Putative serine/threonine-protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NIMA-related kinase, putative

Species:

Leishmania major

UniProt:

Q4QC33_LEIMA

TriTrypDb:

LmjF.21.1565 , LMJLV39_210024400 , LMJSD75_210024600

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC33

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.516
CLV_C14_Caspase3-7	514	518	PF00656	0.740
CLV_C14_Caspase3-7	696	700	PF00656	0.627
CLV_NRD_NRD_1	122	124	PF00675	0.377
CLV_NRD_NRD_1	276	278	PF00675	0.623
CLV_NRD_NRD_1	294	296	PF00675	0.567
CLV_NRD_NRD_1	301	303	PF00675	0.476
CLV_NRD_NRD_1	332	334	PF00675	0.575
CLV_NRD_NRD_1	340	342	PF00675	0.479
CLV_NRD_NRD_1	352	354	PF00675	0.307
CLV_NRD_NRD_1	364	366	PF00675	0.478
CLV_NRD_NRD_1	400	402	PF00675	0.569
CLV_NRD_NRD_1	439	441	PF00675	0.550
CLV_NRD_NRD_1	492	494	PF00675	0.751
CLV_NRD_NRD_1	512	514	PF00675	0.606
CLV_NRD_NRD_1	518	520	PF00675	0.631
CLV_NRD_NRD_1	588	590	PF00675	0.754
CLV_NRD_NRD_1	661	663	PF00675	0.650
CLV_NRD_NRD_1	680	682	PF00675	0.458
CLV_PCSK_KEX2_1	122	124	PF00082	0.377
CLV_PCSK_KEX2_1	245	247	PF00082	0.366
CLV_PCSK_KEX2_1	276	278	PF00082	0.636
CLV_PCSK_KEX2_1	300	302	PF00082	0.489
CLV_PCSK_KEX2_1	331	333	PF00082	0.614
CLV_PCSK_KEX2_1	340	342	PF00082	0.520
CLV_PCSK_KEX2_1	354	356	PF00082	0.405
CLV_PCSK_KEX2_1	400	402	PF00082	0.597
CLV_PCSK_KEX2_1	439	441	PF00082	0.568
CLV_PCSK_KEX2_1	512	514	PF00082	0.606
CLV_PCSK_KEX2_1	660	662	PF00082	0.587
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.397
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.534
CLV_PCSK_SKI1_1	103	107	PF00082	0.315
CLV_PCSK_SKI1_1	122	126	PF00082	0.179
CLV_PCSK_SKI1_1	127	131	PF00082	0.296
CLV_PCSK_SKI1_1	214	218	PF00082	0.304
CLV_PCSK_SKI1_1	259	263	PF00082	0.476
CLV_PCSK_SKI1_1	354	358	PF00082	0.545
CLV_PCSK_SKI1_1	493	497	PF00082	0.727
CLV_PCSK_SKI1_1	520	524	PF00082	0.663
CLV_PCSK_SKI1_1	553	557	PF00082	0.556
CLV_PCSK_SKI1_1	683	687	PF00082	0.734
CLV_PCSK_SKI1_1	702	706	PF00082	0.500
CLV_PCSK_SKI1_1	729	733	PF00082	0.400
DEG_APCC_DBOX_1	258	266	PF00400	0.390
DEG_Nend_UBRbox_2	1	3	PF02207	0.452
DEG_SCF_FBW7_1	480	487	PF00400	0.769
DEG_SCF_FBW7_2	633	638	PF00400	0.738
DEG_SPOP_SBC_1	484	488	PF00917	0.739
DEG_SPOP_SBC_1	571	575	PF00917	0.552
DOC_CKS1_1	481	486	PF01111	0.771
DOC_MAPK_gen_1	127	136	PF00069	0.293
DOC_MAPK_gen_1	273	282	PF00069	0.646
DOC_MAPK_gen_1	340	350	PF00069	0.567
DOC_MAPK_MEF2A_6	724	732	PF00069	0.425
DOC_MAPK_MEF2A_6	73	80	PF00069	0.325
DOC_PP2B_LxvP_1	569	572	PF13499	0.750
DOC_PP4_FxxP_1	710	713	PF00568	0.607
DOC_USP7_MATH_1	247	251	PF00917	0.323
DOC_USP7_MATH_1	485	489	PF00917	0.748
DOC_USP7_MATH_1	547	551	PF00917	0.749
DOC_USP7_MATH_1	564	568	PF00917	0.562
DOC_USP7_MATH_1	697	701	PF00917	0.650
DOC_USP7_MATH_1	713	717	PF00917	0.492
DOC_USP7_MATH_1	792	796	PF00917	0.584
DOC_USP7_MATH_2	42	48	PF00917	0.307
DOC_USP7_UBL2_3	373	377	PF12436	0.643
DOC_USP7_UBL2_3	581	585	PF12436	0.737
DOC_USP7_UBL2_3	678	682	PF12436	0.702
DOC_USP7_UBL2_3	8	12	PF12436	0.366
DOC_WW_Pin1_4	163	168	PF00397	0.293
DOC_WW_Pin1_4	480	485	PF00397	0.661
DOC_WW_Pin1_4	493	498	PF00397	0.644
DOC_WW_Pin1_4	543	548	PF00397	0.726
DOC_WW_Pin1_4	591	596	PF00397	0.723
DOC_WW_Pin1_4	603	608	PF00397	0.617
DOC_WW_Pin1_4	631	636	PF00397	0.708
DOC_WW_Pin1_4	650	655	PF00397	0.745
LIG_14-3-3_CanoR_1	154	158	PF00244	0.293
LIG_14-3-3_CanoR_1	233	239	PF00244	0.365
LIG_14-3-3_CanoR_1	246	255	PF00244	0.247
LIG_14-3-3_CanoR_1	276	280	PF00244	0.625
LIG_14-3-3_CanoR_1	681	686	PF00244	0.706
LIG_14-3-3_CanoR_1	789	799	PF00244	0.621
LIG_Actin_WH2_2	145	162	PF00022	0.307
LIG_Actin_WH2_2	204	219	PF00022	0.323
LIG_Actin_WH2_2	28	43	PF00022	0.397
LIG_AP2alpha_1	685	689	PF02296	0.698
LIG_APCC_ABBA_1	728	733	PF00400	0.412
LIG_APCC_ABBAyCdc20_2	122	128	PF00400	0.284
LIG_BRCT_BRCA1_1	504	508	PF00533	0.713
LIG_FHA_1	129	135	PF00498	0.323
LIG_FHA_1	154	160	PF00498	0.310
LIG_FHA_1	619	625	PF00498	0.715
LIG_FHA_1	62	68	PF00498	0.307
LIG_FHA_1	707	713	PF00498	0.496
LIG_FHA_1	716	722	PF00498	0.471
LIG_FHA_2	494	500	PF00498	0.674
LIG_FHA_2	535	541	PF00498	0.762
LIG_FHA_2	653	659	PF00498	0.696
LIG_LIR_Apic_2	166	172	PF02991	0.293
LIG_LIR_Apic_2	709	713	PF02991	0.588
LIG_LIR_Gen_1	2	10	PF02991	0.332
LIG_LIR_Gen_1	663	673	PF02991	0.570
LIG_LIR_Gen_1	75	83	PF02991	0.342
LIG_LIR_Nem_3	2	7	PF02991	0.307
LIG_LIR_Nem_3	663	669	PF02991	0.576
LIG_LIR_Nem_3	87	92	PF02991	0.307
LIG_LYPXL_S_1	219	223	PF13949	0.323
LIG_LYPXL_yS_3	220	223	PF13949	0.307
LIG_MAD2	214	222	PF02301	0.293
LIG_PCNA_yPIPBox_3	209	220	PF02747	0.326
LIG_PDZ_Class_2	796	801	PF00595	0.674
LIG_Pex14_2	15	19	PF04695	0.293
LIG_Pex14_2	685	689	PF04695	0.698
LIG_PTB_Apo_2	251	258	PF02174	0.221
LIG_SH2_CRK	4	8	PF00017	0.366
LIG_SH2_CRK	89	93	PF00017	0.307
LIG_SH2_GRB2like	82	85	PF00017	0.342
LIG_SH2_SRC	66	69	PF00017	0.307
LIG_SH2_SRC	82	85	PF00017	0.307
LIG_SH2_STAP1	227	231	PF00017	0.323
LIG_SH2_STAT5	169	172	PF00017	0.311
LIG_SH2_STAT5	4	7	PF00017	0.312
LIG_SH2_STAT5	490	493	PF00017	0.673
LIG_SH2_STAT5	66	69	PF00017	0.293
LIG_SH3_3	216	222	PF00018	0.342
LIG_SH3_3	472	478	PF00018	0.654
LIG_SH3_3	557	563	PF00018	0.702
LIG_SH3_3	608	614	PF00018	0.755
LIG_SH3_4	581	588	PF00018	0.678
LIG_SUMO_SIM_par_1	278	284	PF11976	0.618
LIG_TRAF2_1	281	284	PF00917	0.551
LIG_TRAF2_1	394	397	PF00917	0.471
LIG_TRAF2_1	496	499	PF00917	0.663
LIG_UBA3_1	238	245	PF00899	0.374
LIG_WW_3	479	483	PF00397	0.770
MOD_CK1_1	14	20	PF00069	0.301
MOD_CK1_1	229	235	PF00069	0.337
MOD_CK1_1	278	284	PF00069	0.624
MOD_CK1_1	306	312	PF00069	0.424
MOD_CK1_1	794	800	PF00069	0.639
MOD_CK2_1	278	284	PF00069	0.628
MOD_CK2_1	427	433	PF00069	0.614
MOD_CK2_1	493	499	PF00069	0.681
MOD_CK2_1	534	540	PF00069	0.765
MOD_CK2_1	590	596	PF00069	0.653
MOD_CK2_1	650	656	PF00069	0.681
MOD_CK2_1	751	757	PF00069	0.650
MOD_GlcNHglycan	16	19	PF01048	0.307
MOD_GlcNHglycan	305	308	PF01048	0.645
MOD_GlcNHglycan	428	432	PF01048	0.601
MOD_GlcNHglycan	46	49	PF01048	0.307
MOD_GlcNHglycan	468	473	PF01048	0.720
MOD_GlcNHglycan	553	556	PF01048	0.690
MOD_GlcNHglycan	614	617	PF01048	0.645
MOD_GlcNHglycan	715	718	PF01048	0.623
MOD_GlcNHglycan	751	754	PF01048	0.637
MOD_GlcNHglycan	763	766	PF01048	0.605
MOD_GlcNHglycan	794	797	PF01048	0.691
MOD_GSK3_1	159	166	PF00069	0.293
MOD_GSK3_1	225	232	PF00069	0.328
MOD_GSK3_1	480	487	PF00069	0.749
MOD_GSK3_1	489	496	PF00069	0.753
MOD_GSK3_1	530	537	PF00069	0.693
MOD_GSK3_1	543	550	PF00069	0.760
MOD_GSK3_1	577	584	PF00069	0.759
MOD_GSK3_1	590	597	PF00069	0.740
MOD_GSK3_1	790	797	PF00069	0.581
MOD_N-GLC_1	181	186	PF02516	0.293
MOD_N-GLC_1	229	234	PF02516	0.342
MOD_N-GLC_1	247	252	PF02516	0.342
MOD_N-GLC_1	253	258	PF02516	0.342
MOD_N-GLC_1	61	66	PF02516	0.307
MOD_N-GLC_1	713	718	PF02516	0.594
MOD_N-GLC_1	749	754	PF02516	0.595
MOD_NEK2_1	114	119	PF00069	0.461
MOD_NEK2_1	147	152	PF00069	0.293
MOD_NEK2_1	159	164	PF00069	0.293
MOD_NEK2_1	203	208	PF00069	0.405
MOD_NEK2_1	226	231	PF00069	0.374
MOD_NEK2_1	234	239	PF00069	0.331
MOD_NEK2_1	253	258	PF00069	0.440
MOD_NEK2_1	54	59	PF00069	0.436
MOD_NEK2_2	450	455	PF00069	0.626
MOD_PIKK_1	107	113	PF00454	0.323
MOD_PIKK_1	128	134	PF00454	0.293
MOD_PIKK_1	2	8	PF00454	0.388
MOD_PIKK_1	247	253	PF00454	0.342
MOD_PIKK_1	459	465	PF00454	0.704
MOD_PIKK_1	502	508	PF00454	0.702
MOD_PKA_1	681	687	PF00069	0.619
MOD_PKA_2	153	159	PF00069	0.293
MOD_PKA_2	275	281	PF00069	0.644
MOD_PKA_2	44	50	PF00069	0.314
MOD_PKA_2	450	456	PF00069	0.704
MOD_Plk_1	194	200	PF00069	0.307
MOD_Plk_1	229	235	PF00069	0.390
MOD_Plk_1	247	253	PF00069	0.210
MOD_Plk_1	61	67	PF00069	0.315
MOD_Plk_1	698	704	PF00069	0.584
MOD_Plk_4	114	120	PF00069	0.461
MOD_Plk_4	148	154	PF00069	0.307
MOD_Plk_4	234	240	PF00069	0.351
MOD_Plk_4	253	259	PF00069	0.363
MOD_Plk_4	450	456	PF00069	0.692
MOD_Plk_4	668	674	PF00069	0.615
MOD_Plk_4	72	78	PF00069	0.342
MOD_ProDKin_1	163	169	PF00069	0.293
MOD_ProDKin_1	480	486	PF00069	0.661
MOD_ProDKin_1	493	499	PF00069	0.638
MOD_ProDKin_1	543	549	PF00069	0.723
MOD_ProDKin_1	591	597	PF00069	0.723
MOD_ProDKin_1	603	609	PF00069	0.614
MOD_ProDKin_1	631	637	PF00069	0.705
MOD_ProDKin_1	650	656	PF00069	0.742
MOD_SUMO_rev_2	347	356	PF00179	0.592
MOD_SUMO_rev_2	372	378	PF00179	0.516
MOD_SUMO_rev_2	573	583	PF00179	0.682
MOD_SUMO_rev_2	675	684	PF00179	0.599
MOD_SUMO_rev_2	68	75	PF00179	0.411
MOD_SUMO_rev_2	700	710	PF00179	0.668
TRG_DiLeu_BaEn_4	283	289	PF01217	0.595
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.436
TRG_ENDOCYTIC_2	220	223	PF00928	0.293
TRG_ENDOCYTIC_2	4	7	PF00928	0.307
TRG_ENDOCYTIC_2	435	438	PF00928	0.561
TRG_ENDOCYTIC_2	666	669	PF00928	0.557
TRG_ENDOCYTIC_2	745	748	PF00928	0.454
TRG_ENDOCYTIC_2	89	92	PF00928	0.338
TRG_ER_diArg_1	122	124	PF00400	0.377
TRG_ER_diArg_1	299	302	PF00400	0.528
TRG_ER_diArg_1	331	333	PF00400	0.585
TRG_ER_diArg_1	340	342	PF00400	0.570
TRG_ER_diArg_1	438	440	PF00400	0.556
TRG_ER_diArg_1	511	513	PF00400	0.600
TRG_ER_diArg_1	660	662	PF00400	0.704
TRG_NES_CRM1_1	260	275	PF08389	0.508
TRG_NES_CRM1_1	719	733	PF08389	0.423
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W7	Leptomonas seymouri	65%	100%
A0A0S4IQV2	Bodo saltans	35%	91%
A0A0S4JKY4	Bodo saltans	44%	100%
A0A1X0NHD4	Trypanosomatidae	49%	100%
A0A3Q8IBZ9	Leishmania donovani	96%	100%
A0A3R7M6Z7	Trypanosoma rangeli	47%	100%
A4HC09	Leishmania braziliensis	84%	99%
A4HZM2	Leishmania infantum	95%	100%
D0A118	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AVE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BLW4	Trypanosoma cruzi	49%	100%