RF_PROK_I domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RF-1 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QC65_LEIMA

TriTrypDb:

LmjF.21.1300 , LMJLV39_210021200 , LMJSD75_210021400

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC65

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003747	translation release factor activity	5	11
GO:0005488	binding	1	11
GO:0008079	translation termination factor activity	4	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.504
CLV_C14_Caspase3-7	418	422	PF00656	0.411
CLV_C14_Caspase3-7	490	494	PF00656	0.442
CLV_NRD_NRD_1	117	119	PF00675	0.624
CLV_NRD_NRD_1	138	140	PF00675	0.576
CLV_NRD_NRD_1	249	251	PF00675	0.453
CLV_NRD_NRD_1	257	259	PF00675	0.442
CLV_NRD_NRD_1	338	340	PF00675	0.356
CLV_NRD_NRD_1	412	414	PF00675	0.430
CLV_NRD_NRD_1	512	514	PF00675	0.257
CLV_NRD_NRD_1	88	90	PF00675	0.696
CLV_PCSK_FUR_1	254	258	PF00082	0.467
CLV_PCSK_KEX2_1	101	103	PF00082	0.676
CLV_PCSK_KEX2_1	256	258	PF00082	0.464
CLV_PCSK_KEX2_1	313	315	PF00082	0.482
CLV_PCSK_KEX2_1	338	340	PF00082	0.356
CLV_PCSK_KEX2_1	412	414	PF00082	0.430
CLV_PCSK_KEX2_1	449	451	PF00082	0.471
CLV_PCSK_KEX2_1	512	514	PF00082	0.257
CLV_PCSK_KEX2_1	88	90	PF00082	0.683
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.570
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.348
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.471
CLV_PCSK_SKI1_1	174	178	PF00082	0.589
CLV_PCSK_SKI1_1	200	204	PF00082	0.542
CLV_PCSK_SKI1_1	207	211	PF00082	0.537
CLV_PCSK_SKI1_1	446	450	PF00082	0.571
CLV_PCSK_SKI1_1	495	499	PF00082	0.254
CLV_PCSK_SKI1_1	89	93	PF00082	0.652
DEG_APCC_DBOX_1	171	179	PF00400	0.418
DEG_Nend_UBRbox_3	1	3	PF02207	0.518
DEG_SPOP_SBC_1	226	230	PF00917	0.531
DEG_SPOP_SBC_1	37	41	PF00917	0.365
DOC_ANK_TNKS_1	458	465	PF00023	0.431
DOC_CYCLIN_RxL_1	507	519	PF00134	0.446
DOC_MAPK_gen_1	174	184	PF00069	0.436
DOC_MAPK_gen_1	254	264	PF00069	0.429
DOC_MAPK_MEF2A_6	256	264	PF00069	0.424
DOC_MAPK_RevD_3	124	140	PF00069	0.501
DOC_PP1_RVXF_1	510	517	PF00149	0.446
DOC_USP7_MATH_1	220	224	PF00917	0.574
DOC_USP7_MATH_1	244	248	PF00917	0.525
DOC_USP7_MATH_1	37	41	PF00917	0.365
DOC_USP7_MATH_1	394	398	PF00917	0.504
DOC_USP7_MATH_1	417	421	PF00917	0.481
DOC_USP7_MATH_1	438	442	PF00917	0.346
DOC_USP7_MATH_1	458	462	PF00917	0.397
DOC_USP7_MATH_1	491	495	PF00917	0.442
DOC_USP7_MATH_1	72	76	PF00917	0.702
DOC_USP7_MATH_1	79	83	PF00917	0.634
DOC_USP7_UBL2_3	25	29	PF12436	0.483
DOC_WW_Pin1_4	423	428	PF00397	0.668
DOC_WW_Pin1_4	83	88	PF00397	0.700
LIG_14-3-3_CanoR_1	200	209	PF00244	0.558
LIG_14-3-3_CanoR_1	383	393	PF00244	0.576
LIG_14-3-3_CanoR_1	450	454	PF00244	0.430
LIG_Actin_WH2_2	178	195	PF00022	0.488
LIG_BIR_III_2	391	395	PF00653	0.517
LIG_BRCT_BRCA1_1	363	367	PF00533	0.415
LIG_BRCT_BRCA1_1	368	372	PF00533	0.463
LIG_CaM_IQ_9	154	169	PF13499	0.430
LIG_FHA_1	227	233	PF00498	0.593
LIG_FHA_1	39	45	PF00498	0.628
LIG_FHA_1	556	562	PF00498	0.530
LIG_LIR_Gen_1	127	136	PF02991	0.405
LIG_LIR_Gen_1	228	238	PF02991	0.493
LIG_LIR_Gen_1	301	311	PF02991	0.419
LIG_LIR_Gen_1	348	356	PF02991	0.374
LIG_LIR_Gen_1	364	374	PF02991	0.210
LIG_LIR_Gen_1	473	484	PF02991	0.535
LIG_LIR_Nem_3	127	133	PF02991	0.407
LIG_LIR_Nem_3	145	150	PF02991	0.402
LIG_LIR_Nem_3	228	234	PF02991	0.580
LIG_LIR_Nem_3	301	307	PF02991	0.424
LIG_LIR_Nem_3	348	353	PF02991	0.372
LIG_LIR_Nem_3	364	370	PF02991	0.208
LIG_LIR_Nem_3	473	479	PF02991	0.535
LIG_MLH1_MIPbox_1	363	367	PF16413	0.246
LIG_NRBOX	233	239	PF00104	0.462
LIG_Pex14_2	402	406	PF04695	0.311
LIG_SH2_CRK	350	354	PF00017	0.385
LIG_SH2_CRK	476	480	PF00017	0.548
LIG_SH2_PTP2	231	234	PF00017	0.422
LIG_SH2_PTP2	333	336	PF00017	0.477
LIG_SH2_STAP1	350	354	PF00017	0.378
LIG_SH2_STAP1	404	408	PF00017	0.393
LIG_SH2_STAP1	487	491	PF00017	0.510
LIG_SH2_STAT3	148	151	PF00017	0.419
LIG_SH2_STAT5	231	234	PF00017	0.537
LIG_SH2_STAT5	333	336	PF00017	0.416
LIG_SH2_STAT5	340	343	PF00017	0.360
LIG_SH2_STAT5	366	369	PF00017	0.518
LIG_SH2_STAT5	487	490	PF00017	0.445
LIG_SUMO_SIM_anti_2	181	188	PF11976	0.419
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.507
LIG_SxIP_EBH_1	23	35	PF03271	0.478
LIG_TRAF2_1	295	298	PF00917	0.601
LIG_TRAF2_1	521	524	PF00917	0.498
LIG_UBA3_1	26	35	PF00899	0.658
LIG_WRC_WIRS_1	353	358	PF05994	0.437
MOD_CDC14_SPxK_1	86	89	PF00782	0.502
MOD_CDK_SPK_2	83	88	PF00069	0.550
MOD_CDK_SPxK_1	83	89	PF00069	0.507
MOD_CK1_1	106	112	PF00069	0.596
MOD_CK1_1	170	176	PF00069	0.424
MOD_CK1_1	195	201	PF00069	0.483
MOD_CK1_1	269	275	PF00069	0.515
MOD_CK1_1	496	502	PF00069	0.495
MOD_CK1_1	58	64	PF00069	0.717
MOD_CK1_1	73	79	PF00069	0.697
MOD_CK1_1	82	88	PF00069	0.657
MOD_CK2_1	110	116	PF00069	0.541
MOD_CK2_1	149	155	PF00069	0.468
MOD_CK2_1	496	502	PF00069	0.507
MOD_GlcNHglycan	105	108	PF01048	0.579
MOD_GlcNHglycan	396	399	PF01048	0.441
MOD_GlcNHglycan	434	437	PF01048	0.456
MOD_GlcNHglycan	440	443	PF01048	0.419
MOD_GlcNHglycan	460	463	PF01048	0.182
MOD_GlcNHglycan	495	498	PF01048	0.231
MOD_GlcNHglycan	65	68	PF01048	0.589
MOD_GlcNHglycan	72	75	PF01048	0.602
MOD_GlcNHglycan	81	84	PF01048	0.555
