RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QC66_LEIMA

TriTrypDb:

LmjF.21.1295 , LMJLV39_210021100 , LMJSD75_210021300

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0005634	nucleus	5	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4QC66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC66

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005488	binding	1	3
GO:0005515	protein binding	2	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0097602	cullin family protein binding	3	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	187	191	PF00082	0.704
CLV_PCSK_SKI1_1	233	237	PF00082	0.351
CLV_PCSK_SKI1_1	254	258	PF00082	0.403
DOC_CDC14_PxL_1	69	77	PF14671	0.648
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.629
DOC_USP7_MATH_1	10	14	PF00917	0.593
DOC_USP7_MATH_1	122	126	PF00917	0.783
DOC_USP7_MATH_1	189	193	PF00917	0.656
DOC_USP7_MATH_1	196	200	PF00917	0.646
DOC_USP7_MATH_1	213	217	PF00917	0.720
DOC_USP7_MATH_1	57	61	PF00917	0.648
DOC_USP7_MATH_2	102	108	PF00917	0.641
DOC_WW_Pin1_4	115	120	PF00397	0.564
DOC_WW_Pin1_4	136	141	PF00397	0.757
DOC_WW_Pin1_4	191	196	PF00397	0.650
DOC_WW_Pin1_4	201	206	PF00397	0.558
DOC_WW_Pin1_4	265	270	PF00397	0.396
DOC_WW_Pin1_4	80	85	PF00397	0.674
DOC_WW_Pin1_4	98	103	PF00397	0.530
LIG_14-3-3_CanoR_1	254	259	PF00244	0.403
LIG_BIR_III_4	36	40	PF00653	0.530
LIG_FHA_1	106	112	PF00498	0.559
LIG_FHA_1	158	164	PF00498	0.567
LIG_FHA_1	27	33	PF00498	0.659
LIG_FHA_2	188	194	PF00498	0.640
LIG_FHA_2	235	241	PF00498	0.403
LIG_LIR_Gen_1	107	116	PF02991	0.573
LIG_LIR_Nem_3	107	112	PF02991	0.559
LIG_LIR_Nem_3	50	55	PF02991	0.750
LIG_NRBOX	74	80	PF00104	0.637
LIG_Pex14_2	2	6	PF04695	0.555
LIG_SH2_CRK	261	265	PF00017	0.297
LIG_SH2_STAT5	242	245	PF00017	0.318
LIG_SH3_3	109	115	PF00018	0.550
LIG_SH3_3	137	143	PF00018	0.644
LIG_SH3_3	199	205	PF00018	0.649
LIG_SH3_3	96	102	PF00018	0.674
LIG_SUMO_SIM_par_1	74	83	PF11976	0.670
LIG_TRAF2_1	101	104	PF00917	0.641
LIG_WRC_WIRS_1	106	111	PF05994	0.555
MOD_CK1_1	118	124	PF00069	0.805
MOD_CK1_1	13	19	PF00069	0.569
MOD_CK1_1	169	175	PF00069	0.629
MOD_CK1_1	204	210	PF00069	0.676
MOD_CK1_1	80	86	PF00069	0.674
MOD_CK2_1	173	179	PF00069	0.625
MOD_CK2_1	187	193	PF00069	0.541
MOD_CK2_1	234	240	PF00069	0.403
MOD_CK2_1	98	104	PF00069	0.604
MOD_GlcNHglycan	12	15	PF01048	0.587
MOD_GlcNHglycan	172	175	PF01048	0.759
MOD_GlcNHglycan	215	218	PF01048	0.546
MOD_GlcNHglycan	3	6	PF01048	0.657
MOD_GlcNHglycan	52	55	PF01048	0.574
MOD_GlcNHglycan	59	62	PF01048	0.555
MOD_GlcNHglycan	8	11	PF01048	0.595
MOD_GSK3_1	1	8	PF00069	0.743
MOD_GSK3_1	10	17	PF00069	0.569
MOD_GSK3_1	114	121	PF00069	0.628
MOD_GSK3_1	124	131	PF00069	0.658
MOD_GSK3_1	166	173	PF00069	0.585
MOD_GSK3_1	175	182	PF00069	0.524
MOD_GSK3_1	187	194	PF00069	0.642
MOD_GSK3_1	196	203	PF00069	0.698
MOD_GSK3_1	204	211	PF00069	0.557
MOD_GSK3_1	225	232	PF00069	0.687
MOD_GSK3_1	79	86	PF00069	0.622
MOD_N-GLC_1	14	19	PF02516	0.601
MOD_NEK2_1	157	162	PF00069	0.605
MOD_NEK2_1	247	252	PF00069	0.325
MOD_NEK2_1	67	72	PF00069	0.521
MOD_NEK2_1	79	84	PF00069	0.581
MOD_PIKK_1	196	202	PF00454	0.661
MOD_Plk_2-3	234	240	PF00069	0.403
MOD_Plk_4	158	164	PF00069	0.593
MOD_Plk_4	26	32	PF00069	0.656
MOD_ProDKin_1	115	121	PF00069	0.565
MOD_ProDKin_1	136	142	PF00069	0.740
MOD_ProDKin_1	191	197	PF00069	0.653
MOD_ProDKin_1	201	207	PF00069	0.559
MOD_ProDKin_1	265	271	PF00069	0.400
MOD_ProDKin_1	80	86	PF00069	0.674
MOD_ProDKin_1	98	104	PF00069	0.528
MOD_SUMO_rev_2	230	238	PF00179	0.403
TRG_Pf-PMV_PEXEL_1	221	226	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K6	Leptomonas seymouri	35%	94%
A0A3S7WWM2	Leishmania donovani	89%	99%
A4HBY6	Leishmania braziliensis	67%	98%
A4HZC7	Leishmania infantum	88%	99%
E9AVB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%