CLN3 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

CLN3 protein

Gene product:

CLN3 protein, putative

Species:

Leishmania major

UniProt:

Q4QBZ3_LEIMA

TriTrypDb:

LmjF.06.1300 , LMJLV39_060020000 , LMJSD75_220005000

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	13
GO:0016020	membrane	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

Q4QBZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBZ3

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	2
GO:0006885	regulation of pH	8	2
GO:0009987	cellular process	1	2
GO:0019725	cellular homeostasis	2	2
GO:0030003	intracellular monoatomic cation homeostasis	5	2
GO:0030004	obsolete cellular monovalent inorganic cation homeostasis	6	2
GO:0030641	regulation of cellular pH	7	2
GO:0042592	homeostatic process	3	2
GO:0048878	chemical homeostasis	4	2
GO:0050801	monoatomic ion homeostasis	5	2
GO:0051453	regulation of intracellular pH	8	2
GO:0055067	obsolete monovalent inorganic cation homeostasis	7	2
GO:0055080	monoatomic cation homeostasis	6	2
GO:0055082	intracellular chemical homeostasis	3	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0098771	inorganic ion homeostasis	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.518
CLV_C14_Caspase3-7	401	405	PF00656	0.313
CLV_C14_Caspase3-7	586	590	PF00656	0.520
CLV_MEL_PAP_1	129	135	PF00089	0.292
CLV_NRD_NRD_1	254	256	PF00675	0.254
CLV_NRD_NRD_1	28	30	PF00675	0.550
CLV_NRD_NRD_1	354	356	PF00675	0.325
CLV_NRD_NRD_1	528	530	PF00675	0.429
CLV_NRD_NRD_1	536	538	PF00675	0.408
CLV_NRD_NRD_1	605	607	PF00675	0.378
CLV_PCSK_FUR_1	54	58	PF00082	0.386
CLV_PCSK_KEX2_1	354	356	PF00082	0.249
CLV_PCSK_KEX2_1	500	502	PF00082	0.365
CLV_PCSK_KEX2_1	528	530	PF00082	0.422
CLV_PCSK_KEX2_1	56	58	PF00082	0.371
CLV_PCSK_KEX2_1	605	607	PF00082	0.288
CLV_PCSK_KEX2_1	67	69	PF00082	0.303
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.365
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.379
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.261
CLV_PCSK_SKI1_1	255	259	PF00082	0.299
CLV_PCSK_SKI1_1	544	548	PF00082	0.422
CLV_PCSK_SKI1_1	64	68	PF00082	0.331
DEG_APCC_DBOX_1	426	434	PF00400	0.420
DEG_Nend_UBRbox_1	1	4	PF02207	0.683
DOC_CKS1_1	235	240	PF01111	0.403
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.325
DOC_MAPK_gen_1	466	474	PF00069	0.300
DOC_MAPK_gen_1	605	612	PF00069	0.489
DOC_MAPK_MEF2A_6	358	366	PF00069	0.503
DOC_MAPK_MEF2A_6	427	435	PF00069	0.420
DOC_MAPK_MEF2A_6	466	474	PF00069	0.292
DOC_MAPK_MEF2A_6	72	79	PF00069	0.492
DOC_PP1_RVXF_1	310	317	PF00149	0.518
DOC_PP2B_LxvP_1	390	393	PF13499	0.325
DOC_PP4_FxxP_1	155	158	PF00568	0.361
DOC_USP7_MATH_1	143	147	PF00917	0.308
DOC_USP7_MATH_1	203	207	PF00917	0.366
DOC_USP7_MATH_1	325	329	PF00917	0.482
DOC_USP7_MATH_1	562	566	PF00917	0.771
DOC_USP7_MATH_1	94	98	PF00917	0.318
DOC_USP7_UBL2_3	462	466	PF12436	0.254
DOC_USP7_UBL2_3	551	555	PF12436	0.683
DOC_WW_Pin1_4	234	239	PF00397	0.404
DOC_WW_Pin1_4	250	255	PF00397	0.249
DOC_WW_Pin1_4	316	321	PF00397	0.505
DOC_WW_Pin1_4	345	350	PF00397	0.500
LIG_14-3-3_CanoR_1	132	136	PF00244	0.453
LIG_14-3-3_CanoR_1	138	144	PF00244	0.270
LIG_14-3-3_CanoR_1	312	317	PF00244	0.518
LIG_14-3-3_CanoR_1	427	431	PF00244	0.420
LIG_14-3-3_CanoR_1	501	506	PF00244	0.535
LIG_14-3-3_CanoR_1	72	76	PF00244	0.455
LIG_Actin_WH2_2	622	639	PF00022	0.406
LIG_BRCT_BRCA1_1	215	219	PF00533	0.285
LIG_deltaCOP1_diTrp_1	399	407	PF00928	0.272
LIG_eIF4E_1	102	108	PF01652	0.292
LIG_eIF4E_1	419	425	PF01652	0.290
LIG_FHA_1	23	29	PF00498	0.577
LIG_FHA_1	230	236	PF00498	0.302
LIG_FHA_1	616	622	PF00498	0.325
LIG_FHA_2	181	187	PF00498	0.363
LIG_FHA_2	502	508	PF00498	0.521
LIG_FHA_2	582	588	PF00498	0.618
LIG_FHA_2	623	629	PF00498	0.406
LIG_GBD_Chelix_1	169	177	PF00786	0.361
LIG_LIR_Apic_2	154	158	PF02991	0.361
LIG_LIR_Apic_2	395	400	PF02991	0.330
LIG_LIR_Gen_1	112	121	PF02991	0.270
LIG_LIR_Gen_1	166	176	PF02991	0.307
LIG_LIR_Gen_1	473	482	PF02991	0.324
LIG_LIR_Gen_1	490	499	PF02991	0.168
LIG_LIR_Gen_1	74	83	PF02991	0.361
LIG_LIR_Nem_3	112	116	PF02991	0.270
LIG_LIR_Nem_3	216	222	PF02991	0.261
LIG_LIR_Nem_3	370	376	PF02991	0.350
LIG_LIR_Nem_3	473	477	PF02991	0.324
LIG_LIR_Nem_3	490	494	PF02991	0.168
LIG_LIR_Nem_3	74	79	PF02991	0.340
LIG_NRBOX	143	149	PF00104	0.418
LIG_Pex14_1	113	117	PF04695	0.310
LIG_Pex14_1	402	406	PF04695	0.325
LIG_Pex14_1	78	82	PF04695	0.361
LIG_Pex14_2	117	121	PF04695	0.381
LIG_Pex14_2	151	155	PF04695	0.408
LIG_Pex14_2	82	86	PF04695	0.346
LIG_PTB_Apo_2	490	497	PF02174	0.274
LIG_PTB_Apo_2	70	77	PF02174	0.525
LIG_PTB_Apo_2	82	89	PF02174	0.203
LIG_PTB_Phospho_1	490	496	PF10480	0.290
LIG_PTB_Phospho_1	82	88	PF10480	0.271
LIG_Rb_LxCxE_1	268	288	PF01857	0.454
LIG_SH2_CRK	162	166	PF00017	0.186
LIG_SH2_CRK	616	620	PF00017	0.286
LIG_SH2_CRK	88	92	PF00017	0.274
LIG_SH2_GRB2like	491	494	PF00017	0.261
