Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC10_LEIMA

TriTrypDb:

LmjF.21.1730 , LMJLV39_210026800 , LMJSD75_210027000

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QC10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.520
CLV_C14_Caspase3-7	98	102	PF00656	0.656
CLV_NRD_NRD_1	11	13	PF00675	0.568
CLV_NRD_NRD_1	129	131	PF00675	0.491
CLV_NRD_NRD_1	25	27	PF00675	0.468
CLV_NRD_NRD_1	66	68	PF00675	0.433
CLV_PCSK_KEX2_1	121	123	PF00082	0.552
CLV_PCSK_KEX2_1	27	29	PF00082	0.594
CLV_PCSK_KEX2_1	55	57	PF00082	0.544
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.552
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.565
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.544
CLV_PCSK_SKI1_1	121	125	PF00082	0.533
CLV_PCSK_SKI1_1	151	155	PF00082	0.597
CLV_PCSK_SKI1_1	31	35	PF00082	0.486
DEG_APCC_DBOX_1	150	158	PF00400	0.433
DEG_APCC_DBOX_1	47	55	PF00400	0.365
DOC_PP1_RVXF_1	29	36	PF00149	0.488
DOC_PP2B_LxvP_1	123	126	PF13499	0.539
DOC_PP4_FxxP_1	59	62	PF00568	0.454
DOC_USP7_MATH_1	8	12	PF00917	0.556
DOC_USP7_MATH_1	99	103	PF00917	0.610
DOC_USP7_UBL2_3	13	17	PF12436	0.576
DOC_USP7_UBL2_3	132	136	PF12436	0.683
DOC_USP7_UBL2_3	27	31	PF12436	0.428
DOC_WW_Pin1_4	87	92	PF00397	0.587
LIG_Actin_WH2_2	40	57	PF00022	0.461
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BRCT_BRCA1_1	10	14	PF00533	0.590
LIG_FHA_1	34	40	PF00498	0.472
LIG_FHA_1	88	94	PF00498	0.691
LIG_FHA_2	1	7	PF00498	0.722
LIG_FHA_2	114	120	PF00498	0.545
LIG_SH3_4	132	139	PF00018	0.549
LIG_TRAF2_1	86	89	PF00917	0.641
LIG_WRC_WIRS_1	163	168	PF05994	0.523
MOD_CK2_1	113	119	PF00069	0.696
MOD_GlcNHglycan	109	112	PF01048	0.567
MOD_GlcNHglycan	97	100	PF01048	0.595
MOD_GSK3_1	107	114	PF00069	0.709
MOD_GSK3_1	162	169	PF00069	0.528
MOD_GSK3_1	33	40	PF00069	0.557
MOD_GSK3_1	95	102	PF00069	0.595
MOD_NEK2_1	166	171	PF00069	0.652
MOD_PKA_2	37	43	PF00069	0.538
MOD_Plk_2-3	101	107	PF00069	0.619
MOD_Plk_2-3	162	168	PF00069	0.461
MOD_Plk_4	162	168	PF00069	0.562
MOD_ProDKin_1	87	93	PF00069	0.588
MOD_SUMO_for_1	86	89	PF00179	0.504
MOD_SUMO_rev_2	118	123	PF00179	0.591
MOD_SUMO_rev_2	77	86	PF00179	0.534
TRG_DiLeu_BaEn_1	66	71	PF01217	0.406
TRG_ER_diArg_1	56	59	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NH88	Trypanosomatidae	37%	97%
A0A3S7WWT3	Leishmania donovani	88%	100%
A0A422N8U7	Trypanosoma rangeli	36%	98%
A4HC37	Leishmania braziliensis	72%	100%
A4HZH9	Leishmania infantum	88%	100%
D0A0Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	82%
E9AVG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%