TRAF3-interacting protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microtubule-binding protein MIP-T3, putative

Species:

Leishmania major

UniProt:

Q4QC32_LEIMA

TriTrypDb:

LmjF.21.1566 , LMJLV39_210024500 , LMJSD75_210024700

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005930	axoneme	2	2
GO:0030992	intraciliary transport particle B	2	2
GO:0032991	protein-containing complex	1	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC32

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006996	organelle organization	4	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0010970	transport along microtubule	4	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0031503	protein-containing complex localization	2	2
GO:0032886	regulation of microtubule-based process	4	2
GO:0033043	regulation of organelle organization	5	2
GO:0042073	intraciliary transport	3	2
GO:0044782	cilium organization	5	2
GO:0046907	intracellular transport	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051493	regulation of cytoskeleton organization	6	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0060271	cilium assembly	6	2
GO:0065007	biological regulation	1	2
GO:0070507	regulation of microtubule cytoskeleton organization	5	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0099111	microtubule-based transport	4	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0008017	microtubule binding	5	6
GO:0008092	cytoskeletal protein binding	3	6
GO:0015631	tubulin binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	400	404	PF00656	0.636
CLV_C14_Caspase3-7	55	59	PF00656	0.636
CLV_NRD_NRD_1	125	127	PF00675	0.647
CLV_NRD_NRD_1	167	169	PF00675	0.672
CLV_NRD_NRD_1	174	176	PF00675	0.571
CLV_NRD_NRD_1	222	224	PF00675	0.783
CLV_NRD_NRD_1	238	240	PF00675	0.703
CLV_NRD_NRD_1	332	334	PF00675	0.408
CLV_NRD_NRD_1	427	429	PF00675	0.435
CLV_PCSK_FUR_1	164	168	PF00082	0.748
CLV_PCSK_FUR_1	172	176	PF00082	0.657
CLV_PCSK_KEX2_1	166	168	PF00082	0.772
CLV_PCSK_KEX2_1	172	174	PF00082	0.658
CLV_PCSK_KEX2_1	180	182	PF00082	0.521
CLV_PCSK_KEX2_1	224	226	PF00082	0.842
CLV_PCSK_KEX2_1	272	274	PF00082	0.724
CLV_PCSK_KEX2_1	324	326	PF00082	0.435
CLV_PCSK_KEX2_1	332	334	PF00082	0.341
CLV_PCSK_KEX2_1	427	429	PF00082	0.435
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.772
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.521
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.858
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.724
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.435
CLV_PCSK_PC7_1	168	174	PF00082	0.762
CLV_PCSK_PC7_1	220	226	PF00082	0.867
CLV_PCSK_SKI1_1	313	317	PF00082	0.437
CLV_PCSK_SKI1_1	65	69	PF00082	0.435
CLV_PCSK_SKI1_1	90	94	PF00082	0.297
DEG_APCC_DBOX_1	377	385	PF00400	0.636
DEG_Nend_UBRbox_2	1	3	PF02207	0.688
DOC_MAPK_gen_1	65	71	PF00069	0.636
DOC_MAPK_RevD_3	310	325	PF00069	0.636
DOC_PP1_RVXF_1	66	72	PF00149	0.636
DOC_USP7_MATH_1	115	119	PF00917	0.621
DOC_USP7_MATH_1	142	146	PF00917	0.865
DOC_USP7_MATH_1	234	238	PF00917	0.861
DOC_USP7_UBL2_3	199	203	PF12436	0.617
DOC_USP7_UBL2_3	20	24	PF12436	0.552
DOC_USP7_UBL2_3	61	65	PF12436	0.636
DOC_WW_Pin1_4	342	347	PF00397	0.497
DOC_WW_Pin1_4	82	87	PF00397	0.608
LIG_14-3-3_CanoR_1	427	434	PF00244	0.636
LIG_Actin_WH2_2	445	461	PF00022	0.636
LIG_BIR_III_2	260	264	PF00653	0.845
LIG_FHA_1	101	107	PF00498	0.608
LIG_FHA_1	20	26	PF00498	0.636
LIG_FHA_1	226	232	PF00498	0.785
LIG_FHA_1	246	252	PF00498	0.855
LIG_FHA_1	301	307	PF00498	0.715
LIG_FHA_1	404	410	PF00498	0.636
LIG_FHA_1	453	459	PF00498	0.636
LIG_FHA_2	158	164	PF00498	0.738
LIG_FHA_2	188	194	PF00498	0.647
LIG_FHA_2	196	202	PF00498	0.723
LIG_FHA_2	276	282	PF00498	0.771
LIG_FHA_2	6	12	PF00498	0.636
LIG_LIR_Gen_1	105	115	PF02991	0.636
LIG_LIR_Gen_1	286	295	PF02991	0.790
LIG_LIR_Nem_3	105	110	PF02991	0.636
LIG_LIR_Nem_3	286	291	PF02991	0.785
LIG_PCNA_yPIPBox_3	7	16	PF02747	0.636
LIG_SH2_STAT5	33	36	PF00017	0.636
LIG_SH3_1	239	245	PF00018	0.852
LIG_SH3_3	239	245	PF00018	0.852
LIG_TRAF2_1	160	163	PF00917	0.697
LIG_TRAF2_1	198	201	PF00917	0.716
LIG_TRAF2_1	433	436	PF00917	0.636
LIG_TRAF2_1	96	99	PF00917	0.636
LIG_WRC_WIRS_1	38	43	PF05994	0.580
LIG_WW_3	241	245	PF00397	0.850
MOD_CK1_1	150	156	PF00069	0.764
MOD_CK1_1	211	217	PF00069	0.751
MOD_CK1_1	356	362	PF00069	0.622
MOD_CK2_1	143	149	PF00069	0.872
MOD_CK2_1	155	161	PF00069	0.644
MOD_CK2_1	195	201	PF00069	0.717
MOD_CK2_1	275	281	PF00069	0.777
MOD_CK2_1	430	436	PF00069	0.636
MOD_CK2_1	5	11	PF00069	0.636
MOD_Cter_Amidation	270	273	PF01082	0.700
MOD_GlcNHglycan	117	120	PF01048	0.685
MOD_GlcNHglycan	128	131	PF01048	0.605
MOD_GlcNHglycan	149	152	PF01048	0.782
MOD_GlcNHglycan	210	213	PF01048	0.752
MOD_GlcNHglycan	236	239	PF01048	0.861
MOD_GlcNHglycan	58	61	PF01048	0.380
MOD_GSK3_1	143	150	PF00069	0.772
MOD_GSK3_1	195	202	PF00069	0.732
MOD_GSK3_1	230	237	PF00069	0.806
MOD_GSK3_1	352	359	PF00069	0.636
MOD_NEK2_1	42	47	PF00069	0.581
MOD_NEK2_1	458	463	PF00069	0.619
MOD_NEK2_1	472	477	PF00069	0.453
MOD_PIKK_1	5	11	PF00454	0.636
MOD_PKA_1	126	132	PF00069	0.656
MOD_PKA_1	147	153	PF00069	0.766
MOD_PKA_1	224	230	PF00069	0.824
MOD_PKA_1	427	433	PF00069	0.636
MOD_PKA_2	224	230	PF00069	0.824
MOD_PKA_2	427	433	PF00069	0.636
MOD_PKA_2	458	464	PF00069	0.636
MOD_PKA_2	56	62	PF00069	0.486
MOD_PKB_1	223	231	PF00069	0.747
MOD_Plk_1	430	436	PF00069	0.636
MOD_Plk_2-3	277	283	PF00069	0.845
MOD_Plk_4	37	43	PF00069	0.626
MOD_Plk_4	458	464	PF00069	0.636
MOD_Plk_4	472	478	PF00069	0.470
MOD_ProDKin_1	342	348	PF00069	0.497
MOD_ProDKin_1	82	88	PF00069	0.608
MOD_SUMO_for_1	323	326	PF00179	0.469
MOD_SUMO_rev_2	146	156	PF00179	0.762
MOD_SUMO_rev_2	196	205	PF00179	0.639
MOD_SUMO_rev_2	293	300	PF00179	0.815
MOD_SUMO_rev_2	308	315	PF00179	0.458
MOD_SUMO_rev_2	58	67	PF00179	0.636
TRG_DiLeu_BaEn_1	379	384	PF01217	0.608
TRG_ER_diArg_1	172	175	PF00400	0.759
TRG_NES_CRM1_1	400	415	PF08389	0.636
TRG_NLS_MonoExtC_3	271	277	PF00514	0.701
TRG_NLS_MonoExtN_4	269	276	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWV8	Leishmania donovani	95%	100%
A4HC10	Leishmania braziliensis	80%	99%
A4HZM1	Leishmania infantum	94%	100%
E9AVE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%