Exocyst complex component Sec8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sec8 exocyst complex component specific domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QC41_LEIMA

TriTrypDb:

LmjF.21.1540 , LMJLV39_210023500 , LMJSD75_210023700

Length:

1886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000145	exocyst	3	11
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	1
GO:0032991	protein-containing complex	1	11
GO:0099023	vesicle tethering complex	2	11
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

Q4QC41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	10
GO:0006612	protein targeting to membrane	5	10
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0006887	exocytosis	4	2
GO:0006892	post-Golgi vesicle-mediated transport	6	10
GO:0006893	Golgi to plasma membrane transport	5	10
GO:0006904	vesicle docking involved in exocytosis	3	11
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	11

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1045	1049	PF00656	0.509
CLV_C14_Caspase3-7	1573	1577	PF00656	0.516
CLV_C14_Caspase3-7	173	177	PF00656	0.513
CLV_C14_Caspase3-7	228	232	PF00656	0.551
CLV_C14_Caspase3-7	264	268	PF00656	0.528
CLV_C14_Caspase3-7	385	389	PF00656	0.653
CLV_C14_Caspase3-7	799	803	PF00656	0.296
CLV_NRD_NRD_1	1119	1121	PF00675	0.380
CLV_NRD_NRD_1	1177	1179	PF00675	0.393
CLV_NRD_NRD_1	1297	1299	PF00675	0.350

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIB9	Leptomonas seymouri	63%	94%
A0A1X0NHD2	Trypanosomatidae	37%	100%
A0A3R7NVP9	Trypanosoma rangeli	38%	100%
A0A3S7WWU8	Leishmania donovani	91%	94%
A4HC01	Leishmania braziliensis	75%	100%
A4HZG2	Leishmania infantum	91%	92%
D0A132	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AVD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BRE7	Trypanosoma cruzi	39%	100%

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