Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC39_LEIMA

TriTrypDb:

LmjF.21.1560 , LMJLV39_210023700 , LMJSD75_210023900

Length:

530

Annotations

LeishMANIAdb annotations

A small protein family largely unrelated to amastins.. Only expanded mildly during evolution compared to amastins

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QC39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.363
CLV_NRD_NRD_1	320	322	PF00675	0.493
CLV_NRD_NRD_1	337	339	PF00675	0.547
CLV_NRD_NRD_1	79	81	PF00675	0.584
CLV_PCSK_KEX2_1	235	237	PF00082	0.399
CLV_PCSK_KEX2_1	322	324	PF00082	0.481
CLV_PCSK_KEX2_1	336	338	PF00082	0.566
CLV_PCSK_KEX2_1	79	81	PF00082	0.625
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.388
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.475
CLV_PCSK_SKI1_1	102	106	PF00082	0.493
CLV_PCSK_SKI1_1	144	148	PF00082	0.226
CLV_PCSK_SKI1_1	170	174	PF00082	0.648
CLV_PCSK_SKI1_1	232	236	PF00082	0.381
CLV_PCSK_SKI1_1	380	384	PF00082	0.484
CLV_PCSK_SKI1_1	80	84	PF00082	0.604
DEG_APCC_DBOX_1	432	440	PF00400	0.687
DEG_SPOP_SBC_1	119	123	PF00917	0.241
DEG_SPOP_SBC_1	330	334	PF00917	0.742
DOC_CKS1_1	14	19	PF01111	0.597
DOC_CKS1_1	350	355	PF01111	0.641
DOC_CKS1_1	381	386	PF01111	0.680
DOC_CYCLIN_yClb1_LxF_4	123	128	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.373
DOC_MAPK_gen_1	223	231	PF00069	0.580
DOC_MAPK_MEF2A_6	223	231	PF00069	0.584
DOC_PP1_RVXF_1	123	129	PF00149	0.527
DOC_PP2B_LxvP_1	347	350	PF13499	0.697
DOC_PP2B_LxvP_1	511	514	PF13499	0.691
DOC_PP2B_LxvP_1	64	67	PF13499	0.381
DOC_PP4_MxPP_1	488	491	PF00568	0.635
DOC_USP7_MATH_1	181	185	PF00917	0.375
DOC_USP7_MATH_1	259	263	PF00917	0.669
DOC_USP7_MATH_1	330	334	PF00917	0.742
DOC_USP7_MATH_1	376	380	PF00917	0.685
DOC_USP7_MATH_1	46	50	PF00917	0.332
DOC_USP7_MATH_1	493	497	PF00917	0.727
DOC_USP7_MATH_1	503	507	PF00917	0.714
DOC_WW_Pin1_4	13	18	PF00397	0.635
DOC_WW_Pin1_4	281	286	PF00397	0.681
DOC_WW_Pin1_4	349	354	PF00397	0.640
DOC_WW_Pin1_4	380	385	PF00397	0.683
DOC_WW_Pin1_4	512	517	PF00397	0.691
LIG_14-3-3_CanoR_1	24	29	PF00244	0.541
LIG_14-3-3_CanoR_1	279	284	PF00244	0.681
LIG_14-3-3_CanoR_1	336	345	PF00244	0.713
LIG_APCC_ABBA_1	193	198	PF00400	0.330
LIG_BRCT_BRCA1_1	185	189	PF00533	0.443
LIG_BRCT_BRCA1_1	52	56	PF00533	0.339
LIG_deltaCOP1_diTrp_1	19	28	PF00928	0.574
LIG_FHA_1	121	127	PF00498	0.453
LIG_FHA_1	130	136	PF00498	0.537
LIG_FHA_1	147	153	PF00498	0.339
LIG_FHA_1	160	166	PF00498	0.287
LIG_FHA_1	171	177	PF00498	0.362
LIG_FHA_1	195	201	PF00498	0.301
LIG_FHA_1	25	31	PF00498	0.538
LIG_FHA_1	381	387	PF00498	0.680
LIG_FHA_1	476	482	PF00498	0.693
LIG_FHA_1	56	62	PF00498	0.383
LIG_FHA_2	14	20	PF00498	0.545
LIG_FHA_2	146	152	PF00498	0.317
LIG_FHA_2	521	527	PF00498	0.705
LIG_GBD_Chelix_1	30	38	PF00786	0.309
LIG_LIR_Gen_1	134	142	PF02991	0.552
LIG_LIR_Gen_1	148	157	PF02991	0.407
LIG_LIR_Gen_1	27	35	PF02991	0.311
LIG_LIR_Gen_1	388	398	PF02991	0.733
LIG_LIR_Gen_1	452	459	PF02991	0.688
LIG_LIR_LC3C_4	197	201	PF02991	0.224
LIG_LIR_Nem_3	134	140	PF02991	0.554
LIG_LIR_Nem_3	148	153	PF02991	0.407
LIG_LIR_Nem_3	246	251	PF02991	0.582
LIG_LIR_Nem_3	27	31	PF02991	0.381
LIG_LIR_Nem_3	388	393	PF02991	0.728
LIG_LIR_Nem_3	452	456	PF02991	0.692
LIG_PCNA_yPIPBox_3	169	183	PF02747	0.363
LIG_PDZ_Class_2	525	530	PF00595	0.723
LIG_PTB_Apo_2	103	110	PF02174	0.309
LIG_PTB_Apo_2	210	217	PF02174	0.309
LIG_PTB_Apo_2	384	391	PF02174	0.653
LIG_PTB_Apo_2	51	58	PF02174	0.325
LIG_PTB_Apo_2	83	90	PF02174	0.336
LIG_PTB_Phospho_1	103	109	PF10480	0.309
LIG_PTB_Phospho_1	384	390	PF10480	0.652
LIG_PTB_Phospho_1	83	89	PF10480	0.356
LIG_SH2_CRK	137	141	PF00017	0.544
LIG_SH2_CRK	190	194	PF00017	0.396
LIG_SH2_CRK	453	457	PF00017	0.688
LIG_SH2_GRB2like	175	178	PF00017	0.280
LIG_SH2_NCK_1	190	194	PF00017	0.384
LIG_SH2_NCK_1	390	394	PF00017	0.730
LIG_SH2_NCK_1	453	457	PF00017	0.688
LIG_SH2_SRC	109	112	PF00017	0.369
LIG_SH2_SRC	175	178	PF00017	0.280
LIG_SH2_SRC	203	206	PF00017	0.334
LIG_SH2_STAP1	196	200	PF00017	0.273
LIG_SH2_STAT5	109	112	PF00017	0.309
LIG_SH2_STAT5	175	178	PF00017	0.354
LIG_SH2_STAT5	196	199	PF00017	0.304
LIG_SH2_STAT5	203	206	PF00017	0.309
LIG_SH2_STAT5	68	71	PF00017	0.348
LIG_SH2_STAT5	98	101	PF00017	0.335
LIG_SH3_3	347	353	PF00018	0.728
LIG_SH3_3	375	381	PF00018	0.724
LIG_SH3_3	390	396	PF00018	0.680
LIG_SH3_3	486	492	PF00018	0.693
LIG_SH3_3	510	516	PF00018	0.694
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.381
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.381
LIG_SUMO_SIM_par_1	151	158	PF11976	0.334
LIG_TRAF2_1	341	344	PF00917	0.653
LIG_TYR_ITIM	135	140	PF00017	0.411
LIG_WRC_WIRS_1	156	161	PF05994	0.306
MOD_CDK_SPxxK_3	13	20	PF00069	0.492
MOD_CK1_1	428	434	PF00069	0.614
MOD_CK1_1	474	480	PF00069	0.611
MOD_CK1_1	55	61	PF00069	0.394
MOD_CK2_1	13	19	PF00069	0.422
MOD_CK2_1	145	151	PF00069	0.309
MOD_CK2_1	293	299	PF00069	0.566
MOD_CK2_1	336	342	PF00069	0.690
MOD_CK2_1	469	475	PF00069	0.636
MOD_DYRK1A_RPxSP_1	380	384	PF00069	0.605
MOD_GlcNHglycan	185	188	PF01048	0.500
MOD_GlcNHglycan	285	288	PF01048	0.545
MOD_GlcNHglycan	295	298	PF01048	0.570
MOD_GlcNHglycan	347	350	PF01048	0.575
MOD_GlcNHglycan	357	360	PF01048	0.558
MOD_GlcNHglycan	430	433	PF01048	0.613
MOD_GlcNHglycan	459	462	PF01048	0.670
MOD_GlcNHglycan	471	474	PF01048	0.636
MOD_GlcNHglycan	495	498	PF01048	0.636
MOD_GSK3_1	155	162	PF00069	0.361
MOD_GSK3_1	179	186	PF00069	0.471
MOD_GSK3_1	199	206	PF00069	0.311
MOD_GSK3_1	20	27	PF00069	0.466
MOD_GSK3_1	255	262	PF00069	0.582
MOD_GSK3_1	279	286	PF00069	0.646
MOD_GSK3_1	345	352	PF00069	0.667
MOD_GSK3_1	376	383	PF00069	0.606
MOD_GSK3_1	46	53	PF00069	0.378
MOD_GSK3_1	471	478	PF00069	0.606
MOD_GSK3_1	520	527	PF00069	0.635
MOD_N-GLC_1	219	224	PF02516	0.422
MOD_N-GLC_1	75	80	PF02516	0.374
MOD_N-GLC_2	177	179	PF02516	0.324
MOD_NEK2_1	155	160	PF00069	0.358
MOD_NEK2_1	189	194	PF00069	0.519
MOD_NEK2_1	199	204	PF00069	0.257
MOD_NEK2_1	345	350	PF00069	0.581
MOD_NEK2_1	52	57	PF00069	0.361
MOD_PIKK_1	266	272	PF00454	0.508
MOD_PKA_1	336	342	PF00069	0.690
MOD_PKA_2	336	342	PF00069	0.690
MOD_PKA_2	412	418	PF00069	0.550
MOD_PKB_1	336	344	PF00069	0.694
MOD_PKB_1	467	475	PF00069	0.661
MOD_Plk_1	524	530	PF00069	0.639
MOD_Plk_4	155	161	PF00069	0.334
MOD_Plk_4	199	205	PF00069	0.378
MOD_Plk_4	207	213	PF00069	0.488
MOD_Plk_4	24	30	PF00069	0.381
MOD_Plk_4	36	42	PF00069	0.454
MOD_Plk_4	451	457	PF00069	0.613
MOD_Plk_4	476	482	PF00069	0.562
MOD_Plk_4	52	58	PF00069	0.333
MOD_ProDKin_1	13	19	PF00069	0.525
MOD_ProDKin_1	281	287	PF00069	0.599
MOD_ProDKin_1	349	355	PF00069	0.544
MOD_ProDKin_1	380	386	PF00069	0.600
MOD_ProDKin_1	512	518	PF00069	0.617
MOD_SUMO_rev_2	339	348	PF00179	0.745
TRG_DiLeu_BaEn_4	342	348	PF01217	0.567
TRG_ENDOCYTIC_2	137	140	PF00928	0.413
TRG_ENDOCYTIC_2	190	193	PF00928	0.471
TRG_ENDOCYTIC_2	196	199	PF00928	0.394
TRG_ENDOCYTIC_2	248	251	PF00928	0.485
TRG_ENDOCYTIC_2	390	393	PF00928	0.667
TRG_ENDOCYTIC_2	453	456	PF00928	0.612
TRG_ER_diArg_1	321	324	PF00400	0.570
TRG_ER_diArg_1	335	338	PF00400	0.622
TRG_ER_diArg_1	411	414	PF00400	0.551
TRG_ER_diArg_1	466	469	PF00400	0.669
TRG_NES_CRM1_1	151	167	PF08389	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA63	Leptomonas seymouri	50%	91%
A0A3S5H7A1	Leishmania donovani	88%	97%
A4HC03	Leishmania braziliensis	65%	100%
A4HZG0	Leishmania infantum	88%	97%
E9AVE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%