GST_C_6 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 19

Species:

Leishmania major

UniProt:

Q4QC36_LEIMA

TriTrypDb:

LmjF.21.1558 , LMJLV39_210024000 , LMJSD75_210024200

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC36

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006626	protein targeting to mitochondrion	5	2
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.412
CLV_C14_Caspase3-7	318	322	PF00656	0.571
CLV_C14_Caspase3-7	383	387	PF00656	0.583
CLV_NRD_NRD_1	227	229	PF00675	0.405
CLV_NRD_NRD_1	295	297	PF00675	0.429
CLV_NRD_NRD_1	348	350	PF00675	0.399
CLV_NRD_NRD_1	365	367	PF00675	0.447
CLV_PCSK_KEX2_1	177	179	PF00082	0.585
CLV_PCSK_KEX2_1	227	229	PF00082	0.466
CLV_PCSK_KEX2_1	348	350	PF00082	0.377
CLV_PCSK_KEX2_1	365	367	PF00082	0.445
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.557
CLV_PCSK_SKI1_1	297	301	PF00082	0.459
CLV_PCSK_SKI1_1	366	370	PF00082	0.441
CLV_Separin_Metazoa	264	268	PF03568	0.650
DEG_SPOP_SBC_1	154	158	PF00917	0.514
DOC_CDC14_PxL_1	185	193	PF14671	0.309
DOC_MAPK_FxFP_2	75	78	PF00069	0.352
DOC_MAPK_MEF2A_6	135	143	PF00069	0.348
DOC_MAPK_MEF2A_6	54	63	PF00069	0.434
DOC_PP2B_LxvP_1	106	109	PF13499	0.329
DOC_PP4_FxxP_1	75	78	PF00568	0.529
DOC_USP7_MATH_1	145	149	PF00917	0.426
DOC_USP7_MATH_1	154	158	PF00917	0.458
DOC_USP7_MATH_1	187	191	PF00917	0.461
DOC_USP7_MATH_1	326	330	PF00917	0.485
DOC_USP7_MATH_1	68	72	PF00917	0.363
DOC_WW_Pin1_4	141	146	PF00397	0.418
DOC_WW_Pin1_4	33	38	PF00397	0.462
DOC_WW_Pin1_4	41	46	PF00397	0.393
DOC_WW_Pin1_4	458	463	PF00397	0.544
DOC_WW_Pin1_4	70	75	PF00397	0.408
DOC_WW_Pin1_4	87	92	PF00397	0.350
LIG_14-3-3_CanoR_1	227	231	PF00244	0.612
LIG_14-3-3_CanoR_1	267	273	PF00244	0.611
LIG_14-3-3_CanoR_1	296	304	PF00244	0.655
LIG_14-3-3_CanoR_1	405	410	PF00244	0.552
LIG_Actin_WH2_2	45	60	PF00022	0.374
LIG_AP_GAE_1	182	188	PF02883	0.405
LIG_BIR_III_2	186	190	PF00653	0.416
LIG_BIR_III_2	352	356	PF00653	0.620
LIG_BIR_III_2	386	390	PF00653	0.581
LIG_BRCT_BRCA1_1	3	7	PF00533	0.379
LIG_BRCT_BRCA1_1	416	420	PF00533	0.470
LIG_BRCT_BRCA1_1	462	466	PF00533	0.397
LIG_BRCT_BRCA1_1	65	69	PF00533	0.422
LIG_BRCT_BRCA1_1	72	76	PF00533	0.382
LIG_CtBP_PxDLS_1	46	50	PF00389	0.383
LIG_EH_1	252	256	PF12763	0.628
LIG_FHA_1	21	27	PF00498	0.398
LIG_FHA_1	299	305	PF00498	0.592
LIG_FHA_1	373	379	PF00498	0.685
LIG_FHA_2	128	134	PF00498	0.438
LIG_FHA_2	213	219	PF00498	0.507
LIG_FHA_2	316	322	PF00498	0.610
LIG_FHA_2	381	387	PF00498	0.596
LIG_IRF3_LxIS_1	139	144	PF10401	0.414
LIG_LIR_Apic_2	73	78	PF02991	0.516
LIG_LIR_Gen_1	182	193	PF02991	0.442
LIG_LIR_Gen_1	286	295	PF02991	0.599
LIG_LIR_Gen_1	417	428	PF02991	0.345
LIG_LIR_Nem_3	182	188	PF02991	0.438
LIG_LIR_Nem_3	236	241	PF02991	0.525
LIG_LIR_Nem_3	286	292	PF02991	0.598
LIG_LIR_Nem_3	408	414	PF02991	0.352
LIG_LIR_Nem_3	417	423	PF02991	0.297
LIG_LIR_Nem_3	73	79	PF02991	0.556
LIG_LIR_Nem_3	97	102	PF02991	0.376
LIG_MLH1_MIPbox_1	416	420	PF16413	0.470
LIG_MLH1_MIPbox_1	72	76	PF16413	0.350
LIG_NRBOX	427	433	PF00104	0.571
LIG_Pex14_1	411	415	PF04695	0.372
LIG_Pex14_2	213	217	PF04695	0.564
LIG_Pex14_2	75	79	PF04695	0.353
LIG_PTB_Apo_2	250	257	PF02174	0.633
LIG_SH2_NCK_1	129	133	PF00017	0.434
LIG_SH2_NCK_1	325	329	PF00017	0.485
LIG_SH2_SRC	319	322	PF00017	0.571
LIG_SH2_SRC	360	363	PF00017	0.613
LIG_SH2_STAT5	129	132	PF00017	0.433
LIG_SH2_STAT5	214	217	PF00017	0.487
LIG_SH2_STAT5	319	322	PF00017	0.571
LIG_SH2_STAT5	360	363	PF00017	0.512
LIG_SH2_STAT5	376	379	PF00017	0.578
LIG_SH2_STAT5	419	422	PF00017	0.339
LIG_SH3_3	39	45	PF00018	0.412
LIG_SUMO_SIM_par_1	426	433	PF11976	0.532
LIG_SUMO_SIM_par_1	44	51	PF11976	0.381
LIG_TRFH_1	376	380	PF08558	0.669
LIG_UBA3_1	172	177	PF00899	0.375
LIG_WRC_WIRS_1	234	239	PF05994	0.614
MOD_CK1_1	148	154	PF00069	0.484
MOD_CK1_1	157	163	PF00069	0.480
MOD_CK1_1	271	277	PF00069	0.641
MOD_CK1_1	315	321	PF00069	0.586
MOD_CK1_1	32	38	PF00069	0.407
MOD_CK1_1	460	466	PF00069	0.554
MOD_CK1_1	48	54	PF00069	0.367
MOD_CK1_1	70	76	PF00069	0.382
MOD_CK1_1	86	92	PF00069	0.478
MOD_CK2_1	233	239	PF00069	0.616
MOD_GlcNHglycan	150	153	PF01048	0.686
MOD_GlcNHglycan	159	162	PF01048	0.702
MOD_GlcNHglycan	182	185	PF01048	0.615
MOD_GlcNHglycan	257	260	PF01048	0.420
MOD_GlcNHglycan	3	6	PF01048	0.578
MOD_GlcNHglycan	372	375	PF01048	0.399
MOD_GlcNHglycan	402	405	PF01048	0.463
MOD_GlcNHglycan	416	419	PF01048	0.396
MOD_GlcNHglycan	463	466	PF01048	0.741
MOD_GlcNHglycan	70	73	PF01048	0.733
MOD_GSK3_1	137	144	PF00069	0.376
MOD_GSK3_1	153	160	PF00069	0.468
MOD_GSK3_1	29	36	PF00069	0.410
MOD_GSK3_1	291	298	PF00069	0.588
MOD_GSK3_1	311	318	PF00069	0.382
MOD_GSK3_1	37	44	PF00069	0.374
MOD_GSK3_1	405	412	PF00069	0.484
MOD_GSK3_1	454	461	PF00069	0.534
MOD_GSK3_1	63	70	PF00069	0.409
MOD_GSK3_1	77	84	PF00069	0.460
MOD_N-GLC_1	20	25	PF02516	0.624
MOD_NEK2_1	1	6	PF00069	0.385
MOD_NEK2_1	139	144	PF00069	0.424
MOD_NEK2_1	212	217	PF00069	0.563
MOD_NEK2_1	255	260	PF00069	0.574
MOD_NEK2_1	270	275	PF00069	0.626
MOD_NEK2_1	295	300	PF00069	0.591
MOD_NEK2_1	311	316	PF00069	0.573
MOD_NEK2_1	409	414	PF00069	0.348
MOD_NEK2_1	47	52	PF00069	0.383
MOD_PIKK_1	454	460	PF00454	0.540
MOD_PKA_2	127	133	PF00069	0.427
MOD_PKA_2	226	232	PF00069	0.596
MOD_PKA_2	241	247	PF00069	0.468
MOD_PKA_2	295	301	PF00069	0.647
MOD_PKA_2	315	321	PF00069	0.376
MOD_PKA_2	53	59	PF00069	0.435
MOD_PKA_2	63	69	PF00069	0.378
MOD_Plk_1	137	143	PF00069	0.423
MOD_Plk_4	117	123	PF00069	0.405
MOD_Plk_4	233	239	PF00069	0.552
MOD_Plk_4	315	321	PF00069	0.546
MOD_Plk_4	327	333	PF00069	0.443
MOD_Plk_4	405	411	PF00069	0.538
MOD_Plk_4	78	84	PF00069	0.540
MOD_Plk_4	94	100	PF00069	0.361
MOD_ProDKin_1	141	147	PF00069	0.420
MOD_ProDKin_1	33	39	PF00069	0.462
MOD_ProDKin_1	41	47	PF00069	0.395
MOD_ProDKin_1	458	464	PF00069	0.544
MOD_ProDKin_1	70	76	PF00069	0.409
MOD_ProDKin_1	87	93	PF00069	0.348
MOD_SUMO_for_1	164	167	PF00179	0.477
MOD_SUMO_rev_2	229	235	PF00179	0.582
MOD_SUMO_rev_2	329	339	PF00179	0.480
TRG_AP2beta_CARGO_1	286	296	PF09066	0.620
TRG_ENDOCYTIC_2	214	217	PF00928	0.585
TRG_ENDOCYTIC_2	419	422	PF00928	0.329
TRG_ER_diArg_1	226	228	PF00400	0.615
TRG_ER_diArg_1	348	350	PF00400	0.599
TRG_ER_diArg_1	364	366	PF00400	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X3	Leptomonas seymouri	54%	100%
A0A1X0NHP3	Trypanosomatidae	36%	100%
A0A3R7N7N1	Trypanosoma rangeli	35%	100%
A0A3S7WWQ5	Leishmania donovani	90%	100%
A4HZF6	Leishmania infantum	90%	100%
D0A124	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AVE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BLW0	Trypanosoma cruzi	31%	100%