Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QC46_LEIMA

TriTrypDb:

LmjF.21.1490 , LMJLV39_210023000 , LMJSD75_210023200

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.730
CLV_C14_Caspase3-7	344	348	PF00656	0.822
CLV_C14_Caspase3-7	569	573	PF00656	0.858
CLV_NRD_NRD_1	12	14	PF00675	0.695
CLV_NRD_NRD_1	179	181	PF00675	0.767
CLV_NRD_NRD_1	22	24	PF00675	0.723
CLV_NRD_NRD_1	312	314	PF00675	0.733
CLV_NRD_NRD_1	315	317	PF00675	0.699
CLV_PCSK_FUR_1	313	317	PF00082	0.617
CLV_PCSK_KEX2_1	12	14	PF00082	0.698
CLV_PCSK_KEX2_1	179	181	PF00082	0.767
CLV_PCSK_KEX2_1	22	24	PF00082	0.725
CLV_PCSK_KEX2_1	314	316	PF00082	0.621
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.621
CLV_PCSK_SKI1_1	154	158	PF00082	0.638
CLV_PCSK_SKI1_1	182	186	PF00082	0.830
CLV_PCSK_SKI1_1	267	271	PF00082	0.831
CLV_PCSK_SKI1_1	296	300	PF00082	0.622
CLV_PCSK_SKI1_1	405	409	PF00082	0.562
CLV_PCSK_SKI1_1	644	648	PF00082	0.831
DEG_APCC_DBOX_1	153	161	PF00400	0.636
DEG_Nend_UBRbox_3	1	3	PF02207	0.846
DEG_SPOP_SBC_1	38	42	PF00917	0.719
DEG_SPOP_SBC_1	654	658	PF00917	0.759
DOC_ANK_TNKS_1	383	390	PF00023	0.771
DOC_MAPK_DCC_7	154	162	PF00069	0.790
DOC_MAPK_MEF2A_6	154	162	PF00069	0.790
DOC_PP2B_LxvP_1	133	136	PF13499	0.567
DOC_PP2B_LxvP_1	607	610	PF13499	0.856
DOC_PP2B_LxvP_1	94	97	PF13499	0.760
DOC_PP4_FxxP_1	113	116	PF00568	0.628
DOC_USP7_MATH_1	126	130	PF00917	0.811
DOC_USP7_MATH_1	14	18	PF00917	0.766
DOC_USP7_MATH_1	161	165	PF00917	0.564
DOC_USP7_MATH_1	226	230	PF00917	0.765
DOC_USP7_MATH_1	269	273	PF00917	0.695
DOC_USP7_MATH_1	323	327	PF00917	0.718
DOC_USP7_MATH_1	330	334	PF00917	0.666
DOC_USP7_MATH_1	38	42	PF00917	0.614
DOC_USP7_MATH_1	442	446	PF00917	0.759
DOC_USP7_MATH_1	474	478	PF00917	0.742
DOC_USP7_MATH_1	557	561	PF00917	0.872
DOC_USP7_MATH_1	654	658	PF00917	0.759
DOC_USP7_MATH_1	8	12	PF00917	0.822
DOC_WW_Pin1_4	103	108	PF00397	0.773
DOC_WW_Pin1_4	170	175	PF00397	0.703
DOC_WW_Pin1_4	199	204	PF00397	0.631
DOC_WW_Pin1_4	235	240	PF00397	0.760
DOC_WW_Pin1_4	30	35	PF00397	0.796
DOC_WW_Pin1_4	503	508	PF00397	0.823
DOC_WW_Pin1_4	534	539	PF00397	0.867
DOC_WW_Pin1_4	547	552	PF00397	0.645
DOC_WW_Pin1_4	559	564	PF00397	0.675
DOC_WW_Pin1_4	56	61	PF00397	0.730
DOC_WW_Pin1_4	583	588	PF00397	0.842
DOC_WW_Pin1_4	77	82	PF00397	0.770
LIG_14-3-3_CanoR_1	186	196	PF00244	0.748
LIG_14-3-3_CanoR_1	324	334	PF00244	0.616
LIG_14-3-3_CanoR_1	396	402	PF00244	0.565
LIG_14-3-3_CanoR_1	405	410	PF00244	0.557
LIG_14-3-3_CanoR_1	415	420	PF00244	0.634
LIG_14-3-3_CanoR_1	534	538	PF00244	0.772
LIG_14-3-3_CanoR_1	6	14	PF00244	0.765
LIG_14-3-3_CanoR_1	614	623	PF00244	0.845
LIG_deltaCOP1_diTrp_1	395	402	PF00928	0.649
LIG_DLG_GKlike_1	415	422	PF00625	0.712
LIG_FHA_1	255	261	PF00498	0.628
LIG_FHA_1	297	303	PF00498	0.689
LIG_FHA_1	406	412	PF00498	0.678
LIG_FHA_1	77	83	PF00498	0.595
LIG_FHA_2	295	301	PF00498	0.741
LIG_FHA_2	422	428	PF00498	0.598
LIG_LIR_Apic_2	444	450	PF02991	0.842
LIG_MYND_1	98	102	PF01753	0.840
LIG_PTB_Apo_2	432	439	PF02174	0.572
LIG_PTB_Phospho_1	432	438	PF10480	0.571
LIG_SH2_PTP2	447	450	PF00017	0.730
LIG_SH2_PTP2	511	514	PF00017	0.833
LIG_SH2_SRC	447	450	PF00017	0.829
LIG_SH2_STAT3	361	364	PF00017	0.715
LIG_SH2_STAT5	438	441	PF00017	0.720
LIG_SH2_STAT5	447	450	PF00017	0.659
LIG_SH2_STAT5	511	514	PF00017	0.709
LIG_SH2_STAT5	73	76	PF00017	0.554
LIG_SH3_3	114	120	PF00018	0.810
LIG_SH3_3	155	161	PF00018	0.786
LIG_SH3_3	282	288	PF00018	0.762
LIG_SH3_3	300	306	PF00018	0.533
LIG_SH3_3	353	359	PF00018	0.814
LIG_SH3_3	535	541	PF00018	0.839
LIG_SH3_3	54	60	PF00018	0.616
LIG_SH3_3	545	551	PF00018	0.715
LIG_SH3_3	560	566	PF00018	0.602
LIG_SH3_3	585	591	PF00018	0.839
LIG_SH3_3	594	600	PF00018	0.664
LIG_SH3_3	602	608	PF00018	0.685
LIG_SH3_3	78	84	PF00018	0.694
LIG_SUMO_SIM_par_1	121	130	PF11976	0.741
LIG_SUMO_SIM_par_1	204	212	PF11976	0.793
LIG_SUMO_SIM_par_1	512	517	PF11976	0.828
LIG_TRAF2_1	424	427	PF00917	0.666
LIG_WW_3	96	100	PF00397	0.842
MOD_CDC14_SPxK_1	537	540	PF00782	0.857
MOD_CDC14_SPxK_1	59	62	PF00782	0.720
MOD_CDK_SPxK_1	534	540	PF00069	0.866
MOD_CDK_SPxK_1	56	62	PF00069	0.727
MOD_CK1_1	152	158	PF00069	0.708
MOD_CK1_1	164	170	PF00069	0.559
MOD_CK1_1	197	203	PF00069	0.751
MOD_CK1_1	211	217	PF00069	0.564
MOD_CK1_1	292	298	PF00069	0.741
MOD_CK1_1	326	332	PF00069	0.841
MOD_CK1_1	40	46	PF00069	0.799
MOD_CK1_1	519	525	PF00069	0.752
MOD_CK1_1	529	535	PF00069	0.713
MOD_CK1_1	550	556	PF00069	0.862
MOD_CK1_1	612	618	PF00069	0.849
MOD_CK1_1	656	662	PF00069	0.848
MOD_CK2_1	230	236	PF00069	0.707
MOD_CK2_1	397	403	PF00069	0.495
MOD_CK2_1	421	427	PF00069	0.603
MOD_DYRK1A_RPxSP_1	534	538	PF00069	0.790
MOD_GlcNHglycan	151	154	PF01048	0.796
MOD_GlcNHglycan	196	199	PF01048	0.731
MOD_GlcNHglycan	232	235	PF01048	0.759
MOD_GlcNHglycan	242	245	PF01048	0.726
MOD_GlcNHglycan	291	294	PF01048	0.847
MOD_GlcNHglycan	328	331	PF01048	0.753
MOD_GlcNHglycan	480	483	PF01048	0.766
MOD_GlcNHglycan	492	495	PF01048	0.523
MOD_GlcNHglycan	528	531	PF01048	0.801
MOD_GlcNHglycan	568	571	PF01048	0.706
MOD_GlcNHglycan	601	604	PF01048	0.871
MOD_GlcNHglycan	638	641	PF01048	0.779
MOD_GlcNHglycan	659	662	PF01048	0.853
MOD_GSK3_1	145	152	PF00069	0.675
MOD_GSK3_1	160	167	PF00069	0.740
MOD_GSK3_1	178	185	PF00069	0.544
MOD_GSK3_1	188	195	PF00069	0.676
MOD_GSK3_1	226	233	PF00069	0.614
MOD_GSK3_1	292	299	PF00069	0.785
MOD_GSK3_1	325	332	PF00069	0.790
MOD_GSK3_1	411	418	PF00069	0.728
MOD_GSK3_1	474	481	PF00069	0.720
MOD_GSK3_1	484	491	PF00069	0.827
MOD_GSK3_1	499	506	PF00069	0.829
MOD_GSK3_1	51	58	PF00069	0.815
MOD_GSK3_1	512	519	PF00069	0.594
MOD_GSK3_1	522	529	PF00069	0.748
MOD_GSK3_1	553	560	PF00069	0.869
MOD_GSK3_1	610	617	PF00069	0.791
MOD_GSK3_1	65	72	PF00069	0.694
MOD_GSK3_1	653	660	PF00069	0.839
MOD_GSK3_1	73	80	PF00069	0.600
MOD_N-GLC_2	404	406	PF02516	0.646
MOD_NEK2_1	138	143	PF00069	0.645
MOD_NEK2_1	166	171	PF00069	0.706
MOD_NEK2_1	37	42	PF00069	0.655
MOD_NEK2_1	411	416	PF00069	0.741
MOD_NEK2_1	645	650	PF00069	0.783
MOD_NEK2_1	653	658	PF00069	0.751
MOD_NEK2_1	71	76	PF00069	0.785
MOD_PIKK_1	14	20	PF00454	0.799
MOD_PIKK_1	166	172	PF00454	0.749
MOD_PIKK_1	252	258	PF00454	0.736
MOD_PIKK_1	270	276	PF00454	0.522
MOD_PIKK_1	369	375	PF00454	0.708
MOD_PIKK_1	405	411	PF00454	0.737
MOD_PIKK_1	529	535	PF00454	0.873
MOD_PKA_2	178	184	PF00069	0.823
MOD_PKA_2	323	329	PF00069	0.687
MOD_PKA_2	442	448	PF00069	0.763
MOD_PKA_2	487	493	PF00069	0.709
MOD_PKA_2	525	531	PF00069	0.699
MOD_PKA_2	533	539	PF00069	0.720
MOD_Plk_1	211	217	PF00069	0.608
MOD_Plk_1	226	232	PF00069	0.572
MOD_Plk_1	270	276	PF00069	0.749
MOD_Plk_4	161	167	PF00069	0.743
MOD_Plk_4	397	403	PF00069	0.678
MOD_Plk_4	618	624	PF00069	0.766
MOD_ProDKin_1	103	109	PF00069	0.774
MOD_ProDKin_1	170	176	PF00069	0.703
MOD_ProDKin_1	199	205	PF00069	0.633
MOD_ProDKin_1	235	241	PF00069	0.761
MOD_ProDKin_1	30	36	PF00069	0.796
MOD_ProDKin_1	503	509	PF00069	0.822
MOD_ProDKin_1	534	540	PF00069	0.866
MOD_ProDKin_1	547	553	PF00069	0.646
MOD_ProDKin_1	559	565	PF00069	0.673
MOD_ProDKin_1	56	62	PF00069	0.727
MOD_ProDKin_1	583	589	PF00069	0.845
MOD_ProDKin_1	77	83	PF00069	0.771
MOD_SUMO_for_1	216	219	PF00179	0.743
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.787
TRG_ENDOCYTIC_2	511	514	PF00928	0.833
TRG_ER_diArg_1	12	14	PF00400	0.698
TRG_ER_diArg_1	178	180	PF00400	0.773
TRG_ER_diArg_1	22	24	PF00400	0.725
TRG_ER_diArg_1	312	315	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.776
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.805

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWS0	Leishmania donovani	84%	100%
A4HBZ7	Leishmania braziliensis	57%	100%
A4HZE6	Leishmania infantum	85%	100%
E9AVD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%