PEROXIDASE_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxidase, putative

Species:

Leishmania major

UniProt:

Q4QC30_LEIMA

TriTrypDb:

LmjF.21.1567 , LMJLV39_210024700 , LMJSD75_210024900

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QC30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC30

PDB structure(s): 5via_A

Function

Biological processes
Term	Name	Level	Count
GO:0000302	response to reactive oxygen species	4	2
GO:0006950	response to stress	2	12
GO:0006979	response to oxidative stress	3	12
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	12
GO:0034599	cellular response to oxidative stress	4	12
GO:0042221	response to chemical	2	12
GO:0042743	hydrogen peroxide metabolic process	4	2
GO:0042744	hydrogen peroxide catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0062197	cellular response to chemical stress	4	12
GO:0070887	cellular response to chemical stimulus	3	12
GO:0072593	reactive oxygen species metabolic process	3	2
GO:1901700	response to oxygen-containing compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004601	peroxidase activity	2	12
GO:0005488	binding	1	12
GO:0016209	antioxidant activity	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	12
GO:0020037	heme binding	4	12
GO:0046906	tetrapyrrole binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0140825	lactoperoxidase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.481
CLV_NRD_NRD_1	226	228	PF00675	0.533
CLV_NRD_NRD_1	94	96	PF00675	0.496
CLV_PCSK_KEX2_1	226	228	PF00082	0.523
CLV_PCSK_KEX2_1	281	283	PF00082	0.468
CLV_PCSK_KEX2_1	330	332	PF00082	0.548
CLV_PCSK_KEX2_1	94	96	PF00082	0.496
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.468
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.561
CLV_PCSK_SKI1_1	12	16	PF00082	0.453
CLV_PCSK_SKI1_1	86	90	PF00082	0.475
DEG_APCC_KENBOX_2	271	275	PF00400	0.247
DEG_Nend_Nbox_1	1	3	PF02207	0.676
DEG_SPOP_SBC_1	128	132	PF00917	0.302
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.339
DOC_MAPK_gen_1	295	304	PF00069	0.363
DOC_PP4_FxxP_1	182	185	PF00568	0.302
DOC_PP4_FxxP_1	2	5	PF00568	0.662
DOC_USP7_MATH_1	128	132	PF00917	0.358
DOC_USP7_MATH_1	20	24	PF00917	0.608
DOC_USP7_MATH_1	204	208	PF00917	0.277
DOC_USP7_MATH_1	81	85	PF00917	0.304
DOC_USP7_UBL2_3	3	7	PF12436	0.596
DOC_USP7_UBL2_3	56	60	PF12436	0.395
LIG_14-3-3_CanoR_1	12	21	PF00244	0.671
LIG_14-3-3_CanoR_1	226	231	PF00244	0.246
LIG_14-3-3_CanoR_1	333	338	PF00244	0.416
LIG_APCC_ABBA_1	332	337	PF00400	0.413
LIG_deltaCOP1_diTrp_1	156	160	PF00928	0.256
LIG_deltaCOP1_diTrp_1	309	317	PF00928	0.308
LIG_FHA_1	130	136	PF00498	0.287
LIG_FHA_1	168	174	PF00498	0.333
LIG_FHA_1	28	34	PF00498	0.558
LIG_FHA_1	320	326	PF00498	0.289
LIG_FHA_1	85	91	PF00498	0.344
LIG_FHA_2	100	106	PF00498	0.334
LIG_FHA_2	193	199	PF00498	0.263
LIG_FHA_2	296	302	PF00498	0.339
LIG_IBAR_NPY_1	19	21	PF08397	0.650
LIG_LIR_Gen_1	23	32	PF02991	0.569
LIG_LIR_Gen_1	319	329	PF02991	0.300
LIG_LIR_LC3C_4	301	304	PF02991	0.330
LIG_LIR_Nem_3	242	248	PF02991	0.278
LIG_LIR_Nem_3	298	302	PF02991	0.266
LIG_LIR_Nem_3	30	34	PF02991	0.383
LIG_LIR_Nem_3	326	332	PF02991	0.317
LIG_Pex14_1	313	317	PF04695	0.291
LIG_Pex14_2	317	321	PF04695	0.280
LIG_PTB_Apo_2	145	152	PF02174	0.307
LIG_PTB_Apo_2	229	236	PF02174	0.262
LIG_PTB_Phospho_1	145	151	PF10480	0.330
