DUF5745 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC47_LEIMA

TriTrypDb:

LmjF.21.1480 , LMJLV39_210022900 , LMJSD75_210023100

Length:

827

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	7
GO:0005813	centrosome	3	7
GO:0005815	microtubule organizing center	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QC47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	537	541	PF00656	0.667
CLV_C14_Caspase3-7	553	557	PF00656	0.434
CLV_C14_Caspase3-7	620	624	PF00656	0.707
CLV_C14_Caspase3-7	95	99	PF00656	0.619
CLV_NRD_NRD_1	239	241	PF00675	0.446
CLV_NRD_NRD_1	487	489	PF00675	0.727
CLV_NRD_NRD_1	525	527	PF00675	0.773
CLV_NRD_NRD_1	546	548	PF00675	0.649
CLV_NRD_NRD_1	562	564	PF00675	0.625
CLV_NRD_NRD_1	591	593	PF00675	0.685
CLV_NRD_NRD_1	713	715	PF00675	0.480
CLV_NRD_NRD_1	743	745	PF00675	0.429
CLV_NRD_NRD_1	805	807	PF00675	0.437
CLV_NRD_NRD_1	88	90	PF00675	0.710
CLV_PCSK_FUR_1	589	593	PF00082	0.658
CLV_PCSK_FUR_1	711	715	PF00082	0.465
CLV_PCSK_KEX2_1	237	239	PF00082	0.452
CLV_PCSK_KEX2_1	487	489	PF00082	0.727
CLV_PCSK_KEX2_1	525	527	PF00082	0.685
CLV_PCSK_KEX2_1	546	548	PF00082	0.649
CLV_PCSK_KEX2_1	591	593	PF00082	0.685
CLV_PCSK_KEX2_1	616	618	PF00082	0.725
CLV_PCSK_KEX2_1	713	715	PF00082	0.485
CLV_PCSK_KEX2_1	743	745	PF00082	0.438
CLV_PCSK_KEX2_1	800	802	PF00082	0.423
CLV_PCSK_KEX2_1	805	807	PF00082	0.444
CLV_PCSK_KEX2_1	88	90	PF00082	0.697
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.452
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.712
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.406
CLV_PCSK_PC7_1	709	715	PF00082	0.461
CLV_PCSK_PC7_1	801	807	PF00082	0.408
CLV_PCSK_SKI1_1	525	529	PF00082	0.572
CLV_PCSK_SKI1_1	617	621	PF00082	0.677
CLV_PCSK_SKI1_1	672	676	PF00082	0.614
CLV_PCSK_SKI1_1	735	739	PF00082	0.450
CLV_Separin_Metazoa	810	814	PF03568	0.518
DEG_SPOP_SBC_1	312	316	PF00917	0.552
DEG_SPOP_SBC_1	38	42	PF00917	0.681
DEG_SPOP_SBC_1	93	97	PF00917	0.544
DOC_CKS1_1	44	49	PF01111	0.614
DOC_CKS1_1	654	659	PF01111	0.627
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.637
DOC_MAPK_gen_1	237	246	PF00069	0.426
DOC_MAPK_gen_1	732	741	PF00069	0.433
DOC_MAPK_MEF2A_6	237	246	PF00069	0.426
DOC_MAPK_MEF2A_6	274	282	PF00069	0.383
DOC_PP4_FxxP_1	381	384	PF00568	0.662
DOC_PP4_MxPP_1	361	364	PF00568	0.607
DOC_USP7_MATH_1	106	110	PF00917	0.530
DOC_USP7_MATH_1	313	317	PF00917	0.582
DOC_USP7_MATH_1	372	376	PF00917	0.550
DOC_USP7_MATH_1	38	42	PF00917	0.815
DOC_USP7_MATH_1	499	503	PF00917	0.765
DOC_USP7_MATH_1	585	589	PF00917	0.649
DOC_USP7_MATH_1	64	68	PF00917	0.785
DOC_USP7_MATH_1	660	664	PF00917	0.535
DOC_USP7_MATH_1	77	81	PF00917	0.570
DOC_USP7_MATH_1	83	87	PF00917	0.632
DOC_USP7_MATH_1	93	97	PF00917	0.671
DOC_WW_Pin1_4	150	155	PF00397	0.710
DOC_WW_Pin1_4	228	233	PF00397	0.466
DOC_WW_Pin1_4	40	45	PF00397	0.637
DOC_WW_Pin1_4	411	416	PF00397	0.559
DOC_WW_Pin1_4	426	431	PF00397	0.691
DOC_WW_Pin1_4	505	510	PF00397	0.653
DOC_WW_Pin1_4	518	523	PF00397	0.695
DOC_WW_Pin1_4	569	574	PF00397	0.731
DOC_WW_Pin1_4	610	615	PF00397	0.691
DOC_WW_Pin1_4	653	658	PF00397	0.650
LIG_14-3-3_CanoR_1	206	216	PF00244	0.367
LIG_14-3-3_CanoR_1	36	45	PF00244	0.614
LIG_14-3-3_CanoR_1	694	701	PF00244	0.536
LIG_14-3-3_CanoR_1	776	780	PF00244	0.442
LIG_BIR_III_4	323	327	PF00653	0.604
LIG_BIR_III_4	370	374	PF00653	0.628
LIG_BRCT_BRCA1_1	209	213	PF00533	0.358
LIG_BRCT_BRCA1_1	47	51	PF00533	0.568
LIG_BRCT_BRCA1_1	599	603	PF00533	0.575
LIG_CaM_IQ_9	701	716	PF13499	0.451
LIG_FHA_1	442	448	PF00498	0.543
LIG_FHA_1	66	72	PF00498	0.538
LIG_FHA_1	776	782	PF00498	0.435
LIG_FHA_2	169	175	PF00498	0.680
LIG_FHA_2	535	541	PF00498	0.598
LIG_FHA_2	618	624	PF00498	0.808
LIG_FHA_2	666	672	PF00498	0.530
LIG_FHA_2	731	737	PF00498	0.460
LIG_FHA_2	756	762	PF00498	0.412
LIG_FHA_2	805	811	PF00498	0.409
LIG_LIR_Apic_2	386	392	PF02991	0.558
LIG_LIR_Gen_1	193	202	PF02991	0.427
LIG_LIR_Gen_1	210	221	PF02991	0.357
LIG_LIR_Nem_3	193	197	PF02991	0.406
LIG_LIR_Nem_3	209	215	PF02991	0.355
LIG_LIR_Nem_3	449	455	PF02991	0.530
LIG_MLH1_MIPbox_1	209	213	PF16413	0.358
LIG_PDZ_Class_2	822	827	PF00595	0.422
LIG_PTB_Apo_2	451	458	PF02174	0.520
LIG_PTB_Phospho_1	451	457	PF10480	0.515
LIG_REV1ctd_RIR_1	672	678	PF16727	0.567
LIG_SH2_CRK	217	221	PF00017	0.368
LIG_SH2_CRK	350	354	PF00017	0.661
LIG_SH2_CRK	452	456	PF00017	0.539
LIG_SH2_CRK	642	646	PF00017	0.650
LIG_SH2_CRK	756	760	PF00017	0.432
LIG_SH2_NCK_1	350	354	PF00017	0.605
LIG_SH2_NCK_1	642	646	PF00017	0.650
LIG_SH2_PTP2	389	392	PF00017	0.575
LIG_SH2_SRC	350	353	PF00017	0.661
LIG_SH2_SRC	436	439	PF00017	0.610
LIG_SH2_STAP1	716	720	PF00017	0.453
LIG_SH2_STAP1	756	760	PF00017	0.432
LIG_SH2_STAP1	785	789	PF00017	0.404
LIG_SH2_STAP1	814	818	PF00017	0.416
LIG_SH2_STAT3	4	7	PF00017	0.705
LIG_SH2_STAT3	716	719	PF00017	0.462
LIG_SH2_STAT5	389	392	PF00017	0.575
LIG_SH2_STAT5	436	439	PF00017	0.610
LIG_SH2_STAT5	673	676	PF00017	0.615
LIG_SH2_STAT5	700	703	PF00017	0.440
LIG_SH3_1	389	395	PF00018	0.569
LIG_SH3_3	131	137	PF00018	0.661
LIG_SH3_3	14	20	PF00018	0.662
LIG_SH3_3	153	159	PF00018	0.768
LIG_SH3_3	357	363	PF00018	0.663
LIG_SH3_3	389	395	PF00018	0.602
LIG_SH3_3	41	47	PF00018	0.624
LIG_SH3_3	453	459	PF00018	0.641
LIG_SH3_3	593	599	PF00018	0.798
LIG_SH3_3	651	657	PF00018	0.649
LIG_SH3_3	659	665	PF00018	0.727
LIG_SH3_3	71	77	PF00018	0.642
LIG_SUMO_SIM_par_1	164	174	PF11976	0.513
LIG_SUMO_SIM_par_1	242	247	PF11976	0.415
LIG_TRAF2_1	171	174	PF00917	0.655
LIG_TRAF2_1	463	466	PF00917	0.706
LIG_TRAF2_1	574	577	PF00917	0.575
LIG_TRAF2_1	628	631	PF00917	0.668
LIG_TRAF2_1	668	671	PF00917	0.529
LIG_TYR_ITIM	215	220	PF00017	0.358
LIG_WRC_WIRS_1	191	196	PF05994	0.394
LIG_WW_3	652	656	PF00397	0.586
MOD_CDK_SPxK_1	610	616	PF00069	0.636
MOD_CDK_SPxxK_3	518	525	PF00069	0.702
MOD_CDK_SPxxK_3	610	617	PF00069	0.638
MOD_CK1_1	231	237	PF00069	0.470
MOD_CK1_1	39	45	PF00069	0.622
MOD_CK1_1	429	435	PF00069	0.608
MOD_CK1_1	502	508	PF00069	0.639
MOD_CK1_1	72	78	PF00069	0.776
MOD_CK1_1	775	781	PF00069	0.444
MOD_CK2_1	168	174	PF00069	0.661
MOD_CK2_1	50	56	PF00069	0.656
MOD_CK2_1	518	524	PF00069	0.700
MOD_CK2_1	576	582	PF00069	0.674
MOD_CK2_1	615	621	PF00069	0.658
MOD_CK2_1	665	671	PF00069	0.532
MOD_CK2_1	687	693	PF00069	0.503
MOD_CK2_1	723	729	PF00069	0.444
MOD_CK2_1	730	736	PF00069	0.432
MOD_CK2_1	755	761	PF00069	0.412
MOD_CK2_1	804	810	PF00069	0.406
MOD_GlcNHglycan	126	129	PF01048	0.663
MOD_GlcNHglycan	150	153	PF01048	0.661
MOD_GlcNHglycan	315	318	PF01048	0.650
MOD_GlcNHglycan	375	378	PF01048	0.668
MOD_GlcNHglycan	401	404	PF01048	0.641
MOD_GlcNHglycan	408	412	PF01048	0.608
MOD_GlcNHglycan	418	421	PF01048	0.605
MOD_GlcNHglycan	470	473	PF01048	0.695
MOD_GlcNHglycan	505	508	PF01048	0.646
MOD_GlcNHglycan	518	521	PF01048	0.667
MOD_GlcNHglycan	52	55	PF01048	0.655
MOD_GlcNHglycan	599	602	PF01048	0.706
MOD_GlcNHglycan	617	620	PF01048	0.626
MOD_GlcNHglycan	696	699	PF01048	0.537
MOD_GlcNHglycan	71	74	PF01048	0.709
MOD_GlcNHglycan	720	723	PF01048	0.474
MOD_GlcNHglycan	79	82	PF01048	0.673
MOD_GlcNHglycan	816	821	PF01048	0.405
MOD_GlcNHglycan	85	88	PF01048	0.712
MOD_GlcNHglycan	89	92	PF01048	0.780
MOD_GSK3_1	144	151	PF00069	0.791
MOD_GSK3_1	161	168	PF00069	0.633
MOD_GSK3_1	197	204	PF00069	0.549
MOD_GSK3_1	36	43	PF00069	0.681
MOD_GSK3_1	407	414	PF00069	0.565
MOD_GSK3_1	437	444	PF00069	0.590
MOD_GSK3_1	45	52	PF00069	0.674
MOD_GSK3_1	464	471	PF00069	0.715
MOD_GSK3_1	499	506	PF00069	0.637
MOD_GSK3_1	65	72	PF00069	0.593
MOD_GSK3_1	83	90	PF00069	0.784
MOD_NEK2_1	221	226	PF00069	0.432
MOD_NEK2_1	311	316	PF00069	0.705
MOD_NEK2_1	437	442	PF00069	0.598
MOD_NEK2_1	50	55	PF00069	0.647
MOD_NEK2_1	503	508	PF00069	0.666
MOD_NEK2_1	510	515	PF00069	0.690
MOD_NEK2_1	723	728	PF00069	0.457
MOD_NEK2_1	730	735	PF00069	0.456
MOD_NEK2_1	789	794	PF00069	0.409
MOD_NEK2_2	108	113	PF00069	0.618
MOD_NEK2_2	208	213	PF00069	0.357
MOD_NEK2_2	476	481	PF00069	0.702
MOD_PIKK_1	161	167	PF00454	0.561
MOD_PIKK_1	482	488	PF00454	0.718
MOD_PIKK_1	534	540	PF00454	0.573
MOD_PIKK_1	633	639	PF00454	0.755
MOD_PIKK_1	640	646	PF00454	0.655
MOD_PIKK_1	715	721	PF00454	0.457
MOD_PK_1	201	207	PF00069	0.408
MOD_PK_1	23	29	PF00069	0.546
MOD_PKA_2	200	206	PF00069	0.507
MOD_PKA_2	585	591	PF00069	0.625
MOD_PKA_2	687	693	PF00069	0.503
MOD_PKA_2	723	729	PF00069	0.444
MOD_PKA_2	731	737	PF00069	0.430
MOD_PKA_2	775	781	PF00069	0.437
MOD_PKA_2	804	810	PF00069	0.403
MOD_PKA_2	87	93	PF00069	0.721
MOD_Plk_1	221	227	PF00069	0.438
MOD_Plk_1	437	443	PF00069	0.595
MOD_Plk_1	816	822	PF00069	0.405
MOD_Plk_4	130	136	PF00069	0.654
MOD_Plk_4	208	214	PF00069	0.356
MOD_Plk_4	23	29	PF00069	0.571
MOD_Plk_4	437	443	PF00069	0.626
MOD_Plk_4	755	761	PF00069	0.412
MOD_Plk_4	789	795	PF00069	0.414
MOD_ProDKin_1	150	156	PF00069	0.708
MOD_ProDKin_1	228	234	PF00069	0.465
MOD_ProDKin_1	40	46	PF00069	0.636
MOD_ProDKin_1	411	417	PF00069	0.559
MOD_ProDKin_1	426	432	PF00069	0.690
MOD_ProDKin_1	505	511	PF00069	0.654
MOD_ProDKin_1	518	524	PF00069	0.698
MOD_ProDKin_1	569	575	PF00069	0.730
MOD_ProDKin_1	610	616	PF00069	0.693
MOD_ProDKin_1	653	659	PF00069	0.650
MOD_SUMO_for_1	799	802	PF00179	0.431
MOD_SUMO_rev_2	684	692	PF00179	0.482
MOD_SUMO_rev_2	734	739	PF00179	0.445
TRG_DiLeu_BaEn_1	524	529	PF01217	0.572
TRG_DiLeu_BaEn_4	262	268	PF01217	0.415
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.366
TRG_DiLeu_BaLyEn_6	523	528	PF01217	0.564
TRG_ENDOCYTIC_2	217	220	PF00928	0.364
TRG_ENDOCYTIC_2	350	353	PF00928	0.580
TRG_ENDOCYTIC_2	452	455	PF00928	0.536
TRG_ENDOCYTIC_2	756	759	PF00928	0.436
TRG_ER_diArg_1	238	240	PF00400	0.391
TRG_ER_diArg_1	525	527	PF00400	0.599
TRG_ER_diArg_1	545	547	PF00400	0.618
TRG_ER_diArg_1	589	592	PF00400	0.657
TRG_ER_diArg_1	708	711	PF00400	0.454
TRG_ER_diArg_1	712	714	PF00400	0.470
TRG_ER_diArg_1	742	744	PF00400	0.441
TRG_NES_CRM1_1	270	285	PF08389	0.387
TRG_Pf-PMV_PEXEL_1	699	703	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC22	Leptomonas seymouri	52%	88%
A0A3Q8IB84	Leishmania donovani	91%	100%
A4HBZ6	Leishmania braziliensis	73%	100%
A4HZE5	Leishmania infantum	90%	94%
E9AVD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%