Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QC27_LEIMA

TriTrypDb:

LmjF.21.1580 , LMJLV39_210025100 , LMJSD75_210025300

Length:

629

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 122
NetGPI	no	yes: 0, no: 122

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	115
GO:0110165	cellular anatomical entity	1	115
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

Q4QC27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC27

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	53
GO:0022857	transmembrane transporter activity	2	53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.416
CLV_NRD_NRD_1	232	234	PF00675	0.348
CLV_NRD_NRD_1	252	254	PF00675	0.340
CLV_NRD_NRD_1	28	30	PF00675	0.384
CLV_NRD_NRD_1	41	43	PF00675	0.269
CLV_NRD_NRD_1	482	484	PF00675	0.404
CLV_NRD_NRD_1	575	577	PF00675	0.589
CLV_PCSK_KEX2_1	232	234	PF00082	0.347
CLV_PCSK_KEX2_1	41	43	PF00082	0.321
CLV_PCSK_KEX2_1	444	446	PF00082	0.658
CLV_PCSK_KEX2_1	575	577	PF00082	0.565
CLV_PCSK_KEX2_1	621	623	PF00082	0.372
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.634
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.348
CLV_PCSK_SKI1_1	17	21	PF00082	0.472
CLV_PCSK_SKI1_1	177	181	PF00082	0.391
CLV_PCSK_SKI1_1	373	377	PF00082	0.580
CLV_PCSK_SKI1_1	465	469	PF00082	0.379
CLV_PCSK_SKI1_1	483	487	PF00082	0.406
CLV_PCSK_SKI1_1	511	515	PF00082	0.555
DEG_APCC_DBOX_1	482	490	PF00400	0.548
DEG_SPOP_SBC_1	189	193	PF00917	0.258
DOC_CKS1_1	591	596	PF01111	0.416
DOC_MAPK_DCC_7	511	520	PF00069	0.371
DOC_MAPK_gen_1	167	175	PF00069	0.552
DOC_MAPK_gen_1	291	298	PF00069	0.371
DOC_MAPK_gen_1	41	47	PF00069	0.485
DOC_MAPK_gen_1	483	491	PF00069	0.496
DOC_MAPK_MEF2A_6	167	175	PF00069	0.502
DOC_MAPK_MEF2A_6	254	263	PF00069	0.535
DOC_MAPK_MEF2A_6	291	298	PF00069	0.329
DOC_MAPK_MEF2A_6	404	412	PF00069	0.616
DOC_MAPK_MEF2A_6	484	493	PF00069	0.498
DOC_MAPK_MEF2A_6	511	520	PF00069	0.316
DOC_MAPK_MEF2A_6	572	581	PF00069	0.454
DOC_PP1_RVXF_1	463	469	PF00149	0.497
DOC_PP2B_LxvP_1	506	509	PF13499	0.459
DOC_PP2B_LxvP_1	577	580	PF13499	0.474
DOC_PP2B_PxIxI_1	515	521	PF00149	0.423
DOC_PP4_FxxP_1	93	96	PF00568	0.343
DOC_USP7_MATH_1	188	192	PF00917	0.383
DOC_USP7_MATH_1	286	290	PF00917	0.436
DOC_USP7_UBL2_3	13	17	PF12436	0.732
DOC_WW_Pin1_4	234	239	PF00397	0.685
DOC_WW_Pin1_4	491	496	PF00397	0.406
DOC_WW_Pin1_4	590	595	PF00397	0.450
LIG_14-3-3_CanoR_1	373	378	PF00244	0.745
LIG_APCC_ABBA_1	518	523	PF00400	0.401
LIG_BRCT_BRCA1_1	190	194	PF00533	0.521
LIG_Clathr_ClatBox_1	348	352	PF01394	0.583
