Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC63_LEIMA

TriTrypDb:

LmjF.21.1320 , LMJLV39_210021400 , LMJSD75_210021600

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

Q4QC63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC63

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.597
CLV_NRD_NRD_1	93	95	PF00675	0.746
CLV_PCSK_KEX2_1	10	12	PF00082	0.597
CLV_PCSK_KEX2_1	92	94	PF00082	0.763
CLV_PCSK_SKI1_1	102	106	PF00082	0.744
CLV_PCSK_SKI1_1	117	121	PF00082	0.690
DEG_APCC_DBOX_1	131	139	PF00400	0.480
DEG_Nend_UBRbox_1	1	4	PF02207	0.793
LIG_14-3-3_CanoR_1	21	27	PF00244	0.555
LIG_14-3-3_CanoR_1	5	9	PF00244	0.781

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSR8	Leptomonas seymouri	61%	100%
A0A0S4JJA7	Bodo saltans	45%	100%
A0A1X0NXY8	Trypanosomatidae	38%	100%
A0A3R7KIY1	Trypanosoma rangeli	43%	100%
A0A3S7WWM3	Leishmania donovani	91%	100%
A4HBY8	Leishmania braziliensis	64%	99%
A4HZD0	Leishmania infantum	91%	100%
D0A154	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AVB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%

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