Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania major

UniProt:

Q4QC22_LEIMA

TriTrypDb:

LmjF.21.1620 , LMJLV39_210025600 , LMJSD75_210025800

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC22

PDB structure(s): 7aih_Am , 7am2_Am , 7ane_Am

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043631	RNA polyadenylation	6	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.381
CLV_NRD_NRD_1	272	274	PF00675	0.333
CLV_NRD_NRD_1	299	301	PF00675	0.424
CLV_NRD_NRD_1	3	5	PF00675	0.598
CLV_NRD_NRD_1	50	52	PF00675	0.372
CLV_PCSK_KEX2_1	138	140	PF00082	0.378
CLV_PCSK_KEX2_1	204	206	PF00082	0.458
CLV_PCSK_KEX2_1	21	23	PF00082	0.381
CLV_PCSK_KEX2_1	272	274	PF00082	0.394
CLV_PCSK_KEX2_1	299	301	PF00082	0.424
CLV_PCSK_KEX2_1	3	5	PF00082	0.598
CLV_PCSK_KEX2_1	50	52	PF00082	0.372
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.378
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.458
CLV_PCSK_PC7_1	134	140	PF00082	0.354
CLV_PCSK_SKI1_1	205	209	PF00082	0.540
DEG_APCC_KENBOX_2	122	126	PF00400	0.457
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DEG_SIAH_1	42	50	PF03145	0.523
DOC_MAPK_gen_1	3	9	PF00069	0.612
DOC_MAPK_MEF2A_6	37	46	PF00069	0.432
DOC_PP1_RVXF_1	23	30	PF00149	0.438
DOC_PP1_RVXF_1	69	76	PF00149	0.355
DOC_USP7_MATH_1	196	200	PF00917	0.511
DOC_USP7_MATH_1	211	215	PF00917	0.414
DOC_USP7_UBL2_3	204	208	PF12436	0.468
DOC_WW_Pin1_4	82	87	PF00397	0.356
LIG_14-3-3_CanoR_1	3	9	PF00244	0.553
LIG_14-3-3_CanoR_1	30	38	PF00244	0.394
LIG_deltaCOP1_diTrp_1	255	262	PF00928	0.375
LIG_FHA_1	170	176	PF00498	0.380
LIG_LIR_Apic_2	313	317	PF02991	0.380
LIG_LIR_Apic_2	318	322	PF02991	0.428
LIG_LIR_Gen_1	181	189	PF02991	0.288
LIG_LIR_Gen_1	238	249	PF02991	0.466
LIG_LIR_Gen_1	58	66	PF02991	0.363
LIG_LIR_Nem_3	131	136	PF02991	0.385
LIG_LIR_Nem_3	238	244	PF02991	0.459
LIG_LIR_Nem_3	39	44	PF02991	0.409
LIG_LIR_Nem_3	58	64	PF02991	0.341
LIG_LIR_Nem_3	87	93	PF02991	0.354
LIG_LIR_Nem_3	99	105	PF02991	0.342
LIG_SH2_CRK	147	151	PF00017	0.283
LIG_SH2_CRK	314	318	PF00017	0.439
LIG_SH2_CRK	319	323	PF00017	0.459
LIG_SH2_GRB2like	182	185	PF00017	0.283
LIG_SH2_GRB2like	331	334	PF00017	0.607
LIG_SH2_NCK_1	160	164	PF00017	0.293
LIG_SH2_SRC	93	96	PF00017	0.479
LIG_SH2_STAP1	331	335	PF00017	0.583
LIG_SH2_STAT5	136	139	PF00017	0.383
LIG_SH2_STAT5	145	148	PF00017	0.257
LIG_SH2_STAT5	182	185	PF00017	0.283
LIG_SH2_STAT5	202	205	PF00017	0.397
LIG_SH2_STAT5	241	244	PF00017	0.417
LIG_SH2_STAT5	295	298	PF00017	0.544
LIG_SH2_STAT5	331	334	PF00017	0.606
LIG_SH2_STAT5	66	69	PF00017	0.361
LIG_SH2_STAT5	93	96	PF00017	0.374
LIG_SH3_3	323	329	PF00018	0.578
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.470
LIG_UBA3_1	111	120	PF00899	0.370
LIG_WRC_WIRS_1	232	237	PF05994	0.352
MOD_CK2_1	240	246	PF00069	0.446
MOD_CK2_1	283	289	PF00069	0.478
MOD_CMANNOS	257	260	PF00535	0.370
MOD_GlcNHglycan	238	241	PF01048	0.506
MOD_GlcNHglycan	285	288	PF01048	0.447
MOD_GSK3_1	231	238	PF00069	0.418
MOD_GSK3_1	264	271	PF00069	0.481
MOD_NEK2_1	235	240	PF00069	0.538
MOD_NEK2_1	290	295	PF00069	0.434
MOD_NEK2_1	64	69	PF00069	0.399
MOD_PIKK_1	36	42	PF00454	0.424
MOD_PKA_2	2	8	PF00069	0.534
MOD_PKB_1	281	289	PF00069	0.524
MOD_Plk_1	107	113	PF00069	0.427
MOD_Plk_4	107	113	PF00069	0.416
MOD_Plk_4	178	184	PF00069	0.293
MOD_Plk_4	211	217	PF00069	0.521
MOD_Plk_4	290	296	PF00069	0.400
MOD_Plk_4	320	326	PF00069	0.469
MOD_ProDKin_1	82	88	PF00069	0.352
MOD_SUMO_rev_2	265	270	PF00179	0.403
MOD_SUMO_rev_2	34	39	PF00179	0.421
TRG_ENDOCYTIC_2	147	150	PF00928	0.283
TRG_ENDOCYTIC_2	182	185	PF00928	0.287
TRG_ENDOCYTIC_2	241	244	PF00928	0.417
TRG_ER_diArg_1	2	4	PF00400	0.600
TRG_ER_diArg_1	280	283	PF00400	0.491
TRG_ER_diArg_1	49	51	PF00400	0.392
TRG_NES_CRM1_1	164	176	PF08389	0.343
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F9	Leptomonas seymouri	83%	100%
A0A0S4J3G5	Bodo saltans	46%	86%
A0A1X0NHG3	Trypanosomatidae	70%	99%
A0A3Q8IL95	Leishmania donovani	99%	100%
A0A3R7N7R7	Trypanosoma rangeli	67%	99%
A4HC24	Leishmania braziliensis	92%	100%
A4HZG7	Leishmania infantum	98%	100%
D0A108	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
E9AVF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BHD8	Trypanosoma cruzi	70%	100%