Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC49_LEIMA

TriTrypDb:

LmjF.21.1460 , LMJLV39_210022700 , LMJSD75_210022900

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.675
CLV_NRD_NRD_1	219	221	PF00675	0.642
CLV_NRD_NRD_1	252	254	PF00675	0.590
CLV_NRD_NRD_1	279	281	PF00675	0.754
CLV_NRD_NRD_1	331	333	PF00675	0.465
CLV_NRD_NRD_1	366	368	PF00675	0.676
CLV_NRD_NRD_1	443	445	PF00675	0.544
CLV_NRD_NRD_1	494	496	PF00675	0.592
CLV_NRD_NRD_1	502	504	PF00675	0.508
CLV_PCSK_FUR_1	364	368	PF00082	0.671
CLV_PCSK_KEX2_1	219	221	PF00082	0.642
CLV_PCSK_KEX2_1	252	254	PF00082	0.590
CLV_PCSK_KEX2_1	279	281	PF00082	0.662
CLV_PCSK_KEX2_1	331	333	PF00082	0.397
CLV_PCSK_KEX2_1	363	365	PF00082	0.656
CLV_PCSK_KEX2_1	366	368	PF00082	0.652
CLV_PCSK_KEX2_1	443	445	PF00082	0.671
CLV_PCSK_KEX2_1	460	462	PF00082	0.506
CLV_PCSK_KEX2_1	494	496	PF00082	0.594
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.656
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.567
CLV_PCSK_SKI1_1	12	16	PF00082	0.689
CLV_PCSK_SKI1_1	267	271	PF00082	0.624
CLV_PCSK_SKI1_1	383	387	PF00082	0.676
CLV_PCSK_SKI1_1	494	498	PF00082	0.583
CLV_PCSK_SKI1_1	504	508	PF00082	0.503
DEG_APCC_DBOX_1	442	450	PF00400	0.500
DEG_APCC_DBOX_1	493	501	PF00400	0.559
DEG_Nend_UBRbox_3	1	3	PF02207	0.514
DEG_SPOP_SBC_1	115	119	PF00917	0.630
DEG_SPOP_SBC_1	132	136	PF00917	0.506
DEG_SPOP_SBC_1	140	144	PF00917	0.609
DEG_SPOP_SBC_1	237	241	PF00917	0.654
DEG_SPOP_SBC_1	429	433	PF00917	0.669
DOC_CKS1_1	176	181	PF01111	0.710
DOC_CYCLIN_RxL_1	378	390	PF00134	0.661
DOC_CYCLIN_RxL_1	441	451	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	16	22	PF00134	0.632
DOC_MAPK_FxFP_2	20	23	PF00069	0.667
DOC_MAPK_JIP1_4	44	50	PF00069	0.567
DOC_PP2B_LxvP_1	112	115	PF13499	0.566
DOC_PP2B_LxvP_1	16	19	PF13499	0.569
DOC_PP2B_LxvP_1	386	389	PF13499	0.615
DOC_PP2B_LxvP_1	48	51	PF13499	0.570
DOC_PP2B_LxvP_1	64	67	PF13499	0.601
DOC_PP2B_LxvP_1	95	98	PF13499	0.520
DOC_PP4_FxxP_1	20	23	PF00568	0.717
DOC_PP4_FxxP_1	54	57	PF00568	0.580
DOC_USP7_MATH_1	115	119	PF00917	0.653
DOC_USP7_MATH_1	132	136	PF00917	0.636
DOC_USP7_MATH_1	162	166	PF00917	0.695
DOC_USP7_MATH_1	172	176	PF00917	0.576
DOC_USP7_MATH_1	181	185	PF00917	0.530
DOC_USP7_MATH_1	218	222	PF00917	0.732
DOC_USP7_MATH_1	419	423	PF00917	0.678
DOC_USP7_MATH_1	429	433	PF00917	0.644
DOC_USP7_MATH_1	43	47	PF00917	0.593
DOC_USP7_MATH_1	49	53	PF00917	0.552
DOC_USP7_MATH_1	67	71	PF00917	0.605
DOC_WW_Pin1_4	133	138	PF00397	0.757
DOC_WW_Pin1_4	175	180	PF00397	0.709
DOC_WW_Pin1_4	230	235	PF00397	0.622
DOC_WW_Pin1_4	340	345	PF00397	0.599
DOC_WW_Pin1_4	410	415	PF00397	0.668
DOC_WW_Pin1_4	424	429	PF00397	0.566
DOC_WW_Pin1_4	475	480	PF00397	0.621
LIG_14-3-3_CanoR_1	12	17	PF00244	0.483
LIG_14-3-3_CanoR_1	130	138	PF00244	0.623
LIG_14-3-3_CanoR_1	219	223	PF00244	0.651
LIG_14-3-3_CanoR_1	303	309	PF00244	0.503
LIG_14-3-3_CanoR_1	364	370	PF00244	0.670
LIG_14-3-3_CanoR_1	395	401	PF00244	0.643
LIG_AP2alpha_2	489	491	PF02296	0.571
LIG_APCC_ABBA_1	292	297	PF00400	0.607
LIG_BIR_III_4	187	191	PF00653	0.727
LIG_EVH1_1	54	58	PF00568	0.579
LIG_EVH1_1	96	100	PF00568	0.517
LIG_EVH1_2	102	106	PF00568	0.523
LIG_FHA_1	107	113	PF00498	0.579
LIG_FHA_1	271	277	PF00498	0.657
LIG_FHA_1	400	406	PF00498	0.583
LIG_FHA_1	466	472	PF00498	0.632
LIG_FHA_2	353	359	PF00498	0.689
LIG_FHA_2	483	489	PF00498	0.664
LIG_HCF-1_HBM_1	327	330	PF13415	0.450
LIG_Integrin_RGD_1	185	187	PF01839	0.665
LIG_LIR_Apic_2	41	45	PF02991	0.641
LIG_LIR_Apic_2	52	57	PF02991	0.517
LIG_LIR_Gen_1	302	312	PF02991	0.466
LIG_LIR_Gen_1	335	344	PF02991	0.553
LIG_LIR_Gen_1	450	459	PF02991	0.507
LIG_LIR_Nem_3	302	308	PF02991	0.479
LIG_LIR_Nem_3	327	333	PF02991	0.469
LIG_LIR_Nem_3	335	340	PF02991	0.524
LIG_LIR_Nem_3	450	456	PF02991	0.530
LIG_MYND_1	93	97	PF01753	0.562
LIG_PROFILIN_1	97	103	PF00235	0.588
LIG_PTAP_UEV_1	400	405	PF05743	0.636
LIG_PTB_Apo_2	490	497	PF02174	0.555
LIG_SH2_CRK	305	309	PF00017	0.460
LIG_SH2_CRK	330	334	PF00017	0.460
LIG_SH2_SRC	337	340	PF00017	0.566
LIG_SH2_STAP1	305	309	PF00017	0.460
LIG_SH2_STAP1	337	341	PF00017	0.486
LIG_SH2_STAP1	5	9	PF00017	0.640
LIG_SH2_STAT5	322	325	PF00017	0.468
LIG_SH3_1	96	102	PF00018	0.591
LIG_SH3_3	166	172	PF00018	0.725
LIG_SH3_3	173	179	PF00018	0.635
LIG_SH3_3	338	344	PF00018	0.559
LIG_SH3_3	386	392	PF00018	0.591
LIG_SH3_3	398	404	PF00018	0.710
LIG_SH3_3	408	414	PF00018	0.627
LIG_SH3_3	423	429	PF00018	0.560
LIG_SH3_3	468	474	PF00018	0.642
LIG_SH3_3	52	58	PF00018	0.579
LIG_SH3_3	66	72	PF00018	0.602
LIG_SH3_3	79	85	PF00018	0.616
LIG_SH3_3	91	97	PF00018	0.515
MOD_CDC14_SPxK_1	343	346	PF00782	0.625
MOD_CDK_SPxK_1	340	346	PF00069	0.605
MOD_CK1_1	118	124	PF00069	0.634
MOD_CK1_1	125	131	PF00069	0.628
MOD_CK1_1	133	139	PF00069	0.690
MOD_CK1_1	175	181	PF00069	0.630
MOD_CK1_1	198	204	PF00069	0.637
MOD_CK1_1	221	227	PF00069	0.698
MOD_CK1_1	228	234	PF00069	0.772
MOD_CK1_1	236	242	PF00069	0.593
MOD_CK1_1	257	263	PF00069	0.691
MOD_CK1_1	307	313	PF00069	0.566
MOD_CK1_1	35	41	PF00069	0.636
MOD_CK1_1	394	400	PF00069	0.770
MOD_CK1_1	431	437	PF00069	0.684
MOD_CK1_1	438	444	PF00069	0.541
MOD_CK1_1	478	484	PF00069	0.719
MOD_CK1_1	70	76	PF00069	0.574
MOD_CK2_1	314	320	PF00069	0.486
MOD_CK2_1	332	338	PF00069	0.595
MOD_CK2_1	35	41	PF00069	0.636
MOD_CK2_1	352	358	PF00069	0.525
MOD_CK2_1	419	425	PF00069	0.672
MOD_CK2_1	482	488	PF00069	0.660
MOD_DYRK1A_RPxSP_1	410	414	PF00069	0.629
MOD_GlcNHglycan	118	121	PF01048	0.714
MOD_GlcNHglycan	138	141	PF01048	0.816
MOD_GlcNHglycan	150	153	PF01048	0.631
MOD_GlcNHglycan	201	204	PF01048	0.671
MOD_GlcNHglycan	225	228	PF01048	0.720
MOD_GlcNHglycan	235	238	PF01048	0.627
MOD_GlcNHglycan	257	260	PF01048	0.644
MOD_GlcNHglycan	267	270	PF01048	0.672
MOD_GlcNHglycan	316	319	PF01048	0.653
MOD_GlcNHglycan	36	40	PF01048	0.686
MOD_GlcNHglycan	416	419	PF01048	0.678
MOD_GlcNHglycan	421	424	PF01048	0.681
MOD_GlcNHglycan	434	437	PF01048	0.473
MOD_GlcNHglycan	508	511	PF01048	0.573
MOD_GlcNHglycan	69	72	PF01048	0.751
MOD_GSK3_1	114	121	PF00069	0.636
MOD_GSK3_1	122	129	PF00069	0.622
MOD_GSK3_1	132	139	PF00069	0.775
MOD_GSK3_1	140	147	PF00069	0.671
MOD_GSK3_1	195	202	PF00069	0.659
MOD_GSK3_1	221	228	PF00069	0.700
MOD_GSK3_1	229	236	PF00069	0.628
MOD_GSK3_1	237	244	PF00069	0.675
MOD_GSK3_1	255	262	PF00069	0.590
MOD_GSK3_1	303	310	PF00069	0.675
MOD_GSK3_1	370	377	PF00069	0.791
MOD_GSK3_1	410	417	PF00069	0.692
MOD_GSK3_1	424	431	PF00069	0.581
MOD_GSK3_1	434	441	PF00069	0.532
MOD_GSK3_1	465	472	PF00069	0.697
MOD_GSK3_1	477	484	PF00069	0.672
MOD_NEK2_1	106	111	PF00069	0.485
MOD_NEK2_1	225	230	PF00069	0.709
MOD_NEK2_1	265	270	PF00069	0.591
MOD_NEK2_1	430	435	PF00069	0.812
MOD_NEK2_1	448	453	PF00069	0.403
MOD_NEK2_1	506	511	PF00069	0.555
MOD_PIKK_1	448	454	PF00454	0.683
MOD_PK_1	195	201	PF00069	0.669
MOD_PKA_1	195	201	PF00069	0.569
MOD_PKA_2	140	146	PF00069	0.742
MOD_PKA_2	218	224	PF00069	0.710
MOD_PKA_2	278	284	PF00069	0.660
MOD_PKA_2	365	371	PF00069	0.656
MOD_PKA_2	374	380	PF00069	0.650
MOD_PKA_2	394	400	PF00069	0.507
MOD_Plk_4	304	310	PF00069	0.517
MOD_Plk_4	49	55	PF00069	0.519
MOD_ProDKin_1	133	139	PF00069	0.758
MOD_ProDKin_1	175	181	PF00069	0.710
MOD_ProDKin_1	230	236	PF00069	0.623
MOD_ProDKin_1	340	346	PF00069	0.605
MOD_ProDKin_1	410	416	PF00069	0.671
MOD_ProDKin_1	424	430	PF00069	0.566
MOD_ProDKin_1	475	481	PF00069	0.622
TRG_ENDOCYTIC_2	305	308	PF00928	0.463
TRG_ENDOCYTIC_2	330	333	PF00928	0.458
TRG_ENDOCYTIC_2	337	340	PF00928	0.486
TRG_ER_diArg_1	252	254	PF00400	0.689
TRG_ER_diArg_1	278	280	PF00400	0.647
TRG_ER_diArg_1	330	332	PF00400	0.527
TRG_ER_diArg_1	333	336	PF00400	0.461
TRG_ER_diArg_1	364	367	PF00400	0.670
TRG_ER_diArg_1	442	444	PF00400	0.559
TRG_ER_diArg_1	494	496	PF00400	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I273	Leptomonas seymouri	33%	69%
A0A3S7WWP6	Leishmania donovani	87%	100%
A4HC17	Leishmania braziliensis	60%	72%
A4HZE3	Leishmania infantum	86%	100%
E9AVD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	75%