LIG_SH2_NCK_1	162	166	PF00017	0.186
LIG_SH2_NCK_1	616	620	PF00017	0.271
LIG_SH2_PTP2	437	440	PF00017	0.310
LIG_SH2_PTP2	491	494	PF00017	0.261
LIG_SH2_SRC	491	494	PF00017	0.261
LIG_SH2_STAP1	303	307	PF00017	0.499
LIG_SH2_STAP1	386	390	PF00017	0.274
LIG_SH2_STAT3	386	389	PF00017	0.261
LIG_SH2_STAT5	273	276	PF00017	0.522
LIG_SH2_STAT5	303	306	PF00017	0.403
LIG_SH2_STAT5	382	385	PF00017	0.274
LIG_SH2_STAT5	397	400	PF00017	0.220
LIG_SH2_STAT5	412	415	PF00017	0.408
LIG_SH2_STAT5	437	440	PF00017	0.310
LIG_SH2_STAT5	460	463	PF00017	0.335
LIG_SH2_STAT5	491	494	PF00017	0.271
LIG_SH2_STAT5	496	499	PF00017	0.426
LIG_SH2_STAT5	517	520	PF00017	0.628
LIG_SH2_STAT5	88	91	PF00017	0.288
LIG_SH3_3	232	238	PF00018	0.361
LIG_SH3_3	31	37	PF00018	0.566
LIG_SH3_3	319	325	PF00018	0.496
LIG_SH3_3	430	436	PF00018	0.525
LIG_SUMO_SIM_anti_2	428	434	PF11976	0.492
LIG_SUMO_SIM_anti_2	625	632	PF11976	0.281
LIG_SUMO_SIM_par_1	106	112	PF11976	0.362
LIG_SUMO_SIM_par_1	174	180	PF11976	0.441
LIG_SUMO_SIM_par_1	295	302	PF11976	0.513
LIG_TRAF2_1	328	331	PF00917	0.424
LIG_TRAF2_1	584	587	PF00917	0.558
LIG_TYR_ITIM	435	440	PF00017	0.310
LIG_TYR_ITIM	494	499	PF00017	0.290
LIG_UBA3_1	248	256	PF00899	0.308
LIG_WRC_WIRS_1	152	157	PF05994	0.290
LIG_WRC_WIRS_1	189	194	PF05994	0.403
MOD_CDC14_SPxK_1	253	256	PF00782	0.361
MOD_CDK_SPK_2	250	255	PF00069	0.308
MOD_CDK_SPxK_1	250	256	PF00069	0.361
MOD_CK1_1	205	211	PF00069	0.282
MOD_CK1_1	426	432	PF00069	0.261
MOD_CK2_1	180	186	PF00069	0.278
MOD_CK2_1	295	301	PF00069	0.340
MOD_CK2_1	325	331	PF00069	0.345
MOD_CK2_1	39	45	PF00069	0.667
MOD_CK2_1	501	507	PF00069	0.351
MOD_CK2_1	581	587	PF00069	0.512
MOD_CK2_1	94	100	PF00069	0.408
MOD_Cter_Amidation	526	529	PF01082	0.569
MOD_GlcNHglycan	165	168	PF01048	0.395
MOD_GlcNHglycan	205	208	PF01048	0.261
MOD_GlcNHglycan	210	213	PF01048	0.261
MOD_GlcNHglycan	223	226	PF01048	0.261
MOD_GlcNHglycan	326	330	PF01048	0.360
MOD_GlcNHglycan	45	49	PF01048	0.588
MOD_GlcNHglycan	524	528	PF01048	0.507
MOD_GlcNHglycan	570	573	PF01048	0.556
MOD_GlcNHglycan	92	95	PF01048	0.293
MOD_GSK3_1	180	187	PF00069	0.300
MOD_GSK3_1	221	228	PF00069	0.325
MOD_GSK3_1	229	236	PF00069	0.310
MOD_GSK3_1	297	304	PF00069	0.431
MOD_GSK3_1	312	319	PF00069	0.378
MOD_GSK3_1	35	42	PF00069	0.654
MOD_GSK3_1	460	467	PF00069	0.430
MOD_GSK3_1	564	571	PF00069	0.580
MOD_GSK3_1	615	622	PF00069	0.290
MOD_GSK3_1	90	97	PF00069	0.373
MOD_N-GLC_1	163	168	PF02516	0.445
MOD_NEK2_1	128	133	PF00069	0.344
MOD_NEK2_1	142	147	PF00069	0.252
MOD_NEK2_1	151	156	PF00069	0.211
MOD_NEK2_1	177	182	PF00069	0.332
MOD_NEK2_1	220	225	PF00069	0.270
MOD_NEK2_1	233	238	PF00069	0.242
MOD_NEK2_1	258	263	PF00069	0.416
MOD_NEK2_1	367	372	PF00069	0.432
MOD_NEK2_1	499	504	PF00069	0.350
MOD_NEK2_1	615	620	PF00069	0.295
MOD_NEK2_1	629	634	PF00069	0.305
MOD_NEK2_1	636	641	PF00069	0.420
MOD_NEK2_1	66	71	PF00069	0.458
MOD_NEK2_1	90	95	PF00069	0.282
MOD_PIKK_1	225	231	PF00454	0.373
MOD_PIKK_1	39	45	PF00454	0.472
MOD_PIKK_1	562	568	PF00454	0.586
MOD_PIKK_1	573	579	PF00454	0.468
MOD_PIKK_1	581	587	PF00454	0.292
MOD_PKA_1	500	506	PF00069	0.374
MOD_PKA_2	131	137	PF00069	0.294
MOD_PKA_2	426	432	PF00069	0.261
MOD_PKA_2	500	506	PF00069	0.378
MOD_PKA_2	71	77	PF00069	0.366
MOD_Plk_1	163	169	PF00069	0.445
MOD_Plk_1	301	307	PF00069	0.350
MOD_Plk_2-3	295	301	PF00069	0.340
MOD_Plk_4	143	149	PF00069	0.300
MOD_Plk_4	184	190	PF00069	0.313
MOD_Plk_4	196	202	PF00069	0.278
MOD_Plk_4	213	219	PF00069	0.151
MOD_Plk_4	229	235	PF00069	0.256
MOD_Plk_4	408	414	PF00069	0.298
MOD_Plk_4	426	432	PF00069	0.153
MOD_Plk_4	470	476	PF00069	0.369
MOD_Plk_4	487	493	PF00069	0.155
MOD_Plk_4	622	628	PF00069	0.280
MOD_Plk_4	631	637	PF00069	0.423
MOD_Plk_4	71	77	PF00069	0.375
MOD_ProDKin_1	234	240	PF00069	0.404
MOD_ProDKin_1	250	256	PF00069	0.249
MOD_ProDKin_1	316	322	PF00069	0.379
MOD_ProDKin_1	345	351	PF00069	0.373
MOD_SUMO_for_1	550	553	PF00179	0.527
TRG_DiLeu_BaEn_1	543	548	PF01217	0.378
TRG_DiLeu_BaEn_4	330	336	PF01217	0.361
TRG_ENDOCYTIC_2	162	165	PF00928	0.213
TRG_ENDOCYTIC_2	437	440	PF00928	0.310
TRG_ENDOCYTIC_2	491	494	PF00928	0.269
TRG_ENDOCYTIC_2	496	499	PF00928	0.272
TRG_ENDOCYTIC_2	616	619	PF00928	0.271
TRG_ENDOCYTIC_2	88	91	PF00928	0.274
TRG_ER_diArg_1	353	355	PF00400	0.408
TRG_ER_diArg_1	528	530	PF00400	0.431
TRG_NLS_MonoExtC_3	536	542	PF00514	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N3	Leptomonas seymouri	50%	88%
A0A0S4IMH8	Bodo saltans	40%	100%
A0A1X0NL65	Trypanosomatidae	38%	100%
A0A1X0NM99	Trypanosomatidae	40%	100%
A0A3Q8IBB0	Leishmania donovani	92%	100%
A0A3R7MV96	Trypanosoma rangeli	40%	100%
A4HC54	Leishmania braziliensis	79%	100%
A4HT21	Leishmania infantum	91%	100%
C9ZTE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AVI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q29611	Canis lupus familiaris	24%	100%
V5DU41	Trypanosoma cruzi	41%	100%