TPR_MalT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC48_LEIMA

TriTrypDb:

LmjF.21.1470 , LMJLV39_210022800 , LMJSD75_210023000

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.371
CLV_NRD_NRD_1	223	225	PF00675	0.456
CLV_NRD_NRD_1	231	233	PF00675	0.425
CLV_PCSK_KEX2_1	145	147	PF00082	0.371
CLV_PCSK_KEX2_1	231	233	PF00082	0.460
CLV_PCSK_SKI1_1	146	150	PF00082	0.469
DEG_APCC_DBOX_1	145	153	PF00400	0.449
DOC_MAPK_MEF2A_6	22	31	PF00069	0.522
DOC_PP1_RVXF_1	119	126	PF00149	0.503
DOC_PP1_RVXF_1	223	230	PF00149	0.378
DOC_USP7_MATH_1	14	18	PF00917	0.499
DOC_USP7_MATH_1	74	78	PF00917	0.409
LIG_14-3-3_CanoR_1	145	149	PF00244	0.407
LIG_14-3-3_CanoR_1	224	230	PF00244	0.459
LIG_Actin_WH2_2	132	147	PF00022	0.545
LIG_BIR_II_1	1	5	PF00653	0.602
LIG_BIR_III_4	235	239	PF00653	0.536
LIG_Clathr_ClatBox_1	49	53	PF01394	0.389
LIG_FHA_1	19	25	PF00498	0.534
LIG_FHA_2	180	186	PF00498	0.502
LIG_FHA_2	206	212	PF00498	0.421
LIG_LIR_Nem_3	208	213	PF02991	0.503
LIG_LIR_Nem_3	96	101	PF02991	0.452
LIG_Rb_LxCxE_1	47	66	PF01857	0.505
LIG_SH2_SRC	64	67	PF00017	0.513
LIG_SH2_STAP1	64	68	PF00017	0.471
LIG_SH2_STAT5	226	229	PF00017	0.381
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.427
LIG_UBA3_1	245	254	PF00899	0.473
LIG_WRC_WIRS_1	207	212	PF05994	0.519
MOD_CK1_1	147	153	PF00069	0.391
MOD_CK1_1	244	250	PF00069	0.407
MOD_CK2_1	162	168	PF00069	0.525
MOD_CK2_1	179	185	PF00069	0.527
MOD_CK2_1	205	211	PF00069	0.417
MOD_GlcNHglycan	109	112	PF01048	0.398
MOD_GlcNHglycan	131	134	PF01048	0.542
MOD_GlcNHglycan	16	19	PF01048	0.517
MOD_GlcNHglycan	234	239	PF01048	0.586
MOD_GlcNHglycan	7	10	PF01048	0.446
MOD_GSK3_1	14	21	PF00069	0.495
MOD_GSK3_1	154	161	PF00069	0.498
MOD_GSK3_1	162	169	PF00069	0.550
MOD_GSK3_1	264	271	PF00069	0.550
MOD_NEK2_1	144	149	PF00069	0.390
MOD_NEK2_1	152	157	PF00069	0.372
MOD_NEK2_1	52	57	PF00069	0.384
MOD_NEK2_2	219	224	PF00069	0.496
MOD_PIKK_1	214	220	PF00454	0.455
MOD_PIKK_1	52	58	PF00454	0.397
MOD_PKA_2	14	20	PF00069	0.535
MOD_PKA_2	144	150	PF00069	0.385
MOD_Plk_4	179	185	PF00069	0.530
MOD_Plk_4	241	247	PF00069	0.364
MOD_Plk_4	45	51	PF00069	0.393
MOD_Plk_4	74	80	PF00069	0.432
MOD_SUMO_rev_2	127	133	PF00179	0.449
MOD_SUMO_rev_2	165	175	PF00179	0.466
TRG_DiLeu_BaEn_1	114	119	PF01217	0.503
TRG_DiLeu_BaEn_2	93	99	PF01217	0.426
TRG_ENDOCYTIC_2	59	62	PF00928	0.386
TRG_ER_diArg_1	144	146	PF00400	0.385
TRG_NES_CRM1_1	94	106	PF08389	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVJ3	Leptomonas seymouri	73%	73%
A0A0S4JQG6	Bodo saltans	41%	76%
A0A1X0PAZ2	Trypanosomatidae	49%	87%
A0A3Q8IE15	Leishmania donovani	94%	100%
A0A3R7KWQ9	Trypanosoma rangeli	52%	87%
A4HC18	Leishmania braziliensis	86%	100%
A4HZE4	Leishmania infantum	95%	100%
C9ZMM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	85%
E9AVD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BFW6	Trypanosoma cruzi	51%	87%