GBBH-like_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF971), putative

Species:

Leishmania major

UniProt:

Q4QC54_LEIMA

TriTrypDb:

LmjF.21.1410 , LMJLV39_210022200 , LMJSD75_210022400

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC54

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.670
CLV_NRD_NRD_1	137	139	PF00675	0.598
CLV_NRD_NRD_1	175	177	PF00675	0.633
CLV_NRD_NRD_1	33	35	PF00675	0.534
CLV_NRD_NRD_1	339	341	PF00675	0.345
CLV_NRD_NRD_1	397	399	PF00675	0.530
CLV_NRD_NRD_1	422	424	PF00675	0.541
CLV_NRD_NRD_1	79	81	PF00675	0.556
CLV_PCSK_FUR_1	394	398	PF00082	0.574
CLV_PCSK_KEX2_1	110	112	PF00082	0.667
CLV_PCSK_KEX2_1	137	139	PF00082	0.653
CLV_PCSK_KEX2_1	175	177	PF00082	0.633
CLV_PCSK_KEX2_1	32	34	PF00082	0.535
CLV_PCSK_KEX2_1	339	341	PF00082	0.345
CLV_PCSK_KEX2_1	396	398	PF00082	0.528
CLV_PCSK_KEX2_1	404	406	PF00082	0.594
CLV_PCSK_KEX2_1	79	81	PF00082	0.556
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.619
CLV_PCSK_PC7_1	400	406	PF00082	0.606
CLV_PCSK_SKI1_1	138	142	PF00082	0.641
CLV_PCSK_SKI1_1	169	173	PF00082	0.629
CLV_PCSK_SKI1_1	254	258	PF00082	0.749
CLV_PCSK_SKI1_1	277	281	PF00082	0.605
CLV_PCSK_SKI1_1	356	360	PF00082	0.294
CLV_PCSK_SKI1_1	410	414	PF00082	0.534
CLV_PCSK_SKI1_1	418	422	PF00082	0.506
CLV_PCSK_SKI1_1	74	78	PF00082	0.559
CLV_PCSK_SKI1_1	79	83	PF00082	0.525
CLV_Separin_Metazoa	226	230	PF03568	0.519
CLV_Separin_Metazoa	242	246	PF03568	0.710
DEG_Nend_UBRbox_4	1	3	PF02207	0.543
DEG_SCF_FBW7_1	304	311	PF00400	0.465
DEG_SPOP_SBC_1	115	119	PF00917	0.627
DEG_SPOP_SBC_1	139	143	PF00917	0.629
DEG_SPOP_SBC_1	244	248	PF00917	0.761
DEG_SPOP_SBC_1	249	253	PF00917	0.711
DOC_CKS1_1	65	70	PF01111	0.571
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	55	58	PF00134	0.452
DOC_MAPK_DCC_7	45	54	PF00069	0.500
DOC_MAPK_gen_1	155	165	PF00069	0.558
DOC_MAPK_gen_1	211	218	PF00069	0.592
DOC_MAPK_MEF2A_6	45	54	PF00069	0.500
DOC_PP2B_LxvP_1	12	15	PF13499	0.498
DOC_PP2B_LxvP_1	54	57	PF13499	0.466
DOC_PP4_FxxP_1	218	221	PF00568	0.469
DOC_USP7_MATH_1	115	119	PF00917	0.751
DOC_USP7_MATH_1	130	134	PF00917	0.583
DOC_USP7_MATH_1	139	143	PF00917	0.523
DOC_USP7_MATH_1	184	188	PF00917	0.677
DOC_USP7_MATH_1	235	239	PF00917	0.719
DOC_USP7_MATH_1	244	248	PF00917	0.674
DOC_USP7_MATH_1	249	253	PF00917	0.682
DOC_USP7_MATH_1	261	265	PF00917	0.550
DOC_USP7_MATH_1	268	272	PF00917	0.554
DOC_USP7_MATH_1	278	282	PF00917	0.803
DOC_WW_Pin1_4	116	121	PF00397	0.742
DOC_WW_Pin1_4	122	127	PF00397	0.652
DOC_WW_Pin1_4	297	302	PF00397	0.737
DOC_WW_Pin1_4	304	309	PF00397	0.630
DOC_WW_Pin1_4	319	324	PF00397	0.523
DOC_WW_Pin1_4	375	380	PF00397	0.486
DOC_WW_Pin1_4	64	69	PF00397	0.678
LIG_14-3-3_CanoR_1	110	120	PF00244	0.710
LIG_14-3-3_CanoR_1	137	145	PF00244	0.630
LIG_14-3-3_CanoR_1	182	192	PF00244	0.612
LIG_14-3-3_CanoR_1	229	234	PF00244	0.614
LIG_14-3-3_CanoR_1	254	259	PF00244	0.742
LIG_14-3-3_CanoR_1	277	286	PF00244	0.640
LIG_14-3-3_CanoR_1	32	37	PF00244	0.612
LIG_14-3-3_CanoR_1	71	77	PF00244	0.563
LIG_Actin_WH2_2	341	358	PF00022	0.545
LIG_BH_BH3_1	137	153	PF00452	0.690
LIG_BRCT_BRCA1_1	118	122	PF00533	0.613
LIG_FHA_1	139	145	PF00498	0.710
LIG_FHA_1	255	261	PF00498	0.685
LIG_FHA_1	309	315	PF00498	0.450
LIG_FHA_1	343	349	PF00498	0.556
LIG_FHA_1	71	77	PF00498	0.563
LIG_LIR_Apic_2	217	221	PF02991	0.475
LIG_LIR_Gen_1	212	222	PF02991	0.460
LIG_LIR_Gen_1	369	376	PF02991	0.545
LIG_LIR_Nem_3	212	218	PF02991	0.470
LIG_LIR_Nem_3	369	375	PF02991	0.539
LIG_MYND_1	10	14	PF01753	0.487
LIG_RPA_C_Fungi	335	347	PF08784	0.398
LIG_SH2_CRK	370	374	PF00017	0.389
LIG_SH2_STAP1	353	357	PF00017	0.410
LIG_SH2_STAP1	368	372	PF00017	0.410
LIG_SH2_STAP1	411	415	PF00017	0.658
LIG_SH2_STAT5	108	111	PF00017	0.621
LIG_SH2_STAT5	215	218	PF00017	0.486
LIG_SH2_STAT5	317	320	PF00017	0.410
LIG_SH2_STAT5	321	324	PF00017	0.410
LIG_SH2_STAT5	372	375	PF00017	0.356
LIG_SH2_STAT5	389	392	PF00017	0.418
LIG_SH3_2	240	245	PF14604	0.685
LIG_SH3_3	168	174	PF00018	0.704
LIG_SH3_3	234	240	PF00018	0.696
LIG_SH3_3	257	263	PF00018	0.626
LIG_SH3_3	298	304	PF00018	0.741
LIG_SH3_3	3	9	PF00018	0.515
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.430
LIG_TRAF2_1	24	27	PF00917	0.494
LIG_TRFH_1	122	126	PF08558	0.675
LIG_WW_3	242	246	PF00397	0.695
MOD_CDK_SPxK_1	304	310	PF00069	0.478
MOD_CDK_SPxxK_3	375	382	PF00069	0.483
MOD_CDK_SPxxK_3	64	71	PF00069	0.679
MOD_CK1_1	143	149	PF00069	0.628
MOD_CK1_1	151	157	PF00069	0.616
MOD_CK1_1	21	27	PF00069	0.565
MOD_CK1_1	238	244	PF00069	0.690
MOD_CK1_1	248	254	PF00069	0.661
MOD_CK1_1	35	41	PF00069	0.574
MOD_CK1_1	378	384	PF00069	0.502
MOD_CK1_1	72	78	PF00069	0.559
MOD_CK2_1	184	190	PF00069	0.575
MOD_CK2_1	21	27	PF00069	0.565
MOD_Cter_Amidation	337	340	PF01082	0.410
MOD_DYRK1A_RPxSP_1	319	323	PF00069	0.410
MOD_GlcNHglycan	132	135	PF01048	0.692
MOD_GlcNHglycan	20	23	PF01048	0.508
MOD_GlcNHglycan	247	250	PF01048	0.712
MOD_GlcNHglycan	264	267	PF01048	0.612
MOD_GlcNHglycan	280	283	PF01048	0.764
MOD_GlcNHglycan	304	307	PF01048	0.552
MOD_GlcNHglycan	40	43	PF01048	0.539
MOD_GSK3_1	111	118	PF00069	0.693
MOD_GSK3_1	139	146	PF00069	0.647
MOD_GSK3_1	14	21	PF00069	0.544
MOD_GSK3_1	244	251	PF00069	0.770
MOD_GSK3_1	304	311	PF00069	0.465
MOD_GSK3_1	32	39	PF00069	0.562
MOD_GSK3_1	374	381	PF00069	0.542
MOD_N-GLC_1	184	189	PF02516	0.615
MOD_NEK2_1	140	145	PF00069	0.719
MOD_NEK2_1	148	153	PF00069	0.510
MOD_NEK2_1	18	23	PF00069	0.548
MOD_NEK2_1	69	74	PF00069	0.603
MOD_PIKK_1	269	275	PF00454	0.653
MOD_PK_1	32	38	PF00069	0.538
MOD_PKA_1	111	117	PF00069	0.763
MOD_PKA_1	32	38	PF00069	0.538
MOD_PKA_1	396	402	PF00069	0.576
MOD_PKA_2	111	117	PF00069	0.763
MOD_PKA_2	244	250	PF00069	0.705
MOD_PKA_2	261	267	PF00069	0.522
MOD_PKA_2	32	38	PF00069	0.614
MOD_PKA_2	396	402	PF00069	0.576
MOD_PKA_2	70	76	PF00069	0.564
MOD_PKB_1	394	402	PF00069	0.671
MOD_Plk_1	184	190	PF00069	0.612
MOD_Plk_1	216	222	PF00069	0.477
MOD_Plk_4	104	110	PF00069	0.611
MOD_Plk_4	14	20	PF00069	0.557
MOD_Plk_4	140	146	PF00069	0.551
MOD_ProDKin_1	116	122	PF00069	0.745
MOD_ProDKin_1	297	303	PF00069	0.731
MOD_ProDKin_1	304	310	PF00069	0.625
MOD_ProDKin_1	319	325	PF00069	0.378
MOD_ProDKin_1	375	381	PF00069	0.486
MOD_ProDKin_1	64	70	PF00069	0.677
MOD_SUMO_rev_2	161	171	PF00179	0.619
TRG_ENDOCYTIC_2	215	218	PF00928	0.486
TRG_ENDOCYTIC_2	370	373	PF00928	0.360
TRG_ENDOCYTIC_2	383	386	PF00928	0.420
TRG_ER_diArg_1	109	112	PF00400	0.663
TRG_ER_diArg_1	137	139	PF00400	0.653
TRG_ER_diArg_1	174	176	PF00400	0.726
TRG_ER_diArg_1	198	201	PF00400	0.631
TRG_ER_diArg_1	309	312	PF00400	0.509
TRG_ER_diArg_1	32	34	PF00400	0.535
TRG_ER_diArg_1	393	396	PF00400	0.489
TRG_ER_diArg_1	397	400	PF00400	0.514
TRG_ER_diArg_1	79	81	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G8	Leptomonas seymouri	60%	100%
A0A3Q8IAY8	Leishmania donovani	87%	99%
A4HBZ0	Leishmania braziliensis	71%	100%
A4HZD8	Leishmania infantum	88%	91%
E9AVC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	96%