LeishMANIAdb
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Palmitoyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Palmitoyltransferase
Gene product:
palmitoyl acyltransferase 3, putative
Species:
Leishmania major
UniProt:
Q4QC56_LEIMA
TriTrypDb:
LmjF.21.1390 , LMJLV39_210022100 , LMJSD75_210022300
Length:
597

Annotations

LeishMANIAdb annotations

Palmitoyltransferase. Leishmaniids have +2 extra TM segments at the N-terminus while all other Kinetoplastids typically only have the 4 core ones.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 3
GO:0005794 Golgi apparatus 5 3
GO:0016020 membrane 2 7
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 7
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0031090 organelle membrane 3 1

Expansion

Sequence features

Q4QC56
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC56

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 3
GO:0006605 protein targeting 5 3
GO:0006612 protein targeting to membrane 5 3
GO:0006807 nitrogen compound metabolic process 2 3
GO:0006810 transport 3 3
GO:0006886 intracellular protein transport 4 3
GO:0006897 endocytosis 5 3
GO:0008104 protein localization 4 3
GO:0008152 metabolic process 1 3
GO:0009987 cellular process 1 3
GO:0015031 protein transport 4 3
GO:0016192 vesicle-mediated transport 4 3
GO:0018193 peptidyl-amino acid modification 5 3
GO:0018198 peptidyl-cysteine modification 6 3
GO:0018230 peptidyl-L-cysteine S-palmitoylation 7 3
GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 7 3
GO:0018345 protein palmitoylation 6 3
GO:0019538 protein metabolic process 3 3
GO:0033036 macromolecule localization 2 3
GO:0036211 protein modification process 4 3
GO:0043170 macromolecule metabolic process 3 3
GO:0043412 macromolecule modification 4 3
GO:0043543 protein acylation 5 3
GO:0044238 primary metabolic process 2 3
GO:0045184 establishment of protein localization 3 3
GO:0046907 intracellular transport 3 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0051641 cellular localization 2 3
GO:0051649 establishment of localization in cell 3 3
GO:0051668 localization within membrane 3 3
GO:0070727 cellular macromolecule localization 3 3
GO:0071702 organic substance transport 4 3
GO:0071704 organic substance metabolic process 2 3
GO:0071705 nitrogen compound transport 4 3
GO:0072657 protein localization to membrane 4 3
GO:0090150 establishment of protein localization to membrane 4 3
GO:1901564 organonitrogen compound metabolic process 3 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0016409 palmitoyltransferase activity 5 7
GO:0016417 S-acyltransferase activity 5 7
GO:0016740 transferase activity 2 7
GO:0016746 acyltransferase activity 3 7
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 7
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4 7
