Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC35_LEIMA

TriTrypDb:

LmjF.21.1561 , LMJLV39_210024200 , LMJSD75_210024400

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.709
CLV_NRD_NRD_1	222	224	PF00675	0.739
CLV_NRD_NRD_1	45	47	PF00675	0.629
CLV_PCSK_KEX2_1	185	187	PF00082	0.806
CLV_PCSK_KEX2_1	222	224	PF00082	0.739
CLV_PCSK_KEX2_1	277	279	PF00082	0.735
CLV_PCSK_KEX2_1	45	47	PF00082	0.629
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.735
CLV_PCSK_SKI1_1	2	6	PF00082	0.774
CLV_PCSK_SKI1_1	244	248	PF00082	0.543
DEG_Nend_UBRbox_1	1	4	PF02207	0.784
DEG_SCF_FBW7_2	4	11	PF00400	0.750
DEG_SPOP_SBC_1	16	20	PF00917	0.778
DEG_SPOP_SBC_1	24	28	PF00917	0.675
DOC_ANK_TNKS_1	178	185	PF00023	0.726
DOC_CKS1_1	198	203	PF01111	0.688
DOC_CYCLIN_RxL_1	244	255	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.534
DOC_MAPK_gen_1	244	253	PF00069	0.542
DOC_MAPK_gen_1	45	51	PF00069	0.587
DOC_MAPK_MEF2A_6	244	253	PF00069	0.542
DOC_PP4_FxxP_1	306	309	PF00568	0.820
DOC_PP4_FxxP_1	379	382	PF00568	0.612
DOC_USP7_MATH_1	174	178	PF00917	0.667
DOC_USP7_MATH_1	192	196	PF00917	0.777
DOC_USP7_MATH_1	23	27	PF00917	0.829
DOC_USP7_MATH_1	287	291	PF00917	0.700
DOC_USP7_MATH_1	297	301	PF00917	0.706
DOC_USP7_MATH_1	317	321	PF00917	0.691
DOC_USP7_MATH_1	387	391	PF00917	0.757
DOC_USP7_MATH_1	41	45	PF00917	0.547
DOC_USP7_MATH_1	62	66	PF00917	0.723
DOC_USP7_UBL2_3	2	6	PF12436	0.774
DOC_WW_Pin1_4	170	175	PF00397	0.661
DOC_WW_Pin1_4	197	202	PF00397	0.622
DOC_WW_Pin1_4	208	213	PF00397	0.698
DOC_WW_Pin1_4	215	220	PF00397	0.747
DOC_WW_Pin1_4	272	277	PF00397	0.704
DOC_WW_Pin1_4	283	288	PF00397	0.739
DOC_WW_Pin1_4	350	355	PF00397	0.776
DOC_WW_Pin1_4	4	9	PF00397	0.767
DOC_WW_Pin1_4	408	413	PF00397	0.721
DOC_WW_Pin1_4	89	94	PF00397	0.697
LIG_14-3-3_CanoR_1	185	192	PF00244	0.695
LIG_14-3-3_CanoR_1	278	287	PF00244	0.831
LIG_14-3-3_CanoR_1	321	330	PF00244	0.524
LIG_14-3-3_CanoR_1	405	413	PF00244	0.822
LIG_14-3-3_CanoR_1	416	420	PF00244	0.563
LIG_14-3-3_CanoR_1	45	50	PF00244	0.709
LIG_Actin_WH2_2	68	85	PF00022	0.720
LIG_APCC_ABBA_1	74	79	PF00400	0.728
LIG_BIR_III_2	273	277	PF00653	0.733
LIG_BRCT_BRCA1_1	302	306	PF00533	0.793
LIG_CSL_BTD_1	198	201	PF09270	0.675
LIG_FHA_1	127	133	PF00498	0.505
LIG_FHA_1	152	158	PF00498	0.540
