Putative mitochondrial poly(A) polymerase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA polymerase II, putative

Species:

Leishmania major

UniProt:

Q4QC09_LEIMA

TriTrypDb:

LmjF.21.1740 , LMJLV39_210026900 , LMJSD75_210027100

Length:

382

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	14
GO:0005737	cytoplasm	2	12
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QC09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC09

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	14
GO:0006378	mRNA polyadenylation	7	2
GO:0006396	RNA processing	6	14
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016070	RNA metabolic process	5	14
GO:0016071	mRNA metabolic process	6	2
GO:0031123	RNA 3'-end processing	7	14
GO:0031124	mRNA 3'-end processing	8	2
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043631	RNA polyadenylation	6	2
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0046483	heterocycle metabolic process	3	14
GO:0071076	RNA 3' uridylation	8	14
GO:0071704	organic substance metabolic process	2	14
GO:0090304	nucleic acid metabolic process	4	14
GO:1901360	organic cyclic compound metabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	5
GO:0005488	binding	1	9
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016779	nucleotidyltransferase activity	4	14
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0050265	RNA uridylyltransferase activity	4	14
GO:0070566	adenylyltransferase activity	5	5
GO:0070569	uridylyltransferase activity	5	14
GO:0140098	catalytic activity, acting on RNA	3	14
GO:0140640	catalytic activity, acting on a nucleic acid	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.450
CLV_NRD_NRD_1	130	132	PF00675	0.500
CLV_NRD_NRD_1	15	17	PF00675	0.652
CLV_NRD_NRD_1	155	157	PF00675	0.468
CLV_NRD_NRD_1	210	212	PF00675	0.422
CLV_NRD_NRD_1	371	373	PF00675	0.460
CLV_NRD_NRD_1	49	51	PF00675	0.415
CLV_PCSK_KEX2_1	132	134	PF00082	0.408
CLV_PCSK_KEX2_1	15	17	PF00082	0.674
CLV_PCSK_KEX2_1	210	212	PF00082	0.416
CLV_PCSK_KEX2_1	49	51	PF00082	0.427
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.484
CLV_PCSK_SKI1_1	232	236	PF00082	0.465
CLV_PCSK_SKI1_1	282	286	PF00082	0.426
CLV_PCSK_SKI1_1	6	10	PF00082	0.379
DEG_APCC_DBOX_1	188	196	PF00400	0.463
DEG_APCC_DBOX_1	48	56	PF00400	0.433
DEG_Nend_UBRbox_2	1	3	PF02207	0.509
DOC_CKS1_1	291	296	PF01111	0.444
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.398
DOC_MAPK_gen_1	131	139	PF00069	0.499
DOC_MAPK_gen_1	143	151	PF00069	0.350
DOC_MAPK_gen_1	372	378	PF00069	0.476
DOC_MAPK_gen_1	68	77	PF00069	0.341
DOC_MAPK_MEF2A_6	164	171	PF00069	0.408
DOC_MAPK_NFAT4_5	164	172	PF00069	0.428
DOC_PP1_RVXF_1	350	357	PF00149	0.394
DOC_USP7_MATH_1	100	104	PF00917	0.512
DOC_USP7_MATH_1	248	252	PF00917	0.490
DOC_USP7_MATH_1	253	257	PF00917	0.506
DOC_USP7_MATH_1	78	82	PF00917	0.480
DOC_USP7_UBL2_3	66	70	PF12436	0.658
DOC_WW_Pin1_4	212	217	PF00397	0.386
DOC_WW_Pin1_4	290	295	PF00397	0.436
DOC_WW_Pin1_4	70	75	PF00397	0.552
LIG_14-3-3_CanoR_1	10	15	PF00244	0.641
LIG_14-3-3_CanoR_1	131	141	PF00244	0.504
LIG_14-3-3_CanoR_1	232	238	PF00244	0.512
LIG_14-3-3_CanoR_1	311	318	PF00244	0.364
LIG_14-3-3_CanoR_1	35	42	PF00244	0.441
LIG_Actin_RPEL_3	321	340	PF02755	0.218
LIG_Actin_WH2_2	162	177	PF00022	0.437
LIG_AP2alpha_2	343	345	PF02296	0.373
LIG_BRCT_BRCA1_1	123	127	PF00533	0.497
LIG_BRCT_BRCA1_1	161	165	PF00533	0.505
LIG_BRCT_BRCA1_1	352	356	PF00533	0.397
LIG_FHA_2	250	256	PF00498	0.496
LIG_LIR_Gen_1	283	291	PF02991	0.324
LIG_LIR_Gen_1	316	325	PF02991	0.387
LIG_LIR_Gen_1	329	339	PF02991	0.233
LIG_LIR_Gen_1	377	382	PF02991	0.539
LIG_LIR_Nem_3	124	130	PF02991	0.473
LIG_LIR_Nem_3	220	226	PF02991	0.349
LIG_LIR_Nem_3	283	288	PF02991	0.334
LIG_LIR_Nem_3	316	321	PF02991	0.387
LIG_LIR_Nem_3	329	334	PF02991	0.233
LIG_LIR_Nem_3	377	382	PF02991	0.539
LIG_LIR_Nem_3	98	102	PF02991	0.370
LIG_NRBOX	51	57	PF00104	0.456
LIG_Pex14_1	213	217	PF04695	0.367
LIG_REV1ctd_RIR_1	354	362	PF16727	0.408
LIG_SH2_CRK	291	295	PF00017	0.398
LIG_SH2_CRK	42	46	PF00017	0.509
LIG_SH2_CRK	79	83	PF00017	0.441
LIG_SH2_STAP1	217	221	PF00017	0.349
LIG_SH2_STAP1	42	46	PF00017	0.492
LIG_SH2_STAT5	154	157	PF00017	0.479
LIG_SH2_STAT5	223	226	PF00017	0.324
LIG_SH2_STAT5	95	98	PF00017	0.432
LIG_SH3_3	341	347	PF00018	0.366
LIG_SH3_3	72	78	PF00018	0.518
LIG_SH3_3	94	100	PF00018	0.440
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.444
LIG_SUMO_SIM_par_1	276	281	PF11976	0.274
LIG_SUMO_SIM_par_1	302	308	PF11976	0.320
LIG_SUMO_SIM_par_1	337	343	PF11976	0.352
LIG_TRAF2_1	158	161	PF00917	0.617
LIG_TRAF2_1	271	274	PF00917	0.467
LIG_TRAF2_2	271	276	PF00917	0.523
LIG_TYR_ITIM	77	82	PF00017	0.478
LIG_UBA3_1	126	132	PF00899	0.462
LIG_UBA3_1	221	228	PF00899	0.394
MOD_CK1_1	103	109	PF00069	0.601
MOD_CK1_1	81	87	PF00069	0.457
MOD_CK2_1	132	138	PF00069	0.534
MOD_CK2_1	155	161	PF00069	0.530
MOD_CK2_1	233	239	PF00069	0.491
MOD_CK2_1	249	255	PF00069	0.440
MOD_GlcNHglycan	108	111	PF01048	0.522
MOD_GlcNHglycan	157	160	PF01048	0.593
MOD_GlcNHglycan	161	164	PF01048	0.482
MOD_GlcNHglycan	31	35	PF01048	0.537
MOD_GlcNHglycan	367	370	PF01048	0.477
MOD_GlcNHglycan	69	73	PF01048	0.596
MOD_GlcNHglycan	83	86	PF01048	0.385
MOD_GSK3_1	102	109	PF00069	0.548
MOD_GSK3_1	121	128	PF00069	0.422
MOD_GSK3_1	155	162	PF00069	0.570
MOD_GSK3_1	20	27	PF00069	0.475
MOD_GSK3_1	249	256	PF00069	0.453
MOD_GSK3_1	346	353	PF00069	0.475
MOD_GSK3_1	6	13	PF00069	0.507
MOD_NEK2_1	165	170	PF00069	0.337
MOD_NEK2_1	174	179	PF00069	0.349
MOD_NEK2_1	227	232	PF00069	0.405
MOD_NEK2_1	299	304	PF00069	0.401
MOD_PIKK_1	240	246	PF00454	0.453
MOD_PIKK_1	35	41	PF00454	0.472
MOD_PKA_1	132	138	PF00069	0.504
MOD_PKA_2	106	112	PF00069	0.581
MOD_PKA_2	132	138	PF00069	0.417
MOD_PKA_2	155	161	PF00069	0.510
MOD_PKA_2	310	316	PF00069	0.428
MOD_PKB_1	309	317	PF00069	0.444
MOD_PKB_1	363	371	PF00069	0.272
MOD_Plk_1	165	171	PF00069	0.319
MOD_Plk_1	258	264	PF00069	0.514
MOD_Plk_1	299	305	PF00069	0.423
MOD_Plk_1	57	63	PF00069	0.432
MOD_Plk_4	174	180	PF00069	0.348
MOD_Plk_4	20	26	PF00069	0.554
MOD_Plk_4	217	223	PF00069	0.324
MOD_Plk_4	265	271	PF00069	0.509
MOD_Plk_4	299	305	PF00069	0.414
MOD_Plk_4	374	380	PF00069	0.468
MOD_Plk_4	78	84	PF00069	0.420
MOD_ProDKin_1	212	218	PF00069	0.382
MOD_ProDKin_1	290	296	PF00069	0.436
MOD_ProDKin_1	70	76	PF00069	0.540
TRG_DiLeu_BaEn_1	274	279	PF01217	0.288
TRG_DiLeu_BaEn_1	329	334	PF01217	0.398
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.506
TRG_ENDOCYTIC_2	42	45	PF00928	0.454
TRG_ENDOCYTIC_2	79	82	PF00928	0.441
TRG_ER_diArg_1	130	133	PF00400	0.457
TRG_ER_diArg_1	14	16	PF00400	0.679
TRG_ER_diArg_1	145	148	PF00400	0.411
TRG_ER_diArg_1	188	191	PF00400	0.391
TRG_ER_diArg_1	306	309	PF00400	0.403
TRG_ER_diArg_1	49	51	PF00400	0.483
TRG_NLS_MonoExtC_3	130	136	PF00514	0.343
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA71	Leptomonas seymouri	61%	100%
A0A0S4IUE3	Bodo saltans	35%	85%
A0A0S4IXY7	Bodo saltans	21%	100%
A0A1X0NI50	Trypanosomatidae	46%	100%
A0A1X0NT04	Trypanosomatidae	25%	100%
A0A3R7LQY4	Trypanosoma rangeli	27%	100%
A0A3R7M9K0	Trypanosoma rangeli	45%	100%
A0A3S7WWT5	Leishmania donovani	92%	100%
A4HC38	Leishmania braziliensis	80%	100%
A4HZI0	Leishmania infantum	92%	100%
D0A0Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AVH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O13833	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	94%
Q4Q530	Leishmania major	23%	100%
V5B3T6	Trypanosoma cruzi	27%	100%