD_ProDKin_1	430	436	PF00069	0.591
TRG_DiLeu_BaEn_1	136	141	PF01217	0.412
TRG_ENDOCYTIC_2	197	200	PF00928	0.310
TRG_ER_diArg_1	328	331	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9M4	Leptomonas seymouri	41%	68%
A0A3S7WWN0	Leishmania donovani	89%	100%
A4HZC5	Leishmania infantum	89%	100%
E9AVB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	96%