MOD_GSK3_1	106	113	PF00069	0.573
MOD_GSK3_1	163	170	PF00069	0.556
MOD_GSK3_1	221	228	PF00069	0.609
MOD_GSK3_1	262	269	PF00069	0.412
MOD_GSK3_1	293	300	PF00069	0.478
MOD_GSK3_1	361	368	PF00069	0.397
MOD_GSK3_1	454	461	PF00069	0.492
MOD_GSK3_1	55	62	PF00069	0.642
MOD_GSK3_1	70	77	PF00069	0.556
MOD_GSK3_1	79	86	PF00069	0.579
MOD_N-GLC_1	103	108	PF02516	0.731
MOD_N-GLC_1	269	274	PF02516	0.474
MOD_N-GLC_1	468	473	PF02516	0.227
MOD_N-GLC_1	516	521	PF02516	0.278
MOD_NEK2_1	103	108	PF00069	0.697
MOD_NEK2_1	192	197	PF00069	0.571
MOD_NEK2_1	202	207	PF00069	0.430
MOD_NEK2_1	262	267	PF00069	0.437
MOD_NEK2_1	36	41	PF00069	0.546
MOD_NEK2_1	4	9	PF00069	0.502
MOD_NEK2_1	406	411	PF00069	0.376
MOD_NEK2_1	431	436	PF00069	0.339
MOD_NEK2_1	516	521	PF00069	0.512
MOD_NEK2_1	60	65	PF00069	0.694
MOD_PIKK_1	200	206	PF00454	0.650
MOD_PIKK_1	293	299	PF00454	0.500
MOD_PIKK_1	4	10	PF00454	0.525
MOD_PIKK_1	470	476	PF00454	0.451
MOD_PK_1	449	455	PF00069	0.480
MOD_PKA_1	449	455	PF00069	0.477
MOD_PKA_2	192	198	PF00069	0.500
MOD_PKA_2	449	455	PF00069	0.446
MOD_PKA_2	458	464	PF00069	0.443
MOD_Plk_1	167	173	PF00069	0.445
MOD_Plk_1	269	275	PF00069	0.560
MOD_Plk_1	516	522	PF00069	0.493
MOD_Plk_4	227	233	PF00069	0.442
MOD_Plk_4	362	368	PF00069	0.365
MOD_ProDKin_1	423	429	PF00069	0.659
MOD_ProDKin_1	83	89	PF00069	0.702
MOD_SUMO_for_1	176	179	PF00179	0.612
MOD_SUMO_for_1	209	212	PF00179	0.632
MOD_SUMO_for_1	278	281	PF00179	0.548
MOD_SUMO_for_1	521	524	PF00179	0.491
MOD_SUMO_rev_2	155	164	PF00179	0.474
TRG_AP2beta_CARGO_1	127	137	PF09066	0.405
TRG_DiLeu_BaEn_1	524	529	PF01217	0.600
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.424
TRG_ENDOCYTIC_2	147	150	PF00928	0.562
TRG_ENDOCYTIC_2	231	234	PF00928	0.568
TRG_ENDOCYTIC_2	333	336	PF00928	0.392
TRG_ENDOCYTIC_2	350	353	PF00928	0.374
TRG_ENDOCYTIC_2	476	479	PF00928	0.548
TRG_ER_diArg_1	136	139	PF00400	0.507
TRG_ER_diArg_1	254	257	PF00400	0.454
TRG_ER_diArg_1	337	339	PF00400	0.347
TRG_ER_diArg_1	412	414	PF00400	0.530
TRG_ER_diArg_1	512	514	PF00400	0.476
TRG_ER_diArg_1	87	89	PF00400	0.674
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P368	Leptomonas seymouri	61%	89%
A0A0S4JFA6	Bodo saltans	37%	88%
A0A1X0NXZ0	Trypanosomatidae	43%	82%
A0A3Q8IB76	Leishmania donovani	92%	100%
A0A422NSQ1	Trypanosoma rangeli	44%	89%
A4HBY7	Leishmania braziliensis	81%	86%
A4HZC8	Leishmania infantum	92%	100%
D0A156	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	92%
E9AVB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BLU1	Trypanosoma cruzi	42%	91%