Putative pumillio protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumillio protein 3, putative

Species:

Leishmania major

UniProt:

Q4QC15_LEIMA

TriTrypDb:

LmjF.21.1680 , LMJLV39_210026300 , LMJSD75_210026500

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC15

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.689
CLV_NRD_NRD_1	116	118	PF00675	0.600
CLV_NRD_NRD_1	134	136	PF00675	0.496
CLV_NRD_NRD_1	514	516	PF00675	0.492
CLV_PCSK_KEX2_1	101	103	PF00082	0.689
CLV_PCSK_KEX2_1	136	138	PF00082	0.568
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.587
CLV_PCSK_SKI1_1	314	318	PF00082	0.288
CLV_PCSK_SKI1_1	373	377	PF00082	0.314
DEG_SCF_FBW7_1	278	285	PF00400	0.247
DOC_CDC14_PxL_1	414	422	PF14671	0.307
DOC_CKS1_1	48	53	PF01111	0.515
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.729
DOC_MAPK_MEF2A_6	407	416	PF00069	0.291
DOC_PP2B_LxvP_1	88	91	PF13499	0.734
DOC_PP4_FxxP_1	48	51	PF00568	0.557
DOC_PP4_FxxP_1	522	525	PF00568	0.545
DOC_USP7_MATH_1	80	84	PF00917	0.649
DOC_USP7_MATH_1	91	95	PF00917	0.503
DOC_USP7_UBL2_3	36	40	PF12436	0.607
DOC_USP7_UBL2_3	505	509	PF12436	0.338
DOC_WW_Pin1_4	128	133	PF00397	0.621
DOC_WW_Pin1_4	278	283	PF00397	0.247
DOC_WW_Pin1_4	366	371	PF00397	0.307
DOC_WW_Pin1_4	47	52	PF00397	0.542
DOC_WW_Pin1_4	537	542	PF00397	0.677
DOC_WW_Pin1_4	545	550	PF00397	0.635
DOC_WW_Pin1_4	58	63	PF00397	0.540
DOC_WW_Pin1_4	76	81	PF00397	0.432
DOC_WW_Pin1_4	94	99	PF00397	0.596
LIG_14-3-3_CanoR_1	342	351	PF00244	0.346
LIG_Actin_WH2_2	425	440	PF00022	0.247
LIG_AP2alpha_2	390	392	PF02296	0.247
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BIR_III_4	318	322	PF00653	0.263
LIG_BRCT_BRCA1_1	184	188	PF00533	0.428
LIG_BRCT_BRCA1_1	44	48	PF00533	0.548
LIG_EH1_1	285	293	PF00400	0.247
LIG_FHA_1	125	131	PF00498	0.683
LIG_FHA_1	160	166	PF00498	0.418
LIG_FHA_1	283	289	PF00498	0.235
LIG_FHA_1	344	350	PF00498	0.437
LIG_FHA_1	409	415	PF00498	0.309
LIG_FHA_1	66	72	PF00498	0.660
LIG_FHA_2	2	8	PF00498	0.551
LIG_FHA_2	203	209	PF00498	0.337
LIG_FHA_2	219	225	PF00498	0.359
LIG_FHA_2	295	301	PF00498	0.307
LIG_FHA_2	53	59	PF00498	0.603
LIG_LIR_Apic_2	45	51	PF02991	0.559
LIG_LIR_Gen_1	12	22	PF02991	0.622
LIG_LIR_Gen_1	244	255	PF02991	0.247
LIG_LIR_Gen_1	83	92	PF02991	0.593
LIG_LIR_Nem_3	12	18	PF02991	0.585
LIG_LIR_Nem_3	244	250	PF02991	0.276
LIG_LIR_Nem_3	338	344	PF02991	0.235
LIG_LIR_Nem_3	390	395	PF02991	0.237
LIG_LIR_Nem_3	464	469	PF02991	0.235
LIG_LIR_Nem_3	83	88	PF02991	0.553
LIG_MAD2	435	443	PF02301	0.282
LIG_MLH1_MIPbox_1	184	188	PF16413	0.428
LIG_PCNA_yPIPBox_3	317	329	PF02747	0.235
LIG_PTB_Apo_2	496	503	PF02174	0.335
LIG_PTB_Phospho_1	496	502	PF10480	0.341
LIG_Rb_pABgroove_1	250	258	PF01858	0.247
LIG_SH2_CRK	341	345	PF00017	0.285
LIG_SH2_GRB2like	15	18	PF00017	0.617
LIG_SH2_GRB2like	247	250	PF00017	0.247
LIG_SH2_NCK_1	565	569	PF00017	0.499
LIG_SH2_NCK_1	92	96	PF00017	0.597
LIG_SH2_STAP1	247	251	PF00017	0.294
LIG_SH2_STAP1	502	506	PF00017	0.344
LIG_SH2_STAT3	111	114	PF00017	0.596
LIG_SH2_STAT3	395	398	PF00017	0.235
LIG_SH2_STAT3	469	472	PF00017	0.235
LIG_SH2_STAT5	187	190	PF00017	0.566
LIG_SH2_STAT5	214	217	PF00017	0.402
LIG_SH2_STAT5	24	27	PF00017	0.626
LIG_SH2_STAT5	339	342	PF00017	0.299
