PEROXIDASE_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxidase, putative

Species:

Leishmania major

UniProt:

Q4QC30_LEIMA

TriTrypDb:

LmjF.21.1567 , LMJLV39_210024700 , LMJSD75_210024900

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

Q4QC30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC30

PDB structure(s): 5via_A

Function

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Biological processes
Term	Name	Level	Count
GO:0000302	response to reactive oxygen species	4	2
GO:0006950	response to stress	2	12
GO:0006979	response to oxidative stress	3	12
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	12
GO:0034599	cellular response to oxidative stress	4	12
GO:0042221	response to chemical	2	12
GO:0042743	hydrogen peroxide metabolic process	4	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004601	peroxidase activity	2	12
GO:0005488	binding	1	12
GO:0016209	antioxidant activity	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	12
GO:0020037	heme binding	4	12
GO:0046906	tetrapyrrole binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140825	lactoperoxidase activity	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.481
CLV_NRD_NRD_1	226	228	PF00675	0.533
CLV_NRD_NRD_1	94	96	PF00675	0.496
CLV_PCSK_KEX2_1	226	228	PF00082	0.523
CLV_PCSK_KEX2_1	281	283	PF00082	0.468
CLV_PCSK_KEX2_1	330	332	PF00082	0.548
CLV_PCSK_KEX2_1	94	96	PF00082	0.496
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.468
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.561
CLV_PCSK_SKI1_1	12	16	PF00082	0.453

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y9	Leptomonas seymouri	78%	84%
A0A0N0P6I0	Leptomonas seymouri	25%	100%
A0A0S4JPM4	Bodo saltans	48%	68%
A0A1X0NHV6	Trypanosomatidae	55%	93%
A0A1X0P9U7	Trypanosomatidae	29%	100%
A0A3S7WWR4	Leishmania donovani	94%	100%
A0A422N895	Trypanosoma rangeli	55%	90%
A4HC12	Leishmania braziliensis	86%	88%
A4HZF3	Leishmania infantum	94%	100%
A4I9H5	Leishmania infantum	24%	100%

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