Vitamin B6 photo-protection and homoeostasis-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vitamin B6 photo-protection and homoeostasis, putative

Species:

Leishmania major

UniProt:

Q4QC42_LEIMA

TriTrypDb:

LmjF.21.1530 , LMJLV39_210023400 , LMJSD75_210023600

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.624
CLV_C14_Caspase3-7	630	634	PF00656	0.719
CLV_NRD_NRD_1	466	468	PF00675	0.439
CLV_NRD_NRD_1	495	497	PF00675	0.494
CLV_NRD_NRD_1	542	544	PF00675	0.447
CLV_NRD_NRD_1	614	616	PF00675	0.489
CLV_NRD_NRD_1	62	64	PF00675	0.263
CLV_PCSK_FUR_1	439	443	PF00082	0.349
CLV_PCSK_FUR_1	540	544	PF00082	0.438
CLV_PCSK_KEX2_1	441	443	PF00082	0.391
CLV_PCSK_KEX2_1	466	468	PF00082	0.395
CLV_PCSK_KEX2_1	495	497	PF00082	0.477
CLV_PCSK_KEX2_1	542	544	PF00082	0.447
CLV_PCSK_KEX2_1	61	63	PF00082	0.262
CLV_PCSK_KEX2_1	614	616	PF00082	0.509
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.391
CLV_PCSK_PC7_1	462	468	PF00082	0.384
CLV_PCSK_PC7_1	58	64	PF00082	0.305
CLV_PCSK_SKI1_1	108	112	PF00082	0.233
CLV_PCSK_SKI1_1	188	192	PF00082	0.305
CLV_PCSK_SKI1_1	356	360	PF00082	0.363
CLV_PCSK_SKI1_1	386	390	PF00082	0.342
CLV_PCSK_SKI1_1	551	555	PF00082	0.478
CLV_PCSK_SKI1_1	63	67	PF00082	0.299
CLV_PCSK_SKI1_1	70	74	PF00082	0.256
CLV_PCSK_SKI1_1	99	103	PF00082	0.299
DEG_APCC_DBOX_1	107	115	PF00400	0.463
DEG_Nend_Nbox_1	1	3	PF02207	0.584
DEG_SCF_FBW7_1	48	54	PF00400	0.641
DEG_SCF_TRCP1_1	312	317	PF00400	0.641
DEG_SPOP_SBC_1	52	56	PF00917	0.638
DEG_SPOP_SBC_1	603	607	PF00917	0.582
DOC_CDC14_PxL_1	335	343	PF14671	0.581
DOC_CKS1_1	45	50	PF01111	0.711
DOC_CYCLIN_RxL_1	331	340	PF00134	0.596
DOC_CYCLIN_RxL_1	67	75	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.463
DOC_MAPK_DCC_7	361	370	PF00069	0.556
DOC_MAPK_gen_1	310	318	PF00069	0.636
DOC_MAPK_gen_1	506	514	PF00069	0.610
DOC_MAPK_MEF2A_6	108	116	PF00069	0.463
DOC_MAPK_MEF2A_6	361	370	PF00069	0.563
DOC_MAPK_RevD_3	428	442	PF00069	0.608
DOC_PP1_RVXF_1	288	294	PF00149	0.498
DOC_PP2B_LxvP_1	175	178	PF13499	0.453
DOC_PP2B_LxvP_1	286	289	PF13499	0.463
DOC_PP2B_LxvP_1	336	339	PF13499	0.575
DOC_PP4_FxxP_1	35	38	PF00568	0.619
DOC_USP7_MATH_1	199	203	PF00917	0.546
DOC_USP7_MATH_1	227	231	PF00917	0.488
DOC_USP7_MATH_1	252	256	PF00917	0.305
DOC_USP7_MATH_1	264	268	PF00917	0.249
