HMG box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QC43_LEIMA

TriTrypDb:

LmjF.21.1520 , LMJLV39_210023300 , LMJSD75_210023500

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.450
CLV_NRD_NRD_1	163	165	PF00675	0.486
CLV_NRD_NRD_1	169	171	PF00675	0.441
CLV_NRD_NRD_1	23	25	PF00675	0.462
CLV_NRD_NRD_1	324	326	PF00675	0.549
CLV_NRD_NRD_1	9	11	PF00675	0.448
CLV_NRD_NRD_1	96	98	PF00675	0.442
CLV_PCSK_KEX2_1	115	117	PF00082	0.591
CLV_PCSK_KEX2_1	165	167	PF00082	0.504
CLV_PCSK_KEX2_1	169	171	PF00082	0.483
CLV_PCSK_KEX2_1	236	238	PF00082	0.522
CLV_PCSK_KEX2_1	25	27	PF00082	0.443
CLV_PCSK_KEX2_1	324	326	PF00082	0.549
CLV_PCSK_KEX2_1	354	356	PF00082	0.496
CLV_PCSK_KEX2_1	9	11	PF00082	0.448
CLV_PCSK_KEX2_1	96	98	PF00082	0.442
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.483
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.501
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.430
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.496
CLV_PCSK_PC7_1	21	27	PF00082	0.450
DEG_Nend_Nbox_1	1	3	PF02207	0.458
DOC_MAPK_gen_1	21	31	PF00069	0.434
DOC_MAPK_gen_1	309	317	PF00069	0.364
DOC_MAPK_gen_1	96	104	PF00069	0.391
DOC_MAPK_MEF2A_6	72	80	PF00069	0.371
DOC_PP2B_LxvP_1	78	81	PF13499	0.530
DOC_USP7_MATH_1	124	128	PF00917	0.620
DOC_USP7_MATH_1	147	151	PF00917	0.661
DOC_USP7_MATH_1	195	199	PF00917	0.593
DOC_USP7_MATH_1	276	280	PF00917	0.644
DOC_USP7_MATH_1	295	299	PF00917	0.542
DOC_USP7_MATH_1	33	37	PF00917	0.419
DOC_USP7_MATH_1	350	354	PF00917	0.482
DOC_USP7_MATH_1	70	74	PF00917	0.346
DOC_USP7_MATH_1	83	87	PF00917	0.551
DOC_USP7_UBL2_3	322	326	PF12436	0.548
DOC_WW_Pin1_4	229	234	PF00397	0.457
DOC_WW_Pin1_4	296	301	PF00397	0.603
DOC_WW_Pin1_4	360	365	PF00397	0.542
LIG_14-3-3_CanoR_1	139	148	PF00244	0.595
LIG_14-3-3_CanoR_1	169	179	PF00244	0.405
LIG_14-3-3_CanoR_1	309	315	PF00244	0.444
LIG_14-3-3_CanoR_1	337	346	PF00244	0.418
LIG_14-3-3_CanoR_1	54	63	PF00244	0.314
LIG_14-3-3_CanoR_1	72	77	PF00244	0.355
LIG_14-3-3_CanoR_1	97	103	PF00244	0.377
LIG_BIR_III_2	275	279	PF00653	0.639
LIG_DLG_GKlike_1	72	79	PF00625	0.367
LIG_FHA_1	44	50	PF00498	0.322
LIG_FHA_2	230	236	PF00498	0.449
LIG_FHA_2	246	252	PF00498	0.415
LIG_LIR_Gen_1	227	234	PF02991	0.502
LIG_LIR_Gen_1	312	321	PF02991	0.415
LIG_LIR_Gen_1	36	44	PF02991	0.342
LIG_LIR_Nem_3	173	178	PF02991	0.390
LIG_LIR_Nem_3	312	317	PF02991	0.421
LIG_LIR_Nem_3	36	40	PF02991	0.443
LIG_PTAP_UEV_1	363	368	PF05743	0.553
LIG_SH2_NCK_1	347	351	PF00017	0.439
LIG_SH2_STAP1	175	179	PF00017	0.459
LIG_SH2_STAP1	239	243	PF00017	0.418
LIG_SH2_STAP1	347	351	PF00017	0.467
LIG_SH2_STAT5	178	181	PF00017	0.473
LIG_SH3_1	165	171	PF00018	0.461
LIG_SH3_3	117	123	PF00018	0.524
LIG_SH3_3	165	171	PF00018	0.479
LIG_SH3_3	361	367	PF00018	0.561
LIG_SH3_3	5	11	PF00018	0.446
LIG_SUMO_SIM_anti_2	75	80	PF11976	0.500
LIG_TRAF2_1	340	343	PF00917	0.514
LIG_WRC_WIRS_1	34	39	PF05994	0.365
MOD_CDK_SPK_2	296	301	PF00069	0.527
MOD_CDK_SPxxK_3	229	236	PF00069	0.452
MOD_CK1_1	133	139	PF00069	0.633
MOD_CK1_1	150	156	PF00069	0.465
MOD_CK1_1	157	163	PF00069	0.476
MOD_CK1_1	245	251	PF00069	0.473
MOD_CK1_1	310	316	PF00069	0.475
MOD_CK1_1	353	359	PF00069	0.499
MOD_CK2_1	139	145	PF00069	0.559
MOD_CK2_1	170	176	PF00069	0.463
MOD_CK2_1	229	235	PF00069	0.457
MOD_CK2_1	245	251	PF00069	0.408
MOD_CK2_1	337	343	PF00069	0.430
MOD_CK2_1	52	58	PF00069	0.360
MOD_CK2_1	63	69	PF00069	0.322
MOD_Cter_Amidation	113	116	PF01082	0.619
MOD_Cter_Amidation	322	325	PF01082	0.546
MOD_GlcNHglycan	141	144	PF01048	0.573
MOD_GlcNHglycan	149	152	PF01048	0.619
MOD_GlcNHglycan	172	175	PF01048	0.381
MOD_GlcNHglycan	258	261	PF01048	0.658
MOD_GlcNHglycan	268	271	PF01048	0.585
MOD_GlcNHglycan	278	281	PF01048	0.512
MOD_GlcNHglycan	339	342	PF01048	0.421
MOD_GlcNHglycan	364	367	PF01048	0.610
MOD_GlcNHglycan	65	68	PF01048	0.375
MOD_GlcNHglycan	72	75	PF01048	0.343
MOD_GlcNHglycan	85	88	PF01048	0.447
MOD_GSK3_1	130	137	PF00069	0.630
MOD_GSK3_1	150	157	PF00069	0.558
MOD_GSK3_1	245	252	PF00069	0.453
MOD_GSK3_1	296	303	PF00069	0.611
MOD_GSK3_1	358	365	PF00069	0.527
MOD_GSK3_1	43	50	PF00069	0.325
MOD_N-GLC_1	124	129	PF02516	0.589
MOD_N-GLC_1	134	139	PF02516	0.623
MOD_N-GLC_1	337	342	PF02516	0.543
MOD_NEK2_1	1	6	PF00069	0.448
MOD_NEK2_1	14	19	PF00069	0.469
MOD_NEK2_1	52	57	PF00069	0.360
MOD_NEK2_2	134	139	PF00069	0.603
MOD_NEK2_2	35	40	PF00069	0.360
MOD_PIKK_1	154	160	PF00454	0.465
MOD_PIKK_1	358	364	PF00454	0.591
MOD_PKA_1	9	15	PF00069	0.454
MOD_PKA_2	83	89	PF00069	0.482
MOD_PKA_2	9	15	PF00069	0.537
MOD_Plk_1	134	140	PF00069	0.654
MOD_Plk_4	224	230	PF00069	0.504
MOD_Plk_4	310	316	PF00069	0.360
MOD_ProDKin_1	229	235	PF00069	0.457
MOD_ProDKin_1	296	302	PF00069	0.604
MOD_ProDKin_1	360	366	PF00069	0.529
MOD_SUMO_rev_2	340	346	PF00179	0.515
TRG_DiLeu_BaEn_1	27	32	PF01217	0.403
TRG_ER_diArg_1	138	141	PF00400	0.508
TRG_ER_diArg_1	163	166	PF00400	0.496
TRG_ER_diArg_1	168	170	PF00400	0.446
TRG_ER_diArg_1	8	10	PF00400	0.452
TRG_ER_diArg_1	81	84	PF00400	0.475
TRG_NLS_MonoExtC_3	163	168	PF00514	0.460
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX4	Leptomonas seymouri	33%	100%
A0A3Q8IL79	Leishmania donovani	88%	100%
A4HC00	Leishmania braziliensis	60%	100%
A4HZE9	Leishmania infantum	88%	100%
E9AVD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%