LIG_PTB_Phospho_1	229	235	PF10480	0.276
LIG_SH2_CRK	235	239	PF00017	0.264
LIG_SH2_GRB2like	146	149	PF00017	0.330
LIG_SH2_NCK_1	335	339	PF00017	0.422
LIG_SH2_SRC	146	149	PF00017	0.330
LIG_SH2_STAP1	151	155	PF00017	0.358
LIG_SH2_STAT5	122	125	PF00017	0.339
LIG_SH2_STAT5	146	149	PF00017	0.318
LIG_SH2_STAT5	228	231	PF00017	0.320
LIG_SH2_STAT5	270	273	PF00017	0.313
LIG_SH3_1	171	177	PF00018	0.341
LIG_SH3_3	171	177	PF00018	0.322
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.273
LIG_SUMO_SIM_anti_2	290	295	PF11976	0.338
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.452
LIG_TRAF2_1	308	311	PF00917	0.402
MOD_CK1_1	183	189	PF00069	0.330
MOD_CK1_1	319	325	PF00069	0.293
MOD_CK1_1	84	90	PF00069	0.348
MOD_CK2_1	127	133	PF00069	0.368
MOD_CK2_1	192	198	PF00069	0.263
MOD_CK2_1	204	210	PF00069	0.253
MOD_CK2_1	213	219	PF00069	0.330
MOD_CK2_1	295	301	PF00069	0.330
MOD_CK2_1	99	105	PF00069	0.312
MOD_Cter_Amidation	10	13	PF01082	0.506
MOD_Cter_Amidation	224	227	PF01082	0.539
MOD_GlcNHglycan	215	218	PF01048	0.449
MOD_GlcNHglycan	219	222	PF01048	0.448
MOD_GlcNHglycan	318	321	PF01048	0.493
MOD_GlcNHglycan	68	71	PF01048	0.576
MOD_GSK3_1	123	130	PF00069	0.339
MOD_GSK3_1	213	220	PF00069	0.245
MOD_GSK3_1	246	253	PF00069	0.366
MOD_GSK3_1	258	265	PF00069	0.303
MOD_GSK3_1	333	340	PF00069	0.407
MOD_GSK3_1	80	87	PF00069	0.375
MOD_GSK3_1	99	106	PF00069	0.307
MOD_N-GLC_1	162	167	PF02516	0.447
MOD_N-GLC_1	213	218	PF02516	0.391
MOD_N-GLC_1	27	32	PF02516	0.446
MOD_N-GLC_1	295	300	PF02516	0.474
MOD_NEK2_1	123	128	PF00069	0.320
MOD_NEK2_1	27	32	PF00069	0.563
MOD_NEK2_1	324	329	PF00069	0.309
MOD_NEK2_1	80	85	PF00069	0.325
MOD_NEK2_2	81	86	PF00069	0.311
MOD_PIKK_1	250	256	PF00454	0.315
MOD_PKA_1	12	18	PF00069	0.703
MOD_PKA_1	226	232	PF00069	0.274
MOD_PKA_2	226	232	PF00069	0.284
MOD_PKB_1	331	339	PF00069	0.421
MOD_Plk_1	27	33	PF00069	0.558
MOD_Plk_1	295	301	PF00069	0.277
MOD_Plk_4	183	189	PF00069	0.249
MOD_Plk_4	27	33	PF00069	0.546
MOD_SUMO_rev_2	51	57	PF00179	0.452
TRG_DiLeu_BaEn_1	198	203	PF01217	0.253
TRG_ENDOCYTIC_2	151	154	PF00928	0.339
TRG_ENDOCYTIC_2	234	237	PF00928	0.243
TRG_ER_diArg_1	226	228	PF00400	0.354
TRG_ER_diArg_1	331	334	PF00400	0.359
TRG_NLS_MonoExtC_3	329	334	PF00514	0.379
TRG_NLS_MonoExtN_4	278	284	PF00514	0.281
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y9	Leptomonas seymouri	78%	84%
A0A0N0P6I0	Leptomonas seymouri	25%	100%
A0A0S4JPM4	Bodo saltans	48%	68%
A0A1X0NHV6	Trypanosomatidae	55%	93%
A0A1X0P9U7	Trypanosomatidae	29%	100%
A0A3S7WWR4	Leishmania donovani	94%	100%
A0A422N895	Trypanosoma rangeli	55%	90%
A4HC12	Leishmania braziliensis	86%	88%
A4HZF3	Leishmania infantum	94%	100%
A4I9H5	Leishmania infantum	24%	100%
A4R606	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	100%
D0A114	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	91%
E9AVE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B4H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
H6V7N3	Leishmania donovani	24%	100%
Q4Q3K2	Leishmania major	24%	100%
Q4WLG9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q59X94	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	100%
Q6BIB1	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	80%
Q6FMG7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	96%
V5BHD3	Trypanosoma cruzi	55%	100%
V5BM56	Trypanosoma cruzi	26%	100%