F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box-like, putative

Species:

Leishmania major

UniProt:

Q4QC26_LEIMA

TriTrypDb:

LmjF.21.1590 , LMJLV39_210025200 , LMJSD75_210025400

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QC26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.381
CLV_NRD_NRD_1	174	176	PF00675	0.195
CLV_NRD_NRD_1	249	251	PF00675	0.365
CLV_NRD_NRD_1	281	283	PF00675	0.597
CLV_PCSK_FUR_1	172	176	PF00082	0.400
CLV_PCSK_FUR_1	247	251	PF00082	0.436
CLV_PCSK_KEX2_1	158	160	PF00082	0.383
CLV_PCSK_KEX2_1	172	174	PF00082	0.277
CLV_PCSK_KEX2_1	249	251	PF00082	0.409
CLV_PCSK_KEX2_1	37	39	PF00082	0.462
CLV_PCSK_KEX2_1	94	96	PF00082	0.390
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.482
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.390
CLV_PCSK_SKI1_1	147	151	PF00082	0.448
CLV_PCSK_SKI1_1	175	179	PF00082	0.355
CLV_PCSK_SKI1_1	48	52	PF00082	0.355
CLV_Separin_Metazoa	447	451	PF03568	0.610
DEG_APCC_DBOX_1	47	55	PF00400	0.548
DEG_MDM2_SWIB_1	215	223	PF02201	0.427
DEG_MDM2_SWIB_1	286	293	PF02201	0.333
DEG_Nend_Nbox_1	1	3	PF02207	0.715
DEG_SPOP_SBC_1	9	13	PF00917	0.702
DOC_CDC14_PxL_1	239	247	PF14671	0.633
DOC_CKS1_1	461	466	PF01111	0.629
DOC_CYCLIN_RxL_1	247	258	PF00134	0.613
DOC_MAPK_DCC_7	94	104	PF00069	0.651
DOC_MAPK_gen_1	172	180	PF00069	0.528
DOC_MAPK_gen_1	247	256	PF00069	0.573
DOC_MAPK_gen_1	392	400	PF00069	0.539
DOC_MAPK_gen_1	45	54	PF00069	0.526
DOC_MAPK_MEF2A_6	172	180	PF00069	0.517
DOC_MAPK_MEF2A_6	394	402	PF00069	0.544
DOC_MAPK_MEF2A_6	45	54	PF00069	0.548
DOC_PP1_RVXF_1	250	257	PF00149	0.497
DOC_PP1_RVXF_1	36	43	PF00149	0.549
DOC_PP2B_LxvP_1	142	145	PF13499	0.626
DOC_PP2B_LxvP_1	336	339	PF13499	0.341
DOC_SPAK_OSR1_1	332	336	PF12202	0.406
DOC_USP7_MATH_1	143	147	PF00917	0.687
DOC_USP7_MATH_1	347	351	PF00917	0.427
DOC_USP7_UBL2_3	152	156	PF12436	0.633
DOC_WW_Pin1_4	460	465	PF00397	0.623
LIG_14-3-3_CanoR_1	285	289	PF00244	0.386
LIG_14-3-3_CanoR_1	319	327	PF00244	0.632
LIG_14-3-3_CanoR_1	38	43	PF00244	0.641
LIG_14-3-3_CanoR_1	438	448	PF00244	0.429
LIG_APCC_ABBA_1	52	57	PF00400	0.548
LIG_BRCT_BRCA1_1	10	14	PF00533	0.683
LIG_EH1_1	407	415	PF00400	0.356
LIG_eIF4E_1	361	367	PF01652	0.352
LIG_FHA_1	203	209	PF00498	0.411
LIG_FHA_1	259	265	PF00498	0.340
LIG_FHA_1	271	277	PF00498	0.252
LIG_FHA_1	292	298	PF00498	0.348
LIG_FHA_1	4	10	PF00498	0.751
LIG_GBD_Chelix_1	189	197	PF00786	0.420
LIG_GBD_Chelix_1	396	404	PF00786	0.494
LIG_LIR_Gen_1	284	293	PF02991	0.316
LIG_LIR_Gen_1	350	359	PF02991	0.407
LIG_LIR_Nem_3	11	17	PF02991	0.603
LIG_LIR_Nem_3	163	169	PF02991	0.564
LIG_LIR_Nem_3	212	218	PF02991	0.275
LIG_LIR_Nem_3	284	289	PF02991	0.339
LIG_LIR_Nem_3	329	334	PF02991	0.575
LIG_LIR_Nem_3	350	354	PF02991	0.363
LIG_LIR_Nem_3	386	390	PF02991	0.603
LIG_LIR_Nem_3	416	420	PF02991	0.339
LIG_LIR_Nem_3	64	69	PF02991	0.482
LIG_LIR_Nem_3	78	82	PF02991	0.350
LIG_LYPXL_S_1	99	103	PF13949	0.419
LIG_LYPXL_yS_3	100	103	PF13949	0.566
LIG_NRBOX	380	386	PF00104	0.349
LIG_Pex14_2	10	14	PF04695	0.570
LIG_Pex14_2	215	219	PF04695	0.321
LIG_Pex14_2	286	290	PF04695	0.290
LIG_Pex14_2	342	346	PF04695	0.380
LIG_Pex14_2	383	387	PF04695	0.412
LIG_Pex14_2	430	434	PF04695	0.354
LIG_RPA_C_Fungi	433	445	PF08784	0.356
LIG_SH2_CRK	112	116	PF00017	0.540
LIG_SH2_CRK	167	171	PF00017	0.475
LIG_SH2_NCK_1	112	116	PF00017	0.584
LIG_SH2_STAT5	169	172	PF00017	0.415
LIG_SH2_STAT5	222	225	PF00017	0.321
LIG_SH2_STAT5	356	359	PF00017	0.419
LIG_SH2_STAT5	364	367	PF00017	0.321
LIG_SH2_STAT5	439	442	PF00017	0.456
LIG_SH2_STAT5	91	94	PF00017	0.503
LIG_SH3_3	135	141	PF00018	0.643
LIG_SH3_3	95	101	PF00018	0.447
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.358
LIG_SUMO_SIM_par_1	293	298	PF11976	0.427
LIG_SUMO_SIM_par_1	370	375	PF11976	0.348
LIG_TYR_ITIM	134	139	PF00017	0.641
LIG_TYR_ITIM	98	103	PF00017	0.456
LIG_UBA3_1	244	252	PF00899	0.459
LIG_UBA3_1	274	283	PF00899	0.504
LIG_WRC_WIRS_1	14	19	PF05994	0.466
LIG_WRC_WIRS_1	296	301	PF05994	0.427
MOD_CK1_1	13	19	PF00069	0.537
MOD_CK1_1	258	264	PF00069	0.385
MOD_CK2_1	17	23	PF00069	0.700
MOD_CK2_1	38	44	PF00069	0.606
MOD_Cter_Amidation	280	283	PF01082	0.463
MOD_GlcNHglycan	257	260	PF01048	0.325
MOD_GlcNHglycan	442	445	PF01048	0.427
MOD_GSK3_1	291	298	PF00069	0.346
MOD_GSK3_1	71	78	PF00069	0.394
MOD_GSK3_1	9	16	PF00069	0.550
MOD_N-GLC_1	209	214	PF02516	0.427
MOD_N-GLC_2	457	459	PF02516	0.500
MOD_NEK2_1	10	15	PF00069	0.596
MOD_NEK2_1	180	185	PF00069	0.308
MOD_NEK2_1	191	196	PF00069	0.290
MOD_NEK2_1	208	213	PF00069	0.317
MOD_NEK2_1	448	453	PF00069	0.473
MOD_PIKK_1	113	119	PF00454	0.617
MOD_PIKK_1	160	166	PF00454	0.604
MOD_PKA_2	160	166	PF00069	0.502
MOD_PKA_2	284	290	PF00069	0.492
MOD_Plk_1	209	215	PF00069	0.482
MOD_Plk_2-3	23	29	PF00069	0.488
MOD_Plk_4	13	19	PF00069	0.603
MOD_Plk_4	182	188	PF00069	0.368
MOD_Plk_4	209	215	PF00069	0.408
MOD_Plk_4	258	264	PF00069	0.358
MOD_Plk_4	270	276	PF00069	0.249
MOD_Plk_4	38	44	PF00069	0.457
MOD_ProDKin_1	460	466	PF00069	0.535
TRG_DiLeu_BaEn_2	328	334	PF01217	0.534
TRG_DiLeu_BaLyEn_6	121	126	PF01217	0.598
TRG_DiLeu_LyEn_5	240	245	PF01217	0.512
TRG_ENDOCYTIC_2	100	103	PF00928	0.452
TRG_ENDOCYTIC_2	112	115	PF00928	0.490
TRG_ENDOCYTIC_2	136	139	PF00928	0.642
TRG_ENDOCYTIC_2	167	170	PF00928	0.420
TRG_ENDOCYTIC_2	222	225	PF00928	0.311
TRG_ENDOCYTIC_2	305	308	PF00928	0.321
TRG_ENDOCYTIC_2	364	367	PF00928	0.321
TRG_ER_diArg_1	122	125	PF00400	0.515
TRG_ER_diArg_1	157	159	PF00400	0.512
TRG_ER_diArg_1	172	175	PF00400	0.341
TRG_ER_diArg_1	246	249	PF00400	0.455
TRG_NES_CRM1_1	316	329	PF08389	0.545
TRG_NES_CRM1_1	44	57	PF08389	0.420
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVU0	Leptomonas seymouri	76%	100%
A0A0S4JHL9	Bodo saltans	29%	70%
A0A1X0NI23	Trypanosomatidae	51%	100%
A0A3Q8IAZ7	Leishmania donovani	96%	100%
A0A422N8A5	Trypanosoma rangeli	48%	100%
A4HC20	Leishmania braziliensis	85%	100%
A4HZJ5	Leishmania infantum	96%	100%
D0A112	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9AVF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%