GO:0019707 protein-cysteine S-acyltransferase activity 3 7
GO:0140096 catalytic activity, acting on a protein 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 140 144 PF00656 0.759
CLV_C14_Caspase3-7 187 191 PF00656 0.749
CLV_C14_Caspase3-7 230 234 PF00656 0.804
CLV_NRD_NRD_1 13 15 PF00675 0.498
CLV_NRD_NRD_1 268 270 PF00675 0.510
CLV_NRD_NRD_1 324 326 PF00675 0.438
CLV_NRD_NRD_1 331 333 PF00675 0.355
CLV_NRD_NRD_1 399 401 PF00675 0.635
CLV_NRD_NRD_1 403 405 PF00675 0.594
CLV_NRD_NRD_1 529 531 PF00675 0.561
CLV_NRD_NRD_1 552 554 PF00675 0.464
CLV_PCSK_KEX2_1 13 15 PF00082 0.498
CLV_PCSK_KEX2_1 268 270 PF00082 0.510
CLV_PCSK_KEX2_1 324 326 PF00082 0.438
CLV_PCSK_KEX2_1 331 333 PF00082 0.355
CLV_PCSK_KEX2_1 403 405 PF00082 0.622
CLV_PCSK_KEX2_1 463 465 PF00082 0.400
CLV_PCSK_KEX2_1 481 483 PF00082 0.351
CLV_PCSK_KEX2_1 529 531 PF00082 0.520
CLV_PCSK_KEX2_1 552 554 PF00082 0.464
CLV_PCSK_PC1ET2_1 463 465 PF00082 0.380
CLV_PCSK_PC1ET2_1 481 483 PF00082 0.371
CLV_PCSK_SKI1_1 257 261 PF00082 0.556
CLV_PCSK_SKI1_1 331 335 PF00082 0.438
CLV_PCSK_SKI1_1 464 468 PF00082 0.438
CLV_PCSK_SKI1_1 518 522 PF00082 0.502
CLV_PCSK_SKI1_1 529 533 PF00082 0.463
CLV_PCSK_SKI1_1 8 12 PF00082 0.497
DEG_APCC_DBOX_1 13 21 PF00400 0.709
DEG_APCC_DBOX_1 256 264 PF00400 0.691
DEG_APCC_DBOX_1 512 520 PF00400 0.682
DEG_Nend_UBRbox_2 1 3 PF02207 0.721
DOC_CKS1_1 67 72 PF01111 0.516
DOC_CYCLIN_RxL_1 460 471 PF00134 0.473
DOC_CYCLIN_RxL_1 498 507 PF00134 0.692
DOC_CYCLIN_yCln2_LP_2 425 431 PF00134 0.438
DOC_MAPK_gen_1 13 20 PF00069 0.643
DOC_MAPK_gen_1 313 322 PF00069 0.738
DOC_MAPK_gen_1 552 560 PF00069 0.656
DOC_MAPK_MEF2A_6 13 22 PF00069 0.639
DOC_MAPK_MEF2A_6 309 316 PF00069 0.754
DOC_MAPK_MEF2A_6 553 562 PF00069 0.688
DOC_PP1_RVXF_1 36 43 PF00149 0.595
DOC_PP1_RVXF_1 499 506 PF00149 0.693
DOC_PP2B_LxvP_1 320 323 PF13499 0.762
DOC_PP2B_LxvP_1 333 336 PF13499 0.483
DOC_PP2B_LxvP_1 425 428 PF13499 0.438
DOC_PP2B_PxIxI_1 217 223 PF00149 0.742
DOC_PP4_FxxP_1 169 172 PF00568 0.803
DOC_USP7_MATH_1 472 476 PF00917 0.595
DOC_USP7_UBL2_3 518 522 PF12436 0.661
DOC_WW_Pin1_4 142 147 PF00397 0.815
DOC_WW_Pin1_4 168 173 PF00397 0.852
DOC_WW_Pin1_4 190 195 PF00397 0.853
DOC_WW_Pin1_4 409 414 PF00397 0.438
DOC_WW_Pin1_4 492 497 PF00397 0.618
DOC_WW_Pin1_4 66 71 PF00397 0.519
LIG_14-3-3_CanoR_1 268 274 PF00244 0.758
LIG_14-3-3_CanoR_1 287 292 PF00244 0.655
LIG_14-3-3_CanoR_1 529 536 PF00244 0.762
LIG_AP2alpha_1 505 509 PF02296 0.675
LIG_BRCT_BRCA1_1 270 274 PF00533 0.770
LIG_BRCT_BRCA1_1 487 491 PF00533 0.763
LIG_CaM_NSCaTE_8 378 385 PF13499 0.473
LIG_Clathr_ClatBox_1 297 301 PF01394 0.778
LIG_deltaCOP1_diTrp_1 541 547 PF00928 0.695
LIG_EH1_1 444 452 PF00400 0.443
LIG_eIF4E_1 460 466 PF01652 0.534
LIG_eIF4E_1 580 586 PF01652 0.722
LIG_FHA_1 200 206 PF00498 0.806
LIG_FHA_1 237 243 PF00498 0.860
LIG_FHA_1 254 260 PF00498 0.604
