LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QC59_LEIMA
TriTrypDb:
LmjF.21.1360 * , LMJLV39_210021800 * , LMJSD75_210022000 *
Length:
356

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 8, no: 2
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC59
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC59

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 86 92 PF00089 0.405
CLV_NRD_NRD_1 279 281 PF00675 0.596
CLV_NRD_NRD_1 93 95 PF00675 0.542
CLV_PCSK_KEX2_1 278 280 PF00082 0.593
CLV_PCSK_KEX2_1 93 95 PF00082 0.538
CLV_PCSK_PC7_1 89 95 PF00082 0.442
CLV_PCSK_SKI1_1 239 243 PF00082 0.481
CLV_PCSK_SKI1_1 321 325 PF00082 0.609
DEG_APCC_DBOX_1 238 246 PF00400 0.581
DEG_Nend_Nbox_1 1 3 PF02207 0.495
DEG_SPOP_SBC_1 120 124 PF00917 0.535
DOC_CKS1_1 186 191 PF01111 0.505
DOC_MAPK_gen_1 212 221 PF00069 0.472
DOC_PP4_FxxP_1 221 224 PF00568 0.443
DOC_PP4_FxxP_1 232 235 PF00568 0.423
DOC_PP4_FxxP_1 292 295 PF00568 0.552
DOC_USP7_MATH_1 126 130 PF00917 0.597
DOC_USP7_MATH_1 23 27 PF00917 0.520
DOC_USP7_MATH_1 296 300 PF00917 0.650
DOC_USP7_MATH_1 69 73 PF00917 0.611
DOC_USP7_UBL2_3 63 67 PF12436 0.414
DOC_WW_Pin1_4 122 127 PF00397 0.726
DOC_WW_Pin1_4 185 190 PF00397 0.569
DOC_WW_Pin1_4 21 26 PF00397 0.533
DOC_WW_Pin1_4 67 72 PF00397 0.460
LIG_14-3-3_CanoR_1 128 134 PF00244 0.581
LIG_14-3-3_CanoR_1 148 154 PF00244 0.286
LIG_14-3-3_CanoR_1 32 41 PF00244 0.519
LIG_14-3-3_CanoR_1 89 93 PF00244 0.447
LIG_14-3-3_CanoR_1 94 102 PF00244 0.503
LIG_Actin_WH2_2 52 69 PF00022 0.406
LIG_BRCT_BRCA1_1 250 254 PF00533 0.494
LIG_BRCT_BRCA1_1 36 40 PF00533 0.610
LIG_deltaCOP1_diTrp_1 267 277 PF00928 0.392
LIG_FHA_1 257 263 PF00498 0.428
LIG_FHA_1 311 317 PF00498 0.574
LIG_FHA_1 73 79 PF00498 0.615
LIG_FHA_1 85 91 PF00498 0.346
LIG_FHA_2 106 112 PF00498 0.612
LIG_FHA_2 139 145 PF00498 0.489
LIG_FHA_2 241 247 PF00498 0.617
LIG_FHA_2 332 338 PF00498 0.562
LIG_LIR_Apic_2 183 189 PF02991 0.449
LIG_LIR_Apic_2 289 295 PF02991 0.600
LIG_LIR_Gen_1 251 262 PF02991 0.408
LIG_LIR_Gen_1 267 276 PF02991 0.315
LIG_LIR_Nem_3 160 166 PF02991 0.461
LIG_LIR_Nem_3 251 257 PF02991 0.460
LIG_LIR_Nem_3 26 31 PF02991 0.520
LIG_LIR_Nem_3 37 43 PF02991 0.626
LIG_LIR_Nem_3 53 59 PF02991 0.447
LIG_MAD2 212 220 PF02301 0.402
LIG_Rb_LxCxE_1 193 211 PF01857 0.597
LIG_SH2_STAP1 149 153 PF00017 0.420
LIG_SH2_STAT5 112 115 PF00017 0.632
LIG_SH2_STAT5 54 57 PF00017 0.491
LIG_SH3_3 10 16 PF00018 0.521
