Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase PK4, putative

Species:

Leishmania major

UniProt:

Q4QC19_LEIMA

TriTrypDb:

LmjF.21.1650 , LMJLV39_210025900 , LMJSD75_210026100

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC19

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	14
GO:0006793	phosphorus metabolic process	3	14
GO:0006796	phosphate-containing compound metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016310	phosphorylation	5	14
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018107	peptidyl-threonine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0018210	peptidyl-threonine modification	6	2
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004672	protein kinase activity	3	14
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0004713	protein tyrosine kinase activity	4	2
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0016301	kinase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140096	catalytic activity, acting on a protein	2	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.367
CLV_NRD_NRD_1	282	284	PF00675	0.422
CLV_NRD_NRD_1	51	53	PF00675	0.774
CLV_PCSK_KEX2_1	113	115	PF00082	0.427
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.427
CLV_PCSK_SKI1_1	17	21	PF00082	0.546
CLV_PCSK_SKI1_1	227	231	PF00082	0.323
CLV_PCSK_SKI1_1	238	242	PF00082	0.325
CLV_PCSK_SKI1_1	304	308	PF00082	0.316
CLV_PCSK_SKI1_1	46	50	PF00082	0.755
DEG_APCC_DBOX_1	263	271	PF00400	0.427
DEG_APCC_DBOX_1	303	311	PF00400	0.373
DOC_MAPK_FxFP_2	446	449	PF00069	0.334
DOC_MAPK_gen_1	11	18	PF00069	0.546
DOC_MAPK_gen_1	360	369	PF00069	0.294
DOC_MAPK_HePTP_8	357	369	PF00069	0.294
DOC_MAPK_MEF2A_6	360	369	PF00069	0.294
DOC_MAPK_MEF2A_6	372	379	PF00069	0.294
DOC_PP4_FxxP_1	446	449	PF00568	0.334
DOC_SPAK_OSR1_1	90	94	PF12202	0.492
DOC_USP7_MATH_1	2	6	PF00917	0.731
DOC_USP7_MATH_1	329	333	PF00917	0.427
DOC_USP7_MATH_1	56	60	PF00917	0.726
DOC_USP7_UBL2_3	46	50	PF12436	0.690
DOC_WW_Pin1_4	101	106	PF00397	0.579
DOC_WW_Pin1_4	78	83	PF00397	0.592
LIG_14-3-3_CanoR_1	17	23	PF00244	0.551
LIG_14-3-3_CanoR_1	224	230	PF00244	0.422
LIG_14-3-3_CanoR_1	304	313	PF00244	0.386
LIG_14-3-3_CanoR_1	424	429	PF00244	0.306
LIG_14-3-3_CanoR_1	471	477	PF00244	0.362
LIG_14-3-3_CanoR_1	52	56	PF00244	0.771
LIG_14-3-3_CanoR_1	66	71	PF00244	0.717
LIG_Actin_WH2_2	295	313	PF00022	0.427
LIG_Actin_WH2_2	465	483	PF00022	0.430
LIG_APCC_ABBA_1	163	168	PF00400	0.549
LIG_BRCT_BRCA1_1	225	229	PF00533	0.334
LIG_Clathr_ClatBox_1	395	399	PF01394	0.444
LIG_Clathr_ClatBox_1	458	462	PF01394	0.444
LIG_CSL_BTD_1	102	105	PF09270	0.484
LIG_eIF4E_1	262	268	PF01652	0.423
LIG_eIF4E_1	439	445	PF01652	0.427
LIG_FHA_1	269	275	PF00498	0.334
LIG_FHA_1	348	354	PF00498	0.319
LIG_FHA_1	389	395	PF00498	0.314
LIG_FHA_2	170	176	PF00498	0.489
LIG_FHA_2	226	232	PF00498	0.432
LIG_FHA_2	383	389	PF00498	0.411
LIG_HCF-1_HBM_1	463	466	PF13415	0.444
LIG_LIR_Apic_2	359	365	PF02991	0.294
LIG_LIR_Gen_1	140	147	PF02991	0.522
LIG_LIR_Gen_1	179	188	PF02991	0.529
LIG_LIR_Gen_1	272	282	PF02991	0.378
LIG_LIR_Gen_1	463	474	PF02991	0.297
LIG_LIR_Nem_3	129	134	PF02991	0.414
LIG_LIR_Nem_3	140	144	PF02991	0.426
LIG_LIR_Nem_3	179	183	PF02991	0.492
LIG_LIR_Nem_3	259	263	PF02991	0.309
LIG_LIR_Nem_3	272	278	PF02991	0.346
LIG_LIR_Nem_3	463	469	PF02991	0.296
LIG_LIR_Nem_3	69	73	PF02991	0.731
LIG_PCNA_yPIPBox_3	298	307	PF02747	0.444
LIG_PCNA_yPIPBox_3	9	20	PF02747	0.519
LIG_Rb_pABgroove_1	114	122	PF01858	0.538
LIG_SH2_SRC	279	282	PF00017	0.427
LIG_SH2_STAP1	131	135	PF00017	0.295
LIG_SH2_STAP1	281	285	PF00017	0.406
LIG_SH2_STAT3	147	150	PF00017	0.546
LIG_SH2_STAT3	210	213	PF00017	0.460
LIG_SH2_STAT3	429	432	PF00017	0.211
LIG_SH2_STAT5	260	263	PF00017	0.336
LIG_SH2_STAT5	293	296	PF00017	0.308
LIG_SH2_STAT5	356	359	PF00017	0.305
LIG_SH2_STAT5	429	432	PF00017	0.353
LIG_SH2_STAT5	466	469	PF00017	0.334
LIG_SH3_3	191	197	PF00018	0.473
LIG_SH3_3	408	414	PF00018	0.349
LIG_SH3_3	446	452	PF00018	0.389
LIG_SH3_5	118	122	PF00018	0.520
LIG_SUMO_SIM_anti_2	265	272	PF11976	0.444
LIG_SUMO_SIM_par_1	265	272	PF11976	0.400
LIG_SUMO_SIM_par_1	339	346	PF11976	0.427
MOD_CK1_1	140	146	PF00069	0.562
MOD_CK1_1	400	406	PF00069	0.374
MOD_CK1_1	407	413	PF00069	0.325
MOD_CK1_1	59	65	PF00069	0.666
MOD_CK1_1	69	75	PF00069	0.688
MOD_CK2_1	101	107	PF00069	0.575
MOD_CK2_1	169	175	PF00069	0.453
MOD_CK2_1	382	388	PF00069	0.419
MOD_Cter_Amidation	50	53	PF01082	0.746
MOD_GlcNHglycan	4	7	PF01048	0.642
MOD_GlcNHglycan	482	485	PF01048	0.383
MOD_GSK3_1	199	206	PF00069	0.341
MOD_GSK3_1	343	350	PF00069	0.298
MOD_GSK3_1	352	359	PF00069	0.271
MOD_GSK3_1	378	385	PF00069	0.427
MOD_GSK3_1	400	407	PF00069	0.427
MOD_GSK3_1	424	431	PF00069	0.448
MOD_GSK3_1	491	498	PF00069	0.428
MOD_GSK3_1	56	63	PF00069	0.661
MOD_N-GLC_1	424	429	PF02516	0.444
MOD_NEK2_1	203	208	PF00069	0.379
MOD_NEK2_1	312	317	PF00069	0.400
MOD_NEK2_1	343	348	PF00069	0.319
MOD_NEK2_1	349	354	PF00069	0.319
MOD_NEK2_1	382	387	PF00069	0.384
MOD_NEK2_1	404	409	PF00069	0.350
MOD_NEK2_1	428	433	PF00069	0.374
MOD_NEK2_1	493	498	PF00069	0.456
MOD_NEK2_1	83	88	PF00069	0.560
MOD_NEK2_1	91	96	PF00069	0.468
MOD_PIKK_1	428	434	PF00454	0.333
MOD_PIKK_1	84	90	PF00454	0.564
MOD_PKA_2	223	229	PF00069	0.319
MOD_PKA_2	423	429	PF00069	0.317
MOD_PKA_2	480	486	PF00069	0.306
MOD_PKA_2	51	57	PF00069	0.717
MOD_PKA_2	59	65	PF00069	0.690
MOD_Plk_1	424	430	PF00069	0.444
MOD_Plk_4	137	143	PF00069	0.498
MOD_Plk_4	225	231	PF00069	0.444
MOD_Plk_4	352	358	PF00069	0.319
MOD_Plk_4	390	396	PF00069	0.411
MOD_Plk_4	400	406	PF00069	0.343
MOD_Plk_4	424	430	PF00069	0.407
MOD_ProDKin_1	101	107	PF00069	0.593
MOD_ProDKin_1	78	84	PF00069	0.583
MOD_SUMO_for_1	323	326	PF00179	0.294
MOD_SUMO_rev_2	174	180	PF00179	0.476
MOD_SUMO_rev_2	332	341	PF00179	0.312
TRG_DiLeu_BaEn_1	265	270	PF01217	0.444
TRG_DiLeu_BaEn_1	440	445	PF01217	0.355
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.444
TRG_ENDOCYTIC_2	260	263	PF00928	0.324
TRG_ENDOCYTIC_2	293	296	PF00928	0.292
TRG_ENDOCYTIC_2	466	469	PF00928	0.321
TRG_NLS_MonoExtC_3	48	53	PF00514	0.769
TRG_NLS_MonoExtN_4	46	53	PF00514	0.754

