F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box-like, putative

Species:

Leishmania major

UniProt:

Q4QC26_LEIMA

TriTrypDb:

LmjF.21.1590 , LMJLV39_210025200 , LMJSD75_210025400

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

Q4QC26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC26

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.381
CLV_NRD_NRD_1	174	176	PF00675	0.195
CLV_NRD_NRD_1	249	251	PF00675	0.365
CLV_NRD_NRD_1	281	283	PF00675	0.597
CLV_PCSK_FUR_1	172	176	PF00082	0.400
CLV_PCSK_FUR_1	247	251	PF00082	0.436
CLV_PCSK_KEX2_1	158	160	PF00082	0.383
CLV_PCSK_KEX2_1	172	174	PF00082	0.277
CLV_PCSK_KEX2_1	249	251	PF00082	0.409
CLV_PCSK_KEX2_1	37	39	PF00082	0.462

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVU0	Leptomonas seymouri	76%	100%
A0A0S4JHL9	Bodo saltans	29%	70%
A0A1X0NI23	Trypanosomatidae	51%	100%
A0A3Q8IAZ7	Leishmania donovani	96%	100%
A0A422N8A5	Trypanosoma rangeli	48%	100%
A4HC20	Leishmania braziliensis	85%	100%
A4HZJ5	Leishmania infantum	96%	100%
D0A112	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9AVF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%

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