G_PROTEIN_RECEP_F1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC57_LEIMA

TriTrypDb:

LmjF.21.1380 , LMJLV39_210022000 , LMJSD75_210022200

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QC57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.513
CLV_NRD_NRD_1	172	174	PF00675	0.490
CLV_NRD_NRD_1	180	182	PF00675	0.476
CLV_PCSK_KEX2_1	104	106	PF00082	0.513
CLV_PCSK_KEX2_1	142	144	PF00082	0.489
CLV_PCSK_KEX2_1	172	174	PF00082	0.490
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.442
DEG_APCC_DBOX_1	256	264	PF00400	0.761
DEG_APCC_DBOX_1	88	96	PF00400	0.619
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DEG_SPOP_SBC_1	312	316	PF00917	0.701
DOC_CDC14_PxL_1	17	25	PF14671	0.389
DOC_MAPK_gen_1	55	64	PF00069	0.346
DOC_MAPK_MEF2A_6	55	64	PF00069	0.346
DOC_MAPK_RevD_3	90	105	PF00069	0.712
DOC_PP1_RVXF_1	79	86	PF00149	0.624
DOC_PP4_FxxP_1	227	230	PF00568	0.698
DOC_USP7_MATH_1	297	301	PF00917	0.758
DOC_USP7_MATH_1	306	310	PF00917	0.782
DOC_USP7_MATH_1	312	316	PF00917	0.802
DOC_USP7_UBL2_3	178	182	PF12436	0.774
DOC_USP7_UBL2_3	218	222	PF12436	0.660
DOC_WW_Pin1_4	24	29	PF00397	0.486
DOC_WW_Pin1_4	262	267	PF00397	0.801
LIG_14-3-3_CanoR_1	162	168	PF00244	0.667
LIG_14-3-3_CanoR_1	176	181	PF00244	0.609
LIG_14-3-3_CanoR_1	257	266	PF00244	0.795
LIG_14-3-3_CanoR_1	271	279	PF00244	0.685
LIG_14-3-3_CanoR_1	98	102	PF00244	0.648
LIG_Actin_WH2_2	83	100	PF00022	0.627
LIG_BRCT_BRCA1_1	10	14	PF00533	0.375
LIG_BRCT_BRCA1_1	187	191	PF00533	0.680
LIG_deltaCOP1_diTrp_1	183	191	PF00928	0.738
LIG_FHA_1	146	152	PF00498	0.645
LIG_FHA_1	215	221	PF00498	0.647
LIG_FHA_1	49	55	PF00498	0.433
LIG_LIR_Gen_1	11	22	PF02991	0.397
LIG_LIR_Gen_1	188	197	PF02991	0.669
LIG_LIR_Gen_1	327	336	PF02991	0.715
LIG_LIR_Nem_3	11	17	PF02991	0.375
LIG_LIR_Nem_3	188	194	PF02991	0.670
LIG_LIR_Nem_3	327	332	PF02991	0.735
LIG_NBox_RRM_1	216	226	PF00076	0.585
LIG_SH2_CRK	80	84	PF00017	0.626
LIG_SH2_PTP2	59	62	PF00017	0.280
LIG_SH2_STAT5	24	27	PF00017	0.449
LIG_SH2_STAT5	253	256	PF00017	0.827
LIG_SH2_STAT5	59	62	PF00017	0.507
LIG_SH2_STAT5	76	79	PF00017	0.260
LIG_SH3_3	15	21	PF00018	0.411
LIG_SH3_3	223	229	PF00018	0.672
LIG_SH3_3	291	297	PF00018	0.759
LIG_SH3_3	300	306	PF00018	0.751
LIG_SH3_3	59	65	PF00018	0.397
LIG_SUMO_SIM_par_1	60	66	PF11976	0.397
LIG_WW_1	21	24	PF00397	0.436
MOD_CDK_SPK_2	262	267	PF00069	0.765
MOD_CK1_1	127	133	PF00069	0.712
MOD_CK1_1	137	143	PF00069	0.703
MOD_CK1_1	144	150	PF00069	0.679
MOD_CK1_1	265	271	PF00069	0.782
MOD_CK1_1	320	326	PF00069	0.756
MOD_CK2_1	207	213	PF00069	0.641
MOD_CK2_1	37	43	PF00069	0.518
MOD_GlcNHglycan	10	13	PF01048	0.411
MOD_GlcNHglycan	110	113	PF01048	0.432
MOD_GlcNHglycan	126	129	PF01048	0.511
MOD_GlcNHglycan	187	190	PF01048	0.475
MOD_GlcNHglycan	231	234	PF01048	0.474
MOD_GlcNHglycan	267	270	PF01048	0.619
MOD_GlcNHglycan	315	318	PF01048	0.546
MOD_GlcNHglycan	319	322	PF01048	0.516
MOD_GlcNHglycan	39	42	PF01048	0.709
MOD_GSK3_1	133	140	PF00069	0.727
MOD_GSK3_1	141	148	PF00069	0.707
MOD_GSK3_1	181	188	PF00069	0.676
MOD_GSK3_1	258	265	PF00069	0.800
MOD_GSK3_1	313	320	PF00069	0.785
MOD_GSK3_1	336	343	PF00069	0.722
MOD_GSK3_1	93	100	PF00069	0.636
MOD_LATS_1	174	180	PF00433	0.690
MOD_N-GLC_1	117	122	PF02516	0.525
MOD_N-GLC_1	133	138	PF02516	0.432
MOD_N-GLC_1	214	219	PF02516	0.468
MOD_NEK2_1	1	6	PF00069	0.536
MOD_NEK2_1	108	113	PF00069	0.622
MOD_NEK2_1	163	168	PF00069	0.732
MOD_NEK2_1	252	257	PF00069	0.730
MOD_NEK2_1	46	51	PF00069	0.521
MOD_NEK2_2	297	302	PF00069	0.766
MOD_PIKK_1	48	54	PF00454	0.507
MOD_PK_1	176	182	PF00069	0.695
MOD_PKA_1	181	187	PF00069	0.680
MOD_PKA_2	270	276	PF00069	0.684
MOD_PKA_2	306	312	PF00069	0.792
MOD_PKA_2	97	103	PF00069	0.648
MOD_Plk_1	117	123	PF00069	0.726
MOD_Plk_1	335	341	PF00069	0.806
MOD_Plk_1	46	52	PF00069	0.555
MOD_Plk_4	127	133	PF00069	0.679
MOD_Plk_4	181	187	PF00069	0.680
MOD_Plk_4	306	312	PF00069	0.712
MOD_ProDKin_1	24	30	PF00069	0.489
MOD_ProDKin_1	262	268	PF00069	0.802
MOD_SUMO_for_1	167	170	PF00179	0.589
TRG_ENDOCYTIC_2	59	62	PF00928	0.513
TRG_ENDOCYTIC_2	80	83	PF00928	0.625
TRG_ER_diArg_1	171	173	PF00400	0.699

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA48	Leptomonas seymouri	48%	91%
A0A3S7WWN2	Leishmania donovani	89%	100%
A4HC52	Leishmania braziliensis	64%	97%
A4HZD6	Leishmania infantum	89%	100%
E9AVC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%