LIG_FHA_1 268 274 PF00498 0.608
LIG_FHA_1 35 41 PF00498 0.604
LIG_FHA_1 383 389 PF00498 0.473
LIG_FHA_1 435 441 PF00498 0.438
LIG_FHA_1 468 474 PF00498 0.639
LIG_FHA_1 51 57 PF00498 0.315
LIG_FHA_1 580 586 PF00498 0.722
LIG_FHA_2 185 191 PF00498 0.816
LIG_FHA_2 294 300 PF00498 0.759
LIG_FHA_2 347 353 PF00498 0.595
LIG_FHA_2 469 475 PF00498 0.639
LIG_FHA_2 509 515 PF00498 0.668
LIG_Integrin_RGD_1 227 229 PF01839 0.604
LIG_LIR_Apic_2 109 115 PF02991 0.815
LIG_LIR_Apic_2 168 172 PF02991 0.732
LIG_LIR_Gen_1 456 466 PF02991 0.534
LIG_LIR_Gen_1 53 60 PF02991 0.534
LIG_LIR_Gen_1 582 591 PF02991 0.737
LIG_LIR_Gen_1 72 83 PF02991 0.211
LIG_LIR_Nem_3 214 220 PF02991 0.848
LIG_LIR_Nem_3 385 390 PF02991 0.534
LIG_LIR_Nem_3 456 461 PF02991 0.534
LIG_LIR_Nem_3 53 57 PF02991 0.534
LIG_LIR_Nem_3 565 570 PF02991 0.703
LIG_LIR_Nem_3 582 586 PF02991 0.566
LIG_LIR_Nem_3 72 78 PF02991 0.211
LIG_LIR_Nem_3 86 90 PF02991 0.300
LIG_LYPXL_SIV_4 428 436 PF13949 0.438
LIG_NRBOX 293 299 PF00104 0.782
LIG_NRBOX 77 83 PF00104 0.473
LIG_Pex14_1 563 567 PF04695 0.684
LIG_Pex14_2 29 33 PF04695 0.718
LIG_Pex14_2 505 509 PF04695 0.675
LIG_SH2_CRK 112 116 PF00017 0.778
LIG_SH2_CRK 390 394 PF00017 0.534
LIG_SH2_CRK 493 497 PF00017 0.707
LIG_SH2_GRB2like 460 463 PF00017 0.534
LIG_SH2_GRB2like 90 93 PF00017 0.534
LIG_SH2_PTP2 75 78 PF00017 0.473
LIG_SH2_SRC 125 128 PF00017 0.776
LIG_SH2_STAP1 116 120 PF00017 0.759
LIG_SH2_STAT3 9 12 PF00017 0.649
LIG_SH2_STAT5 110 113 PF00017 0.579
LIG_SH2_STAT5 116 119 PF00017 0.719
LIG_SH2_STAT5 16 19 PF00017 0.706
LIG_SH2_STAT5 326 329 PF00017 0.639
LIG_SH2_STAT5 369 372 PF00017 0.534
LIG_SH2_STAT5 392 395 PF00017 0.438
LIG_SH2_STAT5 439 442 PF00017 0.473
LIG_SH2_STAT5 460 463 PF00017 0.534
LIG_SH2_STAT5 477 480 PF00017 0.513
LIG_SH2_STAT5 75 78 PF00017 0.489
LIG_SH2_STAT5 90 93 PF00017 0.329
LIG_SH3_3 177 183 PF00018 0.827
LIG_SH3_3 191 197 PF00018 0.717
LIG_SH3_3 204 210 PF00018 0.707
LIG_SH3_3 282 288 PF00018 0.778
LIG_SH3_3 425 431 PF00018 0.438
LIG_SH3_3 575 581 PF00018 0.775
LIG_SUMO_SIM_par_1 295 301 PF11976 0.778
LIG_TRAF2_1 138 141 PF00917 0.731
LIG_TYR_ITIM 388 393 PF00017 0.473
LIG_TYR_ITIM 73 78 PF00017 0.534
LIG_WRC_WIRS_1 30 35 PF05994 0.651
LIG_WRC_WIRS_1 51 56 PF05994 0.534
LIG_WRC_WIRS_1 567 572 PF05994 0.667
LIG_WRC_WIRS_1 580 585 PF05994 0.493
LIG_WRC_WIRS_1 84 89 PF05994 0.534
LIG_WW_1 107 110 PF00397 0.720
LIG_WW_2 210 213 PF00397 0.813
LIG_WW_3 310 314 PF00397 0.702
MOD_CDC14_SPxK_1 171 174 PF00782 0.810
MOD_CDC14_SPxK_1 412 415 PF00782 0.534
MOD_CDK_SPxK_1 168 174 PF00069 0.807
MOD_CDK_SPxK_1 409 415 PF00069 0.534
MOD_CK1_1 128 134 PF00069 0.840
MOD_CK1_1 135 141 PF00069 0.730
MOD_CK1_1 255 261 PF00069 0.755
MOD_CK1_1 438 444 PF00069 0.443
MOD_CK2_1 135 141 PF00069 0.665
MOD_CK2_1 293 299 PF00069 0.680
MOD_CK2_1 468 474 PF00069 0.534
MOD_CMANNOS 375 378 PF00535 0.534
MOD_GlcNHglycan 229 233 PF01048 0.792
MOD_GlcNHglycan 270 273 PF01048 0.701
MOD_GlcNHglycan 587 590 PF01048 0.751
MOD_GSK3_1 114 121 PF00069 0.670
MOD_GSK3_1 128 135 PF00069 0.724
MOD_GSK3_1 149 156 PF00069 0.769
MOD_GSK3_1 184 191 PF00069 0.773
MOD_GSK3_1 264 271 PF00069 0.751
MOD_GSK3_1 29 36 PF00069 0.645
MOD_GSK3_1 378 385 PF00069 0.534
MOD_GSK3_1 434 441 PF00069 0.482
MOD_GSK3_1 468 475 PF00069 0.482
MOD_GSK3_1 562 569 PF00069 0.610
MOD_GSK3_1 65 72 PF00069 0.581
MOD_GSK3_1 93 100 PF00069 0.544
MOD_N-GLC_1 118 123 PF02516 0.637
MOD_N-GLC_1 188 193 PF02516 0.749
MOD_N-GLC_1 33 38 PF02516 0.588
MOD_N-GLC_1 468 473 PF02516 0.534
MOD_N-GLC_2 359 361 PF02516 0.375
MOD_NEK2_1 184 189 PF00069 0.818
MOD_NEK2_1 29 34 PF00069 0.603
MOD_NEK2_1 382 387 PF00069 0.534
MOD_NEK2_1 435 440 PF00069 0.534
MOD_NEK2_1 453 458 PF00069 0.233
MOD_NEK2_1 467 472 PF00069 0.300
MOD_NEK2_1 508 513 PF00069 0.565
MOD_NEK2_1 94 99 PF00069 0.608
MOD_NEK2_2 472 477 PF00069 0.473
MOD_PIKK_1 128 134 PF00454 0.658
MOD_PIKK_1 149 155 PF00454 0.771
MOD_PIKK_1 205 211 PF00454 0.762
MOD_PKA_1 268 274 PF00069 0.622
MOD_PKA_1 529 535 PF00069 0.698
MOD_PKA_2 252 258 PF00069 0.723
MOD_PKA_2 264 270 PF00069 0.544
MOD_PKA_2 346 352 PF00069 0.245
MOD_PKA_2 393 399 PF00069 0.443
MOD_PKA_2 529 535 PF00069 0.649
MOD_Plk_1 108 114 PF00069 0.691
MOD_Plk_1 135 141 PF00069 0.680
MOD_Plk_1 153 159 PF00069 0.660
MOD_Plk_1 184 190 PF00069 0.847
MOD_Plk_1 468 474 PF00069 0.534
MOD_Plk_4 293 299 PF00069 0.704
MOD_Plk_4 378 384 PF00069 0.534
MOD_Plk_4 435 441 PF00069 0.504
MOD_Plk_4 453 459 PF00069 0.263
MOD_Plk_4 472 478 PF00069 0.216
MOD_ProDKin_1 142 148 PF00069 0.780
MOD_ProDKin_1 168 174 PF00069 0.837
MOD_ProDKin_1 190 196 PF00069 0.833
MOD_ProDKin_1 409 415 PF00069 0.534
MOD_ProDKin_1 492 498 PF00069 0.501
MOD_ProDKin_1 66 72 PF00069 0.642
MOD_SUMO_for_1 521 524 PF00179 0.557
TRG_DiLeu_LyEn_5 590 595 PF01217 0.704
TRG_ENDOCYTIC_2 369 372 PF00928 0.534
TRG_ENDOCYTIC_2 390 393 PF00928 0.534
TRG_ENDOCYTIC_2 580 583 PF00928 0.705
TRG_ENDOCYTIC_2 75 78 PF00928 0.534
TRG_ER_diArg_1 312 315 PF00400 0.718
TRG_ER_diArg_1 323 325 PF00400 0.384
TRG_ER_diArg_1 331 333 PF00400 0.250
TRG_ER_diArg_1 402 404 PF00400 0.516
TRG_ER_diArg_1 552 554 PF00400 0.571
TRG_NES_CRM1_1 154 166 PF08389 0.738
TRG_NLS_MonoExtC_3 399 404 PF00514 0.382
TRG_Pf-PMV_PEXEL_1 101 105 PF00026 0.635
TRG_Pf-PMV_PEXEL_1 257 261 PF00026 0.576
TRG_Pf-PMV_PEXEL_1 403 408 PF00026 0.534
TRG_Pf-PMV_PEXEL_1 552 556 PF00026 0.626

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IAF5 Leishmania donovani 91% 84%
A4HC51 Leishmania braziliensis 67% 100%
A4HZD7 Leishmania infantum 92% 100%
E9AVC4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QC55 Leishmania major 100% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS