MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC16_LEIMA

TriTrypDb:

LmjF.21.1675 , LMJLV39_210026200 , LMJSD75_210026400

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC16

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.722
CLV_PCSK_KEX2_1	41	43	PF00082	0.644
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.576
CLV_PCSK_SKI1_1	56	60	PF00082	0.737
DEG_Nend_UBRbox_2	1	3	PF02207	0.632
DOC_CKS1_1	91	96	PF01111	0.492
DOC_MAPK_gen_1	41	48	PF00069	0.667
DOC_MAPK_HePTP_8	38	50	PF00069	0.559
DOC_MAPK_MEF2A_6	41	50	PF00069	0.677
DOC_PP2B_LxvP_1	52	55	PF13499	0.648
DOC_PP4_FxxP_1	107	110	PF00568	0.466
DOC_USP7_MATH_1	68	72	PF00917	0.545
DOC_USP7_MATH_1	84	88	PF00917	0.758
DOC_WW_Pin1_4	90	95	PF00397	0.523
LIG_14-3-3_CanoR_1	35	39	PF00244	0.518
LIG_14-3-3_CanoR_1	42	47	PF00244	0.544
LIG_14-3-3_CanoR_1	70	76	PF00244	0.725
LIG_FHA_2	14	20	PF00498	0.602
LIG_FHA_2	57	63	PF00498	0.768
LIG_LIR_Gen_1	97	102	PF02991	0.572
LIG_LIR_Nem_3	97	101	PF02991	0.568
LIG_SH2_CRK	98	102	PF00017	0.577
LIG_SH2_STAT3	138	141	PF00017	0.621
LIG_SH2_STAT5	117	120	PF00017	0.417
LIG_SH2_STAT5	138	141	PF00017	0.621
LIG_SH2_STAT5	98	101	PF00017	0.448
LIG_SH3_3	76	82	PF00018	0.719
LIG_SH3_3	88	94	PF00018	0.594
LIG_SH3_5	94	98	PF00018	0.511
LIG_SUMO_SIM_anti_2	33	40	PF11976	0.399
LIG_TRAF2_1	75	78	PF00917	0.565
MOD_CK1_1	34	40	PF00069	0.594
MOD_CK2_1	13	19	PF00069	0.525
MOD_CK2_1	34	40	PF00069	0.513
MOD_CK2_1	72	78	PF00069	0.729
MOD_GlcNHglycan	118	121	PF01048	0.557
MOD_GlcNHglycan	86	89	PF01048	0.718
MOD_GSK3_1	68	75	PF00069	0.595
MOD_N-GLC_1	84	89	PF02516	0.763
MOD_NEK2_1	100	105	PF00069	0.587
MOD_NEK2_1	13	18	PF00069	0.517
MOD_NEK2_1	50	55	PF00069	0.613
MOD_PKA_1	41	47	PF00069	0.592
MOD_PKA_1	56	62	PF00069	0.439
MOD_PKA_2	34	40	PF00069	0.546
MOD_PKA_2	41	47	PF00069	0.560
MOD_PKA_2	69	75	PF00069	0.725
MOD_Plk_4	34	40	PF00069	0.439
MOD_ProDKin_1	90	96	PF00069	0.507
TRG_ENDOCYTIC_2	98	101	PF00928	0.573
TRG_ER_diArg_1	125	128	PF00400	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU38	Leptomonas seymouri	37%	98%
A0A3Q8IAH7	Leishmania donovani	93%	100%
A0A422N8B7	Trypanosoma rangeli	32%	100%
A4HC30	Leishmania braziliensis	67%	97%
A4HZH3	Leishmania infantum	91%	100%
E9AVG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%