LIG_SH2_STAT5	395	398	PF00017	0.235
LIG_SH2_STAT5	399	402	PF00017	0.235
LIG_SH2_STAT5	41	44	PF00017	0.555
LIG_SH2_STAT5	469	472	PF00017	0.235
LIG_SH2_STAT5	555	558	PF00017	0.647
LIG_SH2_STAT5	92	95	PF00017	0.684
LIG_SH3_3	267	273	PF00018	0.285
LIG_SH3_3	385	391	PF00018	0.296
LIG_SH3_3	486	492	PF00018	0.244
LIG_SH3_3	69	75	PF00018	0.670
LIG_SH3_4	36	43	PF00018	0.564
LIG_SUMO_SIM_par_1	276	281	PF11976	0.330
LIG_TRAF2_1	297	300	PF00917	0.214
MOD_CDC14_SPxK_1	61	64	PF00782	0.521
MOD_CDK_SPK_2	366	371	PF00069	0.372
MOD_CDK_SPxK_1	58	64	PF00069	0.653
MOD_CDK_SPxxK_3	128	135	PF00069	0.585
MOD_CDK_SPxxK_3	366	373	PF00069	0.341
MOD_CDK_SPxxK_3	537	544	PF00069	0.703
MOD_CDK_SPxxK_3	94	101	PF00069	0.690
MOD_CK1_1	124	130	PF00069	0.590
MOD_CK1_1	178	184	PF00069	0.556
MOD_CK1_1	35	41	PF00069	0.650
MOD_CK1_1	52	58	PF00069	0.610
MOD_CK1_1	537	543	PF00069	0.688
MOD_CK1_1	84	90	PF00069	0.649
MOD_CK1_1	94	100	PF00069	0.607
MOD_CK2_1	1	7	PF00069	0.636
MOD_CK2_1	120	126	PF00069	0.629
MOD_CK2_1	293	299	PF00069	0.236
MOD_CK2_1	52	58	PF00069	0.589
MOD_GlcNHglycan	111	114	PF01048	0.669
MOD_GlcNHglycan	179	183	PF01048	0.607
MOD_GlcNHglycan	189	192	PF01048	0.454
MOD_GlcNHglycan	440	443	PF01048	0.296
MOD_GlcNHglycan	536	539	PF01048	0.721
MOD_GlcNHglycan	93	96	PF01048	0.614
MOD_GSK3_1	120	127	PF00069	0.545
MOD_GSK3_1	178	185	PF00069	0.645
MOD_GSK3_1	187	194	PF00069	0.490
MOD_GSK3_1	278	285	PF00069	0.253
MOD_GSK3_1	28	35	PF00069	0.640
MOD_GSK3_1	343	350	PF00069	0.387
MOD_GSK3_1	533	540	PF00069	0.655
MOD_GSK3_1	74	81	PF00069	0.609
MOD_GSK3_1	90	97	PF00069	0.489
MOD_N-GLC_1	107	112	PF02516	0.621
MOD_N-GLC_1	408	413	PF02516	0.370
MOD_N-GLC_1	81	86	PF02516	0.658
MOD_NEK2_1	1	6	PF00069	0.615
MOD_NEK2_1	107	112	PF00069	0.675
MOD_NEK2_1	291	296	PF00069	0.247
MOD_NEK2_1	67	72	PF00069	0.563
MOD_PIKK_1	159	165	PF00454	0.479
MOD_PIKK_1	42	48	PF00454	0.550
MOD_Plk_1	28	34	PF00069	0.703
MOD_Plk_1	408	414	PF00069	0.424
MOD_Plk_1	81	87	PF00069	0.645
MOD_ProDKin_1	128	134	PF00069	0.620
MOD_ProDKin_1	278	284	PF00069	0.247
MOD_ProDKin_1	366	372	PF00069	0.307
MOD_ProDKin_1	47	53	PF00069	0.535
MOD_ProDKin_1	537	543	PF00069	0.677
MOD_ProDKin_1	545	551	PF00069	0.636
MOD_ProDKin_1	58	64	PF00069	0.541
MOD_ProDKin_1	76	82	PF00069	0.432
MOD_ProDKin_1	94	100	PF00069	0.597
MOD_SUMO_rev_2	110	119	PF00179	0.593
MOD_SUMO_rev_2	402	408	PF00179	0.347
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.466
TRG_ENDOCYTIC_2	15	18	PF00928	0.617
TRG_ENDOCYTIC_2	247	250	PF00928	0.275
TRG_ENDOCYTIC_2	341	344	PF00928	0.272
TRG_ER_diArg_1	198	201	PF00400	0.507
TRG_NLS_Bipartite_1	117	139	PF00514	0.553
TRG_NLS_MonoExtN_4	132	139	PF00514	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC50	Leptomonas seymouri	72%	99%
A0A0S4IY52	Bodo saltans	48%	80%
A0A0S4JMB8	Bodo saltans	31%	81%
A0A1X0NHM5	Trypanosomatidae	57%	100%
A0A3S7WWX7	Leishmania donovani	93%	100%
A0A422N8V0	Trypanosoma rangeli	53%	100%
A4HC32	Leishmania braziliensis	83%	99%
A4HZH4	Leishmania infantum	93%	100%
D0A0Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
E9AVG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P39016	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	66%
V5B1W9	Trypanosoma cruzi	54%	100%