Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC63_LEIMA

TriTrypDb:

LmjF.21.1320 , LMJLV39_210021400 , LMJSD75_210021600

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QC63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.597
CLV_NRD_NRD_1	93	95	PF00675	0.746
CLV_PCSK_KEX2_1	10	12	PF00082	0.597
CLV_PCSK_KEX2_1	92	94	PF00082	0.763
CLV_PCSK_SKI1_1	102	106	PF00082	0.744
CLV_PCSK_SKI1_1	117	121	PF00082	0.690
DEG_APCC_DBOX_1	131	139	PF00400	0.480
DEG_Nend_UBRbox_1	1	4	PF02207	0.793
LIG_14-3-3_CanoR_1	21	27	PF00244	0.555
LIG_14-3-3_CanoR_1	5	9	PF00244	0.781
LIG_14-3-3_CanoR_1	58	64	PF00244	0.534
LIG_APCC_ABBA_1	118	123	PF00400	0.519
LIG_APCC_ABBAyCdc20_2	117	123	PF00400	0.510
LIG_BRCT_BRCA1_1	150	154	PF00533	0.576
LIG_FHA_2	138	144	PF00498	0.561
LIG_FHA_2	94	100	PF00498	0.512
LIG_LIR_Gen_1	151	158	PF02991	0.505
LIG_LIR_Gen_1	45	52	PF02991	0.409
LIG_LIR_Nem_3	143	149	PF02991	0.483
LIG_LIR_Nem_3	151	157	PF02991	0.468
LIG_LIR_Nem_3	45	50	PF02991	0.409
LIG_NBox_RRM_1	32	42	PF00076	0.286
LIG_SH2_SRC	68	71	PF00017	0.415
LIG_WRC_WIRS_1	105	110	PF05994	0.473
MOD_CK1_1	133	139	PF00069	0.586
MOD_CK1_1	25	31	PF00069	0.786
MOD_CK1_1	45	51	PF00069	0.333
MOD_CK1_1	87	93	PF00069	0.543
MOD_CK2_1	104	110	PF00069	0.507
MOD_CK2_1	137	143	PF00069	0.537
MOD_Cter_Amidation	114	117	PF01082	0.714
MOD_GlcNHglycan	134	138	PF01048	0.762
MOD_GlcNHglycan	15	18	PF01048	0.529
MOD_GlcNHglycan	150	153	PF01048	0.755
MOD_GlcNHglycan	87	90	PF01048	0.774
MOD_GSK3_1	121	128	PF00069	0.559
MOD_GSK3_1	133	140	PF00069	0.414
MOD_GSK3_1	21	28	PF00069	0.788
MOD_N-GLC_1	13	18	PF02516	0.436
MOD_NEK2_2	142	147	PF00069	0.514
MOD_PK_1	125	131	PF00069	0.535
MOD_PKA_1	93	99	PF00069	0.564
MOD_PKA_2	4	10	PF00069	0.790
MOD_PKA_2	93	99	PF00069	0.536
MOD_PKB_1	19	27	PF00069	0.721
MOD_Plk_1	142	148	PF00069	0.513
MOD_Plk_4	104	110	PF00069	0.530
MOD_Plk_4	125	131	PF00069	0.565
MOD_Plk_4	27	33	PF00069	0.565
MOD_Plk_4	4	10	PF00069	0.786
MOD_Plk_4	42	48	PF00069	0.496
MOD_Plk_4	59	65	PF00069	0.506
MOD_SUMO_rev_2	110	118	PF00179	0.535
TRG_DiLeu_BaEn_1	114	119	PF01217	0.492
TRG_ER_diArg_1	19	22	PF00400	0.777
TRG_ER_diArg_1	9	11	PF00400	0.778
TRG_ER_diArg_1	91	94	PF00400	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR8	Leptomonas seymouri	61%	100%
A0A0S4JJA7	Bodo saltans	45%	100%
A0A1X0NXY8	Trypanosomatidae	38%	100%
A0A3R7KIY1	Trypanosoma rangeli	43%	100%
A0A3S7WWM3	Leishmania donovani	91%	100%
A4HBY8	Leishmania braziliensis	64%	99%
A4HZD0	Leishmania infantum	91%	100%
D0A154	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AVB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%