LeishMANIAdb
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TRAF3-interacting protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TRAF3-interacting protein 1
Gene product:
Microtubule-binding protein MIP-T3, putative
Species:
Leishmania major
UniProt:
Q4QC32_LEIMA
TriTrypDb:
LmjF.21.1566 , LMJLV39_210024500 * , LMJSD75_210024700
Length:
484

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005813 centrosome 3 2
GO:0005815 microtubule organizing center 2 2
GO:0005930 axoneme 2 2
GO:0030992 intraciliary transport particle B 2 2
GO:0032991 protein-containing complex 1 2
GO:0036064 ciliary basal body 3 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QC32
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC32

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006996 organelle organization 4 2
GO:0007017 microtubule-based process 2 2
GO:0007018 microtubule-based movement 3 2
GO:0009987 cellular process 1 2
GO:0010970 transport along microtubule 4 2
GO:0016043 cellular component organization 3 2
GO:0022607 cellular component assembly 4 2
GO:0030030 cell projection organization 4 2
GO:0030031 cell projection assembly 5 2
GO:0030705 cytoskeleton-dependent intracellular transport 4 2
GO:0031503 protein-containing complex localization 2 2
GO:0032886 regulation of microtubule-based process 4 2
GO:0033043 regulation of organelle organization 5 2
GO:0042073 intraciliary transport 3 2
GO:0044782 cilium organization 5 2
GO:0046907 intracellular transport 3 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051128 regulation of cellular component organization 4 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0051493 regulation of cytoskeleton organization 6 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
GO:0060271 cilium assembly 6 2
GO:0065007 biological regulation 1 2
GO:0070507 regulation of microtubule cytoskeleton organization 5 2
GO:0070925 organelle assembly 5 2
GO:0071840 cellular component organization or biogenesis 2 2
GO:0099111 microtubule-based transport 4 2
GO:0120031 plasma membrane bounded cell projection assembly 6 2
GO:0120036 plasma membrane bounded cell projection organization 5 2
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0005515 protein binding 2 6
GO:0008017 microtubule binding 5 6
GO:0008092 cytoskeletal protein binding 3 6
GO:0015631 tubulin binding 4 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 400 404 PF00656 0.636
CLV_C14_Caspase3-7 55 59 PF00656 0.636
CLV_NRD_NRD_1 125 127 PF00675 0.647
CLV_NRD_NRD_1 167 169 PF00675 0.672
CLV_NRD_NRD_1 174 176 PF00675 0.571
CLV_NRD_NRD_1 222 224 PF00675 0.783
CLV_NRD_NRD_1 238 240 PF00675 0.703
CLV_NRD_NRD_1 332 334 PF00675 0.408
CLV_NRD_NRD_1 427 429 PF00675 0.435
CLV_PCSK_FUR_1 164 168 PF00082 0.748
CLV_PCSK_FUR_1 172 176 PF00082 0.657
CLV_PCSK_KEX2_1 166 168 PF00082 0.772
CLV_PCSK_KEX2_1 172 174 PF00082 0.658
CLV_PCSK_KEX2_1 180 182 PF00082 0.521
CLV_PCSK_KEX2_1 224 226 PF00082 0.842
CLV_PCSK_KEX2_1 272 274 PF00082 0.724
CLV_PCSK_KEX2_1 324 326 PF00082 0.435
CLV_PCSK_KEX2_1 332 334 PF00082 0.341
CLV_PCSK_KEX2_1 427 429 PF00082 0.435
CLV_PCSK_PC1ET2_1 166 168 PF00082 0.772
CLV_PCSK_PC1ET2_1 180 182 PF00082 0.521
CLV_PCSK_PC1ET2_1 224 226 PF00082 0.858
CLV_PCSK_PC1ET2_1 272 274 PF00082 0.724
CLV_PCSK_PC1ET2_1 324 326 PF00082 0.435
CLV_PCSK_PC7_1 168 174 PF00082 0.762
CLV_PCSK_PC7_1 220 226 PF00082 0.867
CLV_PCSK_SKI1_1 313 317 PF00082 0.437
CLV_PCSK_SKI1_1 65 69 PF00082 0.435
CLV_PCSK_SKI1_1 90 94 PF00082 0.297