LIG_FHA_1	408	414	PF00498	0.715
LIG_FHA_2	338	344	PF00498	0.720
LIG_HCF-1_HBM_1	123	126	PF13415	0.562
LIG_LIR_Apic_2	303	309	PF02991	0.783
LIG_LIR_Gen_1	103	114	PF02991	0.597
LIG_LIR_Gen_1	255	264	PF02991	0.551
LIG_LIR_Nem_3	103	109	PF02991	0.612
LIG_LIR_Nem_3	255	261	PF02991	0.522
LIG_NRBOX	144	150	PF00104	0.510
LIG_NRBOX	423	429	PF00104	0.637
LIG_SH2_CRK	106	110	PF00017	0.565
LIG_SH2_STAT3	131	134	PF00017	0.536
LIG_SH2_STAT3	426	429	PF00017	0.641
LIG_SH2_STAT5	106	109	PF00017	0.568
LIG_SH2_STAT5	131	134	PF00017	0.488
LIG_SH2_STAT5	426	429	PF00017	0.604
LIG_SH3_3	177	183	PF00018	0.737
LIG_SH3_3	195	201	PF00018	0.775
LIG_SH3_3	265	271	PF00018	0.643
LIG_SH3_3	302	308	PF00018	0.718
LIG_SH3_3	409	415	PF00018	0.663
LIG_SH3_3	91	97	PF00018	0.744
LIG_TRFH_1	72	76	PF08558	0.740
MOD_CDC14_SPxK_1	275	278	PF00782	0.726
MOD_CDK_SPK_2	272	277	PF00069	0.704
MOD_CDK_SPK_2	350	355	PF00069	0.623
MOD_CDK_SPK_2	4	9	PF00069	0.767
MOD_CDK_SPxK_1	272	278	PF00069	0.709
MOD_CDK_SPxxK_3	215	222	PF00069	0.849
MOD_CK1_1	28	34	PF00069	0.735
MOD_CK1_1	280	286	PF00069	0.776
MOD_CK1_1	300	306	PF00069	0.765
MOD_CK1_1	320	326	PF00069	0.625
MOD_CK1_1	368	374	PF00069	0.826
MOD_CK1_1	380	386	PF00069	0.622
MOD_CK1_1	407	413	PF00069	0.672
MOD_CK1_1	44	50	PF00069	0.678
MOD_CK1_1	63	69	PF00069	0.508
MOD_CK1_1	85	91	PF00069	0.632
MOD_CK1_1	92	98	PF00069	0.651
MOD_CK2_1	320	326	PF00069	0.587
MOD_Cter_Amidation	183	186	PF01082	0.803
MOD_GlcNHglycan	174	177	PF01048	0.697
MOD_GlcNHglycan	194	197	PF01048	0.681
MOD_GlcNHglycan	206	209	PF01048	0.821
MOD_GlcNHglycan	282	285	PF01048	0.733
MOD_GlcNHglycan	289	292	PF01048	0.729
MOD_GlcNHglycan	299	302	PF01048	0.544
MOD_GlcNHglycan	314	317	PF01048	0.607
MOD_GlcNHglycan	374	377	PF01048	0.753
MOD_GlcNHglycan	379	382	PF01048	0.711
MOD_GlcNHglycan	401	404	PF01048	0.761
MOD_GlcNHglycan	406	409	PF01048	0.708
MOD_GlcNHglycan	62	65	PF01048	0.748
MOD_GlcNHglycan	84	87	PF01048	0.803
MOD_GlcNHglycan	89	92	PF01048	0.682
MOD_GSK3_1	11	18	PF00069	0.772
MOD_GSK3_1	140	147	PF00069	0.458
MOD_GSK3_1	170	177	PF00069	0.647
MOD_GSK3_1	19	26	PF00069	0.827
MOD_GSK3_1	204	211	PF00069	0.700
MOD_GSK3_1	213	220	PF00069	0.654
MOD_GSK3_1	283	290	PF00069	0.692
MOD_GSK3_1	308	315	PF00069	0.618
MOD_GSK3_1	368	375	PF00069	0.778
MOD_GSK3_1	399	406	PF00069	0.823
MOD_GSK3_1	41	48	PF00069	0.661
MOD_GSK3_1	58	65	PF00069	0.521
MOD_GSK3_1	85	92	PF00069	0.718
MOD_GSK3_1	96	103	PF00069	0.539
MOD_N-GLC_1	126	131	PF02516	0.499
MOD_N-GLC_1	192	197	PF02516	0.781
MOD_N-GLC_1	214	219	PF02516	0.749
MOD_N-GLC_1	24	29	PF02516	0.752
MOD_N-GLC_1	251	256	PF02516	0.652
MOD_NEK2_1	204	209	PF00069	0.726
MOD_NEK2_1	251	256	PF00069	0.652
MOD_NEK2_1	372	377	PF00069	0.775
MOD_NEK2_1	427	432	PF00069	0.639
MOD_NEK2_1	82	87	PF00069	0.596
MOD_NEK2_2	126	131	PF00069	0.527
MOD_PIKK_1	300	306	PF00454	0.796
MOD_PIKK_1	387	393	PF00454	0.759
MOD_PIKK_1	92	98	PF00454	0.703
MOD_PK_1	45	51	PF00069	0.587
MOD_PKA_1	185	191	PF00069	0.805
MOD_PKA_1	277	283	PF00069	0.835
MOD_PKA_1	45	51	PF00069	0.587
MOD_PKA_2	185	191	PF00069	0.734
MOD_PKA_2	204	210	PF00069	0.839
MOD_PKA_2	277	283	PF00069	0.837
MOD_PKA_2	320	326	PF00069	0.587
MOD_PKA_2	372	378	PF00069	0.748
MOD_PKA_2	404	410	PF00069	0.823
MOD_PKA_2	415	421	PF00069	0.564
MOD_PKA_2	44	50	PF00069	0.755
MOD_Plk_1	100	106	PF00069	0.566
MOD_Plk_1	126	132	PF00069	0.479
MOD_Plk_1	387	393	PF00069	0.759
MOD_Plk_1	53	59	PF00069	0.669
MOD_Plk_2-3	420	426	PF00069	0.643
MOD_Plk_4	104	110	PF00069	0.518
MOD_Plk_4	11	17	PF00069	0.717
MOD_Plk_4	140	146	PF00069	0.505
MOD_Plk_4	152	158	PF00069	0.540
MOD_Plk_4	308	314	PF00069	0.721
MOD_ProDKin_1	170	176	PF00069	0.666
MOD_ProDKin_1	197	203	PF00069	0.629
MOD_ProDKin_1	208	214	PF00069	0.699
MOD_ProDKin_1	215	221	PF00069	0.747
MOD_ProDKin_1	272	278	PF00069	0.709
MOD_ProDKin_1	283	289	PF00069	0.741
MOD_ProDKin_1	350	356	PF00069	0.770
MOD_ProDKin_1	4	10	PF00069	0.768
MOD_ProDKin_1	408	414	PF00069	0.718
MOD_ProDKin_1	89	95	PF00069	0.694
TRG_DiLeu_BaEn_1	11	16	PF01217	0.723
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.697
TRG_ENDOCYTIC_2	106	109	PF00928	0.568
TRG_ENDOCYTIC_2	258	261	PF00928	0.509
TRG_ER_diArg_1	160	163	PF00400	0.544
TRG_ER_diArg_1	185	187	PF00400	0.690
TRG_ER_diArg_1	222	225	PF00400	0.741
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K6	Leptomonas seymouri	57%	100%
A0A3S7WWV7	Leishmania donovani	95%	100%
A4HC07	Leishmania braziliensis	83%	100%
A4HZG3	Leishmania infantum	95%	100%
E9AVE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%