Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBY9_LEIMA

TriTrypDb:

LmjF.22.0050 , LMJLV39_220005500 , LMJSD75_220005600

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.706
CLV_C14_Caspase3-7	407	411	PF00656	0.740
CLV_NRD_NRD_1	138	140	PF00675	0.459
CLV_NRD_NRD_1	261	263	PF00675	0.628
CLV_NRD_NRD_1	271	273	PF00675	0.586
CLV_NRD_NRD_1	311	313	PF00675	0.479
CLV_NRD_NRD_1	336	338	PF00675	0.614
CLV_NRD_NRD_1	420	422	PF00675	0.680
CLV_PCSK_FUR_1	418	422	PF00082	0.710
CLV_PCSK_KEX2_1	140	142	PF00082	0.532
CLV_PCSK_KEX2_1	205	207	PF00082	0.473
CLV_PCSK_KEX2_1	216	218	PF00082	0.582
CLV_PCSK_KEX2_1	231	233	PF00082	0.606
CLV_PCSK_KEX2_1	261	263	PF00082	0.604
CLV_PCSK_KEX2_1	311	313	PF00082	0.479
CLV_PCSK_KEX2_1	336	338	PF00082	0.614
CLV_PCSK_KEX2_1	354	356	PF00082	0.637
CLV_PCSK_KEX2_1	420	422	PF00082	0.754
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.379
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.521
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.467
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.623
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.679
CLV_PCSK_SKI1_1	420	424	PF00082	0.786
CLV_PCSK_SKI1_1	434	438	PF00082	0.629
CLV_PCSK_SKI1_1	456	460	PF00082	0.612
CLV_PCSK_SKI1_1	73	77	PF00082	0.596
CLV_Separin_Metazoa	165	169	PF03568	0.494
CLV_Separin_Metazoa	253	257	PF03568	0.618
DEG_APCC_DBOX_1	121	129	PF00400	0.549
DEG_APCC_DBOX_1	402	410	PF00400	0.724
DEG_COP1_1	17	26	PF00400	0.644
DEG_SPOP_SBC_1	5	9	PF00917	0.744
DOC_MAPK_gen_1	278	285	PF00069	0.574
DOC_PP2B_LxvP_1	466	469	PF13499	0.539
DOC_PP4_MxPP_1	1	4	PF00568	0.774
DOC_USP7_MATH_1	113	117	PF00917	0.473
DOC_USP7_MATH_1	37	41	PF00917	0.631
DOC_USP7_MATH_1	428	432	PF00917	0.676
DOC_USP7_MATH_1	5	9	PF00917	0.552
DOC_WW_Pin1_4	15	20	PF00397	0.737
DOC_WW_Pin1_4	426	431	PF00397	0.679
LIG_14-3-3_CanoR_1	122	130	PF00244	0.596
LIG_14-3-3_CanoR_1	171	175	PF00244	0.566
LIG_14-3-3_CanoR_1	29	34	PF00244	0.673
LIG_14-3-3_CanoR_1	420	427	PF00244	0.670
LIG_14-3-3_CanoR_1	456	466	PF00244	0.711
LIG_14-3-3_CanoR_1	73	78	PF00244	0.658
LIG_Actin_WH2_2	222	239	PF00022	0.572
LIG_Actin_WH2_2	331	348	PF00022	0.606
LIG_Actin_WH2_2	79	96	PF00022	0.607
LIG_BRCT_BRCA1_1	158	162	PF00533	0.534
LIG_BRCT_BRCA1_1	367	371	PF00533	0.588
LIG_Clathr_ClatBox_1	111	115	PF01394	0.496
LIG_deltaCOP1_diTrp_1	27	33	PF00928	0.669
LIG_DLG_GKlike_1	217	225	PF00625	0.572
LIG_EH1_1	105	113	PF00400	0.620
LIG_FHA_1	118	124	PF00498	0.514
LIG_FHA_1	151	157	PF00498	0.503
LIG_FHA_1	18	24	PF00498	0.762
LIG_FHA_1	98	104	PF00498	0.402
LIG_FHA_2	302	308	PF00498	0.588
LIG_FHA_2	9	15	PF00498	0.735
LIG_LIR_Gen_1	250	257	PF02991	0.562
LIG_LIR_Gen_1	27	37	PF02991	0.590
LIG_LIR_Gen_1	279	289	PF02991	0.515
LIG_LIR_Nem_3	190	195	PF02991	0.523
LIG_LIR_Nem_3	250	254	PF02991	0.553
LIG_LIR_Nem_3	27	33	PF02991	0.571
LIG_LIR_Nem_3	279	285	PF02991	0.520
LIG_SH2_GRB2like	189	192	PF00017	0.414
LIG_SH2_NCK_1	425	429	PF00017	0.693
LIG_SH2_SRC	68	71	PF00017	0.624
LIG_SH2_STAP1	203	207	PF00017	0.564
LIG_SH2_STAP1	251	255	PF00017	0.623
LIG_SUMO_SIM_par_1	109	117	PF11976	0.572
LIG_TRAF2_1	12	15	PF00917	0.751
LIG_TRAF2_1	239	242	PF00917	0.628
LIG_TRAF2_1	25	28	PF00917	0.532
LIG_TRAF2_1	300	303	PF00917	0.587
LIG_TRAF2_1	328	331	PF00917	0.503
LIG_TRAF2_1	460	463	PF00917	0.674
LIG_TRAF2_1	67	70	PF00917	0.628
MOD_CK1_1	40	46	PF00069	0.589
MOD_CK1_1	457	463	PF00069	0.645
MOD_CK1_1	48	54	PF00069	0.597
MOD_CK1_1	8	14	PF00069	0.599
MOD_CK2_1	187	193	PF00069	0.587
MOD_CK2_1	22	28	PF00069	0.616
MOD_CK2_1	236	242	PF00069	0.624
MOD_CK2_1	43	49	PF00069	0.662
MOD_CK2_1	457	463	PF00069	0.649
MOD_CK2_1	8	14	PF00069	0.738
MOD_CK2_1	96	102	PF00069	0.433
MOD_GlcNHglycan	406	409	PF01048	0.710
MOD_GlcNHglycan	456	459	PF01048	0.665
MOD_GSK3_1	113	120	PF00069	0.315
MOD_GSK3_1	15	22	PF00069	0.653
MOD_GSK3_1	166	173	PF00069	0.533
MOD_GSK3_1	187	194	PF00069	0.604
MOD_GSK3_1	236	243	PF00069	0.555
MOD_GSK3_1	4	11	PF00069	0.727
MOD_GSK3_1	93	100	PF00069	0.455
MOD_NEK2_1	118	123	PF00069	0.550
MOD_NEK2_1	156	161	PF00069	0.547
MOD_NEK2_1	170	175	PF00069	0.450
MOD_NEK2_1	225	230	PF00069	0.540
MOD_NEK2_1	6	11	PF00069	0.769
MOD_PIKK_1	68	74	PF00454	0.621
MOD_PKA_1	420	426	PF00069	0.742
MOD_PKA_2	170	176	PF00069	0.527
MOD_PKA_2	28	34	PF00069	0.671
MOD_PKA_2	404	410	PF00069	0.719
MOD_PKA_2	420	426	PF00069	0.742
MOD_PKA_2	93	99	PF00069	0.602
MOD_PKB_1	299	307	PF00069	0.640
MOD_PKB_1	418	426	PF00069	0.704
MOD_PKB_1	447	455	PF00069	0.655
MOD_Plk_1	301	307	PF00069	0.614
MOD_Plk_1	40	46	PF00069	0.604
MOD_Plk_4	301	307	PF00069	0.620
MOD_ProDKin_1	15	21	PF00069	0.735
MOD_ProDKin_1	426	432	PF00069	0.680
MOD_SUMO_for_1	230	233	PF00179	0.612
MOD_SUMO_rev_2	137	142	PF00179	0.375
TRG_DiLeu_BaEn_1	250	255	PF01217	0.622
TRG_DiLeu_BaEn_4	137	143	PF01217	0.610
TRG_ENDOCYTIC_2	189	192	PF00928	0.492
TRG_ENDOCYTIC_2	251	254	PF00928	0.587
TRG_ER_diArg_1	139	142	PF00400	0.566
TRG_ER_diArg_1	298	301	PF00400	0.590
TRG_ER_diArg_1	336	338	PF00400	0.574
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S5	Leptomonas seymouri	67%	91%
A0A1X0NTJ5	Trypanosomatidae	32%	78%
A0A3S7WWY1	Leishmania donovani	93%	100%
A0A422N4N0	Trypanosoma rangeli	35%	75%
A4HC57	Leishmania braziliensis	85%	100%
E9AGY5	Leishmania infantum	94%	81%
E9AVJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BK97	Trypanosoma cruzi	36%	100%