DEG_APCC_DBOX_1 377 385 PF00400 0.636
DEG_Nend_UBRbox_2 1 3 PF02207 0.688
DOC_MAPK_gen_1 65 71 PF00069 0.636
DOC_MAPK_RevD_3 310 325 PF00069 0.636
DOC_PP1_RVXF_1 66 72 PF00149 0.636
DOC_USP7_MATH_1 115 119 PF00917 0.621
DOC_USP7_MATH_1 142 146 PF00917 0.865
DOC_USP7_MATH_1 234 238 PF00917 0.861
DOC_USP7_UBL2_3 199 203 PF12436 0.617
DOC_USP7_UBL2_3 20 24 PF12436 0.552
DOC_USP7_UBL2_3 61 65 PF12436 0.636
DOC_WW_Pin1_4 342 347 PF00397 0.497
DOC_WW_Pin1_4 82 87 PF00397 0.608
LIG_14-3-3_CanoR_1 427 434 PF00244 0.636
LIG_Actin_WH2_2 445 461 PF00022 0.636
LIG_BIR_III_2 260 264 PF00653 0.845
LIG_FHA_1 101 107 PF00498 0.608
LIG_FHA_1 20 26 PF00498 0.636
LIG_FHA_1 226 232 PF00498 0.785
LIG_FHA_1 246 252 PF00498 0.855
LIG_FHA_1 301 307 PF00498 0.715
LIG_FHA_1 404 410 PF00498 0.636
LIG_FHA_1 453 459 PF00498 0.636
LIG_FHA_2 158 164 PF00498 0.738
LIG_FHA_2 188 194 PF00498 0.647
LIG_FHA_2 196 202 PF00498 0.723
LIG_FHA_2 276 282 PF00498 0.771
LIG_FHA_2 6 12 PF00498 0.636
LIG_LIR_Gen_1 105 115 PF02991 0.636
LIG_LIR_Gen_1 286 295 PF02991 0.790
LIG_LIR_Nem_3 105 110 PF02991 0.636
LIG_LIR_Nem_3 286 291 PF02991 0.785
LIG_PCNA_yPIPBox_3 7 16 PF02747 0.636
LIG_SH2_STAT5 33 36 PF00017 0.636
LIG_SH3_1 239 245 PF00018 0.852
LIG_SH3_3 239 245 PF00018 0.852
LIG_TRAF2_1 160 163 PF00917 0.697
LIG_TRAF2_1 198 201 PF00917 0.716
LIG_TRAF2_1 433 436 PF00917 0.636
LIG_TRAF2_1 96 99 PF00917 0.636
LIG_WRC_WIRS_1 38 43 PF05994 0.580
LIG_WW_3 241 245 PF00397 0.850
MOD_CK1_1 150 156 PF00069 0.764
MOD_CK1_1 211 217 PF00069 0.751
MOD_CK1_1 356 362 PF00069 0.622
MOD_CK2_1 143 149 PF00069 0.872
MOD_CK2_1 155 161 PF00069 0.644
MOD_CK2_1 195 201 PF00069 0.717
MOD_CK2_1 275 281 PF00069 0.777
MOD_CK2_1 430 436 PF00069 0.636
MOD_CK2_1 5 11 PF00069 0.636
MOD_Cter_Amidation 270 273 PF01082 0.700
MOD_GlcNHglycan 117 120 PF01048 0.685
MOD_GlcNHglycan 128 131 PF01048 0.605
MOD_GlcNHglycan 149 152 PF01048 0.782
MOD_GlcNHglycan 210 213 PF01048 0.752
MOD_GlcNHglycan 236 239 PF01048 0.861
MOD_GlcNHglycan 58 61 PF01048 0.380
MOD_GSK3_1 143 150 PF00069 0.772
MOD_GSK3_1 195 202 PF00069 0.732
MOD_GSK3_1 230 237 PF00069 0.806
MOD_GSK3_1 352 359 PF00069 0.636
MOD_NEK2_1 42 47 PF00069 0.581
MOD_NEK2_1 458 463 PF00069 0.619
MOD_NEK2_1 472 477 PF00069 0.453
MOD_PIKK_1 5 11 PF00454 0.636
MOD_PKA_1 126 132 PF00069 0.656
MOD_PKA_1 147 153 PF00069 0.766
MOD_PKA_1 224 230 PF00069 0.824
MOD_PKA_1 427 433 PF00069 0.636
MOD_PKA_2 224 230 PF00069 0.824
MOD_PKA_2 427 433 PF00069 0.636
MOD_PKA_2 458 464 PF00069 0.636
MOD_PKA_2 56 62 PF00069 0.486
MOD_PKB_1 223 231 PF00069 0.747
MOD_Plk_1 430 436 PF00069 0.636
MOD_Plk_2-3 277 283 PF00069 0.845
MOD_Plk_4 37 43 PF00069 0.626
MOD_Plk_4 458 464 PF00069 0.636
MOD_Plk_4 472 478 PF00069 0.470
MOD_ProDKin_1 342 348 PF00069 0.497
MOD_ProDKin_1 82 88 PF00069 0.608
MOD_SUMO_for_1 323 326 PF00179 0.469
MOD_SUMO_rev_2 146 156 PF00179 0.762
MOD_SUMO_rev_2 196 205 PF00179 0.639
MOD_SUMO_rev_2 293 300 PF00179 0.815
MOD_SUMO_rev_2 308 315 PF00179 0.458
MOD_SUMO_rev_2 58 67 PF00179 0.636
TRG_DiLeu_BaEn_1 379 384 PF01217 0.608
TRG_ER_diArg_1 172 175 PF00400 0.759
TRG_NES_CRM1_1 400 415 PF08389 0.636
TRG_NLS_MonoExtC_3 271 277 PF00514 0.701
TRG_NLS_MonoExtN_4 269 276 PF00514 0.714
TRG_Pf-PMV_PEXEL_1 32 36 PF00026 0.435

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WWV8 Leishmania donovani 95% 100%
A4HC10 Leishmania braziliensis 80% 99%
A4HZM1 Leishmania infantum 94% 100%
E9AVE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS