LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QC64_LEIMA
TriTrypDb:
LmjF.21.1310 , LMJLV39_210021300 , LMJSD75_210021500 *
Length:
358

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC64
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC64

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016491 oxidoreductase activity 2 3
GO:0051213 dioxygenase activity 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 207 209 PF00675 0.479
CLV_PCSK_KEX2_1 207 209 PF00082 0.470
CLV_PCSK_SKI1_1 134 138 PF00082 0.414
CLV_PCSK_SKI1_1 172 176 PF00082 0.398
CLV_PCSK_SKI1_1 20 24 PF00082 0.442
CLV_PCSK_SKI1_1 5 9 PF00082 0.634
DEG_Nend_UBRbox_1 1 4 PF02207 0.590
DEG_SPOP_SBC_1 353 357 PF00917 0.641
DOC_CKS1_1 188 193 PF01111 0.399
DOC_MAPK_gen_1 169 178 PF00069 0.392
DOC_PP2B_LxvP_1 109 112 PF13499 0.588
DOC_PP2B_LxvP_1 151 154 PF13499 0.423
DOC_PP4_FxxP_1 160 163 PF00568 0.476
DOC_PP4_FxxP_1 37 40 PF00568 0.530
DOC_USP7_MATH_1 100 104 PF00917 0.441
DOC_USP7_MATH_1 154 158 PF00917 0.489
DOC_USP7_MATH_1 353 357 PF00917 0.641
DOC_WW_Pin1_4 181 186 PF00397 0.394
DOC_WW_Pin1_4 187 192 PF00397 0.383
DOC_WW_Pin1_4 231 236 PF00397 0.596
LIG_14-3-3_CanoR_1 195 203 PF00244 0.462
LIG_14-3-3_CanoR_1 207 211 PF00244 0.335
LIG_BRCT_BRCA1_1 156 160 PF00533 0.514
LIG_EH_1 254 258 PF12763 0.381
LIG_FHA_1 115 121 PF00498 0.507
LIG_FHA_1 146 152 PF00498 0.491
LIG_FHA_1 16 22 PF00498 0.473
LIG_FHA_1 188 194 PF00498 0.398
LIG_FHA_1 23 29 PF00498 0.506
LIG_FHA_2 347 353 PF00498 0.708
LIG_FHA_2 79 85 PF00498 0.478
LIG_Integrin_RGD_1 221 223 PF01839 0.493
LIG_LIR_Apic_2 157 163 PF02991 0.474
LIG_LIR_Apic_2 35 40 PF02991 0.421
LIG_LIR_Gen_1 202 210 PF02991 0.402
LIG_LIR_Gen_1 50 60 PF02991 0.377
LIG_LIR_Nem_3 202 206 PF02991 0.404
LIG_LIR_Nem_3 338 342 PF02991 0.478
LIG_LIR_Nem_3 50 55 PF02991 0.360
LIG_SH2_CRK 203 207 PF00017 0.396
LIG_SH2_SRC 38 41 PF00017 0.457
LIG_SH2_STAT3 273 276 PF00017 0.444
LIG_SH2_STAT5 226 229 PF00017 0.419
LIG_SH2_STAT5 273 276 PF00017 0.359
LIG_SH2_STAT5 52 55 PF00017 0.355
LIG_SH3_3 26 32 PF00018 0.450
LIG_SH3_3 96 102 PF00018 0.467
LIG_SUMO_SIM_anti_2 171 177 PF11976 0.376
LIG_SUMO_SIM_par_1 190 197 PF11976 0.500
LIG_WRC_WIRS_1 275 280 PF05994 0.391
MOD_CDK_SPxxK_3 231 238 PF00069 0.596
MOD_CK1_1 125 131 PF00069 0.446
MOD_CK1_1 196 202 PF00069 0.420
MOD_CK1_1 277 283 PF00069 0.394
MOD_CK2_1 102 108 PF00069 0.593
MOD_CK2_1 257 263 PF00069 0.408
MOD_CK2_1 328 334 PF00069 0.460
MOD_CK2_1 346 352 PF00069 0.586
MOD_CK2_1 78 84 PF00069 0.437
MOD_GlcNHglycan 104 107 PF01048 0.633
MOD_GlcNHglycan 124 127 PF01048 0.417
MOD_GlcNHglycan 259 262 PF01048 0.479
MOD_GlcNHglycan 309 312 PF01048 0.585
MOD_GSK3_1 125 132 PF00069 0.466
MOD_GSK3_1 141 148 PF00069 0.326
MOD_GSK3_1 239 246 PF00069 0.561
MOD_GSK3_1 267 274 PF00069 0.446
MOD_N-GLC_1 280 285 PF02516 0.385
MOD_NEK2_1 193 198 PF00069 0.461
MOD_NEK2_1 206 211 PF00069 0.338
MOD_NEK2_1 257 262 PF00069 0.392
MOD_NEK2_1 267 272 PF00069 0.356
MOD_NEK2_1 55 60 PF00069 0.507
MOD_PIKK_1 70 76 PF00454 0.500
MOD_PK_1 161 167 PF00069 0.371
MOD_PKA_2 168 174 PF00069 0.404
MOD_PKA_2 194 200 PF00069 0.441
MOD_PKA_2 206 212 PF00069 0.345
MOD_Plk_4 125 131 PF00069 0.445
MOD_Plk_4 161 167 PF00069 0.387
MOD_Plk_4 246 252 PF00069 0.573
MOD_Plk_4 268 274 PF00069 0.358
MOD_Plk_4 323 329 PF00069 0.532
MOD_ProDKin_1 181 187 PF00069 0.401
MOD_ProDKin_1 231 237 PF00069 0.593
MOD_SUMO_for_1 335 338 PF00179 0.530
TRG_DiLeu_BaEn_1 263 268 PF01217 0.464
TRG_DiLeu_BaLyEn_6 188 193 PF01217 0.534
TRG_DiLeu_BaLyEn_6 26 31 PF01217 0.380
TRG_ENDOCYTIC_2 203 206 PF00928 0.396
TRG_ENDOCYTIC_2 52 55 PF00928 0.355
TRG_ER_diArg_1 206 208 PF00400 0.462
TRG_Pf-PMV_PEXEL_1 330 334 PF00026 0.550

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBK0 Leptomonas seymouri 82% 99%
A0A0S4JR98 Bodo saltans 51% 100%
A0A1X0NXW7 Trypanosomatidae 62% 100%
A0A3S7WWQ0 Leishmania donovani 96% 100%
A0A422NSQ3 Trypanosoma rangeli 60% 100%
A4HZC9 Leishmania infantum 95% 100%
D0A155 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9AIQ4 Leishmania braziliensis 88% 100%
E9AVB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
V5BRD2 Trypanosoma cruzi 64% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS