Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBZ8_LEIMA

TriTrypDb:

LmjF.21.1850 , LMJLV39_210028000 , LMJSD75_210028200

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QBZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBZ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.375
CLV_C14_Caspase3-7	262	266	PF00656	0.363
CLV_NRD_NRD_1	156	158	PF00675	0.452
CLV_NRD_NRD_1	249	251	PF00675	0.413
CLV_NRD_NRD_1	283	285	PF00675	0.450
CLV_NRD_NRD_1	358	360	PF00675	0.475
CLV_NRD_NRD_1	385	387	PF00675	0.589
CLV_PCSK_FUR_1	117	121	PF00082	0.488
CLV_PCSK_KEX2_1	119	121	PF00082	0.435
CLV_PCSK_KEX2_1	156	158	PF00082	0.452
CLV_PCSK_KEX2_1	249	251	PF00082	0.413
CLV_PCSK_KEX2_1	27	29	PF00082	0.563
CLV_PCSK_KEX2_1	282	284	PF00082	0.475
CLV_PCSK_KEX2_1	358	360	PF00082	0.474
CLV_PCSK_KEX2_1	385	387	PF00082	0.601
CLV_PCSK_KEX2_1	621	623	PF00082	0.482
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.435
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.548
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.521
CLV_PCSK_PC7_1	354	360	PF00082	0.576
CLV_PCSK_SKI1_1	107	111	PF00082	0.529
CLV_PCSK_SKI1_1	144	148	PF00082	0.485
CLV_PCSK_SKI1_1	24	28	PF00082	0.533
CLV_PCSK_SKI1_1	325	329	PF00082	0.498
CLV_PCSK_SKI1_1	409	413	PF00082	0.547
CLV_PCSK_SKI1_1	542	546	PF00082	0.678
DEG_APCC_DBOX_1	43	51	PF00400	0.542
DEG_Nend_UBRbox_1	1	4	PF02207	0.472
DEG_SCF_FBW7_1	445	451	PF00400	0.537
DEG_SCF_TRCP1_1	491	496	PF00400	0.514
DEG_SPOP_SBC_1	402	406	PF00917	0.539
DOC_ANK_TNKS_1	282	289	PF00023	0.456
DOC_CKS1_1	108	113	PF01111	0.473
DOC_CKS1_1	445	450	PF01111	0.562
DOC_CYCLIN_RxL_1	406	417	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	169	175	PF00134	0.427
DOC_MAPK_gen_1	44	52	PF00069	0.546
DOC_MAPK_RevD_3	106	120	PF00069	0.452
DOC_MAPK_RevD_3	301	314	PF00069	0.418
DOC_PP2B_LxvP_1	225	228	PF13499	0.354
DOC_PP2B_LxvP_1	411	414	PF13499	0.527
DOC_PP2B_LxvP_1	50	53	PF13499	0.567
DOC_PP4_FxxP_1	173	176	PF00568	0.446
DOC_USP7_MATH_1	139	143	PF00917	0.325
DOC_USP7_MATH_1	391	395	PF00917	0.495
DOC_USP7_MATH_1	448	452	PF00917	0.611
DOC_USP7_MATH_1	456	460	PF00917	0.589
DOC_USP7_MATH_1	464	468	PF00917	0.568
DOC_USP7_MATH_1	548	552	PF00917	0.566
DOC_USP7_MATH_1	556	560	PF00917	0.545
DOC_USP7_MATH_1	581	585	PF00917	0.634
DOC_USP7_MATH_1	607	611	PF00917	0.438
DOC_WW_Pin1_4	107	112	PF00397	0.604
DOC_WW_Pin1_4	17	22	PF00397	0.554
DOC_WW_Pin1_4	171	176	PF00397	0.542
DOC_WW_Pin1_4	249	254	PF00397	0.464
DOC_WW_Pin1_4	414	419	PF00397	0.604
DOC_WW_Pin1_4	426	431	PF00397	0.536
DOC_WW_Pin1_4	444	449	PF00397	0.550
DOC_WW_Pin1_4	493	498	PF00397	0.667
DOC_WW_Pin1_4	552	557	PF00397	0.574
DOC_WW_Pin1_4	571	576	PF00397	0.648
DOC_WW_Pin1_4	61	66	PF00397	0.617
LIG_14-3-3_CanoR_1	138	148	PF00244	0.422
LIG_14-3-3_CanoR_1	401	411	PF00244	0.627
LIG_14-3-3_CanoR_1	425	429	PF00244	0.602
LIG_14-3-3_CanoR_1	449	453	PF00244	0.521
LIG_14-3-3_CanoR_1	66	75	PF00244	0.505
LIG_BRCT_BRCA1_1	495	499	PF00533	0.634
LIG_FHA_1	440	446	PF00498	0.788
LIG_FHA_1	514	520	PF00498	0.541
LIG_FHA_1	62	68	PF00498	0.578
LIG_FHA_2	252	258	PF00498	0.414
LIG_FHA_2	572	578	PF00498	0.534
LIG_Integrin_isoDGR_2	488	490	PF01839	0.585
LIG_LIR_Apic_2	170	176	PF02991	0.522
LIG_LIR_Gen_1	270	280	PF02991	0.357
LIG_LIR_Nem_3	270	276	PF02991	0.432
LIG_LIR_Nem_3	90	96	PF02991	0.505
LIG_MYND_1	301	305	PF01753	0.682
LIG_NRBOX	243	249	PF00104	0.356
LIG_NRBOX	592	598	PF00104	0.428
LIG_NRBOX	626	632	PF00104	0.504
LIG_Pex14_1	215	219	PF04695	0.321
LIG_SH2_PTP2	159	162	PF00017	0.482
LIG_SH2_SRC	159	162	PF00017	0.482
LIG_SH2_STAP1	632	636	PF00017	0.418
LIG_SH2_STAT3	45	48	PF00017	0.448
LIG_SH2_STAT3	98	101	PF00017	0.434
LIG_SH2_STAT5	159	162	PF00017	0.482
LIG_SH2_STAT5	218	221	PF00017	0.504
LIG_SH2_STAT5	96	99	PF00017	0.482
LIG_SH3_3	169	175	PF00018	0.497
LIG_SH3_3	188	194	PF00018	0.477
LIG_SH3_3	431	437	PF00018	0.556
LIG_SH3_3	442	448	PF00018	0.580
LIG_SH3_3	50	56	PF00018	0.512
LIG_SH3_3	575	581	PF00018	0.511
LIG_SUMO_SIM_anti_2	592	597	PF11976	0.494
LIG_SUMO_SIM_par_1	48	55	PF11976	0.576
LIG_TRAF2_1	102	105	PF00917	0.470
LIG_TRAF2_1	237	240	PF00917	0.381
LIG_TRAF2_1	259	262	PF00917	0.431
LIG_TRAF2_1	395	398	PF00917	0.667
LIG_TRAF2_1	87	90	PF00917	0.525
LIG_WRC_WIRS_1	129	134	PF05994	0.383
LIG_WRC_WIRS_1	230	235	PF05994	0.427
LIG_WRC_WIRS_1	273	278	PF05994	0.314
MOD_CDC14_SPxK_1	252	255	PF00782	0.451
MOD_CDK_SPK_2	17	22	PF00069	0.554
MOD_CDK_SPK_2	430	435	PF00069	0.628
MOD_CDK_SPK_2	444	449	PF00069	0.530
MOD_CDK_SPK_2	61	66	PF00069	0.617
MOD_CDK_SPxK_1	249	255	PF00069	0.458
MOD_CDK_SPxxK_3	17	24	PF00069	0.462
MOD_CK1_1	29	35	PF00069	0.737
MOD_CK1_1	295	301	PF00069	0.537
MOD_CK1_1	403	409	PF00069	0.490
MOD_CK1_1	438	444	PF00069	0.608
MOD_CK1_1	451	457	PF00069	0.603
MOD_CK1_1	476	482	PF00069	0.824
MOD_CK1_1	517	523	PF00069	0.641
MOD_CK1_1	563	569	PF00069	0.631
MOD_CK1_1	68	74	PF00069	0.462
MOD_CK2_1	196	202	PF00069	0.655
MOD_CK2_1	251	257	PF00069	0.532
MOD_CK2_1	391	397	PF00069	0.578
MOD_GlcNHglycan	141	144	PF01048	0.417
MOD_GlcNHglycan	148	151	PF01048	0.489
MOD_GlcNHglycan	199	202	PF01048	0.476
MOD_GlcNHglycan	244	247	PF01048	0.582
MOD_GlcNHglycan	28	31	PF01048	0.768
MOD_GlcNHglycan	289	293	PF01048	0.725
MOD_GlcNHglycan	306	309	PF01048	0.449
MOD_GlcNHglycan	38	42	PF01048	0.508
MOD_GlcNHglycan	387	390	PF01048	0.542
MOD_GlcNHglycan	392	396	PF01048	0.558
MOD_GlcNHglycan	459	462	PF01048	0.636
MOD_GlcNHglycan	484	487	PF01048	0.681
MOD_GlcNHglycan	491	494	PF01048	0.637
MOD_GlcNHglycan	504	507	PF01048	0.487
MOD_GlcNHglycan	609	612	PF01048	0.545
MOD_GSK3_1	11	18	PF00069	0.556
MOD_GSK3_1	167	174	PF00069	0.546
MOD_GSK3_1	193	200	PF00069	0.466
MOD_GSK3_1	249	256	PF00069	0.462
MOD_GSK3_1	288	295	PF00069	0.573
MOD_GSK3_1	401	408	PF00069	0.592
MOD_GSK3_1	424	431	PF00069	0.639
MOD_GSK3_1	435	442	PF00069	0.591
MOD_GSK3_1	444	451	PF00069	0.486
MOD_GSK3_1	471	478	PF00069	0.608
MOD_GSK3_1	489	496	PF00069	0.631
MOD_GSK3_1	513	520	PF00069	0.547
MOD_GSK3_1	548	555	PF00069	0.626
MOD_GSK3_1	556	563	PF00069	0.670
MOD_GSK3_1	61	68	PF00069	0.611
MOD_GSK3_1	630	637	PF00069	0.474
MOD_NEK2_1	515	520	PF00069	0.523
MOD_NEK2_1	630	635	PF00069	0.473
MOD_NEK2_2	11	16	PF00069	0.543
MOD_NEK2_2	548	553	PF00069	0.543
MOD_NEK2_2	568	573	PF00069	0.492
MOD_OFUCOSY	565	572	PF10250	0.471
MOD_PIKK_1	333	339	PF00454	0.484
MOD_PIKK_1	560	566	PF00454	0.577
MOD_PIKK_1	581	587	PF00454	0.511
MOD_PK_1	435	441	PF00069	0.540
MOD_PKA_1	385	391	PF00069	0.480
MOD_PKA_2	167	173	PF00069	0.510
MOD_PKA_2	36	42	PF00069	0.469
MOD_PKA_2	385	391	PF00069	0.480
MOD_PKA_2	400	406	PF00069	0.534
MOD_PKA_2	424	430	PF00069	0.596
MOD_PKA_2	448	454	PF00069	0.529
MOD_PKA_2	489	495	PF00069	0.514
MOD_PKA_2	65	71	PF00069	0.550
MOD_PKB_1	399	407	PF00069	0.476
MOD_Plk_1	11	17	PF00069	0.543
MOD_Plk_1	256	262	PF00069	0.410
MOD_Plk_1	464	470	PF00069	0.633
MOD_Plk_2-3	128	134	PF00069	0.385
MOD_Plk_2-3	345	351	PF00069	0.433
MOD_Plk_4	272	278	PF00069	0.405
MOD_ProDKin_1	107	113	PF00069	0.608
MOD_ProDKin_1	17	23	PF00069	0.552
MOD_ProDKin_1	171	177	PF00069	0.547
MOD_ProDKin_1	249	255	PF00069	0.458
MOD_ProDKin_1	414	420	PF00069	0.609
MOD_ProDKin_1	426	432	PF00069	0.538
MOD_ProDKin_1	444	450	PF00069	0.549
MOD_ProDKin_1	493	499	PF00069	0.668
MOD_ProDKin_1	552	558	PF00069	0.575
MOD_ProDKin_1	571	577	PF00069	0.646
MOD_ProDKin_1	61	67	PF00069	0.610
MOD_SUMO_for_1	3	6	PF00179	0.506
MOD_SUMO_rev_2	307	315	PF00179	0.412
TRG_DiLeu_BaEn_1	104	109	PF01217	0.413
TRG_DiLeu_BaEn_1	626	631	PF01217	0.502
TRG_DiLeu_BaEn_4	344	350	PF01217	0.496
TRG_DiLeu_LyEn_5	626	631	PF01217	0.502
TRG_ENDOCYTIC_2	273	276	PF00928	0.331
TRG_ER_diArg_1	156	158	PF00400	0.452
TRG_ER_diArg_1	21	24	PF00400	0.550
TRG_ER_diArg_1	248	250	PF00400	0.393
TRG_ER_diArg_1	281	284	PF00400	0.461
TRG_ER_diArg_1	358	361	PF00400	0.521
TRG_ER_diArg_1	399	402	PF00400	0.470
TRG_NES_CRM1_1	42	55	PF08389	0.581
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	580	585	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	622	626	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRK6	Leptomonas seymouri	44%	68%
A0A3Q8IC18	Leishmania donovani	89%	100%
A0A3R7MG27	Trypanosoma rangeli	28%	85%
A4HLC7	Leishmania braziliensis	69%	69%
E9AVI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	89%