EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC20_LEIMA

TriTrypDb:

LmjF.21.1640 , LMJLV39_210025800 , LMJSD75_210026000

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC20

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.560
CLV_PCSK_KEX2_1	12	14	PF00082	0.587
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.587
CLV_PCSK_SKI1_1	208	212	PF00082	0.551
CLV_PCSK_SKI1_1	6	10	PF00082	0.715
DEG_Nend_UBRbox_3	1	3	PF02207	0.454
DOC_CDC14_PxL_1	195	203	PF14671	0.514
DOC_CYCLIN_yCln2_LP_2	197	200	PF00134	0.527
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.400
DOC_MAPK_gen_1	12	19	PF00069	0.476
DOC_MAPK_RevD_3	1	14	PF00069	0.471
DOC_PP1_RVXF_1	59	66	PF00149	0.515
DOC_PP2B_LxvP_1	197	200	PF13499	0.527
DOC_USP7_MATH_1	200	204	PF00917	0.527
DOC_USP7_MATH_1	210	214	PF00917	0.526
DOC_USP7_MATH_1	220	224	PF00917	0.366
LIG_14-3-3_CanoR_1	6	11	PF00244	0.483
LIG_14-3-3_CanoR_1	61	66	PF00244	0.644
LIG_FHA_1	112	118	PF00498	0.389
LIG_FHA_1	119	125	PF00498	0.359
LIG_FHA_1	212	218	PF00498	0.421
LIG_FHA_1	43	49	PF00498	0.374
LIG_FHA_1	57	63	PF00498	0.376
LIG_FHA_2	18	24	PF00498	0.585
LIG_HCF-1_HBM_1	125	128	PF13415	0.347
LIG_LIR_Gen_1	137	147	PF02991	0.404
LIG_LIR_Gen_1	50	58	PF02991	0.517
LIG_LIR_Gen_1	98	109	PF02991	0.383
LIG_LIR_Nem_3	137	143	PF02991	0.577
LIG_LIR_Nem_3	169	173	PF02991	0.443
LIG_LIR_Nem_3	50	55	PF02991	0.465
LIG_LIR_Nem_3	98	104	PF02991	0.403
LIG_MYND_1	196	200	PF01753	0.530
LIG_PCNA_yPIPBox_3	127	140	PF02747	0.557
LIG_PDZ_Class_1	226	231	PF00595	0.608
LIG_SH2_CRK	170	174	PF00017	0.456
LIG_SH2_CRK	52	56	PF00017	0.479
LIG_SH2_STAP1	42	46	PF00017	0.635
LIG_SH2_STAP1	52	56	PF00017	0.333
LIG_SH2_STAP1	96	100	PF00017	0.545
LIG_SH2_STAT5	218	221	PF00017	0.517
LIG_SH3_3	193	199	PF00018	0.567
LIG_SH3_3	43	49	PF00018	0.464
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.490
LIG_SUMO_SIM_par_1	120	125	PF11976	0.431
LIG_SUMO_SIM_par_1	44	50	PF11976	0.361
LIG_TRAF2_1	68	71	PF00917	0.648
LIG_WRC_WIRS_1	62	67	PF05994	0.455
MOD_CK1_1	103	109	PF00069	0.578
MOD_CK1_1	185	191	PF00069	0.468
MOD_CK1_1	30	36	PF00069	0.543
MOD_CK1_1	44	50	PF00069	0.651
MOD_CK2_1	131	137	PF00069	0.546
MOD_GlcNHglycan	189	193	PF01048	0.479
MOD_GlcNHglycan	31	35	PF01048	0.597
MOD_GlcNHglycan	52	55	PF01048	0.509
MOD_GSK3_1	216	223	PF00069	0.559
MOD_GSK3_1	22	29	PF00069	0.636
MOD_GSK3_1	96	103	PF00069	0.421
MOD_LATS_1	129	135	PF00433	0.531
MOD_N-GLC_1	110	115	PF02516	0.502
MOD_NEK2_1	100	105	PF00069	0.540
MOD_NEK2_1	211	216	PF00069	0.467
MOD_NEK2_1	226	231	PF00069	0.556
MOD_NEK2_2	96	101	PF00069	0.339
MOD_PKA_2	72	78	PF00069	0.451
MOD_Plk_4	47	53	PF00069	0.417
MOD_Plk_4	96	102	PF00069	0.410
MOD_SUMO_rev_2	144	150	PF00179	0.481
TRG_DiLeu_BaEn_1	81	86	PF01217	0.357
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.517
TRG_ENDOCYTIC_2	170	173	PF00928	0.583
TRG_ENDOCYTIC_2	52	55	PF00928	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NI68	Trypanosomatidae	30%	73%
A0A3S5H7A2	Leishmania donovani	90%	100%
A0A422N8A3	Trypanosoma rangeli	31%	78%
A4HC26	Leishmania braziliensis	70%	94%
A4HZG9	Leishmania infantum	90%	100%
D0A106	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	76%
E9AVF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5B1W6	Trypanosoma cruzi	31%	77%