LIG_Clathr_ClatBox_1	407	411	PF01394	0.538
LIG_Clathr_ClatBox_1	519	523	PF01394	0.408
LIG_deltaCOP1_diTrp_1	411	419	PF00928	0.393
LIG_EH1_1	264	272	PF00400	0.263
LIG_eIF4E_1	265	271	PF01652	0.333
LIG_FHA_1	134	140	PF00498	0.375
LIG_FHA_1	21	27	PF00498	0.641
LIG_FHA_1	298	304	PF00498	0.406
LIG_FHA_1	337	343	PF00498	0.683
LIG_FHA_1	4	10	PF00498	0.678
LIG_FHA_1	433	439	PF00498	0.357
LIG_FHA_1	452	458	PF00498	0.369
LIG_FHA_1	591	597	PF00498	0.339
LIG_FHA_1	83	89	PF00498	0.361
LIG_FHA_2	158	164	PF00498	0.387
LIG_FHA_2	191	197	PF00498	0.344
LIG_FHA_2	358	364	PF00498	0.815
LIG_FHA_2	400	406	PF00498	0.579
LIG_FHA_2	74	80	PF00498	0.348
LIG_GBD_Chelix_1	295	303	PF00786	0.354
LIG_LIR_Gen_1	140	149	PF02991	0.373
LIG_LIR_Gen_1	200	210	PF02991	0.318
LIG_LIR_Gen_1	217	227	PF02991	0.337
LIG_LIR_Gen_1	411	420	PF02991	0.359
LIG_LIR_Gen_1	450	459	PF02991	0.336
LIG_LIR_Gen_1	550	559	PF02991	0.371
LIG_LIR_Gen_1	59	69	PF02991	0.430
LIG_LIR_Gen_1	94	104	PF02991	0.421
LIG_LIR_Nem_3	140	146	PF02991	0.331
LIG_LIR_Nem_3	200	205	PF02991	0.289
LIG_LIR_Nem_3	217	222	PF02991	0.307
LIG_LIR_Nem_3	450	456	PF02991	0.369
LIG_LIR_Nem_3	524	530	PF02991	0.445
LIG_LIR_Nem_3	59	65	PF02991	0.369
LIG_LIR_Nem_3	94	100	PF02991	0.362
LIG_MAD2	484	492	PF02301	0.588
LIG_MLH1_MIPbox_1	191	195	PF16413	0.383
LIG_NRBOX	413	419	PF00104	0.294
LIG_PDZ_Class_2	624	629	PF00595	0.624
LIG_Pex14_2	107	111	PF04695	0.389
LIG_Pex14_2	205	209	PF04695	0.392
LIG_Pex14_2	46	50	PF04695	0.374
LIG_Pex14_2	535	539	PF04695	0.583
LIG_Pex14_2	65	69	PF04695	0.373
LIG_PTB_Apo_2	545	552	PF02174	0.562
LIG_SH2_CRK	143	147	PF00017	0.292
LIG_SH2_CRK	265	269	PF00017	0.427
LIG_SH2_CRK	97	101	PF00017	0.343
LIG_SH2_STAP1	251	255	PF00017	0.651
LIG_SH2_STAP1	265	269	PF00017	0.446
LIG_SH2_STAP1	453	457	PF00017	0.401
LIG_SH2_STAP1	60	64	PF00017	0.368
LIG_SH2_STAP1	616	620	PF00017	0.570
LIG_SH2_STAP1	97	101	PF00017	0.357
LIG_SH2_STAT3	392	395	PF00017	0.703
LIG_SH2_STAT5	157	160	PF00017	0.409
LIG_SH2_STAT5	204	207	PF00017	0.343
LIG_SH2_STAT5	226	229	PF00017	0.524
LIG_SH2_STAT5	406	409	PF00017	0.568
LIG_SH2_STAT5	453	456	PF00017	0.304
LIG_SH2_STAT5	474	477	PF00017	0.559
LIG_SH2_STAT5	92	95	PF00017	0.334
LIG_SH2_STAT5	97	100	PF00017	0.339
LIG_SH3_3	100	106	PF00018	0.556
LIG_SH3_3	219	225	PF00018	0.355
LIG_SH3_3	253	259	PF00018	0.556
LIG_SH3_3	365	371	PF00018	0.757
LIG_SH3_3	489	495	PF00018	0.318
LIG_SH3_3	510	516	PF00018	0.365
LIG_SH3_3	588	594	PF00018	0.356
LIG_Sin3_3	142	149	PF02671	0.382
LIG_SUMO_SIM_anti_2	217	224	PF11976	0.409
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.337
LIG_SUMO_SIM_anti_2	78	85	PF11976	0.368
LIG_SUMO_SIM_par_1	299	304	PF11976	0.379
LIG_SUMO_SIM_par_1	593	599	PF11976	0.375
LIG_TYR_ITIM	141	146	PF00017	0.341
LIG_TYR_ITIM	263	268	PF00017	0.406
LIG_TYR_ITIM	95	100	PF00017	0.349
LIG_UBA3_1	503	511	PF00899	0.420
LIG_WRC_WIRS_1	558	563	PF05994	0.399
MOD_CK1_1	156	162	PF00069	0.399
MOD_CK1_1	289	295	PF00069	0.357
MOD_CK1_1	3	9	PF00069	0.720
MOD_CK1_1	382	388	PF00069	0.692
MOD_CK1_1	434	440	PF00069	0.355
MOD_CK1_1	557	563	PF00069	0.390
MOD_CK1_1	78	84	PF00069	0.308
MOD_CK2_1	157	163	PF00069	0.432
MOD_CK2_1	190	196	PF00069	0.545
MOD_CK2_1	357	363	PF00069	0.713
MOD_CK2_1	380	386	PF00069	0.675
MOD_GlcNHglycan	112	115	PF01048	0.306
MOD_GlcNHglycan	149	152	PF01048	0.368
MOD_GlcNHglycan	288	291	PF01048	0.618
MOD_GlcNHglycan	363	367	PF01048	0.534
MOD_GlcNHglycan	449	452	PF01048	0.505
MOD_GlcNHglycan	9	12	PF01048	0.479
MOD_GSK3_1	110	117	PF00069	0.400
MOD_GSK3_1	133	140	PF00069	0.380
MOD_GSK3_1	153	160	PF00069	0.379
MOD_GSK3_1	177	184	PF00069	0.376
MOD_GSK3_1	297	304	PF00069	0.399
MOD_GSK3_1	3	10	PF00069	0.659
MOD_GSK3_1	358	365	PF00069	0.773
MOD_GSK3_1	376	383	PF00069	0.755
MOD_GSK3_1	430	437	PF00069	0.445
MOD_GSK3_1	443	450	PF00069	0.392
MOD_GSK3_1	50	57	PF00069	0.360
MOD_GSK3_1	586	593	PF00069	0.401
MOD_GSK3_1	64	71	PF00069	0.343
MOD_GSK3_1	78	85	PF00069	0.303
MOD_GSK3_1	91	98	PF00069	0.343
MOD_N-GLC_1	286	291	PF02516	0.602
MOD_N-GLC_1	373	378	PF02516	0.543
MOD_N-GLC_1	431	436	PF02516	0.585
MOD_N-GLC_1	547	552	PF02516	0.469
MOD_NEK2_1	110	115	PF00069	0.300
MOD_NEK2_1	182	187	PF00069	0.409
MOD_NEK2_1	190	195	PF00069	0.447
MOD_NEK2_1	244	249	PF00069	0.553
MOD_NEK2_1	303	308	PF00069	0.356
MOD_NEK2_1	430	435	PF00069	0.343
MOD_NEK2_1	50	55	PF00069	0.329
MOD_NEK2_1	538	543	PF00069	0.552
MOD_NEK2_1	64	69	PF00069	0.369
MOD_NEK2_1	73	78	PF00069	0.378
MOD_NEK2_2	137	142	PF00069	0.317
MOD_NEK2_2	399	404	PF00069	0.622
MOD_NEK2_2	547	552	PF00069	0.529
MOD_OFUCOSY	585	590	PF10250	0.536
MOD_PIKK_1	18	24	PF00454	0.676
MOD_PIKK_1	380	386	PF00454	0.812
MOD_PIKK_1	64	70	PF00454	0.340
MOD_PKA_2	358	364	PF00069	0.803
MOD_Plk_1	153	159	PF00069	0.351
MOD_Plk_1	195	201	PF00069	0.376
MOD_Plk_1	373	379	PF00069	0.709
MOD_Plk_1	431	437	PF00069	0.353
MOD_Plk_1	547	553	PF00069	0.469
MOD_Plk_1	78	84	PF00069	0.292
MOD_Plk_4	153	159	PF00069	0.358
MOD_Plk_4	182	188	PF00069	0.398
MOD_Plk_4	190	196	PF00069	0.472
MOD_Plk_4	215	221	PF00069	0.283
MOD_Plk_4	244	250	PF00069	0.573
MOD_Plk_4	303	309	PF00069	0.389
MOD_Plk_4	4	10	PF00069	0.698
MOD_Plk_4	547	553	PF00069	0.353
MOD_Plk_4	554	560	PF00069	0.331
MOD_Plk_4	596	602	PF00069	0.356
MOD_Plk_4	78	84	PF00069	0.351
MOD_Plk_4	95	101	PF00069	0.396
MOD_ProDKin_1	234	240	PF00069	0.683
MOD_ProDKin_1	491	497	PF00069	0.406
MOD_ProDKin_1	590	596	PF00069	0.419
TRG_DiLeu_BaEn_1	344	349	PF01217	0.578
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.637
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.187
TRG_ENDOCYTIC_2	143	146	PF00928	0.313
TRG_ENDOCYTIC_2	265	268	PF00928	0.393
TRG_ENDOCYTIC_2	422	425	PF00928	0.369
TRG_ENDOCYTIC_2	453	456	PF00928	0.334
TRG_ENDOCYTIC_2	616	619	PF00928	0.545
TRG_ENDOCYTIC_2	92	95	PF00928	0.341
TRG_ENDOCYTIC_2	97	100	PF00928	0.351
TRG_ER_diArg_1	166	169	PF00400	0.593
TRG_ER_diArg_1	231	233	PF00400	0.622
TRG_ER_diArg_1	291	294	PF00400	0.405
TRG_ER_diArg_1	40	42	PF00400	0.490
TRG_ER_diArg_1	575	577	PF00400	0.402
TRG_ER_FFAT_1	328	339	PF00635	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	27%	99%
A0A0N1HT40	Leptomonas seymouri	27%	100%
A0A0N1HZC2	Leptomonas seymouri	47%	100%
A0A0N1IKC5	Leptomonas seymouri	27%	100%
A0A0N1PB63	Leptomonas seymouri	67%	95%
A0A0N1PD04	Leptomonas seymouri	24%	98%
A0A0N1PFR4	Leptomonas seymouri	27%	95%
A0A0S4JR45	Bodo saltans	25%	100%
A0A1X0NKK0	Trypanosomatidae	50%	100%
A0A1X0NM09	Trypanosomatidae	50%	100%
A0A1X0NRW5	Trypanosomatidae	26%	90%
A0A1X0NV13	Trypanosomatidae	29%	97%
A0A1X0NV19	Trypanosomatidae	29%	100%
A0A1X0NV27	Trypanosomatidae	29%	100%
A0A1X0NVF9	Trypanosomatidae	22%	94%
A0A1X0NVH8	Trypanosomatidae	25%	95%
A0A1X0NVM7	Trypanosomatidae	28%	98%
A0A1X0NWQ1	Trypanosomatidae	26%	98%
A0A1X0NZE6	Trypanosomatidae	27%	100%
A0A1X0NZU2	Trypanosomatidae	25%	97%
A0A1X0NZU5	Trypanosomatidae	27%	100%
A0A1X0NZW1	Trypanosomatidae	26%	100%
A0A1X0P0M7	Trypanosomatidae	27%	100%
A0A381MMW5	Leishmania infantum	26%	96%
A0A3Q8I7Y9	Leishmania donovani	27%	100%
A0A3Q8IEC4	Leishmania donovani	26%	97%
A0A3Q8IF95	Leishmania donovani	50%	100%
A0A3Q8IIT5	Leishmania donovani	26%	94%
A0A3Q8ISY9	Leishmania donovani	25%	99%
A0A3R7JSQ9	Trypanosoma rangeli	23%	100%
A0A3R7KKN8	Trypanosoma rangeli	26%	100%
A0A3R7MAQ7	Trypanosoma rangeli	24%	89%
A0A3R7N3S6	Trypanosoma rangeli	22%	98%
A0A3R7N415	Trypanosoma rangeli	25%	100%
A0A3R7N921	Trypanosoma rangeli	29%	100%
A0A3R7R443	Trypanosoma rangeli	25%	100%
A0A3S7WRJ4	Leishmania donovani	27%	98%
A0A3S7WRJ5	Leishmania donovani	26%	90%
A0A3S7WRL4	Leishmania donovani	28%	100%
A0A3S7WRS3	Leishmania donovani	22%	100%
A0A3S7WSR4	Leishmania donovani	26%	100%
A0A3S7WWU1	Leishmania donovani	95%	95%
A0A3S7X2G0	Leishmania donovani	26%	96%
A0A3S7X2K5	Leishmania donovani	25%	100%
A0A3S7XB11	Leishmania donovani	47%	100%
A0A422MSE4	Trypanosoma rangeli	30%	100%
A0A422MSP6	Trypanosoma rangeli	25%	100%
A0A422MST9	Trypanosoma rangeli	26%	100%
A0A422MU68	Trypanosoma rangeli	48%	100%
A4H6J0	Leishmania braziliensis	26%	98%
A4H6J1	Leishmania braziliensis	27%	96%
A4H6J3	Leishmania braziliensis	28%	100%
A4H6Q5	Leishmania braziliensis	23%	100%
A4HC19	Leishmania braziliensis	76%	98%
A4HHG2	Leishmania braziliensis	25%	93%
A4HHG3	Leishmania braziliensis	27%	97%
A4HHG4	Leishmania braziliensis	28%	96%
A4HJW3	Leishmania braziliensis	24%	99%
A4HPE2	Leishmania braziliensis	48%	100%
A4HUX5	Leishmania infantum	27%	98%
A4HUX6	Leishmania infantum	26%	90%
A4HUX7	Leishmania infantum	28%	100%
A4HUX8	Leishmania infantum	28%	100%
A4HV40	Leishmania infantum	22%	100%
A4HZF5	Leishmania infantum	50%	100%
A4HZJ4	Leishmania infantum	94%	95%
A4I4L2	Leishmania infantum	25%	94%
A4I7C5	Leishmania infantum	25%	99%
A4ICI3	Leishmania infantum	48%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	98%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	92%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AE01	Leishmania major	26%	100%
E9AE09	Leishmania major	25%	100%
E9AE10	Leishmania major	25%	100%
E9AE11	Leishmania major	27%	100%
E9AGK5	Leishmania infantum	26%	100%
E9AHJ0	Leishmania infantum	26%	97%
E9AHJ1	Leishmania infantum	25%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	97%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	94%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	98%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	96%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	99%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	95%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	99%
Q4Q1E4	Leishmania major	48%	99%
Q4Q5T8	Leishmania major	24%	100%
Q4QC28	Leishmania major	49%	100%
Q4QFY5	Leishmania major	25%	100%
Q4QGU8	Leishmania major	23%	100%
Q4QH10	Leishmania major	26%	100%
Q4QH11	Leishmania major	27%	100%
Q4QH12	Leishmania major	27%	100%
Q4QH13	Leishmania major	27%	100%
Q4QH14	Leishmania major	27%	96%
Q4QH15	Leishmania major	26%	100%
V5B647	Trypanosoma cruzi	29%	100%
V5B983	Trypanosoma cruzi	28%	100%
V5BBB1	Trypanosoma cruzi	24%	100%
V5BFV8	Trypanosoma cruzi	26%	94%
V5BQY6	Trypanosoma cruzi	26%	89%
V5BVP0	Trypanosoma cruzi	27%	100%
V5DT25	Trypanosoma cruzi	27%	100%