RNA-directed RNA polymerase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC45_LEIMA

TriTrypDb:

LmjF.21.1500 , LMJLV39_210023100 , LMJSD75_210023300

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC45

PDB structure(s): 7aih_Ah , 7am2_Ah , 7ane_Ah

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.370
CLV_C14_Caspase3-7	361	365	PF00656	0.514
CLV_C14_Caspase3-7	375	379	PF00656	0.487
CLV_C14_Caspase3-7	96	100	PF00656	0.374
CLV_NRD_NRD_1	213	215	PF00675	0.342
CLV_NRD_NRD_1	426	428	PF00675	0.404
CLV_NRD_NRD_1	471	473	PF00675	0.392
CLV_NRD_NRD_1	497	499	PF00675	0.527
CLV_NRD_NRD_1	525	527	PF00675	0.515
CLV_NRD_NRD_1	540	542	PF00675	0.504
CLV_PCSK_KEX2_1	213	215	PF00082	0.376
CLV_PCSK_KEX2_1	31	33	PF00082	0.535
CLV_PCSK_KEX2_1	426	428	PF00082	0.404
CLV_PCSK_KEX2_1	470	472	PF00082	0.388
CLV_PCSK_KEX2_1	497	499	PF00082	0.512
CLV_PCSK_KEX2_1	525	527	PF00082	0.515
CLV_PCSK_KEX2_1	540	542	PF00082	0.504
CLV_PCSK_KEX2_1	550	552	PF00082	0.509
CLV_PCSK_KEX2_1	65	67	PF00082	0.487
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.717
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.388
CLV_PCSK_PC1ET2_1	550	552	PF00082	0.584
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.529
CLV_PCSK_PC7_1	521	527	PF00082	0.522
CLV_PCSK_SKI1_1	202	206	PF00082	0.320
CLV_PCSK_SKI1_1	315	319	PF00082	0.391
CLV_PCSK_SKI1_1	32	36	PF00082	0.572
CLV_PCSK_SKI1_1	338	342	PF00082	0.319
CLV_PCSK_SKI1_1	394	398	PF00082	0.413
CLV_PCSK_SKI1_1	412	416	PF00082	0.317
CLV_PCSK_SKI1_1	440	444	PF00082	0.464
CLV_PCSK_SKI1_1	453	457	PF00082	0.415
CLV_PCSK_SKI1_1	525	529	PF00082	0.525
CLV_PCSK_SKI1_1	551	555	PF00082	0.492
CLV_PCSK_SKI1_1	59	63	PF00082	0.568
DEG_APCC_DBOX_1	201	209	PF00400	0.356
DEG_ODPH_VHL_1	332	343	PF01847	0.424
DEG_SCF_FBW7_1	407	413	PF00400	0.444
DOC_ANK_TNKS_1	226	233	PF00023	0.375
DOC_ANK_TNKS_1	349	356	PF00023	0.493
DOC_CKS1_1	125	130	PF01111	0.328
DOC_CKS1_1	407	412	PF01111	0.389
DOC_CYCLIN_RxL_1	210	220	PF00134	0.413
DOC_MAPK_gen_1	160	170	PF00069	0.339
DOC_MAPK_gen_1	210	219	PF00069	0.350
DOC_MAPK_gen_1	31	37	PF00069	0.645
DOC_MIT_MIM_1	107	116	PF04212	0.431
DOC_PP1_RVXF_1	117	123	PF00149	0.330
DOC_PP4_FxxP_1	125	128	PF00568	0.320
DOC_PP4_FxxP_1	279	282	PF00568	0.357
DOC_PP4_FxxP_1	291	294	PF00568	0.417
DOC_USP7_MATH_1	306	310	PF00917	0.475
DOC_USP7_MATH_1	479	483	PF00917	0.543
DOC_USP7_MATH_1	68	72	PF00917	0.545
DOC_USP7_MATH_2	43	49	PF00917	0.488
DOC_USP7_UBL2_3	119	123	PF12436	0.398
DOC_USP7_UBL2_3	545	549	PF12436	0.612
DOC_WW_Pin1_4	124	129	PF00397	0.325
DOC_WW_Pin1_4	290	295	PF00397	0.483
DOC_WW_Pin1_4	320	325	PF00397	0.448
DOC_WW_Pin1_4	406	411	PF00397	0.385
LIG_14-3-3_CanoR_1	108	112	PF00244	0.484
LIG_14-3-3_CanoR_1	177	181	PF00244	0.434
LIG_14-3-3_CanoR_1	426	434	PF00244	0.397
LIG_Actin_WH2_2	306	322	PF00022	0.388
LIG_Actin_WH2_2	411	428	PF00022	0.395
LIG_APCC_ABBA_1	133	138	PF00400	0.330
LIG_APCC_ABBA_1	311	316	PF00400	0.405
LIG_BIR_III_4	22	26	PF00653	0.473
LIG_BRCT_BRCA1_1	109	113	PF00533	0.379
LIG_Clathr_ClatBox_1	205	209	PF01394	0.314
LIG_deltaCOP1_diTrp_1	226	233	PF00928	0.341
LIG_FHA_1	116	122	PF00498	0.336
LIG_FHA_1	125	131	PF00498	0.373
LIG_FHA_1	413	419	PF00498	0.327
LIG_FHA_1	505	511	PF00498	0.640
LIG_FHA_2	257	263	PF00498	0.377
LIG_FHA_2	299	305	PF00498	0.428
LIG_FHA_2	441	447	PF00498	0.411
LIG_FHA_2	506	512	PF00498	0.568
LIG_IBAR_NPY_1	248	250	PF08397	0.392
LIG_LIR_Apic_2	278	282	PF02991	0.390
LIG_LIR_Apic_2	288	294	PF02991	0.395
LIG_LIR_Gen_1	284	294	PF02991	0.503
LIG_LIR_Gen_1	358	366	PF02991	0.381
LIG_LIR_Gen_1	53	61	PF02991	0.448
LIG_LIR_Gen_1	552	562	PF02991	0.534
LIG_LIR_Nem_3	110	116	PF02991	0.390
LIG_LIR_Nem_3	226	231	PF02991	0.365
LIG_LIR_Nem_3	274	279	PF02991	0.373
LIG_LIR_Nem_3	284	290	PF02991	0.387
LIG_LIR_Nem_3	348	352	PF02991	0.428
LIG_LIR_Nem_3	358	362	PF02991	0.384
LIG_LIR_Nem_3	454	459	PF02991	0.351
LIG_LIR_Nem_3	53	57	PF02991	0.442
LIG_LIR_Nem_3	552	557	PF02991	0.523
LIG_NRBOX	487	493	PF00104	0.485
LIG_PCNA_yPIPBox_3	307	320	PF02747	0.370
LIG_Pex14_1	474	478	PF04695	0.407
LIG_Pex14_1	91	95	PF04695	0.422
LIG_Pex14_2	287	291	PF04695	0.438
LIG_PTB_Apo_2	561	568	PF02174	0.517
LIG_PTB_Phospho_1	561	567	PF10480	0.517
LIG_REV1ctd_RIR_1	394	404	PF16727	0.483
LIG_SH2_CRK	40	44	PF00017	0.564
LIG_SH2_CRK	54	58	PF00017	0.463
LIG_SH2_PTP2	250	253	PF00017	0.422
LIG_SH2_SRC	250	253	PF00017	0.403
LIG_SH2_STAP1	158	162	PF00017	0.308
LIG_SH2_STAT3	95	98	PF00017	0.488
LIG_SH2_STAT5	158	161	PF00017	0.456
LIG_SH2_STAT5	223	226	PF00017	0.319
LIG_SH2_STAT5	241	244	PF00017	0.370
LIG_SH2_STAT5	250	253	PF00017	0.369
LIG_SH2_STAT5	342	345	PF00017	0.311
LIG_SH2_STAT5	408	411	PF00017	0.374
LIG_SH2_STAT5	421	424	PF00017	0.276
LIG_SH2_STAT5	490	493	PF00017	0.507
LIG_SH2_STAT5	72	75	PF00017	0.530
LIG_SUMO_SIM_anti_2	259	265	PF11976	0.529
LIG_SxIP_EBH_1	1	11	PF03271	0.491
LIG_TRAF2_1	286	289	PF00917	0.475
LIG_TRAF2_1	358	361	PF00917	0.401
LIG_TRAF2_1	482	485	PF00917	0.468
LIG_TRFH_1	54	58	PF08558	0.542
LIG_TYR_ITIM	457	462	PF00017	0.363
LIG_WRPW_2	92	95	PF00400	0.459
MOD_CDK_SPxK_1	406	412	PF00069	0.410
MOD_CK1_1	13	19	PF00069	0.792
MOD_CK1_1	295	301	PF00069	0.473
MOD_CK1_1	81	87	PF00069	0.476
MOD_CK2_1	355	361	PF00069	0.421
MOD_CK2_1	440	446	PF00069	0.399
MOD_CK2_1	479	485	PF00069	0.532
MOD_CK2_1	505	511	PF00069	0.580
MOD_CMANNOS	225	228	PF00535	0.342
MOD_Cter_Amidation	495	498	PF01082	0.510
MOD_Cter_Amidation	63	66	PF01082	0.503
MOD_GlcNHglycan	143	146	PF01048	0.368
MOD_GlcNHglycan	28	31	PF01048	0.673
MOD_GlcNHglycan	343	346	PF01048	0.327
MOD_GSK3_1	191	198	PF00069	0.388
MOD_GSK3_1	406	413	PF00069	0.458
MOD_GSK3_1	479	486	PF00069	0.534
MOD_GSK3_1	545	552	PF00069	0.543
MOD_N-GLC_1	13	18	PF02516	0.500
MOD_N-GLC_1	306	311	PF02516	0.420
MOD_N-GLC_1	75	80	PF02516	0.514
MOD_NEK2_1	195	200	PF00069	0.383
MOD_NEK2_1	21	26	PF00069	0.672
MOD_NEK2_1	3	8	PF00069	0.492
MOD_NEK2_1	341	346	PF00069	0.385
MOD_NEK2_1	383	388	PF00069	0.349
MOD_PIKK_1	195	201	PF00454	0.363
MOD_PK_1	549	555	PF00069	0.566
MOD_PKA_1	549	555	PF00069	0.566
MOD_PKA_1	59	65	PF00069	0.496
MOD_PKA_2	10	16	PF00069	0.564
MOD_PKA_2	107	113	PF00069	0.460
MOD_PKA_2	176	182	PF00069	0.530
MOD_PKA_2	539	545	PF00069	0.598
MOD_Plk_1	136	142	PF00069	0.347
MOD_Plk_1	306	312	PF00069	0.477
MOD_Plk_1	410	416	PF00069	0.422
MOD_Plk_1	483	489	PF00069	0.477
MOD_Plk_1	81	87	PF00069	0.489
MOD_Plk_2-3	484	490	PF00069	0.477
MOD_Plk_4	191	197	PF00069	0.403
MOD_Plk_4	306	312	PF00069	0.362
MOD_ProDKin_1	124	130	PF00069	0.324
MOD_ProDKin_1	290	296	PF00069	0.479
MOD_ProDKin_1	320	326	PF00069	0.458
MOD_ProDKin_1	406	412	PF00069	0.383
MOD_SUMO_rev_2	348	358	PF00179	0.384
MOD_SUMO_rev_2	372	377	PF00179	0.306
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.475
TRG_ENDOCYTIC_2	276	279	PF00928	0.367
TRG_ENDOCYTIC_2	314	317	PF00928	0.378
TRG_ENDOCYTIC_2	459	462	PF00928	0.362
TRG_ENDOCYTIC_2	54	57	PF00928	0.482
TRG_ER_diArg_1	212	214	PF00400	0.340
TRG_ER_diArg_1	425	427	PF00400	0.402
TRG_ER_diArg_1	471	473	PF00400	0.395
TRG_ER_diArg_1	525	527	PF00400	0.515
TRG_ER_diArg_1	539	541	PF00400	0.498
TRG_NLS_MonoExtN_4	469	474	PF00514	0.477
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W4	Leptomonas seymouri	84%	100%
A0A0S4JTY1	Bodo saltans	56%	100%
A0A1X0NHH6	Trypanosomatidae	66%	100%
A0A3R7KIX4	Trypanosoma rangeli	72%	100%
A0A3S7WWP5	Leishmania donovani	96%	100%
A4HBZ8	Leishmania braziliensis	92%	100%
A4HZE7	Leishmania infantum	96%	100%
D0A135	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AVD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5B1V1	Trypanosoma cruzi	72%	100%