LIG_SH3_3 263 269 PF00018 0.512
LIG_SxIP_EBH_1 321 334 PF03271 0.414
LIG_TRAF2_1 178 181 PF00917 0.496
LIG_TRAF2_2 48 53 PF00917 0.416
MOD_CDC14_SPxK_1 125 128 PF00782 0.568
MOD_CDK_SPxK_1 122 128 PF00069 0.594
MOD_CDK_SPxK_1 185 191 PF00069 0.642
MOD_CK1_1 118 124 PF00069 0.717
MOD_CK1_1 129 135 PF00069 0.744
MOD_CK1_1 208 214 PF00069 0.616
MOD_CK1_1 24 30 PF00069 0.411
MOD_CK1_1 72 78 PF00069 0.616
MOD_CK2_1 138 144 PF00069 0.454
MOD_GlcNHglycan 128 131 PF01048 0.732
MOD_GlcNHglycan 134 137 PF01048 0.742
MOD_GlcNHglycan 225 228 PF01048 0.598
MOD_GlcNHglycan 249 253 PF01048 0.452
MOD_GlcNHglycan 34 37 PF01048 0.548
MOD_GlcNHglycan 71 74 PF01048 0.584
MOD_GSK3_1 111 118 PF00069 0.641
MOD_GSK3_1 120 127 PF00069 0.693
MOD_GSK3_1 310 317 PF00069 0.452
MOD_GSK3_1 32 39 PF00069 0.562
MOD_GSK3_1 323 330 PF00069 0.497
MOD_GSK3_1 69 76 PF00069 0.553
MOD_GSK3_1 80 87 PF00069 0.441
MOD_GSK3_1 93 100 PF00069 0.592
MOD_N-GLC_1 314 319 PF02516 0.477
MOD_N-GLC_1 84 89 PF02516 0.417
MOD_N-GLC_2 131 133 PF02516 0.496
MOD_NEK2_1 1 6 PF00069 0.545
MOD_NEK2_1 34 39 PF00069 0.606
MOD_NEK2_2 149 154 PF00069 0.405
MOD_NEK2_2 157 162 PF00069 0.482
MOD_NEK2_2 84 89 PF00069 0.396
MOD_PIKK_1 205 211 PF00454 0.587
MOD_PIKK_1 323 329 PF00454 0.624
MOD_PKA_1 93 99 PF00069 0.488
MOD_PKA_2 88 94 PF00069 0.452
MOD_Plk_1 115 121 PF00069 0.513
MOD_Plk_1 157 163 PF00069 0.429
MOD_Plk_1 288 294 PF00069 0.786
MOD_Plk_1 296 302 PF00069 0.698
MOD_Plk_1 84 90 PF00069 0.454
MOD_Plk_4 1 7 PF00069 0.522
MOD_ProDKin_1 122 128 PF00069 0.728
MOD_ProDKin_1 185 191 PF00069 0.579
MOD_ProDKin_1 21 27 PF00069 0.519
MOD_ProDKin_1 67 73 PF00069 0.472
MOD_SUMO_for_1 62 65 PF00179 0.483
MOD_SUMO_rev_2 58 64 PF00179 0.412
TRG_ENDOCYTIC_2 163 166 PF00928 0.419
TRG_ENDOCYTIC_2 54 57 PF00928 0.434
TRG_ER_diArg_1 210 213 PF00400 0.504
TRG_ER_diArg_1 277 280 PF00400 0.500
TRG_ER_diArg_1 92 94 PF00400 0.531
TRG_Pf-PMV_PEXEL_1 239 244 PF00026 0.492

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1F8 Leptomonas seymouri 50% 90%
A0A1X0NHQ9 Trypanosomatidae 25% 100%
A0A3Q8IC12 Leishmania donovani 89% 100%
A0A3R7KKV6 Trypanosoma rangeli 27% 100%
A4HBZ4 Leishmania braziliensis 68% 91%
A4HZD4 Leishmania infantum 90% 100%
D0A150 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AVC1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
V5BHB3 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS