Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QC58_LEIMA

TriTrypDb:

LmjF.21.1370 , LMJLV39_210021900 , LMJSD75_210022100

Length:

1049

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QC58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC58

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.812
CLV_C14_Caspase3-7	558	562	PF00656	0.809
CLV_C14_Caspase3-7	717	721	PF00656	0.776
CLV_NRD_NRD_1	140	142	PF00675	0.532
CLV_NRD_NRD_1	4	6	PF00675	0.565
CLV_NRD_NRD_1	406	408	PF00675	0.508
CLV_NRD_NRD_1	495	497	PF00675	0.585
CLV_NRD_NRD_1	75	77	PF00675	0.632
CLV_NRD_NRD_1	891	893	PF00675	0.624
CLV_PCSK_KEX2_1	140	142	PF00082	0.532
CLV_PCSK_KEX2_1	495	497	PF00082	0.579
CLV_PCSK_KEX2_1	75	77	PF00082	0.632
CLV_PCSK_KEX2_1	891	893	PF00082	0.624
CLV_PCSK_KEX2_1	925	927	PF00082	0.543
CLV_PCSK_PC1ET2_1	925	927	PF00082	0.543
CLV_PCSK_SKI1_1	1013	1017	PF00082	0.624
CLV_PCSK_SKI1_1	140	144	PF00082	0.540
CLV_PCSK_SKI1_1	232	236	PF00082	0.537
CLV_PCSK_SKI1_1	261	265	PF00082	0.565
CLV_PCSK_SKI1_1	725	729	PF00082	0.500
CLV_PCSK_SKI1_1	929	933	PF00082	0.575
DEG_Nend_UBRbox_2	1	3	PF02207	0.866
DEG_SCF_FBW7_1	354	361	PF00400	0.877
DEG_SCF_FBW7_1	853	860	PF00400	0.800
DEG_SCF_FBW7_1	890	897	PF00400	0.729
DEG_SPOP_SBC_1	768	772	PF00917	0.725
DOC_CDC14_PxL_1	64	72	PF14671	0.464
DOC_CKS1_1	1007	1012	PF01111	0.825
DOC_CYCLIN_RxL_1	432	442	PF00134	0.807
DOC_CYCLIN_RxL_1	840	849	PF00134	0.689
DOC_CYCLIN_RxL_1	925	936	PF00134	0.756
DOC_CYCLIN_yClb1_LxF_4	800	805	PF00134	0.788
DOC_MAPK_gen_1	140	146	PF00069	0.745
DOC_MAPK_gen_1	217	225	PF00069	0.727
DOC_MAPK_gen_1	258	268	PF00069	0.766
DOC_MAPK_gen_1	75	84	PF00069	0.433
DOC_MAPK_gen_1	799	808	PF00069	0.793
DOC_MAPK_gen_1	925	932	PF00069	0.782
DOC_MAPK_HePTP_8	72	84	PF00069	0.451
DOC_MAPK_JIP1_4	799	805	PF00069	0.788
DOC_MAPK_MEF2A_6	19	27	PF00069	0.760
DOC_MAPK_MEF2A_6	258	266	PF00069	0.756
DOC_MAPK_MEF2A_6	75	84	PF00069	0.433
DOC_MAPK_MEF2A_6	802	810	PF00069	0.799
DOC_MAPK_NFAT4_5	261	269	PF00069	0.767
DOC_MAPK_RevD_3	62	76	PF00069	0.518
DOC_PP1_RVXF_1	800	806	PF00149	0.788
DOC_PP4_FxxP_1	351	354	PF00568	0.875
DOC_PP4_FxxP_1	781	784	PF00568	0.742
DOC_PP4_FxxP_1	924	927	PF00568	0.795
DOC_USP7_MATH_1	162	166	PF00917	0.715
DOC_USP7_MATH_1	289	293	PF00917	0.783
DOC_USP7_MATH_1	358	362	PF00917	0.763
DOC_USP7_MATH_1	37	41	PF00917	0.724
DOC_USP7_MATH_1	427	431	PF00917	0.753
DOC_USP7_MATH_1	456	460	PF00917	0.751
DOC_USP7_MATH_1	534	538	PF00917	0.701
DOC_USP7_MATH_1	610	614	PF00917	0.754
DOC_USP7_MATH_1	643	647	PF00917	0.760
DOC_USP7_MATH_1	653	657	PF00917	0.668
DOC_USP7_MATH_1	670	674	PF00917	0.612
DOC_USP7_MATH_1	754	758	PF00917	0.750
DOC_USP7_MATH_1	776	780	PF00917	0.694
DOC_USP7_MATH_1	857	861	PF00917	0.807
DOC_USP7_MATH_1	882	886	PF00917	0.788
DOC_USP7_MATH_2	716	722	PF00917	0.748
DOC_USP7_UBL2_3	925	929	PF12436	0.738
DOC_WW_Pin1_4	1006	1011	PF00397	0.852
DOC_WW_Pin1_4	354	359	PF00397	0.877
DOC_WW_Pin1_4	483	488	PF00397	0.785
DOC_WW_Pin1_4	581	586	PF00397	0.840
DOC_WW_Pin1_4	815	820	PF00397	0.687
DOC_WW_Pin1_4	853	858	PF00397	0.853
DOC_WW_Pin1_4	883	888	PF00397	0.851
DOC_WW_Pin1_4	890	895	PF00397	0.805
LIG_14-3-3_CanoR_1	1022	1028	PF00244	0.836
LIG_14-3-3_CanoR_1	1035	1039	PF00244	0.691
LIG_14-3-3_CanoR_1	106	116	PF00244	0.689
LIG_14-3-3_CanoR_1	140	145	PF00244	0.687
LIG_14-3-3_CanoR_1	154	159	PF00244	0.722
LIG_14-3-3_CanoR_1	172	176	PF00244	0.606
LIG_14-3-3_CanoR_1	261	267	PF00244	0.708
LIG_14-3-3_CanoR_1	314	320	PF00244	0.776
LIG_14-3-3_CanoR_1	424	433	PF00244	0.810
LIG_14-3-3_CanoR_1	495	501	PF00244	0.777
LIG_14-3-3_CanoR_1	568	573	PF00244	0.697
LIG_14-3-3_CanoR_1	594	604	PF00244	0.736
LIG_14-3-3_CanoR_1	697	705	PF00244	0.643
LIG_14-3-3_CanoR_1	725	733	PF00244	0.697
LIG_14-3-3_CanoR_1	756	762	PF00244	0.697
LIG_14-3-3_CanoR_1	802	806	PF00244	0.639
LIG_14-3-3_CanoR_1	867	875	PF00244	0.700
LIG_APCC_ABBA_1	572	577	PF00400	0.688
LIG_APCC_ABBA_1	633	638	PF00400	0.711
LIG_BRCT_BRCA1_1	264	268	PF00533	0.770
LIG_BRCT_BRCA1_1	676	680	PF00533	0.812
LIG_Clathr_ClatBox_1	634	638	PF01394	0.711
LIG_deltaCOP1_diTrp_1	218	221	PF00928	0.642
LIG_DLG_GKlike_1	785	793	PF00625	0.733
LIG_FHA_1	137	143	PF00498	0.654
LIG_FHA_1	210	216	PF00498	0.797
LIG_FHA_1	345	351	PF00498	0.840
LIG_FHA_1	373	379	PF00498	0.867
LIG_FHA_1	508	514	PF00498	0.810
LIG_FHA_1	52	58	PF00498	0.530
LIG_FHA_1	630	636	PF00498	0.758
LIG_FHA_1	816	822	PF00498	0.716
LIG_FHA_1	896	902	PF00498	0.808
LIG_FHA_2	133	139	PF00498	0.706
LIG_FHA_2	355	361	PF00498	0.877
LIG_FHA_2	697	703	PF00498	0.815
LIG_FHA_2	834	840	PF00498	0.807
LIG_FHA_2	912	918	PF00498	0.764
LIG_IRF3_LxIS_1	249	255	PF10401	0.717
LIG_IRF3_LxIS_1	541	548	PF10401	0.767
LIG_LIR_Apic_2	348	354	PF02991	0.870
LIG_LIR_Apic_2	707	713	PF02991	0.656
LIG_LIR_Apic_2	779	784	PF02991	0.667
LIG_LIR_Apic_2	921	927	PF02991	0.796
LIG_LIR_Gen_1	1041	1048	PF02991	0.646
LIG_LIR_Gen_1	265	276	PF02991	0.779
LIG_LIR_Gen_1	47	57	PF02991	0.483
LIG_LIR_Gen_1	628	637	PF02991	0.723
LIG_LIR_Nem_3	1041	1045	PF02991	0.823
LIG_LIR_Nem_3	218	222	PF02991	0.752
LIG_LIR_Nem_3	265	271	PF02991	0.774
LIG_LIR_Nem_3	47	52	PF02991	0.425
LIG_LIR_Nem_3	628	633	PF02991	0.719
LIG_LIR_Nem_3	677	683	PF02991	0.787
LIG_LIR_Nem_3	804	808	PF02991	0.637
LIG_MLH1_MIPbox_1	264	268	PF16413	0.770
LIG_MYND_3	899	903	PF01753	0.795
LIG_NRBOX	221	227	PF00104	0.747
LIG_PCNA_yPIPBox_3	1000	1013	PF02747	0.716
LIG_PTAP_UEV_1	321	326	PF05743	0.783
LIG_PTB_Apo_2	38	45	PF02174	0.710
LIG_RPA_C_Fungi	270	282	PF08784	0.525
LIG_SH2_PTP2	81	84	PF00017	0.530
LIG_SH2_STAP1	657	661	PF00017	0.693
LIG_SH2_STAT3	649	652	PF00017	0.623
LIG_SH2_STAT3	99	102	PF00017	0.678
LIG_SH2_STAT5	125	128	PF00017	0.703
LIG_SH2_STAT5	148	151	PF00017	0.556
LIG_SH2_STAT5	267	270	PF00017	0.725
LIG_SH2_STAT5	665	668	PF00017	0.732
LIG_SH2_STAT5	687	690	PF00017	0.706
LIG_SH2_STAT5	71	74	PF00017	0.478
LIG_SH2_STAT5	710	713	PF00017	0.793
LIG_SH2_STAT5	81	84	PF00017	0.501
LIG_SH3_1	156	162	PF00018	0.704
LIG_SH3_1	710	716	PF00018	0.719
LIG_SH3_3	156	162	PF00018	0.704
LIG_SH3_3	20	26	PF00018	0.773
LIG_SH3_3	319	325	PF00018	0.818
LIG_SH3_3	388	394	PF00018	0.834
LIG_SH3_3	606	612	PF00018	0.752
LIG_SH3_3	62	68	PF00018	0.346
LIG_SH3_3	710	716	PF00018	0.761
LIG_SH3_3	806	812	PF00018	0.793
LIG_SH3_3	81	87	PF00018	0.530
LIG_SxIP_EBH_1	495	506	PF03271	0.673
LIG_TRAF2_1	161	164	PF00917	0.727
LIG_TRAF2_1	370	373	PF00917	0.792
LIG_UBA3_1	222	228	PF00899	0.617
LIG_UBA3_1	30	34	PF00899	0.677
LIG_UBA3_1	685	692	PF00899	0.637
LIG_WRC_WIRS_1	268	273	PF05994	0.731
LIG_WRC_WIRS_1	786	791	PF05994	0.740
LIG_WW_1	68	71	PF00397	0.632
MOD_CDK_SPK_2	1006	1011	PF00069	0.638
MOD_CDK_SPK_2	585	590	PF00069	0.730
MOD_CDK_SPxxK_3	1006	1013	PF00069	0.758
MOD_CDK_SPxxK_3	585	592	PF00069	0.772
MOD_CK1_1	1023	1029	PF00069	0.807
MOD_CK1_1	171	177	PF00069	0.626
MOD_CK1_1	346	352	PF00069	0.854
MOD_CK1_1	376	382	PF00069	0.846
MOD_CK1_1	40	46	PF00069	0.698
MOD_CK1_1	459	465	PF00069	0.848
MOD_CK1_1	584	590	PF00069	0.770
MOD_CK1_1	598	604	PF00069	0.603
MOD_CK1_1	672	678	PF00069	0.701
MOD_CK1_1	742	748	PF00069	0.654
MOD_CK1_1	757	763	PF00069	0.697
MOD_CK1_1	770	776	PF00069	0.684
MOD_CK1_1	779	785	PF00069	0.610
MOD_CK1_1	855	861	PF00069	0.810
MOD_CK1_1	895	901	PF00069	0.758
MOD_CK1_1	959	965	PF00069	0.785
MOD_CK1_1	966	972	PF00069	0.754
MOD_CK2_1	132	138	PF00069	0.655
MOD_CK2_1	315	321	PF00069	0.649
MOD_CK2_1	342	348	PF00069	0.810
MOD_CK2_1	354	360	PF00069	0.745
MOD_CK2_1	454	460	PF00069	0.858
MOD_CK2_1	696	702	PF00069	0.766
MOD_CK2_1	833	839	PF00069	0.753
MOD_CK2_1	882	888	PF00069	0.826
MOD_CK2_1	911	917	PF00069	0.702
MOD_GlcNHglycan	109	112	PF01048	0.617
MOD_GlcNHglycan	163	167	PF01048	0.627
MOD_GlcNHglycan	190	193	PF01048	0.673
MOD_GlcNHglycan	236	239	PF01048	0.532
MOD_GlcNHglycan	284	287	PF01048	0.775
MOD_GlcNHglycan	297	300	PF01048	0.665
MOD_GlcNHglycan	302	305	PF01048	0.622
MOD_GlcNHglycan	309	312	PF01048	0.650
MOD_GlcNHglycan	321	325	PF01048	0.790
MOD_GlcNHglycan	366	369	PF01048	0.704
MOD_GlcNHglycan	429	432	PF01048	0.683
MOD_GlcNHglycan	456	459	PF01048	0.800
MOD_GlcNHglycan	481	484	PF01048	0.674
MOD_GlcNHglycan	536	539	PF01048	0.721
MOD_GlcNHglycan	547	550	PF01048	0.746
MOD_GlcNHglycan	557	560	PF01048	0.707
MOD_GlcNHglycan	605	608	PF01048	0.764
MOD_GlcNHglycan	641	644	PF01048	0.697
MOD_GlcNHglycan	658	662	PF01048	0.533
MOD_GlcNHglycan	741	744	PF01048	0.623
MOD_GlcNHglycan	848	851	PF01048	0.776
MOD_GlcNHglycan	859	862	PF01048	0.597
MOD_GlcNHglycan	871	874	PF01048	0.628
MOD_GSK3_1	1002	1009	PF00069	0.827
MOD_GSK3_1	13	20	PF00069	0.576
MOD_GSK3_1	132	139	PF00069	0.532
MOD_GSK3_1	230	237	PF00069	0.538
MOD_GSK3_1	262	269	PF00069	0.711
MOD_GSK3_1	342	349	PF00069	0.857
MOD_GSK3_1	354	361	PF00069	0.669
MOD_GSK3_1	372	379	PF00069	0.558
MOD_GSK3_1	40	47	PF00069	0.696
MOD_GSK3_1	462	469	PF00069	0.765
MOD_GSK3_1	479	486	PF00069	0.575
MOD_GSK3_1	495	502	PF00069	0.642
MOD_GSK3_1	539	546	PF00069	0.814
MOD_GSK3_1	562	569	PF00069	0.729
MOD_GSK3_1	581	588	PF00069	0.573
MOD_GSK3_1	625	632	PF00069	0.526
MOD_GSK3_1	639	646	PF00069	0.629
MOD_GSK3_1	653	660	PF00069	0.487
MOD_GSK3_1	670	677	PF00069	0.496
MOD_GSK3_1	714	721	PF00069	0.724
MOD_GSK3_1	725	732	PF00069	0.594
MOD_GSK3_1	735	742	PF00069	0.650
MOD_GSK3_1	770	777	PF00069	0.786
MOD_GSK3_1	833	840	PF00069	0.740
MOD_GSK3_1	853	860	PF00069	0.531
MOD_GSK3_1	87	94	PF00069	0.530
MOD_GSK3_1	890	897	PF00069	0.738
MOD_GSK3_1	916	923	PF00069	0.736
MOD_GSK3_1	938	945	PF00069	0.770
MOD_GSK3_1	959	966	PF00069	0.825
MOD_GSK3_1	975	982	PF00069	0.590
MOD_LATS_1	312	318	PF00433	0.765
MOD_N-GLC_1	358	363	PF02516	0.801
MOD_N-GLC_1	578	583	PF02516	0.816
MOD_N-GLC_1	883	888	PF02516	0.750
MOD_NEK2_1	1	6	PF00069	0.801
MOD_NEK2_1	17	22	PF00069	0.498
MOD_NEK2_1	183	188	PF00069	0.723
MOD_NEK2_1	234	239	PF00069	0.590
MOD_NEK2_1	252	257	PF00069	0.583
MOD_NEK2_1	262	267	PF00069	0.498
MOD_NEK2_1	287	292	PF00069	0.661
MOD_NEK2_1	300	305	PF00069	0.610
MOD_NEK2_1	342	347	PF00069	0.839
MOD_NEK2_1	44	49	PF00069	0.475
MOD_NEK2_1	466	471	PF00069	0.777
MOD_NEK2_1	545	550	PF00069	0.749
MOD_NEK2_1	595	600	PF00069	0.636
MOD_NEK2_1	674	679	PF00069	0.652
MOD_NEK2_1	686	691	PF00069	0.565
MOD_NEK2_1	801	806	PF00069	0.506
MOD_NEK2_1	838	843	PF00069	0.701
MOD_NEK2_2	776	781	PF00069	0.610
MOD_NEK2_2	968	973	PF00069	0.611
MOD_PIKK_1	373	379	PF00454	0.854
MOD_PIKK_1	956	962	PF00454	0.769
MOD_PIKK_1	966	972	PF00454	0.638
MOD_PK_1	418	424	PF00069	0.629
MOD_PKA_1	140	146	PF00069	0.684
MOD_PKA_1	495	501	PF00069	0.728
MOD_PKA_1	925	931	PF00069	0.664
MOD_PKA_2	1034	1040	PF00069	0.736
MOD_PKA_2	140	146	PF00069	0.578
MOD_PKA_2	168	174	PF00069	0.667
MOD_PKA_2	313	319	PF00069	0.708
MOD_PKA_2	494	500	PF00069	0.741
MOD_PKA_2	596	602	PF00069	0.749
MOD_PKA_2	696	702	PF00069	0.556
MOD_PKA_2	735	741	PF00069	0.579
MOD_PKA_2	755	761	PF00069	0.712
MOD_PKA_2	762	768	PF00069	0.743
MOD_PKA_2	801	807	PF00069	0.539
MOD_PKA_2	868	874	PF00069	0.838
MOD_PKA_2	925	931	PF00069	0.742
MOD_PKB_1	362	370	PF00069	0.792
MOD_PKB_1	695	703	PF00069	0.560
MOD_PKB_1	867	875	PF00069	0.776
MOD_Plk_1	1033	1039	PF00069	0.586
MOD_Plk_1	17	23	PF00069	0.609
MOD_Plk_1	459	465	PF00069	0.782
MOD_Plk_1	625	631	PF00069	0.544
MOD_Plk_1	670	676	PF00069	0.742
MOD_Plk_1	728	734	PF00069	0.769
MOD_Plk_1	823	829	PF00069	0.714
MOD_Plk_1	916	922	PF00069	0.736
MOD_Plk_2-3	714	720	PF00069	0.695
MOD_Plk_2-3	938	944	PF00069	0.767
MOD_Plk_4	262	268	PF00069	0.710
MOD_Plk_4	315	321	PF00069	0.798
MOD_Plk_4	346	352	PF00069	0.782
MOD_Plk_4	40	46	PF00069	0.698
MOD_Plk_4	48	54	PF00069	0.398
MOD_Plk_4	495	501	PF00069	0.726
MOD_Plk_4	625	631	PF00069	0.668
MOD_Plk_4	776	782	PF00069	0.750
MOD_Plk_4	785	791	PF00069	0.686
MOD_Plk_4	801	807	PF00069	0.484
MOD_Plk_4	87	93	PF00069	0.503
MOD_Plk_4	94	100	PF00069	0.387
MOD_Plk_4	968	974	PF00069	0.610
MOD_ProDKin_1	1006	1012	PF00069	0.833
MOD_ProDKin_1	354	360	PF00069	0.868
MOD_ProDKin_1	483	489	PF00069	0.736
MOD_ProDKin_1	581	587	PF00069	0.815
MOD_ProDKin_1	815	821	PF00069	0.601
MOD_ProDKin_1	853	859	PF00069	0.835
MOD_ProDKin_1	883	889	PF00069	0.831
MOD_ProDKin_1	890	896	PF00069	0.763
MOD_SUMO_for_1	33	36	PF00179	0.663
MOD_SUMO_rev_2	442	450	PF00179	0.740
MOD_SUMO_rev_2	971	981	PF00179	0.760
TRG_DiLeu_BaEn_1	218	223	PF01217	0.614
TRG_DiLeu_BaEn_3	203	209	PF01217	0.779
TRG_DiLeu_BaEn_4	714	720	PF01217	0.726
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.621
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.530
TRG_ENDOCYTIC_2	81	84	PF00928	0.530
TRG_ENDOCYTIC_2	98	101	PF00928	0.252
TRG_ER_diArg_1	1010	1013	PF00400	0.680
TRG_ER_diArg_1	140	142	PF00400	0.665
TRG_ER_diArg_1	494	496	PF00400	0.743
TRG_ER_diArg_1	589	592	PF00400	0.620
TRG_ER_diArg_1	75	78	PF00400	0.589
TRG_ER_diArg_1	890	892	PF00400	0.758
TRG_ER_diArg_1	988	991	PF00400	0.760
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.852
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.745
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.724
TRG_Pf-PMV_PEXEL_1	985	990	PF00026	0.825

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBZ0	Leishmania donovani	87%	100%
A4HBZ5	Leishmania braziliensis	55%	100%
A4HZD5	Leishmania infantum	87%	100%
E9AVC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%