LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QC39_LEIMA
TriTrypDb:
LmjF.21.1560 , LMJLV39_210023700 * , LMJSD75_210023900 *
Length:
530

Annotations

LeishMANIAdb annotations

A small protein family largely unrelated to amastins.. Only expanded mildly during evolution compared to amastins

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
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Expansion

Sequence features

Q4QC39
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC39

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 142 144 PF00675 0.363
CLV_NRD_NRD_1 320 322 PF00675 0.493
CLV_NRD_NRD_1 337 339 PF00675 0.547
CLV_NRD_NRD_1 79 81 PF00675 0.584
CLV_PCSK_KEX2_1 235 237 PF00082 0.399
CLV_PCSK_KEX2_1 322 324 PF00082 0.481
CLV_PCSK_KEX2_1 336 338 PF00082 0.566
CLV_PCSK_KEX2_1 79 81 PF00082 0.625
CLV_PCSK_PC1ET2_1 235 237 PF00082 0.388
CLV_PCSK_PC1ET2_1 322 324 PF00082 0.475
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PA63 Leptomonas seymouri 50% 91%
A0A3S5H7A1 Leishmania donovani 88% 97%
A4HC03 Leishmania braziliensis 65% 100%
A4HZG0 Leishmania infantum 88% 97%
E9AVE0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 98%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS