NopRA1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC17_LEIMA

TriTrypDb:

LmjF.21.1670 , LMJLV39_210026100 , LMJSD75_210026300

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	26	28	PF00082	0.619
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.557
CLV_PCSK_PC7_1	22	28	PF00082	0.388
CLV_PCSK_SKI1_1	22	26	PF00082	0.482
CLV_PCSK_SKI1_1	339	343	PF00082	0.492
CLV_PCSK_SKI1_1	357	361	PF00082	0.279
CLV_PCSK_SKI1_1	397	401	PF00082	0.466
CLV_PCSK_SKI1_1	85	89	PF00082	0.458
DEG_APCC_DBOX_1	356	364	PF00400	0.448
DEG_MDM2_SWIB_1	169	177	PF02201	0.476
DEG_Nend_UBRbox_2	1	3	PF02207	0.459
DOC_CKS1_1	31	36	PF01111	0.526
DOC_CYCLIN_RxL_1	394	405	PF00134	0.419
DOC_MAPK_gen_1	224	232	PF00069	0.450
DOC_MAPK_MEF2A_6	316	324	PF00069	0.448
DOC_MAPK_MEF2A_6	7	15	PF00069	0.448
DOC_PP1_RVXF_1	83	90	PF00149	0.466
DOC_PP2B_LxvP_1	88	91	PF13499	0.503
DOC_PP4_FxxP_1	135	138	PF00568	0.452
DOC_PP4_FxxP_1	77	80	PF00568	0.542
DOC_USP7_MATH_1	110	114	PF00917	0.522
DOC_USP7_MATH_1	126	130	PF00917	0.435
DOC_USP7_MATH_1	157	161	PF00917	0.506
DOC_USP7_MATH_1	256	260	PF00917	0.508
DOC_USP7_MATH_1	265	269	PF00917	0.570
DOC_USP7_MATH_1	380	384	PF00917	0.431
DOC_USP7_MATH_1	395	399	PF00917	0.543
DOC_USP7_MATH_1	431	435	PF00917	0.602
DOC_WW_Pin1_4	30	35	PF00397	0.442
DOC_WW_Pin1_4	309	314	PF00397	0.482
DOC_WW_Pin1_4	326	331	PF00397	0.243
DOC_WW_Pin1_4	348	353	PF00397	0.512
LIG_14-3-3_CanoR_1	216	221	PF00244	0.438
LIG_14-3-3_CanoR_1	273	281	PF00244	0.305
LIG_14-3-3_CanoR_1	307	313	PF00244	0.435
LIG_14-3-3_CanoR_1	316	321	PF00244	0.374
LIG_14-3-3_CanoR_1	409	414	PF00244	0.519
LIG_Actin_WH2_2	301	318	PF00022	0.459
LIG_BRCT_BRCA1_1	228	232	PF00533	0.436
LIG_deltaCOP1_diTrp_1	171	179	PF00928	0.488
LIG_FHA_1	172	178	PF00498	0.376
LIG_FHA_1	206	212	PF00498	0.458
LIG_FHA_1	217	223	PF00498	0.427
LIG_FHA_1	23	29	PF00498	0.549
LIG_FHA_1	273	279	PF00498	0.544
LIG_FHA_1	294	300	PF00498	0.529
LIG_FHA_1	301	307	PF00498	0.535
LIG_FHA_1	317	323	PF00498	0.280
LIG_FHA_1	336	342	PF00498	0.262
LIG_FHA_1	45	51	PF00498	0.524
LIG_FHA_2	348	354	PF00498	0.448
LIG_FHA_2	400	406	PF00498	0.522
LIG_FHA_2	410	416	PF00498	0.542
LIG_LIR_Apic_2	74	80	PF02991	0.532
LIG_LIR_Gen_1	171	181	PF02991	0.482
LIG_LIR_Gen_1	229	238	PF02991	0.395
LIG_LIR_Gen_1	276	286	PF02991	0.374
LIG_LIR_Gen_1	64	73	PF02991	0.385
LIG_LIR_Nem_3	171	176	PF02991	0.490
LIG_LIR_Nem_3	229	235	PF02991	0.374
LIG_LIR_Nem_3	276	282	PF02991	0.382
LIG_LIR_Nem_3	64	69	PF02991	0.382
LIG_Pex14_2	169	173	PF04695	0.486
LIG_Pex14_2	95	99	PF04695	0.462
LIG_Rb_pABgroove_1	147	155	PF01858	0.360
LIG_REV1ctd_RIR_1	334	343	PF16727	0.495
LIG_SH2_NCK_1	198	202	PF00017	0.396
LIG_SH2_STAT5	198	201	PF00017	0.357
LIG_SH2_STAT5	234	237	PF00017	0.498
LIG_SH3_3	206	212	PF00018	0.448
LIG_SH3_3	57	63	PF00018	0.322
LIG_SUMO_SIM_anti_2	240	245	PF11976	0.462
LIG_SUMO_SIM_anti_2	434	441	PF11976	0.609
LIG_SUMO_SIM_par_1	207	213	PF11976	0.469
LIG_TRAF2_1	389	392	PF00917	0.421
MOD_CDK_SPxxK_3	309	316	PF00069	0.445
MOD_CK1_1	113	119	PF00069	0.491
MOD_CK1_1	284	290	PF00069	0.474
MOD_CK1_1	309	315	PF00069	0.484
MOD_CK1_1	335	341	PF00069	0.350
MOD_CK1_1	383	389	PF00069	0.498
MOD_CK1_1	435	441	PF00069	0.631
MOD_CK1_1	81	87	PF00069	0.562
MOD_CK2_1	399	405	PF00069	0.499
MOD_CK2_1	409	415	PF00069	0.547
MOD_GlcNHglycan	102	105	PF01048	0.464
MOD_GlcNHglycan	159	162	PF01048	0.562
MOD_GlcNHglycan	201	204	PF01048	0.374
MOD_GlcNHglycan	212	215	PF01048	0.452
MOD_GlcNHglycan	283	286	PF01048	0.493
MOD_GlcNHglycan	386	389	PF01048	0.564
MOD_GlcNHglycan	434	437	PF01048	0.608
MOD_GSK3_1	106	113	PF00069	0.464
MOD_GSK3_1	18	25	PF00069	0.482
MOD_GSK3_1	281	288	PF00069	0.418
MOD_GSK3_1	307	314	PF00069	0.541
MOD_GSK3_1	380	387	PF00069	0.397
MOD_GSK3_1	395	402	PF00069	0.413
MOD_GSK3_1	431	438	PF00069	0.607
MOD_N-GLC_1	11	16	PF02516	0.563
MOD_N-GLC_1	162	167	PF02516	0.553
MOD_N-GLC_1	196	201	PF02516	0.520
MOD_N-GLC_1	332	337	PF02516	0.426
MOD_NEK2_1	281	286	PF00069	0.509
MOD_NEK2_1	308	313	PF00069	0.476
MOD_NEK2_1	315	320	PF00069	0.368
MOD_NEK2_1	332	337	PF00069	0.285
MOD_NEK2_1	369	374	PF00069	0.452
MOD_NEK2_1	384	389	PF00069	0.312
MOD_NEK2_1	399	404	PF00069	0.433
MOD_NEK2_1	408	413	PF00069	0.537
MOD_NEK2_2	395	400	PF00069	0.439
MOD_PIKK_1	285	291	PF00454	0.422
MOD_PIKK_1	419	425	PF00454	0.502
MOD_PIKK_1	75	81	PF00454	0.540
MOD_PK_1	237	243	PF00069	0.448
MOD_PKA_2	272	278	PF00069	0.319
MOD_PKA_2	306	312	PF00069	0.496
MOD_PKA_2	315	321	PF00069	0.385
MOD_PKA_2	408	414	PF00069	0.536
MOD_PKA_2	419	425	PF00069	0.414
MOD_PKA_2	81	87	PF00069	0.525
MOD_Plk_1	11	17	PF00069	0.463
MOD_Plk_1	162	168	PF00069	0.551
MOD_Plk_1	181	187	PF00069	0.359
MOD_Plk_1	196	202	PF00069	0.484
MOD_Plk_1	226	232	PF00069	0.522
MOD_Plk_1	332	338	PF00069	0.477
MOD_Plk_4	172	178	PF00069	0.401
MOD_Plk_4	257	263	PF00069	0.462
MOD_Plk_4	332	338	PF00069	0.355
MOD_Plk_4	380	386	PF00069	0.376
MOD_Plk_4	435	441	PF00069	0.615
MOD_ProDKin_1	30	36	PF00069	0.443
MOD_ProDKin_1	309	315	PF00069	0.474
MOD_ProDKin_1	326	332	PF00069	0.242
MOD_ProDKin_1	348	354	PF00069	0.512
MOD_SUMO_rev_2	156	166	PF00179	0.511
MOD_SUMO_rev_2	81	87	PF00179	0.492
TRG_DiLeu_BaEn_2	130	136	PF01217	0.494
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.375
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.436
TRG_DiLeu_LyEn_5	189	194	PF01217	0.465
TRG_ER_diArg_1	215	218	PF00400	0.449
TRG_NES_CRM1_1	4	17	PF08389	0.458
TRG_Pf-PMV_PEXEL_1	51	56	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1III8	Leptomonas seymouri	59%	100%
A0A1X0NJ75	Trypanosomatidae	35%	100%
A0A3Q8IC10	Leishmania donovani	93%	100%
A0A3S5IQQ3	Trypanosoma rangeli	34%	100%
A4HC29	Leishmania braziliensis	82%	99%
A4HZH2	Leishmania infantum	94%	100%
D0A102	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AVG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BRG3	Trypanosoma cruzi	34%	100%