DOC_USP7_MATH_1	347	351	PF00917	0.636
DOC_USP7_MATH_1	403	407	PF00917	0.583
DOC_USP7_MATH_1	51	55	PF00917	0.648
DOC_USP7_MATH_1	582	586	PF00917	0.704
DOC_USP7_MATH_1	636	640	PF00917	0.654
DOC_WW_Pin1_4	322	327	PF00397	0.559
DOC_WW_Pin1_4	41	46	PF00397	0.682
DOC_WW_Pin1_4	47	52	PF00397	0.677
DOC_WW_Pin1_4	472	477	PF00397	0.796
DOC_WW_Pin1_4	590	595	PF00397	0.666
DOC_WW_Pin1_4	599	604	PF00397	0.594
LIG_14-3-3_CanoR_1	155	160	PF00244	0.463
LIG_14-3-3_CanoR_1	209	213	PF00244	0.463
LIG_14-3-3_CanoR_1	232	236	PF00244	0.484
LIG_14-3-3_CanoR_1	62	72	PF00244	0.505
LIG_14-3-3_CanoR_1	9	14	PF00244	0.521
LIG_BRCT_BRCA1_1	140	144	PF00533	0.463
LIG_BRCT_BRCA1_1	347	351	PF00533	0.740
LIG_CSL_BTD_1	178	181	PF09270	0.505
LIG_FHA_1	100	106	PF00498	0.380
LIG_FHA_1	134	140	PF00498	0.453
LIG_FHA_1	156	162	PF00498	0.505
LIG_FHA_1	164	170	PF00498	0.454
LIG_FHA_1	184	190	PF00498	0.474
LIG_FHA_1	365	371	PF00498	0.605
LIG_FHA_1	417	423	PF00498	0.563
LIG_FHA_1	605	611	PF00498	0.689
LIG_FHA_1	670	676	PF00498	0.611
LIG_FHA_1	80	86	PF00498	0.463
LIG_FHA_2	23	29	PF00498	0.550
LIG_FHA_2	447	453	PF00498	0.603
LIG_FHA_2	604	610	PF00498	0.675
LIG_FHA_2	64	70	PF00498	0.505
LIG_FHA_2	655	661	PF00498	0.568
LIG_GBD_Chelix_1	261	269	PF00786	0.252
LIG_GBD_Chelix_1	64	72	PF00786	0.284
LIG_LIR_Apic_2	33	38	PF02991	0.609
LIG_LIR_Gen_1	158	165	PF02991	0.536
LIG_LIR_Gen_1	292	301	PF02991	0.536
LIG_LIR_Gen_1	349	359	PF02991	0.632
LIG_LIR_Gen_1	419	428	PF02991	0.536
LIG_LIR_Gen_1	669	678	PF02991	0.621
LIG_LIR_LC3C_4	257	262	PF02991	0.252
LIG_LIR_Nem_3	141	147	PF02991	0.463
LIG_LIR_Nem_3	158	162	PF02991	0.463
LIG_LIR_Nem_3	185	190	PF02991	0.495
LIG_LIR_Nem_3	237	241	PF02991	0.325
LIG_LIR_Nem_3	274	278	PF02991	0.471
LIG_LIR_Nem_3	292	296	PF02991	0.476
LIG_LIR_Nem_3	349	355	PF02991	0.605
LIG_LIR_Nem_3	377	382	PF02991	0.532
LIG_LIR_Nem_3	417	423	PF02991	0.521
LIG_LIR_Nem_3	426	430	PF02991	0.566
LIG_LIR_Nem_3	639	643	PF02991	0.569
LIG_LIR_Nem_3	669	674	PF02991	0.615
LIG_MAD2	70	78	PF02301	0.484
LIG_NRBOX	377	383	PF00104	0.515
LIG_NRBOX	660	666	PF00104	0.552
LIG_Pex14_1	527	531	PF04695	0.491
LIG_Pex14_2	212	216	PF04695	0.463
LIG_PTB_Apo_2	665	672	PF02174	0.594
LIG_PTB_Phospho_1	665	671	PF10480	0.591
LIG_SH2_CRK	275	279	PF00017	0.463
LIG_SH2_CRK	352	356	PF00017	0.736
LIG_SH2_CRK	362	366	PF00017	0.715
LIG_SH2_CRK	536	540	PF00017	0.583
LIG_SH2_CRK	640	644	PF00017	0.562
LIG_SH2_CRK	671	675	PF00017	0.612
LIG_SH2_PTP2	249	252	PF00017	0.258
LIG_SH2_PTP2	421	424	PF00017	0.560
LIG_SH2_STAP1	671	675	PF00017	0.612
LIG_SH2_STAT3	440	443	PF00017	0.544
LIG_SH2_STAT5	249	252	PF00017	0.289
LIG_SH2_STAT5	362	365	PF00017	0.635
LIG_SH2_STAT5	421	424	PF00017	0.580
LIG_SH2_STAT5	427	430	PF00017	0.578
LIG_SH2_STAT5	5	8	PF00017	0.627
LIG_SH2_STAT5	529	532	PF00017	0.534
LIG_SH2_STAT5	671	674	PF00017	0.617
LIG_SH3_3	140	146	PF00018	0.430
LIG_SH3_3	175	181	PF00018	0.463
LIG_SH3_3	341	347	PF00018	0.633
LIG_SH3_3	39	45	PF00018	0.716
LIG_SH3_3	419	425	PF00018	0.516
LIG_SH3_3	478	484	PF00018	0.636
LIG_SH3_3	509	515	PF00018	0.610
LIG_SH3_3	588	594	PF00018	0.604
LIG_SUMO_SIM_anti_2	333	340	PF11976	0.565
LIG_SUMO_SIM_par_1	320	325	PF11976	0.556
LIG_SUMO_SIM_par_1	333	340	PF11976	0.559
LIG_TYR_ITIM	521	526	PF00017	0.509
LIG_Vh1_VBS_1	189	207	PF01044	0.432
LIG_WRC_WIRS_1	235	240	PF05994	0.325
MOD_CDK_SPK_2	322	327	PF00069	0.559
MOD_CK1_1	230	236	PF00069	0.473
MOD_CK1_1	274	280	PF00069	0.432
MOD_CK1_1	325	331	PF00069	0.548
MOD_CK1_1	44	50	PF00069	0.722
MOD_CK1_1	585	591	PF00069	0.701
MOD_CK1_1	602	608	PF00069	0.621
MOD_CK1_1	79	85	PF00069	0.505
MOD_CK2_1	22	28	PF00069	0.551
MOD_CK2_1	296	302	PF00069	0.502
MOD_CK2_1	446	452	PF00069	0.603
MOD_CK2_1	63	69	PF00069	0.505
MOD_CK2_1	654	660	PF00069	0.565
MOD_CK2_1	77	83	PF00069	0.417
MOD_Cter_Amidation	493	496	PF01082	0.462
MOD_GlcNHglycan	124	127	PF01048	0.237
MOD_GlcNHglycan	312	315	PF01048	0.442
MOD_GlcNHglycan	327	330	PF01048	0.251
MOD_GlcNHglycan	401	404	PF01048	0.341
MOD_GlcNHglycan	457	460	PF01048	0.402
MOD_GlcNHglycan	476	479	PF01048	0.577
MOD_GlcNHglycan	55	58	PF01048	0.463
MOD_GSK3_1	122	129	PF00069	0.463
MOD_GSK3_1	227	234	PF00069	0.457
MOD_GSK3_1	306	313	PF00069	0.669
MOD_GSK3_1	347	354	PF00069	0.685
MOD_GSK3_1	399	406	PF00069	0.632
MOD_GSK3_1	40	47	PF00069	0.683
MOD_GSK3_1	470	477	PF00069	0.729
MOD_GSK3_1	598	605	PF00069	0.605
MOD_GSK3_1	632	639	PF00069	0.775
MOD_GSK3_1	99	106	PF00069	0.472
MOD_LATS_1	384	390	PF00433	0.537
MOD_N-GLC_1	205	210	PF02516	0.252
MOD_N-GLC_1	559	564	PF02516	0.489
MOD_N-GLC_1	99	104	PF02516	0.305
MOD_NEK2_1	138	143	PF00069	0.512
MOD_NEK2_1	306	311	PF00069	0.666
MOD_NEK2_1	351	356	PF00069	0.739
MOD_NEK2_1	654	659	PF00069	0.562
MOD_NEK2_2	183	188	PF00069	0.452
MOD_NEK2_2	347	352	PF00069	0.642
MOD_NEK2_2	366	371	PF00069	0.503
MOD_NEK2_2	374	379	PF00069	0.520
MOD_PKA_1	310	316	PF00069	0.636
MOD_PKA_2	208	214	PF00069	0.453
MOD_PKA_2	231	237	PF00069	0.484
MOD_PKA_2	455	461	PF00069	0.648
MOD_PKA_2	654	660	PF00069	0.565
MOD_PKB_1	61	69	PF00069	0.484
MOD_Plk_1	416	422	PF00069	0.535
MOD_Plk_1	446	452	PF00069	0.551
MOD_Plk_1	559	565	PF00069	0.686
MOD_Plk_2-3	426	432	PF00069	0.562
MOD_Plk_4	126	132	PF00069	0.463
MOD_Plk_4	138	144	PF00069	0.463
MOD_Plk_4	192	198	PF00069	0.474
MOD_Plk_4	234	240	PF00069	0.282
MOD_Plk_4	264	270	PF00069	0.290
MOD_Plk_4	296	302	PF00069	0.528
MOD_Plk_4	314	320	PF00069	0.735
MOD_Plk_4	347	353	PF00069	0.641
MOD_Plk_4	374	380	PF00069	0.556
MOD_Plk_4	416	422	PF00069	0.653
MOD_Plk_4	670	676	PF00069	0.611
MOD_ProDKin_1	322	328	PF00069	0.558
MOD_ProDKin_1	41	47	PF00069	0.683
MOD_ProDKin_1	472	478	PF00069	0.796
MOD_ProDKin_1	590	596	PF00069	0.665
MOD_ProDKin_1	599	605	PF00069	0.593
MOD_SUMO_rev_2	299	306	PF00179	0.526
TRG_DiLeu_BaEn_1	302	307	PF01217	0.495
TRG_DiLeu_BaEn_1	37	42	PF01217	0.710
TRG_DiLeu_BaEn_1	660	665	PF01217	0.552
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.482
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.536
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.511
TRG_ENDOCYTIC_2	275	278	PF00928	0.463
TRG_ENDOCYTIC_2	298	301	PF00928	0.639
TRG_ENDOCYTIC_2	352	355	PF00928	0.639
TRG_ENDOCYTIC_2	420	423	PF00928	0.513
TRG_ENDOCYTIC_2	427	430	PF00928	0.563
TRG_ENDOCYTIC_2	523	526	PF00928	0.518
TRG_ENDOCYTIC_2	531	534	PF00928	0.546
TRG_ENDOCYTIC_2	536	539	PF00928	0.618
TRG_ENDOCYTIC_2	640	643	PF00928	0.565
TRG_ENDOCYTIC_2	671	674	PF00928	0.617
TRG_ER_diArg_1	539	542	PF00400	0.612
TRG_ER_diArg_1	61	63	PF00400	0.466
TRG_ER_diArg_1	614	616	PF00400	0.652
TRG_NES_CRM1_1	646	660	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	380	385	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W6	Leptomonas seymouri	53%	99%
A0A3S7WWW0	Leishmania donovani	88%	100%
A4HZF0	Leishmania infantum	88%	100%
E9AVD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%