Peroxisomal membrane protein PEX14

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxin 14, putative

Species:

Leishmania major

UniProt:

Q4QBZ9_LEIMA

TriTrypDb:

LmjF.21.1840 , LMJLV39_210027900 , LMJSD75_210028100

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0005778	peroxisomal membrane	6	7
GO:0016020	membrane	2	7
GO:0020015	glycosome	7	2
GO:0031090	organelle membrane	3	7
GO:0031903	microbody membrane	5	7
GO:0032991	protein-containing complex	1	2
GO:0042579	microbody	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0098588	bounding membrane of organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990351	transporter complex	2	2
GO:1990429	peroxisomal importomer complex	3	2

Expansion

Sequence features

Q4QBZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBZ9

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	7
GO:0009987	cellular process	1	7
GO:0016560	protein import into peroxisome matrix, docking	5	7
GO:0033036	macromolecule localization	2	7
GO:0051179	localization	1	7
GO:0051641	cellular localization	2	7
GO:0070727	cellular macromolecule localization	3	7

Molecular functions
Term	Name	Level	Count
GO:0005102	signaling receptor binding	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.711
CLV_C14_Caspase3-7	26	30	PF00656	0.520
CLV_NRD_NRD_1	182	184	PF00675	0.655
CLV_NRD_NRD_1	268	270	PF00675	0.526
CLV_PCSK_KEX2_1	182	184	PF00082	0.655
CLV_PCSK_KEX2_1	252	254	PF00082	0.538
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.541
CLV_PCSK_SKI1_1	262	266	PF00082	0.498
CLV_PCSK_SKI1_1	56	60	PF00082	0.353
CLV_PCSK_SKI1_1	69	73	PF00082	0.353
CLV_PCSK_SKI1_1	77	81	PF00082	0.518
DOC_ANK_TNKS_1	152	159	PF00023	0.550
DOC_CKS1_1	104	109	PF01111	0.550
DOC_MAPK_gen_1	269	277	PF00069	0.545
DOC_PP1_RVXF_1	146	153	PF00149	0.618
DOC_PP2B_LxvP_1	13	16	PF13499	0.705
DOC_PP2B_LxvP_1	223	226	PF13499	0.657
DOC_USP7_MATH_1	235	239	PF00917	0.698
DOC_USP7_MATH_1	351	355	PF00917	0.597
DOC_USP7_MATH_1	50	54	PF00917	0.367
DOC_USP7_UBL2_3	184	188	PF12436	0.671
DOC_WW_Pin1_4	103	108	PF00397	0.710
DOC_WW_Pin1_4	121	126	PF00397	0.572
DOC_WW_Pin1_4	134	139	PF00397	0.614
DOC_WW_Pin1_4	174	179	PF00397	0.572
DOC_WW_Pin1_4	213	218	PF00397	0.734
DOC_WW_Pin1_4	240	245	PF00397	0.713
DOC_WW_Pin1_4	376	381	PF00397	0.665
DOC_WW_Pin1_4	413	418	PF00397	0.746
DOC_WW_Pin1_4	422	427	PF00397	0.675
DOC_WW_Pin1_4	456	461	PF00397	0.770
DOC_WW_Pin1_4	46	51	PF00397	0.367
LIG_14-3-3_CanoR_1	145	151	PF00244	0.667
LIG_14-3-3_CanoR_1	182	191	PF00244	0.623
LIG_14-3-3_CanoR_1	193	201	PF00244	0.631
LIG_14-3-3_CanoR_1	295	303	PF00244	0.562
LIG_14-3-3_CanoR_1	352	360	PF00244	0.625
LIG_14-3-3_CanoR_1	77	84	PF00244	0.594
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BRCT_BRCA1_1	337	341	PF00533	0.769
LIG_EVH1_1	223	227	PF00568	0.649
LIG_EVH1_2	417	421	PF00568	0.543
LIG_FHA_1	128	134	PF00498	0.787
LIG_FHA_1	145	151	PF00498	0.522
LIG_FHA_1	246	252	PF00498	0.584
LIG_FHA_1	295	301	PF00498	0.565
LIG_FHA_1	423	429	PF00498	0.599
LIG_FHA_2	254	260	PF00498	0.531
LIG_FHA_2	322	328	PF00498	0.590
LIG_FHA_2	344	350	PF00498	0.723
LIG_FHA_2	434	440	PF00498	0.696
LIG_LIR_Apic_2	102	107	PF02991	0.549
LIG_LIR_Nem_3	149	155	PF02991	0.536
LIG_LIR_Nem_3	168	173	PF02991	0.429
LIG_LIR_Nem_3	338	344	PF02991	0.782
LIG_MLH1_MIPbox_1	337	341	PF16413	0.769
LIG_SH2_CRK	104	108	PF00017	0.550
LIG_SH2_SRC	427	430	PF00017	0.660
LIG_SH2_STAP1	129	133	PF00017	0.692
LIG_SH2_STAT5	129	132	PF00017	0.796
LIG_SH2_STAT5	340	343	PF00017	0.787
LIG_SH2_STAT5	427	430	PF00017	0.543
LIG_SH3_3	132	138	PF00018	0.730
LIG_SH3_3	17	23	PF00018	0.758
LIG_SH3_3	221	227	PF00018	0.678
LIG_SH3_3	3	9	PF00018	0.670
LIG_SH3_3	330	336	PF00018	0.668
LIG_SH3_3	369	375	PF00018	0.733
LIG_SH3_3	387	393	PF00018	0.761
LIG_SH3_3	411	417	PF00018	0.641
LIG_SH3_3	437	443	PF00018	0.753
LIG_SH3_3	84	90	PF00018	0.590
LIG_SUMO_SIM_par_1	443	449	PF11976	0.568
MOD_CDK_SPxK_1	213	219	PF00069	0.730
MOD_CK1_1	206	212	PF00069	0.819
MOD_CK1_1	240	246	PF00069	0.631
MOD_CK1_1	343	349	PF00069	0.764
MOD_CK1_1	359	365	PF00069	0.526
MOD_CK1_1	446	452	PF00069	0.570
MOD_CK2_1	174	180	PF00069	0.581
MOD_CK2_1	204	210	PF00069	0.688
MOD_CK2_1	21	27	PF00069	0.725
MOD_CK2_1	321	327	PF00069	0.584
MOD_CK2_1	343	349	PF00069	0.721
MOD_CK2_1	433	439	PF00069	0.768
MOD_CK2_1	46	52	PF00069	0.353
MOD_Cter_Amidation	311	314	PF01082	0.438
MOD_GlcNHglycan	108	111	PF01048	0.667
MOD_GlcNHglycan	167	170	PF01048	0.603
MOD_GlcNHglycan	206	209	PF01048	0.728
MOD_GlcNHglycan	239	242	PF01048	0.684
MOD_GlcNHglycan	277	280	PF01048	0.537
MOD_GlcNHglycan	315	318	PF01048	0.604
MOD_GlcNHglycan	35	38	PF01048	0.411
MOD_GlcNHglycan	353	356	PF01048	0.709
MOD_GlcNHglycan	361	364	PF01048	0.754
MOD_GlcNHglycan	448	451	PF01048	0.643
MOD_GSK3_1	204	211	PF00069	0.676
MOD_GSK3_1	29	36	PF00069	0.358
MOD_GSK3_1	336	343	PF00069	0.753
MOD_GSK3_1	351	358	PF00069	0.575
MOD_GSK3_1	361	368	PF00069	0.686
MOD_GSK3_1	376	383	PF00069	0.596
MOD_GSK3_1	456	463	PF00069	0.580
MOD_GSK3_1	46	53	PF00069	0.378
MOD_GSK3_1	99	106	PF00069	0.691
MOD_NEK2_1	275	280	PF00069	0.536
MOD_NEK2_1	421	426	PF00069	0.532
MOD_PIKK_1	127	133	PF00454	0.761
MOD_PIKK_1	294	300	PF00454	0.566
MOD_PIKK_1	319	325	PF00454	0.741
MOD_PIKK_1	4	10	PF00454	0.596
MOD_PIKK_1	50	56	PF00454	0.411
MOD_PK_1	83	89	PF00069	0.534
MOD_PKA_1	182	188	PF00069	0.665
MOD_PKA_1	313	319	PF00069	0.454
MOD_PKA_2	144	150	PF00069	0.663
MOD_PKA_2	182	188	PF00069	0.641
MOD_PKA_2	192	198	PF00069	0.620
MOD_PKA_2	294	300	PF00069	0.566
MOD_PKA_2	351	357	PF00069	0.618
MOD_Plk_1	30	36	PF00069	0.474
MOD_Plk_1	355	361	PF00069	0.700
MOD_Plk_1	380	386	PF00069	0.678
MOD_Plk_2-3	21	27	PF00069	0.491
MOD_Plk_2-3	306	312	PF00069	0.428
MOD_Plk_4	336	342	PF00069	0.723
MOD_ProDKin_1	103	109	PF00069	0.711
MOD_ProDKin_1	121	127	PF00069	0.568
MOD_ProDKin_1	134	140	PF00069	0.612
MOD_ProDKin_1	174	180	PF00069	0.581
MOD_ProDKin_1	213	219	PF00069	0.738
MOD_ProDKin_1	240	246	PF00069	0.705
MOD_ProDKin_1	376	382	PF00069	0.668
MOD_ProDKin_1	413	419	PF00069	0.747
MOD_ProDKin_1	422	428	PF00069	0.675
MOD_ProDKin_1	456	462	PF00069	0.770
MOD_ProDKin_1	46	52	PF00069	0.367
MOD_SUMO_rev_2	180	189	PF00179	0.662
MOD_SUMO_rev_2	249	254	PF00179	0.564
MOD_SUMO_rev_2	257	264	PF00179	0.564
MOD_SUMO_rev_2	306	315	PF00179	0.461
TRG_DiLeu_BaEn_4	249	255	PF01217	0.581
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.745
TRG_ENDOCYTIC_2	129	132	PF00928	0.778
TRG_ENDOCYTIC_2	170	173	PF00928	0.529
TRG_ER_diArg_1	181	183	PF00400	0.618
TRG_ER_diArg_1	198	201	PF00400	0.537
TRG_ER_diArg_1	44	47	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA53	Leptomonas seymouri	60%	95%
A0A3S7WWU5	Leishmania donovani	92%	100%
A4HLC6	Leishmania braziliensis	71%	100%
A4HZJ0	Leishmania infantum	92%	100%
E9AVI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%