Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC53_LEIMA

TriTrypDb:

LmjF.21.1420 , LMJLV39_210022300 , LMJSD75_210022500

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QC53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.619
CLV_NRD_NRD_1	230	232	PF00675	0.515
CLV_NRD_NRD_1	255	257	PF00675	0.641
CLV_NRD_NRD_1	52	54	PF00675	0.503
CLV_NRD_NRD_1	82	84	PF00675	0.501
CLV_PCSK_FUR_1	253	257	PF00082	0.623
CLV_PCSK_KEX2_1	229	231	PF00082	0.503
CLV_PCSK_KEX2_1	255	257	PF00082	0.578
CLV_PCSK_KEX2_1	82	84	PF00082	0.501
CLV_PCSK_PC7_1	225	231	PF00082	0.540
CLV_PCSK_SKI1_1	143	147	PF00082	0.662
CLV_PCSK_SKI1_1	18	22	PF00082	0.559
CLV_PCSK_SKI1_1	204	208	PF00082	0.433
CLV_PCSK_SKI1_1	35	39	PF00082	0.390
CLV_PCSK_SKI1_1	82	86	PF00082	0.528
DEG_SPOP_SBC_1	89	93	PF00917	0.531
DOC_AGCK_PIF_1	45	50	PF00069	0.525
DOC_CYCLIN_RxL_1	15	24	PF00134	0.516
DOC_PP1_RVXF_1	65	71	PF00149	0.518
DOC_PP1_RVXF_1	80	87	PF00149	0.522
DOC_PP2B_LxvP_1	106	109	PF13499	0.616
DOC_USP7_MATH_1	158	162	PF00917	0.637
DOC_USP7_MATH_1	89	93	PF00917	0.663
DOC_USP7_MATH_1	97	101	PF00917	0.652
LIG_14-3-3_CanoR_1	260	267	PF00244	0.686
LIG_14-3-3_CanoR_1	40	45	PF00244	0.460
LIG_14-3-3_CanoR_1	96	106	PF00244	0.545
LIG_APCC_ABBA_1	115	120	PF00400	0.497
LIG_APCC_ABBA_1	194	199	PF00400	0.585
LIG_APCC_ABBAyCdc20_2	193	199	PF00400	0.588
LIG_APCC_Cbox_2	199	205	PF00515	0.361
LIG_CaM_IQ_9	27	42	PF13499	0.479
LIG_Clathr_ClatBox_1	116	120	PF01394	0.479
LIG_Clathr_ClatBox_1	20	24	PF01394	0.428
LIG_CtBP_PxDLS_1	111	115	PF00389	0.482
LIG_deltaCOP1_diTrp_1	254	259	PF00928	0.642
LIG_FHA_1	50	56	PF00498	0.477
LIG_FHA_2	142	148	PF00498	0.543
LIG_GBD_Chelix_1	202	210	PF00786	0.356
LIG_LIR_Gen_1	185	196	PF02991	0.495
LIG_LIR_Gen_1	39	50	PF02991	0.463
LIG_LIR_Gen_1	7	17	PF02991	0.589
LIG_LIR_Nem_3	205	210	PF02991	0.460
LIG_LIR_Nem_3	39	45	PF02991	0.456
LIG_LIR_Nem_3	7	12	PF02991	0.539
LIG_Pex14_1	222	226	PF04695	0.565
LIG_Pex14_2	44	48	PF04695	0.485
LIG_PTB_Apo_2	217	224	PF02174	0.448
LIG_REV1ctd_RIR_1	83	92	PF16727	0.605
LIG_SH2_CRK	211	215	PF00017	0.448
LIG_SH2_CRK	9	13	PF00017	0.523
LIG_SH2_STAT5	188	191	PF00017	0.523
LIG_SH2_STAT5	211	214	PF00017	0.515
LIG_SH2_STAT5	226	229	PF00017	0.474
LIG_SH2_STAT5	36	39	PF00017	0.435
LIG_SH2_STAT5	69	72	PF00017	0.655
LIG_SUMO_SIM_anti_2	112	118	PF11976	0.490
LIG_WRC_WIRS_1	47	52	PF05994	0.515
MOD_CK1_1	128	134	PF00069	0.551
MOD_CK1_1	163	169	PF00069	0.610
MOD_CK1_1	263	269	PF00069	0.540
MOD_CK1_1	49	55	PF00069	0.485
MOD_CK1_1	72	78	PF00069	0.468
MOD_CK1_1	92	98	PF00069	0.393
MOD_CK2_1	141	147	PF00069	0.658
MOD_CK2_1	244	250	PF00069	0.588
MOD_GlcNHglycan	160	163	PF01048	0.648
MOD_GlcNHglycan	92	95	PF01048	0.650
MOD_GlcNHglycan	99	102	PF01048	0.637
MOD_GSK3_1	121	128	PF00069	0.476
MOD_GSK3_1	158	165	PF00069	0.610
MOD_GSK3_1	182	189	PF00069	0.631
MOD_GSK3_1	88	95	PF00069	0.645
MOD_N-GLC_1	147	152	PF02516	0.562
MOD_N-GLC_1	186	191	PF02516	0.636
MOD_N-GLC_1	40	45	PF02516	0.460
MOD_NEK2_1	182	187	PF00069	0.572
MOD_NEK2_1	202	207	PF00069	0.501
MOD_NEK2_1	4	9	PF00069	0.514
MOD_NEK2_1	90	95	PF00069	0.561
MOD_PIKK_1	11	17	PF00454	0.649
MOD_PIKK_1	121	127	PF00454	0.600
MOD_PK_1	244	250	PF00069	0.501
MOD_PKA_2	4	10	PF00069	0.515
MOD_PKA_2	95	101	PF00069	0.536
MOD_Plk_1	141	147	PF00069	0.571
MOD_Plk_1	186	192	PF00069	0.544
MOD_Plk_1	244	250	PF00069	0.560
MOD_Plk_1	40	46	PF00069	0.456
MOD_Plk_2-3	141	147	PF00069	0.644
MOD_Plk_4	125	131	PF00069	0.511
MOD_Plk_4	244	250	PF00069	0.464
MOD_SUMO_rev_2	141	151	PF00179	0.478
TRG_DiLeu_BaEn_1	112	117	PF01217	0.562
TRG_DiLeu_BaEn_2	178	184	PF01217	0.547
TRG_ENDOCYTIC_2	188	191	PF00928	0.504
TRG_ENDOCYTIC_2	211	214	PF00928	0.438
TRG_ENDOCYTIC_2	9	12	PF00928	0.517
TRG_ER_diArg_1	229	231	PF00400	0.494
TRG_ER_diArg_1	255	257	PF00400	0.590
TRG_ER_diArg_1	33	36	PF00400	0.563
TRG_ER_diArg_1	65	68	PF00400	0.613
TRG_ER_diArg_1	81	83	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V9	Leptomonas seymouri	60%	98%
A0A0S4IH77	Bodo saltans	30%	100%
A0A1X0NHE8	Trypanosomatidae	42%	100%
A0A3S7WWT7	Leishmania donovani	93%	100%
A4HBY9	Leishmania braziliensis	79%	99%
A4HZD9	Leishmania infantum	93%	100%
D0A146	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AVC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B1U8	Trypanosoma cruzi	40%	100%