Putative histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone deacetylase, putative

Species:

Leishmania major

UniProt:

Q4QBZ5_LEIMA

TriTrypDb:

LmjF.21.1870 , LMJLV39_210028400 , LMJSD75_210028600

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4QBZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBZ5

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	2
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0006476	protein deacetylation	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0016570	histone modification	5	2
GO:0016575	histone deacetylation	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0035601	protein deacylation	5	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0045892	negative regulation of DNA-templated transcription	7	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:0098732	macromolecule deacylation	5	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1902679	negative regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903507	negative regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004407	histone deacetylase activity	4	2
GO:0016787	hydrolase activity	2	3
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	2
GO:0019213	deacetylase activity	3	2
GO:0033558	protein lysine deacetylase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.214
CLV_NRD_NRD_1	153	155	PF00675	0.272
CLV_NRD_NRD_1	23	25	PF00675	0.523
CLV_NRD_NRD_1	310	312	PF00675	0.231
CLV_NRD_NRD_1	373	375	PF00675	0.577
CLV_PCSK_KEX2_1	140	142	PF00082	0.240
CLV_PCSK_KEX2_1	153	155	PF00082	0.258
CLV_PCSK_KEX2_1	23	25	PF00082	0.555
CLV_PCSK_KEX2_1	3	5	PF00082	0.620
CLV_PCSK_KEX2_1	373	375	PF00082	0.568
CLV_PCSK_KEX2_1	614	616	PF00082	0.370
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.620
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.407
CLV_PCSK_SKI1_1	145	149	PF00082	0.297
CLV_PCSK_SKI1_1	207	211	PF00082	0.243
CLV_PCSK_SKI1_1	583	587	PF00082	0.240
DEG_APCC_DBOX_1	518	526	PF00400	0.576
DEG_SCF_FBW7_1	48	55	PF00400	0.697
DEG_SCF_FBW7_2	324	330	PF00400	0.589
DEG_SPOP_SBC_1	407	411	PF00917	0.659
DEG_SPOP_SBC_1	425	429	PF00917	0.597
DOC_ANK_TNKS_1	176	183	PF00023	0.474
DOC_CDC14_PxL_1	50	58	PF14671	0.691
DOC_CKS1_1	324	329	PF01111	0.428
DOC_CKS1_1	49	54	PF01111	0.697
DOC_CYCLIN_RxL_1	580	589	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	46	49	PF00134	0.612
DOC_MAPK_gen_1	516	525	PF00069	0.474
DOC_MAPK_MEF2A_6	10	19	PF00069	0.529
DOC_MAPK_MEF2A_6	516	524	PF00069	0.440
DOC_PIKK_1	330	337	PF02985	0.582
DOC_PP2B_LxvP_1	46	49	PF13499	0.725
DOC_PP2B_PxIxI_1	268	274	PF00149	0.497
DOC_PP4_FxxP_1	117	120	PF00568	0.198
DOC_USP7_MATH_1	354	358	PF00917	0.787
DOC_USP7_MATH_1	366	370	PF00917	0.500
DOC_USP7_MATH_1	407	411	PF00917	0.663
DOC_USP7_MATH_1	417	421	PF00917	0.663
DOC_USP7_MATH_1	57	61	PF00917	0.718
DOC_USP7_MATH_1	575	579	PF00917	0.440
DOC_USP7_MATH_1	68	72	PF00917	0.665
DOC_WW_Pin1_4	108	113	PF00397	0.513
DOC_WW_Pin1_4	323	328	PF00397	0.535
DOC_WW_Pin1_4	449	454	PF00397	0.800
DOC_WW_Pin1_4	478	483	PF00397	0.421
DOC_WW_Pin1_4	48	53	PF00397	0.664
DOC_WW_Pin1_4	540	545	PF00397	0.454
DOC_WW_Pin1_4	84	89	PF00397	0.639
LIG_14-3-3_CanoR_1	122	128	PF00244	0.437
LIG_14-3-3_CanoR_1	311	321	PF00244	0.474
LIG_BIR_III_2	479	483	PF00653	0.511
LIG_BRCT_BRCA1_1	525	529	PF00533	0.440
LIG_Clathr_ClatBox_1	399	403	PF01394	0.585
LIG_EH1_1	547	555	PF00400	0.534
LIG_eIF4E_1	548	554	PF01652	0.534
LIG_FHA_1	282	288	PF00498	0.430
LIG_FHA_1	433	439	PF00498	0.624
LIG_FHA_1	442	448	PF00498	0.552
LIG_FHA_1	468	474	PF00498	0.440
LIG_FHA_1	96	102	PF00498	0.385
LIG_FHA_2	331	337	PF00498	0.504
LIG_FHA_2	456	462	PF00498	0.640
LIG_FHA_2	74	80	PF00498	0.675
LIG_IRF3_LxIS_1	292	298	PF10401	0.534
LIG_LIR_Apic_2	116	120	PF02991	0.282
LIG_LIR_Apic_2	286	292	PF02991	0.425
LIG_LIR_Apic_2	85	89	PF02991	0.554
LIG_LIR_Gen_1	215	224	PF02991	0.474
LIG_LIR_Gen_1	380	388	PF02991	0.516
LIG_LIR_Gen_1	500	511	PF02991	0.440
LIG_LIR_Nem_3	168	173	PF02991	0.524
LIG_LIR_Nem_3	215	221	PF02991	0.474
LIG_LIR_Nem_3	380	384	PF02991	0.516
LIG_LIR_Nem_3	500	506	PF02991	0.440
LIG_MYND_1	40	44	PF01753	0.760
LIG_MYND_1	48	52	PF01753	0.582
LIG_NRBOX	336	342	PF00104	0.534
LIG_SH2_CRK	239	243	PF00017	0.534
LIG_SH2_CRK	381	385	PF00017	0.599
LIG_SH2_NCK_1	239	243	PF00017	0.534
LIG_SH2_NCK_1	289	293	PF00017	0.430
LIG_SH2_SRC	289	292	PF00017	0.440
LIG_SH2_STAP1	102	106	PF00017	0.354
LIG_SH2_STAT5	28	31	PF00017	0.485
LIG_SH2_STAT5	503	506	PF00017	0.440
LIG_SH2_STAT5	548	551	PF00017	0.440
LIG_SH3_3	218	224	PF00018	0.454
LIG_SH3_3	34	40	PF00018	0.545
LIG_SH3_3	348	354	PF00018	0.628
LIG_SH3_3	46	52	PF00018	0.528
LIG_SH3_3	507	513	PF00018	0.455
LIG_SH3_3	85	91	PF00018	0.640
LIG_SUMO_SIM_anti_2	293	298	PF11976	0.440
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.474
LIG_SUMO_SIM_par_1	270	275	PF11976	0.472
LIG_SUMO_SIM_par_1	293	298	PF11976	0.440
LIG_SUMO_SIM_par_1	521	526	PF11976	0.474
LIG_SUMO_SIM_par_1	561	566	PF11976	0.441
LIG_TRAF2_1	460	463	PF00917	0.647
LIG_TYR_ITIM	379	384	PF00017	0.534
LIG_TYR_ITIM	501	506	PF00017	0.440
MOD_CDK_SPxK_1	323	329	PF00069	0.438
MOD_CDK_SPxxK_3	449	456	PF00069	0.593
MOD_CK1_1	18	24	PF00069	0.623
MOD_CK1_1	188	194	PF00069	0.474
MOD_CK1_1	325	331	PF00069	0.571
MOD_CK1_1	342	348	PF00069	0.525
MOD_CK1_1	408	414	PF00069	0.585
MOD_CK1_1	415	421	PF00069	0.566
MOD_CK1_1	424	430	PF00069	0.487
MOD_CK1_1	622	628	PF00069	0.437
MOD_CK2_1	349	355	PF00069	0.638
MOD_CK2_1	445	451	PF00069	0.570
MOD_CK2_1	455	461	PF00069	0.556
MOD_Cter_Amidation	21	24	PF01082	0.598
MOD_Cter_Amidation	371	374	PF01082	0.731
MOD_GlcNHglycan	20	23	PF01048	0.615
MOD_GlcNHglycan	210	213	PF01048	0.274
MOD_GlcNHglycan	314	317	PF01048	0.388
MOD_GlcNHglycan	341	344	PF01048	0.659
MOD_GlcNHglycan	351	354	PF01048	0.684
MOD_GlcNHglycan	415	418	PF01048	0.635
MOD_GlcNHglycan	423	426	PF01048	0.637
MOD_GlcNHglycan	530	533	PF01048	0.237
MOD_GlcNHglycan	544	547	PF01048	0.230
MOD_GlcNHglycan	587	591	PF01048	0.452
MOD_GlcNHglycan	70	73	PF01048	0.550
MOD_GSK3_1	185	192	PF00069	0.491
MOD_GSK3_1	208	215	PF00069	0.557
MOD_GSK3_1	403	410	PF00069	0.571
MOD_GSK3_1	411	418	PF00069	0.558
MOD_GSK3_1	421	428	PF00069	0.557
MOD_GSK3_1	441	448	PF00069	0.619
MOD_GSK3_1	48	55	PF00069	0.663
MOD_GSK3_1	536	543	PF00069	0.444
MOD_GSK3_1	68	75	PF00069	0.592
MOD_N-GLC_1	412	417	PF02516	0.725
MOD_N-GLC_1	418	423	PF02516	0.683
MOD_N-GLC_1	432	437	PF02516	0.687
MOD_NEK2_1	295	300	PF00069	0.552
MOD_NEK2_1	536	541	PF00069	0.434
MOD_NEK2_1	585	590	PF00069	0.384
MOD_NEK2_2	283	288	PF00069	0.443
MOD_NEK2_2	619	624	PF00069	0.377
MOD_PIKK_1	263	269	PF00454	0.398
MOD_PIKK_1	622	628	PF00454	0.489
MOD_PKA_1	311	317	PF00069	0.474
MOD_PKA_2	42	48	PF00069	0.698
MOD_PKA_2	455	461	PF00069	0.714
MOD_Plk_1	102	108	PF00069	0.494
MOD_Plk_1	15	21	PF00069	0.631
MOD_Plk_1	418	424	PF00069	0.646
MOD_Plk_1	425	431	PF00069	0.794
MOD_Plk_1	78	84	PF00069	0.733
MOD_Plk_4	102	108	PF00069	0.434
MOD_Plk_4	283	289	PF00069	0.451
MOD_Plk_4	290	296	PF00069	0.462
MOD_Plk_4	42	48	PF00069	0.708
MOD_Plk_4	605	611	PF00069	0.340
MOD_ProDKin_1	108	114	PF00069	0.523
MOD_ProDKin_1	323	329	PF00069	0.535
MOD_ProDKin_1	449	455	PF00069	0.635
MOD_ProDKin_1	478	484	PF00069	0.421
MOD_ProDKin_1	48	54	PF00069	0.663
MOD_ProDKin_1	540	546	PF00069	0.454
MOD_ProDKin_1	84	90	PF00069	0.639
MOD_SUMO_rev_2	7	12	PF00179	0.635
TRG_DiLeu_BaEn_1	502	507	PF01217	0.474
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.591
TRG_ENDOCYTIC_2	239	242	PF00928	0.534
TRG_ENDOCYTIC_2	381	384	PF00928	0.521
TRG_ENDOCYTIC_2	503	506	PF00928	0.440
TRG_ENDOCYTIC_2	547	550	PF00928	0.425
TRG_ER_diArg_1	140	142	PF00400	0.417
TRG_ER_diArg_1	152	154	PF00400	0.468
TRG_ER_diArg_1	23	25	PF00400	0.612
TRG_ER_diArg_1	373	376	PF00400	0.618
TRG_NES_CRM1_1	162	175	PF08389	0.506
TRG_NLS_MonoExtC_3	2	8	PF00514	0.676
TRG_NLS_MonoExtN_4	2	7	PF00514	0.686
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.240
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R2	Leptomonas seymouri	61%	93%
A0A0S4JEE2	Bodo saltans	38%	100%
A0A1X0NJV3	Trypanosomatidae	47%	96%
A0A3S7WWW4	Leishmania donovani	93%	100%
A0A422N700	Trypanosoma rangeli	49%	99%
A4HLD0	Leishmania braziliensis	81%	100%
A4HTR2	Leishmania infantum	93%	100%
C9ZIZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	92%
E9AVI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	90%
V5BFA4	Trypanosoma cruzi	47%	100%