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D6	Leptomonas seymouri	33%	69%
A0A0N1IJ52	Leptomonas seymouri	64%	99%
A0A0N1PBM1	Leptomonas seymouri	31%	68%
A0A0S4IIU2	Bodo saltans	32%	100%
A0A0S4IUF2	Bodo saltans	32%	91%
A0A0S4IVF2	Bodo saltans	26%	100%
A0A0S4IYY9	Bodo saltans	26%	100%
A0A0S4J2K6	Bodo saltans	31%	100%
A0A0S4J343	Bodo saltans	45%	89%
A0A0S4JUY0	Bodo saltans	27%	84%
A0A0S4JZV2	Bodo saltans	27%	100%
A0A1X0NHA6	Trypanosomatidae	47%	95%
A0A1X0NQT9	Trypanosomatidae	28%	100%
A0A1X0P6U6	Trypanosomatidae	23%	100%
A0A3Q8IC55	Leishmania donovani	97%	100%
A0A3Q8ITZ9	Leishmania donovani	26%	100%
A0A3R7KRM5	Trypanosoma rangeli	35%	74%
A0A3R7MWP2	Trypanosoma rangeli	24%	100%
A0A3S5H6C8	Leishmania donovani	26%	100%
A0A3S5H7N7	Leishmania donovani	25%	100%
A0A3S7WQK7	Leishmania donovani	26%	100%
A0A3S7WR45	Leishmania donovani	28%	100%
A0A3S7WTA3	Leishmania donovani	31%	67%
A0A3S7X9D1	Leishmania donovani	30%	87%
A0A422N7C9	Trypanosoma rangeli	25%	80%
A0A422N878	Trypanosoma rangeli	47%	95%
A4H5L7	Leishmania braziliensis	26%	100%
A4H641	Leishmania braziliensis	29%	100%
A4HA94	Leishmania braziliensis	25%	100%
A4HC27	Leishmania braziliensis	88%	100%
A4HIM5	Leishmania braziliensis	26%	100%
A4HLJ9	Leishmania braziliensis	27%	100%
A4HMK7	Leishmania braziliensis	32%	87%
A4HTV4	Leishmania infantum	26%	100%
A4HTV5	Leishmania infantum	26%	100%
A4HUG1	Leishmania infantum	28%	100%
A4HWB5	Leishmania infantum	31%	67%
A4HZH0	Leishmania infantum	97%	100%
A4I5X0	Leishmania infantum	25%	100%
A4I910	Leishmania infantum	26%	100%
A4IB86	Leishmania infantum	30%	87%
B0Y4X4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	27%	100%
B6DTC0	Bodo saltans	27%	100%
C9ZNW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	73%
D0A0U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A105	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
E8NHK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AF07	Leishmania major	31%	87%
E9AMP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AN59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AQ15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	67%
E9AVG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B3X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B663	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	87%
F4HRJ4	Arabidopsis thaliana	25%	82%
G4N374	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	100%
O04160	Brassica napus	26%	100%
O13352	Magnaporthe oryzae	26%	100%
O35491	Mus musculus	26%	100%
O35492	Mus musculus	28%	78%
O35493	Mus musculus	26%	100%
P22518	Mus musculus	26%	100%
P40417	Drosophila melanogaster	28%	100%
P49759	Homo sapiens	26%	100%
P49760	Homo sapiens	26%	100%
P49761	Homo sapiens	28%	78%
P51566	Arabidopsis thaliana	27%	100%
P51567	Arabidopsis thaliana	28%	100%
P51568	Arabidopsis thaliana	26%	100%
Q06060	Pisum sativum	27%	100%
Q07176	Medicago sativa	26%	100%
Q07538	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q10156	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	72%
Q39023	Arabidopsis thaliana	26%	100%
Q39026	Arabidopsis thaliana	25%	100%
Q3SX21	Bos taurus	28%	100%
Q40531	Nicotiana tabacum	25%	100%
Q40532	Nicotiana tabacum	27%	100%
Q45FA5	Physarum polycephalum	24%	100%
Q4Q449	Leishmania major	26%	100%
Q4Q701	Leishmania major	26%	100%
Q4QFG6	Leishmania major	31%	96%
Q4QHG6	Leishmania major	28%	100%
Q4QHY3	Leishmania major	26%	100%
Q4QHY4	Leishmania major	26%	100%
Q4WQR3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	100%
Q5U4C9	Mus musculus	33%	83%
Q5VP69	Oryza sativa subsp. japonica	27%	100%
Q5ZCI1	Oryza sativa subsp. japonica	27%	82%
Q63117	Rattus norvegicus	28%	100%
Q84UI5	Oryza sativa subsp. japonica	26%	100%
Q8SQZ4	Encephalitozoon cuniculi (strain GB-M1)	29%	100%
Q90327	Cyprinus carpio	29%	100%
Q92630	Homo sapiens	33%	83%
Q9DGD9	Danio rerio	29%	100%
Q9HAZ1	Homo sapiens	26%	100%
Q9P6P3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	93%
V5AWK7	Trypanosoma cruzi	33%	73%
V5B8U8	Trypanosoma cruzi	24%	100%
V5BN23	Trypanosoma cruzi	24%	100%
V5DIC3	Trypanosoma cruzi	47%	83%